Transactions of the Association of American Physicians最新文献

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The role of outer membrane protein A in Escherichia coli K-1 pathogenesis. 外膜蛋白A在大肠杆菌K-1发病机制中的作用。
J N Weiser, E C Gotschlich
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引用次数: 0
Targeting of single-chain urokinase plasminogen activator by conjugation to an antiplatelet antibody results in enhanced clot lysis. 通过偶联抗血小板抗体靶向单链尿激酶纤溶酶原激活剂可增强凝块溶解。
C Bode, T Nordt, U Detlefs-Bartels, M S Runge, M Arens, W Kübler, E Haber
{"title":"Targeting of single-chain urokinase plasminogen activator by conjugation to an antiplatelet antibody results in enhanced clot lysis.","authors":"C Bode, T Nordt, U Detlefs-Bartels, M S Runge, M Arens, W Kübler, E Haber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types. 含有人类免疫缺陷病毒包膜多决定簇的肽可诱导不同组织相容性类型的小鼠和人t细胞反应。
J A Berzofsky, C D Pendleton, M Clerici, J Ahlers, D R Lucey, S D Putney, G M Shearer
{"title":"Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types.","authors":"J A Berzofsky, C D Pendleton, M Clerici, J Ahlers, D R Lucey, S D Putney, G M Shearer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional analyses of the type I human T-cell leukemia virus tax gene product. I型人t细胞白血病病毒tax基因产物的功能分析。
M R Smith, W C Greene
{"title":"Functional analyses of the type I human T-cell leukemia virus tax gene product.","authors":"M R Smith, W C Greene","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"78-91"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human gamma delta T cells amplify IgE production by Epstein-Barr virus-activated B cells. 人γ δ T细胞通过eb病毒激活的B细胞扩增IgE的产生。
L Di Fabrizio, M Nassef, R Ware, V P Butler, L Chess
{"title":"Human gamma delta T cells amplify IgE production by Epstein-Barr virus-activated B cells.","authors":"L Di Fabrizio,&nbsp;M Nassef,&nbsp;R Ware,&nbsp;V P Butler,&nbsp;L Chess","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In summary, these data document that gamma delta T cells regulate B cell differentiation, antibody synthesis, and IgE secretion in EBV-activated B cells. The classical \"helper\" subset of CD4+ alpha beta T cells, although potent inducers of other Ig isotypes, are not as efficient in augmenting IgE synthesis. However, interactions between alpha beta and gamma delta cells enhance the IgE response further. The precise mechanism by which gamma delta T cells function to augment IgE secretion is under study. It will be important, for example, to determine whether gamma delta T cells, or products of these cells, directly regulate class switching or mediate the clonal expansion of IgE-expressing B cells. In this regard, we ruled out the possibility that IL-4 release alone could replace gamma delta cells in increasing IgE secretion. Finally, we think it is of potential interest that gamma delta cells migrate to skin epithelia as well as gastrointestinal and pulmonary mucosa, sites of invasion by parasitic organisms and contact with allergens. If gamma delta T cells were specifically activated, either directly or indirectly, by these foreign pathogens, then the data presented here might elucidate the cellular basis for the events leading to IgE secretion, a critical step in the immune response to both parasites and allergens.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"155-63"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12835122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor. -肾上腺素能受体激酶在- 2-肾上腺素能受体脱敏中的作用。
S B Liggett, J Ostrowski, L C Chesnut, M G Caron, R J Lefkowitz
{"title":"Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor.","authors":"S B Liggett,&nbsp;J Ostrowski,&nbsp;L C Chesnut,&nbsp;M G Caron,&nbsp;R J Lefkowitz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"40-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12835125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrin-fibrin and alpha 2-antiplasmin-fibrin cross-linking by platelet factor XIII increases the resistance of platelet clots to fibrinolysis. 纤维蛋白-纤维蛋白和α 2-抗纤溶蛋白-纤维蛋白通过血小板因子XIII交联增加血小板凝块对纤维蛋白溶解的抵抗力。
G L Reed, G R Matsueda, E Haber
{"title":"Fibrin-fibrin and alpha 2-antiplasmin-fibrin cross-linking by platelet factor XIII increases the resistance of platelet clots to fibrinolysis.","authors":"G L Reed,&nbsp;G R Matsueda,&nbsp;E Haber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"21-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dose pooled immunoglobulin in the therapy of systemic vasculitis. 大剂量混合免疫球蛋白治疗全身性血管炎。
D R Jayne, C M Lockwood
{"title":"High-dose pooled immunoglobulin in the therapy of systemic vasculitis.","authors":"D R Jayne,&nbsp;C M Lockwood","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"304-12"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular response to activation of leukocytes in atherosclerotic primates. 动脉粥样硬化灵长类动物对白细胞活化的血管反应。
D D Heistad, J A Lopez, A Mügge, P Densen, R Padgett, M L Armstrong
{"title":"Vascular response to activation of leukocytes in atherosclerotic primates.","authors":"D D Heistad,&nbsp;J A Lopez,&nbsp;A Mügge,&nbsp;P Densen,&nbsp;R Padgett,&nbsp;M L Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"150-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13007239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport. 二酰基甘油/蛋白激酶C信号在胰岛素刺激的葡萄糖运输中的作用。
R V Farese, M L Standaert, T Ishizuka, B Yu, T P Arnold, D R Cooper
{"title":"The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport.","authors":"R V Farese,&nbsp;M L Standaert,&nbsp;T Ishizuka,&nbsp;B Yu,&nbsp;T P Arnold,&nbsp;D R Cooper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There seems to be little doubt that insulin rapidly perturbs phospholipid metabolism, and this appears to increase DAG/PKC signaling in many target tissues. Considerable new evidence further suggests that DAG/PKC signaling plays an important role in insulin-stimulated glucose transport. Further studies are needed to test this hypothesis and examine its importance in states of clinical insulin resistance.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"187-93"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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