{"title":"The role of outer membrane protein A in Escherichia coli K-1 pathogenesis.","authors":"J N Weiser, E C Gotschlich","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"278-84"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Bode, T Nordt, U Detlefs-Bartels, M S Runge, M Arens, W Kübler, E Haber
{"title":"Targeting of single-chain urokinase plasminogen activator by conjugation to an antiplatelet antibody results in enhanced clot lysis.","authors":"C Bode, T Nordt, U Detlefs-Bartels, M S Runge, M Arens, W Kübler, E Haber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J A Berzofsky, C D Pendleton, M Clerici, J Ahlers, D R Lucey, S D Putney, G M Shearer
{"title":"Peptides containing multideterminant clusters of human immunodeficiency virus envelope induce murine and human T-cell responses in diverse histocompatibility types.","authors":"J A Berzofsky, C D Pendleton, M Clerici, J Ahlers, D R Lucey, S D Putney, G M Shearer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional analyses of the type I human T-cell leukemia virus tax gene product.","authors":"M R Smith, W C Greene","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"78-91"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Di Fabrizio, M Nassef, R Ware, V P Butler, L Chess
{"title":"Human gamma delta T cells amplify IgE production by Epstein-Barr virus-activated B cells.","authors":"L Di Fabrizio, M Nassef, R Ware, V P Butler, L Chess","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In summary, these data document that gamma delta T cells regulate B cell differentiation, antibody synthesis, and IgE secretion in EBV-activated B cells. The classical \"helper\" subset of CD4+ alpha beta T cells, although potent inducers of other Ig isotypes, are not as efficient in augmenting IgE synthesis. However, interactions between alpha beta and gamma delta cells enhance the IgE response further. The precise mechanism by which gamma delta T cells function to augment IgE secretion is under study. It will be important, for example, to determine whether gamma delta T cells, or products of these cells, directly regulate class switching or mediate the clonal expansion of IgE-expressing B cells. In this regard, we ruled out the possibility that IL-4 release alone could replace gamma delta cells in increasing IgE secretion. Finally, we think it is of potential interest that gamma delta cells migrate to skin epithelia as well as gastrointestinal and pulmonary mucosa, sites of invasion by parasitic organisms and contact with allergens. If gamma delta T cells were specifically activated, either directly or indirectly, by these foreign pathogens, then the data presented here might elucidate the cellular basis for the events leading to IgE secretion, a critical step in the immune response to both parasites and allergens.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"155-63"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12835122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S B Liggett, J Ostrowski, L C Chesnut, M G Caron, R J Lefkowitz
{"title":"Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor.","authors":"S B Liggett, J Ostrowski, L C Chesnut, M G Caron, R J Lefkowitz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"40-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12835125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibrin-fibrin and alpha 2-antiplasmin-fibrin cross-linking by platelet factor XIII increases the resistance of platelet clots to fibrinolysis.","authors":"G L Reed, G R Matsueda, E Haber","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"21-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-dose pooled immunoglobulin in the therapy of systemic vasculitis.","authors":"D R Jayne, C M Lockwood","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"304-12"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D D Heistad, J A Lopez, A Mügge, P Densen, R Padgett, M L Armstrong
{"title":"Vascular response to activation of leukocytes in atherosclerotic primates.","authors":"D D Heistad, J A Lopez, A Mügge, P Densen, R Padgett, M L Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"150-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13007239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R V Farese, M L Standaert, T Ishizuka, B Yu, T P Arnold, D R Cooper
{"title":"The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport.","authors":"R V Farese, M L Standaert, T Ishizuka, B Yu, T P Arnold, D R Cooper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There seems to be little doubt that insulin rapidly perturbs phospholipid metabolism, and this appears to increase DAG/PKC signaling in many target tissues. Considerable new evidence further suggests that DAG/PKC signaling plays an important role in insulin-stimulated glucose transport. Further studies are needed to test this hypothesis and examine its importance in states of clinical insulin resistance.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"187-93"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}