Transactions of the Association of American Physicians最新文献_第7页

{"title":"Aromatase expression in extragonadal tissues of the Sebright chicken is controlled by a retroviral promoter.","authors":"M J McPhaul, H Matsumine, M A Herbst, J D Wilson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>These studies have clarified a number of issues regarding the genetic control of extragonadal aromatase expression in birds carrying the henny-feathering trait. The marked increased in extragonadal aromatase expression of a unique species of aromatase mRNA is apparently controlled by a retrovirus. We have not yet established whether this promoter is the consequence of a new retroviral insertion or is due to a mutation in a preexisting retrovirus. It is of interest in this regard that the chicken aromatase gene is located in a region of chromosome 1 known to be rich in retroviral insertions. Second, the relationship of the henny-feathering trait to normal and abnormal extragonadal aromatase expression in man remains to be determined. At one extreme, it is possible that a similar mechanism may underlie syndromes typified by increases in extraglandular aromatase expression. Even if the parallel proves to be less exact, the Sebright chicken provides important insight into how aromatase expression may be modulated differently in different tissues. Finally, the discovery that retroviral sequences appear to modulate the expression of aromatase in extragonadal tissues represents an unusual method by which the genetic control of genes can be altered. In the case of the henny-feathering trait, the alteration in the dimorphic feathering pattern was the principal clue to the altered regulation of extragonadal aromatase. This relation is in keeping with the other examples of altered gene expression caused by retroviruses that have also caused morphologic alterations such as changes in coat color or the appearance of neoplasms (for examples, see Refs. 14-16).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"104 ","pages":"141-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical dilemma in continuing a zidovudine-placebo trial in symptomatic human immunodeficiency virus infection. 在症状性人类免疫缺陷病毒感染中继续进行齐多夫定安慰剂试验的伦理困境。

Transactions of the Association of American Physicians Pub Date : 1991-01-01

M S Simberkoff, P M Hartigan, J D Hamilton

引用次数: 0

Human Fc gamma receptor structure/function relationships. 人类Fc γ受体结构/功能关系。

Transactions of the Association of American Physicians Pub Date : 1991-01-01

Z Indik, P Chien, A I Levinson, A D Schreiber

引用次数: 0