{"title":"Homing of liver-derived hemopoietic stem cells to fetal bone marrow.","authors":"E D Zanjani, J L Ascensao, M Tavassoli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tissue distribution of HSC in fetal sheep was studied by in utero transplantation during the period when a switch in the site of hemopoiesis occurs from liver/spleen to the bone marrow. At day 50 of gestation, transplanted cells exclusively homed to the liver/spleen. By day 60, some HSC also homed to the marrow and, between days 60-80, their proportion in the marrow increased. By day 100 almost all engrafted donor HSC homed to the marrow. Nonetheless, expression of these stem cells did not occur in the blood until birth (day 145) when marrow assumed the function of hemopoiesis from liver/spleen. During this latter part of gestation, although homing sites in the marrow are available to transplanted HSC, the marrow does not contribute to the function of hemopoiesis. The significance of these observations in the context of in utero gene therapy via stem cell transplantation is discussed.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J A Mollick, G G Miller, J M Musser, R G Cook, R R Rich
{"title":"Isolation and characterization of a novel streptococcal superantigen.","authors":"J A Mollick, G G Miller, J M Musser, R G Cook, R R Rich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The involvement of S. pyogenes (group A Streptococcus) in severe invasive disease, toxic-shock-like syndrome, and episodes of rheumatic fever led us to explore the possibility that these strains produce a novel superantigen. By using a superantigen-specific assay, we purified a 28-kDa protein from culture supernatants that stimulated T cells in an MHC class II-dependent, V beta-specific manner and designated it SSA, streptococcal superantigen. The amino terminus of SSA showed striking resemblance to SEB, SEC1, and SEC3. The structural homology exhibited by SSA to SEB was reflected functionally in that both of these superantigens bound the same class II isotypes. In contrast, SSA differed from SEB and other known bacterial superantigens with respect to its pattern of V beta-specific T-cell activation. SSA stimulated human T cells that expressed V beta 1, 3, 15, and perhaps V beta 5.2. Using SSA-specific antibodies in an immunoblot assay, we screened 26 strains of Lancefield group A Streptococcus and 16 strains of group B, C, and G Streptococcus. We found that SSA was expressed with high frequency in group A strains, but was absent from all other groups tested. These data establish SSA as a novel superantigen secreted by S. pyogenes. Further study of the structure and expression of SSA may reveal a role for this molecule in current episodes of severe streptococcal diseases.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"110-22"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R A DeLa Cadena, R B Sartor, A Adam, B Raymond, F Legris, R W Colman
{"title":"Role of kallikrein-kinin system in the pathogenesis of bacterial cell wall-induced inflammation and enterocolitis.","authors":"R A DeLa Cadena, R B Sartor, A Adam, B Raymond, F Legris, R W Colman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"229-37"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acceptance of the George M. Kober Medal.","authors":"E D Thomas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"cliii-cliv"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37).","authors":"G H Holz, W M Kuhtreiber, J F Habener","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"260-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulation of renal Na-K-ATPase by eicosanoids: central role of the cytochrome P450-monooxygenase pathway.","authors":"T Satoh, H T Cohen, A I Katz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Differential utilization of translation initiation sites in alternatively spliced mRNAs arising from the protein 4.1 gene.","authors":"S C Huang, F Baklouti, T K Tang, E J Benz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R P Lifton, R G Dluhy, M Powers, S Ulick, J M Lalouel
{"title":"The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension.","authors":"R P Lifton, R G Dluhy, M Powers, S Ulick, J M Lalouel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"64-71"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mutations in the insulin receptor and their effect on glucose transport.","authors":"N Longo, S D Langley, L D Griffin, L J Elsas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"204-13"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of American Physicians.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"vi-lxxxvii"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}