Transactions of the Association of American Physicians最新文献

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Homing of liver-derived hemopoietic stem cells to fetal bone marrow. 肝源性造血干细胞向胎儿骨髓的归巢。
E D Zanjani, J L Ascensao, M Tavassoli
{"title":"Homing of liver-derived hemopoietic stem cells to fetal bone marrow.","authors":"E D Zanjani,&nbsp;J L Ascensao,&nbsp;M Tavassoli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tissue distribution of HSC in fetal sheep was studied by in utero transplantation during the period when a switch in the site of hemopoiesis occurs from liver/spleen to the bone marrow. At day 50 of gestation, transplanted cells exclusively homed to the liver/spleen. By day 60, some HSC also homed to the marrow and, between days 60-80, their proportion in the marrow increased. By day 100 almost all engrafted donor HSC homed to the marrow. Nonetheless, expression of these stem cells did not occur in the blood until birth (day 145) when marrow assumed the function of hemopoiesis from liver/spleen. During this latter part of gestation, although homing sites in the marrow are available to transplanted HSC, the marrow does not contribute to the function of hemopoiesis. The significance of these observations in the context of in utero gene therapy via stem cell transplantation is discussed.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and characterization of a novel streptococcal superantigen. 一种新型链球菌超抗原的分离与鉴定。
J A Mollick, G G Miller, J M Musser, R G Cook, R R Rich
{"title":"Isolation and characterization of a novel streptococcal superantigen.","authors":"J A Mollick,&nbsp;G G Miller,&nbsp;J M Musser,&nbsp;R G Cook,&nbsp;R R Rich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The involvement of S. pyogenes (group A Streptococcus) in severe invasive disease, toxic-shock-like syndrome, and episodes of rheumatic fever led us to explore the possibility that these strains produce a novel superantigen. By using a superantigen-specific assay, we purified a 28-kDa protein from culture supernatants that stimulated T cells in an MHC class II-dependent, V beta-specific manner and designated it SSA, streptococcal superantigen. The amino terminus of SSA showed striking resemblance to SEB, SEC1, and SEC3. The structural homology exhibited by SSA to SEB was reflected functionally in that both of these superantigens bound the same class II isotypes. In contrast, SSA differed from SEB and other known bacterial superantigens with respect to its pattern of V beta-specific T-cell activation. SSA stimulated human T cells that expressed V beta 1, 3, 15, and perhaps V beta 5.2. Using SSA-specific antibodies in an immunoblot assay, we screened 26 strains of Lancefield group A Streptococcus and 16 strains of group B, C, and G Streptococcus. We found that SSA was expressed with high frequency in group A strains, but was absent from all other groups tested. These data establish SSA as a novel superantigen secreted by S. pyogenes. Further study of the structure and expression of SSA may reveal a role for this molecule in current episodes of severe streptococcal diseases.</p>","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"110-22"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of kallikrein-kinin system in the pathogenesis of bacterial cell wall-induced inflammation and enterocolitis. 激肽激肽系统在细菌性细胞壁炎症和小肠结肠炎发病机制中的作用。
R A DeLa Cadena, R B Sartor, A Adam, B Raymond, F Legris, R W Colman
{"title":"Role of kallikrein-kinin system in the pathogenesis of bacterial cell wall-induced inflammation and enterocolitis.","authors":"R A DeLa Cadena,&nbsp;R B Sartor,&nbsp;A Adam,&nbsp;B Raymond,&nbsp;F Legris,&nbsp;R W Colman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"229-37"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acceptance of the George M. Kober Medal. 接受乔治·m·科伯奖章。
E D Thomas
{"title":"Acceptance of the George M. Kober Medal.","authors":"E D Thomas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"cliii-cliv"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37). 胰高血糖素样肽-1诱导胰腺细胞的葡萄糖能力(7-37)。
G H Holz, W M Kuhtreiber, J F Habener
{"title":"Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37).","authors":"G H Holz,&nbsp;W M Kuhtreiber,&nbsp;J F Habener","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"260-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of renal Na-K-ATPase by eicosanoids: central role of the cytochrome P450-monooxygenase pathway. 类二十烷对肾na - k - atp酶的调节:细胞色素p450 -单加氧酶途径的中心作用。
T Satoh, H T Cohen, A I Katz
{"title":"Regulation of renal Na-K-ATPase by eicosanoids: central role of the cytochrome P450-monooxygenase pathway.","authors":"T Satoh,&nbsp;H T Cohen,&nbsp;A I Katz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential utilization of translation initiation sites in alternatively spliced mRNAs arising from the protein 4.1 gene. 蛋白4.1基因产生的可选剪接mrna中翻译起始位点的差异利用。
S C Huang, F Baklouti, T K Tang, E J Benz
{"title":"Differential utilization of translation initiation sites in alternatively spliced mRNAs arising from the protein 4.1 gene.","authors":"S C Huang,&nbsp;F Baklouti,&nbsp;T K Tang,&nbsp;E J Benz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension. 糖皮质激素可补救醛固酮增多症的分子基础,人类高血压的孟德尔原因。
R P Lifton, R G Dluhy, M Powers, S Ulick, J M Lalouel
{"title":"The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension.","authors":"R P Lifton,&nbsp;R G Dluhy,&nbsp;M Powers,&nbsp;S Ulick,&nbsp;J M Lalouel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"64-71"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutations in the insulin receptor and their effect on glucose transport. 胰岛素受体的突变及其对葡萄糖转运的影响。
N Longo, S D Langley, L D Griffin, L J Elsas
{"title":"Mutations in the insulin receptor and their effect on glucose transport.","authors":"N Longo,&nbsp;S D Langley,&nbsp;L D Griffin,&nbsp;L J Elsas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"204-13"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12482670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of American Physicians. 美国医师协会。
{"title":"Association of American Physicians.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23470,"journal":{"name":"Transactions of the Association of American Physicians","volume":"105 ","pages":"vi-lxxxvii"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12483482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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