R V Farese, M L Standaert, T Ishizuka, B Yu, T P Arnold, D R Cooper
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The role of diacylglycerol/protein kinase C signaling in insulin-stimulated glucose transport.
There seems to be little doubt that insulin rapidly perturbs phospholipid metabolism, and this appears to increase DAG/PKC signaling in many target tissues. Considerable new evidence further suggests that DAG/PKC signaling plays an important role in insulin-stimulated glucose transport. Further studies are needed to test this hypothesis and examine its importance in states of clinical insulin resistance.
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