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Survey on lung ultrasound usage by portuguese pulmonologists 葡萄牙肺科医生肺部超声使用情况调查
Ultrasound Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa1817
Bruno S. Silva, Beatriz Ferraz, Filipa Correia, Maria Inês Costa, Maria Esteves Brandão, Nuno Cortesão
{"title":"Survey on lung ultrasound usage by portuguese pulmonologists","authors":"Bruno S. Silva, Beatriz Ferraz, Filipa Correia, Maria Inês Costa, Maria Esteves Brandão, Nuno Cortesão","doi":"10.1183/13993003.congress-2023.pa1817","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa1817","url":null,"abstract":"<b>Introduction:</b> Lung ultrasound (LUS) performed by non-radiologist doctors has evolved over the last few decades, placing it as a useful diagnostic, prognostic and monitoring bedside tool in patients with respiratory disease. Despite its proven clinical applications, LUS training has not been standardized in Portugal. <b>Objetctives:</b> To characterize LUS learning processes and clinical usage amongst portuguese pulmonologists as well as to assess future needs. <b>Methods:</b> From August to November 2022 an online survey was sent to all members of the Portuguese Pulmonology Society. Degrees of confidence were assessed through Likert scales. Pearson’s chi-squared test and non-parametric tests were used. Outcomes were considered statistically significant if the probability of error was below 5% (p < 0.05). <b>Results:</b> 114 valid answers were obtained. Most responders (81%) had LUS training and 22% had attended other ultrasound-related courses. The majority had an ultrasound machine available. However, only 17% performed LUS > 3 times per week. Overall confidence in LUS usage for diagnostic purpose (median: 7/10), disease monitoring (median: 7/10) and support of invasive procedures (median: 8/10) were high. There was a significant relation between higher levels of confidence and regularly attending LUS courses and performing LUS > 3 times per week. The main reasons preventing regular use of LUS were availability/cost of courses, availability/cost of equipment and lack of time. <b>Conclusions:</b> Physician`s confidence degree on ultrasound utility is related to regular LUS training as well as regular usage. Costs involved with&nbsp;LUS training hamper its wider use.","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136194438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative US echogenicity to differentiate exudate from transudate pleural effusion 定量超声超声鉴别渗出液与渗出性胸腔积液
Ultrasound Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa1825
Mona El Hoshy, Alaa Amin, Maged Hassan
{"title":"Quantitative US echogenicity to differentiate exudate from transudate pleural effusion","authors":"Mona El Hoshy, Alaa Amin, Maged Hassan","doi":"10.1183/13993003.congress-2023.pa1825","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa1825","url":null,"abstract":"<b>Background:</b> The echo-texture of pleural effusion (PE) can be determined by ultrasound (US) which gives a clue about its etiology. Echogenic PEs are usually due to exudates while anaechoic PEs can be transudate or exudate. This study aims to determine if quantitative measurement of PE echogenicity can non-invasively differentiate exudative from transudative PEs and to explore its correlation with PE biochemical and cellular content. <b>Methods:</b> The study prospectively recruited patients with PE US greyscale images were transferred to a computer to be analysed by an image analysis software. To control the sonographic window difference between patients, liver echogenicity was measured (using the same US settings image depth, gain, and focus position) and compared to that of PE. Pleural fluid relative echogenicity (PFRE) was calculated as the ratio of the PE echogenicity: liver echogenicity. <b>Results:</b> 54 patients were examined, 25males (46.3%) with mean age 52+15.7, exudates were (59%)). PE was due to malignancy in 17 cases, heart failure 9, liver cirrhosis 8, TB 7, empyema 6, Renal disease 5, inflammation 2. Exudates’ median LDH was 499 [298- 1388], Protein 4.2 [3.9- 4.8], and PFRE 0.51 [0.25 – 0.82].Transudates had a median LDH 74 [69-164], Protein 1.9 [1.5 – 2.8] and PFRE 0.24 [.09-.35]. PFRE significantly correlated with LDH (R 0.392, P=0.004) and serum protein (R 0.316, P=0.021). PFRE predicted PE nature with area under the curve for PFRE of 0.77[95%CI 0.64 -00.89]. A PFRE &gt; 0.32 had a sensitivity of 70% and specificity of 74% to predict an exudate. <b>Conclusion:</b> PFRE can predict the nature of Pleural effusion (Exudates VS Transudates) non-invasively with moderate degree of accuracy.","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136201017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diaphragmatic contraction speed at follow-up of patients admitted for myasthenia gravis 重症肌无力患者随访时膈肌收缩速度
Ultrasound Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa1815
Santos Ferrer Espinosa, Antonio Quezada Reynoso, Jesus Sancho Chinesta, Juan Carbonell Asins, Jaime Signes-Costa Miñana
{"title":"Diaphragmatic contraction speed at follow-up of patients admitted for myasthenia gravis","authors":"Santos Ferrer Espinosa, Antonio Quezada Reynoso, Jesus Sancho Chinesta, Juan Carbonell Asins, Jaime Signes-Costa Miñana","doi":"10.1183/13993003.congress-2023.pa1815","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa1815","url":null,"abstract":"Myasthenic crisis (MC) is the most life-threatening complication of myasthenia gravis (MG). Our hypothesis is that repeated measures of the rate of diaphragmatic contraction (((v10-v1)/(v1))x100) after performing snip maneuvers using ultrasound can predict the need for mechanical ventilation in patients admitted for MG.&nbsp;1 year duration prospective observational study. Patients who met admission criteria according to the Neurology Department with a diagnosis of MG and were evaluated by Pulmonology in the first 24 hours of admission were included. Demographic data, pulmonary function variables, and ultrasound data were collected. The percentage change between the first and tenth measurement of diaphragmatic contraction velocity were determined by this formula: (((v10-v1)/v1))x100). Statistical analysis: Wilcoxon test.&nbsp;18 patients were included in the study. 52.9% were male with a mean age of 57.94 +/- 21.01 years. Demographic and clinical data are shown in Table 133.3% had a MC. The correlation between percentage change in diaphragmatic contraction velocity and snip and PImax were -0.593 (p=0.020) and -0.552 (p=0.041) respectively. After statistical analysis, we observed differences in (((v10-v1)/v1))x100) between the group of patients who required mechanical ventilation (and were classified as myasthenic crisis) vs the group of patients who did not require NIV (p= 0.0018). (figure 2)&nbsp;The percentage of change in diaphragmatic contraction velocity after repeated snip maneuvers may be an indicator of diaphragm fatigability in patients with MG and may be useful in determining the need for ventilation in these patients.","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"368 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136195188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleural irregularity and diaphragm mobility among patients with systemic sclerosis 系统性硬化症患者胸膜不规则和横膈膜活动
Ultrasound Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa1818
Anja Ljilja Posavec, Boris Karanović, Ivana Ježić, Renata Huzjan Korunić, Nevenka Piskač Živković, Josip Tečer, Stela Hrkač, Joško Mitrović
{"title":"Pleural irregularity and diaphragm mobility among patients with systemic sclerosis","authors":"Anja Ljilja Posavec, Boris Karanović, Ivana Ježić, Renata Huzjan Korunić, Nevenka Piskač Živković, Josip Tečer, Stela Hrkač, Joško Mitrović","doi":"10.1183/13993003.congress-2023.pa1818","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa1818","url":null,"abstract":"<b>Background:</b> Pleural irregularity visualized by ultrasound has a higher specificity for interstitial lung disease (ILD) than B lines. It is manifested as a loss of the normal hyperechoic pleural contour. Diaphragm mobility has not been studied so far in patients with systemic sclerosis (SSc). Patients may have reduced diaphragm function due to ILD, disuse atrophy, malnutrition, corticosteroid therapy, etc. <b>Aims and objectives:</b> To investigate whether pleural irregularity is associated with diaphragm mobility in patients with SSc. <b>Methods:</b> In this cross sectional multicentric research participated 50 patients with systemic sclerosis. The patients underwent an ultrasound of the pleura. The mobility of the right diaphragm was measured in M mode with convex probe. We applied reference values for diaphragm mobility in deep breathing according to Boussuges et al. (1). <b>Results:</b> In patients with reduced mobility of the diaphragm in deep breathing, regression analysis pointed that irregular pleura on ultrasound was an independent factor predicting reduced diaphragm mobility (OR=40.0, 95% CI: 1.98 to 807.1). <b>Conclusion:</b> According to the results, irregular pleura on ultrasound is independent factor that predicts reduced mobility of the diaphragm in deep breathing among the patients with SSc. Literature: 1. Boussuges A, Gole Y, Blanc P. Diaphragmatic motion studied by m-mode ultrasonography: methods, reproducibility, and normal values. Chest 2009;135:391-400.","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136200957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Lung Ultrasound in detection and assessment of severity of ILD in patients with Systemic sclerosis 肺超声在系统性硬化症患者ILD严重程度的检测和评估中的作用
Ultrasound Pub Date : 2023-09-09 DOI: 10.1183/13993003.congress-2023.pa1821
Richa Gupta, Davis Joseph K J, Avinash Nair, John Mathew, Manisha Mane
{"title":"Role of Lung Ultrasound in detection and assessment of severity of ILD in patients with Systemic sclerosis","authors":"Richa Gupta, Davis Joseph K J, Avinash Nair, John Mathew, Manisha Mane","doi":"10.1183/13993003.congress-2023.pa1821","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa1821","url":null,"abstract":"<b>ABSTRACT TITLE:</b> Role of Lung Ultrasound in detection and assessment of severity of ILD in patients with Systemic sclerosis <b>BACKGROUND:</b> HRCT Thorax is gold standard for diagnosing ILD but has limitations because of cost and radiation exposure issues. Lung Ultrasound (LUS) has shown to be useful alternative for diagnosing ILD. <b>AIM:</b> To find out the diagnostic yield of Lung Ultrasound to detect ILD in patients with SSc-ILD. <b>METHODS:</b> All consecutive patients with Systemic sclerosis underwent HRCT, Pulmonary Function Test and Lung Ultrasound (LUS). LUS was done by chest physician who was blinded to the clinical, physiological, and radiological status of the patient. Presence of B-lines (number and sites)and broken pleura sign were recorded as sonographic features of ILD and correlated with the Warrick score in HRCT. <b>RESULTS:</b> A total of 117 patients (103 women) were included in the study. The number of B-lines detected on thoracic USG showed significant positive correlation with the Warrick score on HRCT (r=0.947;p<0.001). A significant relationship between presence of broken pleural sign in LUS and severity of Warrick score in HRCT was also found (p <0.001). With HRCT as the gold standard: the sensitivity, specificity, positive predicted value, and negative predicted value for LUS were found to be 100%, 98%, 98.9%, and 100% respectively. <b>CONCLUSIONS:</b> LUS is a good alternative to HRCT Thorax for early diagnosing of SSc-ILD. We propose LUS can be used as a screening tool for diagnosing lung interstitial involvement. It can also be used as a follow up tool to look for disease progression of ILD in patients with Systemic sclerosis.","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136194283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mixed method study into obstetric sonographer-led-discharge and other forms of sonographer role extension. 产科超声引导出院及其他形式超声医师角色扩展的混合方法研究。
IF 0.8
Ultrasound Pub Date : 2022-08-01 Epub Date: 2021-09-13 DOI: 10.1177/1742271X211038296
L S Kettlewell, S P Richards
{"title":"A mixed method study into obstetric sonographer-led-discharge and other forms of sonographer role extension.","authors":"L S Kettlewell,&nbsp;S P Richards","doi":"10.1177/1742271X211038296","DOIUrl":"https://doi.org/10.1177/1742271X211038296","url":null,"abstract":"<p><strong>Introduction: </strong>Sonographer-led-discharge was proposed in a maternity unit to provide a holistic service, cut waiting times, ease staffing pressures and increase job satisfaction. This study explored sonographers' experiences and perspectives of this new extended role and other areas of non-obstetric role extension. Understanding these will inform future practice and the success of the proposed obstetric sonographer-led-discharge and career structure.</p><p><strong>Methods: </strong>A mixed methodology, cross-sectional study was performed, with a purposive, non-probability sample using an online data collection tool. The data were analysed using descriptive statistics and thematic analysis.</p><p><strong>Results: </strong>In total, 93 sonographers participated in the study. Of these, 25% of sonographers currently practising obstetric ultrasound said they would not undertake the proposed obstetric sonographer-led-discharge role extension although 90% of the participants said role extension provides job satisfaction. Several themes emerged from the data, including job satisfaction, benefits to the hospital, improved patient pathway, time, personal factors, litigation and intra- and interprofessional resistance. A total of 54% of staff currently performing a role extension have experienced either inter- or intraprofessional conflict and only 48.5% said their workload was manageable.</p><p><strong>Conclusions: </strong>The data collected suggested that, with training and support, the proposed obstetric sonographer-led-discharge role is an appropriate role extension for sonographers. These findings support the premise of the proposed sonographic career structure, although the inter- and intraprofessional resistance identified in the study could form a significant barrier if it is not appropriately considered and managed.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"209-217"},"PeriodicalIF":0.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40700882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Concurrent validity and intrarater reliability of two ultrasound-based methods for assessing patellar tendon stiffness. 两种基于超声的髌骨肌腱刚度评估方法的并发有效性和内部可靠性。
IF 0.8
Ultrasound Pub Date : 2022-02-01 Epub Date: 2021-02-21 DOI: 10.1177/1742271X21994609
P Henriksen, K Brage, T Junge, B Juul-Kristensen, J Bojsen-Møller, J B Thorlund
{"title":"Concurrent validity and intrarater reliability of two ultrasound-based methods for assessing patellar tendon stiffness.","authors":"P Henriksen,&nbsp;K Brage,&nbsp;T Junge,&nbsp;B Juul-Kristensen,&nbsp;J Bojsen-Møller,&nbsp;J B Thorlund","doi":"10.1177/1742271X21994609","DOIUrl":"https://doi.org/10.1177/1742271X21994609","url":null,"abstract":"<p><strong>Introduction: </strong>Assessment of tendon stiffness in vivo traditionally involves maximal muscle contractions, which can be challenging in pain populations. Alternative methods are suggested, although the clinimetric properties are sparse. This study investigated the concurrent validity and the intrarater reliability of two ultrasound-based methods for assessing patellar tendon stiffness.</p><p><strong>Methods: </strong>Patellar tendon stiffness was assessed in 17 healthy adults with (a) the dynamometer and B-mode ultrasonography method (DBUS) and (b) the strain elastography method. Correlations between the two methods were analysed using Kendall's Tau-b. The relative reliability of both methods was evaluated using intraclass correlation coefficient (ICC). The absolute reliability was presented by Bland-Altman plots, standard error of measurement (SEM) and minimum detectable change (MDC).</p><p><strong>Results: </strong>No correlation was found between the two methods, irrespective of reference tissue in strain elastography (Kendall's Tau-b Hoffa = -0.01 (p = 1.00), Kendall's Tau-b subcutis = 0.04 (p = 0.87)). Tracking of the tendon elongation in the DBUS method had good to excellent relative reliability (ICC = 0.95 (95% confidence interval - CI: 0.85-0.98)) and high absolute reliability (SEM = 0.04 mm (1%), MDC = 0.11 mm (3%)). The strain elastography method had good to excellent relative reliability, regardless of reference tissue (ICC Hoffa = 0.95 (95% CI: 0.86-0.98), ICC subcutis = 0.94 (95% CI: 0.82-0.98)), but low absolute reliability (SEM Hoffa = 0.06 (20%), MDC Hoffa = 0.18 (60%), SEM subcutis = 0.12 (41%), MDC subcutis = 0.32 (110%)).</p><p><strong>Conclusions: </strong>No concurrent validity existed for DBUS and strain elastography, suggesting that the two methods measure different tendon properties. The overall reliability for the DBUS method was high, but the absolute reliability was low for strain elastography stiffness ratios. Therefore, the strain elastography method may not be recommended for tracking differences in patellar tendon stiffness in healthy adults.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"18-27"},"PeriodicalIF":0.8,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1742271X21994609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39930309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Primary lung tumour invading the chest wall. 侵袭胸壁的原发性肺肿瘤。
IF 0.8
Ultrasound Pub Date : 2021-11-01 Epub Date: 2021-01-10 DOI: 10.1177/1742271X20979731
Mark Charnock
{"title":"Primary lung tumour invading the chest wall.","authors":"Mark Charnock","doi":"10.1177/1742271X20979731","DOIUrl":"https://doi.org/10.1177/1742271X20979731","url":null,"abstract":"<p><strong>Introduction: </strong>This case study describes a primary lung tumour invading the chest wall, that clinically was thought likely to be a lipoma, and was imaged first using ultrasound.</p><p><strong>Case report: </strong>A 67 year old male presented to his GP with a six month history of a lump increasing in size on the left upper chest wall. The ultrasound scan demonstrated a hypoechoic and hypervascular soft tissue mass, extending out of the chest into the subcutaneous tissue and starting to erode the overlying rib. The appearances were highly suspicious for a chest malignancy. Further imaging and an ultrasound guided biopsy confirmed the diagnosis of a squamous cell carcinoma.</p><p><strong>Discussion: </strong>The majority of patients who present to their general practitioner with a soft tissue mass commonly have benign abnormalities such as a lipoma or epidermoid cyst. Tumours of the chest wall are varied and are divided into benign and malignant tumours, and those that arise from the rib cage. Primary lung tumours are uncommonly seen on ultrasound. Lung cancers account for around 20% of all cancer deaths and the chest wall is involved in around 5% of primary lung tumours.</p><p><strong>Conclusion: </strong>This case highlights the need for prompt investigation of enlarging superficial masses. Ultrasound imaging offers excellent detail for superficial structures and in this case, due to the location of the mass, identified a primary lung tumour.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"29 4","pages":"264-267"},"PeriodicalIF":0.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1742271X20979731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39712244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker. 左心室肥厚发展过程中室内压力梯度的变化:丹酚酸B和受体阻滞剂的作用。
IF 0.8
Ultrasound Pub Date : 2021-11-01 Epub Date: 2021-02-04 DOI: 10.1177/1742271X20987584
Danfu Ma, Ahmed S Mandour, Tomohiko Yoshida, Katsuhiro Matsuura, Kazumi Shimada, Pitipat Kitpipatkun, Akiko Uemura, Mayumi Ifuku, Ken Takahashi, Ryou Tanaka
{"title":"Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker.","authors":"Danfu Ma,&nbsp;Ahmed S Mandour,&nbsp;Tomohiko Yoshida,&nbsp;Katsuhiro Matsuura,&nbsp;Kazumi Shimada,&nbsp;Pitipat Kitpipatkun,&nbsp;Akiko Uemura,&nbsp;Mayumi Ifuku,&nbsp;Ken Takahashi,&nbsp;Ryou Tanaka","doi":"10.1177/1742271X20987584","DOIUrl":"https://doi.org/10.1177/1742271X20987584","url":null,"abstract":"<p><strong>Introduction: </strong>Intraventricular pressure gradient is regarded as a non-invasive indicator of diastolic function. Salvianolic acid B (Sal-B), a traditional Asian medicine, revealed its usefulness in myocardial infarction models; however, the hemodynamic effect of salvianolic acid B is still unknown. The present study aimed to investigate the intraventricular pressure gradient changes during the development of left ventricular hypertrophy with or without salvianolic acid B and a beta-blocker.</p><p><strong>Methods: </strong>In total, 48 rats were divided into four groups; Sham, Non-treatment, salvianolic acid B, and Carvedilol. Aortic coarctation-induced left ventricular hypertrophy was done in three groups and the treatment was started from the third to the sixth week. Blood pressure, conventional echocardiography, and color M-mode echocardiography for measurement of intraventricular pressure gradient were carried out for six consecutive weeks.</p><p><strong>Results: </strong>At 4.5 weeks, the LV mass was elevated in the coarctation groups but the blood pressure was significantly lower in salvianolic acid B and Carvedilol groups (<i>P</i> < 0.05). In the Non-treatment group, the total intraventricular pressure gradient was increased at 4.5 and 6 weeks (2.60 and 2.65, respectively). Meanwhile, the basal intraventricular pressure gradient was elevated at 3 and 6 weeks (1.67 and 1.75) compared with the Sham group. Salvianolic acid B and Carvedilol significantly reduced the basal intraventricular pressure gradient at six weeks compared with the Non-treatment group (1.52 and 1.51 vs 1.75, respectively).</p><p><strong>Conclusions: </strong>Salvianolic acid B and Carvedilol promote cardiac function by decreasing the elevated basal intraventricular pressure gradient. The current preclinical results revealed the efficacy of salvianolic acid B as a potential therapy for left ventricular hypertrophy because of the non-blood pressure lowering effect.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"29 4","pages":"229-240"},"PeriodicalIF":0.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1742271X20987584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39712240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Hyperechoic kidneys in a patient with bronchiectasis. 支气管扩张患者肾高回声。
IF 0.8
Ultrasound Pub Date : 2021-11-01 Epub Date: 2021-02-11 DOI: 10.1177/1742271X21989064
A G Umolu, R Venn, D Maxwell, Z Al Shiekh Ali, D C Howlett
{"title":"Hyperechoic kidneys in a patient with bronchiectasis.","authors":"A G Umolu,&nbsp;R Venn,&nbsp;D Maxwell,&nbsp;Z Al Shiekh Ali,&nbsp;D C Howlett","doi":"10.1177/1742271X21989064","DOIUrl":"https://doi.org/10.1177/1742271X21989064","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperechoic renal cortex in a normal-sized kidney has a range of causes, some of which irreparably damage the kidney and should initiate further investigations.</p><p><strong>Case report: </strong>We present a 72-year-old woman with longstanding bronchiectasis, noticed to have worsening renal function. Renal tract ultrasonography showed hyperechoic normal-sized kidneys. Renal biopsy confirmed amyloidosis.</p><p><strong>Discussion: </strong>Imaging findings in renal amyloidosis tend to be non-specific and are not always present. However, ultrasonography findings of hyperechoic cortex in normal-sized kidneys should not be ignored.</p><p><strong>Conclusion: </strong>Renal impairment from blood chemistry in addition to hyperechoic kidneys may be the key to diagnosing secondary amyloidosis in a patient with bronchiectasis, a rare association but important to recognise.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"29 4","pages":"260-263"},"PeriodicalIF":0.8,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1742271X21989064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39712243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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