Ultrasound最新文献

{"title":"Investigation of S-Detect AI (a computer-aided diagnosis tool) versus ultrasound operators for thyroid nodule classification using British Thyroid Association guidelines: A pilot diagnostic accuracy study.","authors":"Kieran Walker, James Michael, Mark Ballard, Geoffrey Chilvers, Steve Colley, Khalid Hussain, Lloyd Rickard","doi":"10.1177/1742271X261479402","DOIUrl":"10.1177/1742271X261479402","url":null,"abstract":"<p><strong>Introduction: </strong>Thyroid nodules affect more than 60% of the population, approximately 5% being malignant. The British Thyroid Association U-classification guides ultrasound risk stratification across the United Kingdom but is subject to inter-observer variability. Artificial intelligence decision support tools may offer more standardised assessment, yet no peer-reviewed study has validated S-Detect, a computer-aided diagnosis tool integrated into Samsung ultrasound systems, against the British Thyroid Association framework. This study compares S-Detect with experienced ultrasound operators using histology as the reference standard.</p><p><strong>Methods: </strong>This retrospective pilot diagnostic accuracy study assessed 32 thyroid nodules (September 2023 to August 2024). S-Detect served as the index test applied retrospectively on a Samsung RS85 Prestige platform; prospectively assigned U-scores were the comparator and surgical histology the reference standard. A secondary analysis varied Doppler input across all four options in the 11 malignancies misclassified by S-Detect to test whether Doppler selection contributed to misclassification.</p><p><strong>Results: </strong>Operators achieved superior balanced performance (sensitivity: 78.9%, specificity: 84.6%, accuracy: 81.3%, and area under the curve: 0.870) compared with S-Detect (42.1%, 100%, 65.6%, area under the curve: 0.729), which under-classified 58% of malignancies. Inter-method agreement was slight (<i>κ</i> = 0.175), with significant directional discordance (McNemar <i>p</i> = 0.008). Doppler manipulation produced substantial variability: 81.8% of misclassified cases showed U-score change attributable solely to Doppler selection, with peripheral patterns yielding zero correct malignancy classifications.</p><p><strong>Conclusion: </strong>Operators achieved superior diagnostic performance. S-Detect's high false-negative rate appears largely driven by over-reliance on Doppler. Its clinical utility is limited within this single-centre study. Future iterations excluding Doppler would likely achieve substantially improved sensitivity.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261479402"},"PeriodicalIF":0.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal ultrasonography versus standing radiography in grading knee osteoarthritis: A comparison study.","authors":"Mohadese Yadolahi, Elahe Mohammadnia, Ehsan Hedayat, Farzin Halabchi","doi":"10.1177/1742271X261459305","DOIUrl":"10.1177/1742271X261459305","url":null,"abstract":"<p><strong>Aims: </strong>Musculoskeletal ultrasonography is an accessible imaging modality with potential utility in knee osteoarthritis. This study aims to compare the sonographic features of knee osteoarthritis with standing radiographic grading and to assess the association with pain severity.</p><p><strong>Methods: </strong>In this cross-sectional study, patients with knee osteoarthritis underwent knee ultrasonography and standing anteroposterior and lateral radiographs. Radiographs were independently assessed by a blinded reviewer and graded using the Kellgren-Lawrence system. Kellgren-Lawrence grades 1-2 were classified as mild osteoarthritis and grades 3-4 as moderate to severe osteoarthritis. Sonographic findings were compared with radiographic grades, and the association with pain severity measured by the visual analogue scale (VAS) was evaluated.</p><p><strong>Results: </strong>Sonographic measurements of medial femoral osteophytes, suprapatellar effusion, Baker's cyst, and medial meniscal protrusion significantly correlated to radiographic osteoarthritis severity (<i>p</i> ⩽ 0.05). A composite score derived from these four variables demonstrated acceptable diagnostic performance (Youden index: 0.61). This composite score significantly correlated to VAS pain scores (<i>p</i> = 0.003), whereas VAS was not significantly associated with the Kellgren-Lawrence grade.</p><p><strong>Conclusion: </strong>Ultrasonography may serve as a valuable adjunct or alternative to plain radiography for estimating knee osteoarthritis severity and its clinical impact. Further well-designed studies are warranted to confirm these findings.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261459305"},"PeriodicalIF":0.7,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel evaluation of the sternocleidomastoid muscle of head and neck cancer patients using shear wave elastography: A preliminary exploratory pilot study.","authors":"Mei S L Lai, Chin C Ooi, Ia C C Tan, Q H M Leow, Zhan H S Quek, Mahalakshmi S Rangabashyam, Wen L J Lau, Hiang K Tan, Meng A Png","doi":"10.1177/1742271X261469653","DOIUrl":"10.1177/1742271X261469653","url":null,"abstract":"<p><strong>Aim: </strong>Shear wave elastography is commonly used to evaluate muscle stiffness and thickness. This study aimed to evaluate the stiffness and thickness of the sternocleidomastoid muscle in patients diagnosed with head and neck cancer undergoing neck dissection (removal of lymph nodes).</p><p><strong>Materials and methods: </strong>Ten subjects with head and neck cancer were recruited. Two radiographers performed ultrasound and shear wave elastography scans to evaluate muscle stiffness and thickness in the sternocleidomastoid muscle pre-surgery, at 6 weeks, and at 6 months post-surgery.</p><p><strong>Results: </strong>The cohort had a mean age of 56.8 (±8.22) years, with equal numbers of males and females. Half had unilateral surgery (four left and one right), while the other half had bilateral surgery. One patient had the entire sternocleidomastoid muscle resected (participant HN2). Comparing all time points from pre-surgery to 6 weeks and 6 months, there was no significant change in sternocleidomastoid muscle thickness (pre-surgery to 6 weeks: 0.11 ± 2.45 cm; <i>t</i> = 0.18, <i>p</i> = 0.86; pre-surgery to 6 months: 0.36 ± 2.08 cm; <i>t</i> = -0.64, <i>p</i> = 0.53; 6 weeks to 6 months: 0.47 ± 1.53 cm; <i>t</i> = -1.15, <i>p</i> = 0.26). From pre-surgery to 6 weeks and 6 months, there was no statistically significant change in shear wave elastography readings (pre-surgery to 6 weeks: 3.62 ± 7.45 kPa; <i>t</i> = -1.82, <i>p</i> = 0.08; pre-surgery to 6 months: 3.33 ± 11.2 kPa; <i>t</i> = 1.11, <i>p</i> = 0.28). However, from 6 weeks to 6 months, the shear wave elastography values increased significantly by 6.95 ± 6.48 kPa (<i>t</i> = 4.01, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This preliminary exploratory study demonstrates the feasibility of longitudinal shear wave elastography assessment in this cohort and identifies an increase in sternocleidomastoid muscle stiffness between 6 weeks and 6 months, which warrants further investigation in larger, stratified studies with functional correlation.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261469653"},"PeriodicalIF":0.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of region of interest size and measurement location on ultrasound-derived hamstrings muscle quality indices in children.","authors":"Chrysostomos Sahinis, Anthi Angelou, Nikolaos Varvariotis, Anastasios Lykidis, Rafail Georgios Pechlivanos, Eleftherios Kellis","doi":"10.1177/1742271X261459300","DOIUrl":"10.1177/1742271X261459300","url":null,"abstract":"<p><strong>Objectives: </strong>This study primarily examined sex differences in ultrasound-derived hamstring muscle quality in physically active prepubertal children and secondarily evaluated the effects of region of interest selection and measurement site on these indices.</p><p><strong>Methods: </strong>Twenty-six prepubertal children (9-11 years, 13 girls) underwent quantitative ultrasound assessment of the semitendinosus and biceps femoris at five measurement sites along the femur. Mean uncorrected echo intensity, corrected echo intensity, echovariation, and texture features were extracted from longitudinal ultrasound images using two region of interest approaches: maximal and standardised rectangular region of interest.</p><p><strong>Results: </strong>Linear mixed-effects models indicated that girls exhibited higher corrected echo intensity and homogeneity and lower contrast and correlation values in the semitendinosus (<i>p</i> < .05), while no sex differences were found in the biceps femoris (<i>p</i> > .05). Region of interest size affected the values of corrected echo intensity, echovariation, and correlation, with higher values observed in maximal region of interest, without altering group-level findings (<i>p</i> > .05). Corrected echo intensity was greater in the biceps femoris than the semitendinosus. Corrected echo intensity varied across the measurement sites, showing higher values at the proximal and proximal-middle locations (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>Region of interest size, sex, muscle, and measurement site influence muscle quality parameters in prepubertal children. Site- and muscle-specific differences underscore the need for standardised assessment protocols.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261459300"},"PeriodicalIF":0.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Doppler ultrasound in the evaluation of venous thoracic outlet syndrome: A bivariate diagnostic meta-analysis.","authors":"Victor A Ohannesian, Bruno M Ishizuka, Isabelle R Menezes, Luciano Falcão, Luiza G Schmitt, Miriana Mariussi, Matheus A Cabral, Henrique V Busch, Gabriel N Vicente, Victor A Jabour, Guilherme C Del Guerra, Miguel J F Neto, Marcelo R C Silva, Marcos R G Queiroz, Ahmet Günkan, Carlos A V Pinto","doi":"10.1177/1742271X261472364","DOIUrl":"https://doi.org/10.1177/1742271X261472364","url":null,"abstract":"<p><strong>Background: </strong>Doppler ultrasound is a widely used non-invasive imaging modality for evaluating venous thoracic outlet syndrome (vTOS), a condition marked by subclavian vein compression that can lead to complications such as thrombosis and pulmonary embolism. Despite recommendations from the American College of Radiology (ACR) supporting its use as a screening tool for vTOS, the available evidence derives mostly from small, non-randomised studies.</p><p><strong>Methods: </strong>We performed a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy (PRISMA-DTA) guidelines. Diagnostic accuracy measures such as sensitivity, specificity, likelihood ratios (LRs), diagnostic odds ratio (DOR), and area under the curve (AUC) were pooled using a bivariate random-effects model. We also assessed heterogeneity, threshold effect, and publication bias. The review protocol was prospectively registered in the PROSPERO under registration number CRD42024621782.</p><p><strong>Results: </strong>Five studies with 293 patients were included. The pooled sensitivity and specificity were 91.4% (95% CI: 83.5-95.7; I² = 25.4%) and 91.1% (95% CI: 63.8-98.3; I² = 82.0%), respectively. The AUC was 0.919 (95% CI: 0.80-0.94), and the DOR was 54.1 (95% CI: 13.6-215.5; I² = 57%). The positive LR (LR+) and negative LR (LR-) were 10.3 (95% CI: 2.15-49.6) and 0.10 (95% CI: 0.06-0.2), respectively, indicating strong diagnostic performance. Sensitivity heterogeneity was resolved (I² = 0%) after excluding one outlier study, yielding a revised pooled sensitivity of 88.6% (95% CI: 81.0%-93.1%). Deeks' funnel plot asymmetry test showed no evidence of publication bias (<i>p</i> = 0.60). Fagan's nomogram showed that a positive test increased the post-test probability from 25% to 77%, while a negative test reduced it to 3%. LR scatterplots confirmed high diagnostic utility.</p><p><strong>Conclusion: </strong>Doppler ultrasound shows high accuracy and is a valuable first-line tool for the initial assessment of vTOS in symptomatic patients. Its non-invasiveness and bedside use make it ideal for early triage. However, broader clinical implementation requires standardised scanning protocols, training to reduce interobserver variability, and harmonisation of diagnostic criteria across centres to ensure reproducibility and reliability.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261472364"},"PeriodicalIF":0.7,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial.","authors":"Penelope Moores","doi":"10.1177/1742271X261466346","DOIUrl":"10.1177/1742271X261466346","url":null,"abstract":"","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":"34 3","pages":"175"},"PeriodicalIF":0.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tips for writing a paper for publication.","authors":"Michelle Fenech","doi":"10.1177/1742271X261466360","DOIUrl":"10.1177/1742271X261466360","url":null,"abstract":"","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261466360"},"PeriodicalIF":0.7,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound measurements of gestational sac diameter and crown-rump length in intrauterine pregnancy of uncertain prognosis: A systematic review.","authors":"Hossein Kalantari, Getaw W Hassen, Christopher R Hanuscin, Shahriar Zehtabchi","doi":"10.1177/1742271X261462478","DOIUrl":"10.1177/1742271X261462478","url":null,"abstract":"<p><strong>Background: </strong>Pelvic ultrasound examination is the diagnostic modality of choice for the determination of early pregnancy loss.</p><p><strong>Objective: </strong>To evaluate the diagnostic performance of mean gestational sac diameter and crown-rump length for identifying early pregnancy loss in patients with an intrauterine pregnancy of uncertain prognosis.</p><p><strong>Methods: </strong>We searched MEDLINE, Embase, Cochrane Library, Scopus, and other databases to identify studies of first-trimester pregnant patients with intrauterine pregnancy of uncertain prognosis that reported diagnostic accuracy for mean gestational sac diameter and crown-rump length. Two reviewers separately screened studies, extracted data, and assessed quality using modified QUADAS-2. We reported operating characteristics (sensitivity, specificity, likelihood ratios) of mean gestational sac diameter and crown-rump length for predicting early pregnancy loss.</p><p><strong>Results: </strong>Fourteen studies met the inclusion criteria. Study methods, cutoff values, and outcome standards varied widely. Across all clinical categories, studies consistently demonstrated high specificity for early pregnancy loss using mean gestational sac diameter and crown-rump length thresholds, ranging from 88% to 100%. In contrast, sensitivity was highly variable and generally low, ranging from 2% to 100%. The positive likelihood ratio was typically high (median = 30; interquartile range = 19-76), indicating that meeting diagnostic thresholds substantially increased the probability of early pregnancy loss. However, the negative likelihood ratio was less informative (median = 0.64; interquartile range = 0.46-0.85), limiting the ability of these criteria to reliably exclude early pregnancy loss.</p><p><strong>Conclusion: </strong>Mean gestational sac diameter and crown-rump length measurements have high specificity and high positive likelihood ratio for identifying early pregnancy loss. Their low sensitivity and higher negative likelihood ratio limit their use in ruling out early pregnancy loss. Conservative cutoff values are useful for confirming early pregnancy loss when clearly met; however, early ultrasound findings alone are often insufficient to rule out pregnancy loss with confidence.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261462478"},"PeriodicalIF":0.7,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13407674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148607900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric outcomes of ultrasound-guided microwave ablation for benign thyroid nodules: A single-centre retrospective cohort study.","authors":"İsmail Engin, Ali H Emirkadı, Zafer Ü Coşkun","doi":"10.1177/1742271X261469983","DOIUrl":"10.1177/1742271X261469983","url":null,"abstract":"<p><strong>Introduction: </strong>Ultrasound-guided microwave ablation is a minimally invasive alternative to surgery for symptomatic benign thyroid nodules, but most outcome data originates from East Asian centres, and evidence from European and Middle Eastern populations is limited. We evaluated the 12-month volumetric response, safety and subgroup outcomes of microwave ablation in a Turkish cohort.</p><p><strong>Methods: </strong>In this single-centre retrospective cohort, 180 consecutive patients with cytologically benign thyroid nodules and complete follow-up underwent ultrasound-guided microwave ablation between January 2019 and May 2025. Thyroid nodule volume was measured by ultrasound at baseline and at 3, 6 and 12 months; volume reduction rate was the primary outcome. Change over time was assessed with repeated-measures analysis of variance (volume) and the Friedman test (volume reduction rate).</p><p><strong>Results: </strong>Mean volume of benign thyroid nodules fell from 10.29 ± 4.15 to 2.86 ± 1.23 cm³ (<i>F</i> = 999.7, <i>p</i> < 0.001, <math> <mrow><msubsup><mi>η</mi> <mi>p</mi> <mn>2</mn></msubsup> </mrow> </math>  = 0.848). The median volume reduction rate rose from 40.9% at 3 months to 62.5% at 6 months and 72.6% at 12 months (<i>p</i> < 0.001). All patients reached ⩾50% volume reduction rate by 6 months, and 65.6% reached ⩾70% by 12 months. Outcomes were independent of sex and baseline volume. No major complications occurred, and 80.6% reported complete symptom resolution.</p><p><strong>Conclusion: </strong>Ultrasound-guided microwave ablation achieved substantial and safe 12-month volume reduction in benign thyroid nodules, supporting it as a viable alternative to thyroidectomy in carefully selected patients.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261469983"},"PeriodicalIF":0.7,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between ultrasound-derived muscle morphology, adiposity, and VO_2max in young, trained runners: An exploratory cross-sectional study.","authors":"Ryan A Gordon, Charles K Hill, Jon Rattenborg, Adrien Martens, Shelby Houchlei, Stacy Goddard","doi":"10.1177/1742271X261467453","DOIUrl":"10.1177/1742271X261467453","url":null,"abstract":"<p><strong>Objective: </strong>This exploratory cross-sectional study examined how muscle thickness and echo intensity of quadriceps and calf musculature are associated with maximal oxygen consumption (VO_2max) in trained runners.</p><p><strong>Methods: </strong>Male and female runners (<i>n</i> = 25; 22 ± 3.0 years; 150-300+ min running per week) participated in this study. Participants' rectus femoris, vastus intermedius, vastus lateralis, and medial gastrocnemius were imaged via B-mode ultrasound and analysed for muscle thickness, corrected echo intensity, and subcutaneous adipose tissue. Participants then completed an incremental treadmill test. Associations between muscle thickness, corrected echo intensity, and VO_2max were determined using Pearson's correlation coefficient. Multiple linear regression was used to determine whether muscle thickness, corrected echo intensity, or subcutaneous adipose tissue were predictive of VO_2max.</p><p><strong>Results: </strong>VO_2max was not associated with muscle thickness. VO_2max was positively associated with corrected echo intensity of the medial gastrocnemius (<i>r</i> = 0.413; <i>p</i> = 0.04). In addition, VO_2max was negatively associated with body mass index (<i>r</i> = -0.670), fat mass (<i>r</i> = -0.791), body fat percentage (<i>r</i> = -0.707), and subcutaneous adipose tissue of the vastus lateralis (<i>r</i> = -0.436; all <i>p</i> < 0.05). Stepwise multiple linear regression indicated corrected echo intensity of the medial gastrocnemius (<i>F</i> = 4.14, <i>p</i> = 0.047, <i>R</i> = 0.409, <i>R</i> ² = 0.167) and corrected echo intensity of the medial gastrocnemius and vastus lateralis (<i>F</i> = 4.79, <i>p</i> = 0.019, <i>R</i> = 0.560, <i>R</i> ² = 0.314) were the strongest predictors of VO_2max.</p><p><strong>Conclusion: </strong>VO_2max was not associated with muscle thickness of lower extremity musculature, but was associated with subcutaneous adipose tissue, corrected echo intensity, and more favorable whole-body fat mass and deposition in young, trained runners.</p>","PeriodicalId":23440,"journal":{"name":"Ultrasound","volume":" ","pages":"1742271X261467453"},"PeriodicalIF":0.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148593432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}