Urologia Internationalis最新文献_第9页

Metformin Regulates the miR-205/VEGFA Axis in Renal Cell Carcinoma Cells: Exploring a Clinical Synergism with Tyrosine Kinase Inhibitors. 二甲双胍调节肾细胞癌细胞中miR-205/VEGFA轴-探索与酪氨酸激酶抑制剂的临床协同作用

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1159/000535025

Markus Krebs, Mischa J Kotlyar, Julian Fahl, Sudha Janaki Raman, Florian Röhrig, André Marquardt, Hubert Kübler, Burkhard Kneitz, Almut Schulze, Charis Kalogirou

{"title":"Metformin Regulates the miR-205/VEGFA Axis in Renal Cell Carcinoma Cells: Exploring a Clinical Synergism with Tyrosine Kinase Inhibitors.","authors":"Markus Krebs, Mischa J Kotlyar, Julian Fahl, Sudha Janaki Raman, Florian Röhrig, André Marquardt, Hubert Kübler, Burkhard Kneitz, Almut Schulze, Charis Kalogirou","doi":"10.1159/000535025","DOIUrl":"10.1159/000535025","url":null,"abstract":"Introduction: Metformin (MF) intake could be associated with a favorable outcome in sunitinib (SUT)- and axitinib (AX)-treated clear cell renal cell carcinoma (ccRCC) patients. Functionally, MF induces miR-205, a microRNA serving as a tumor suppressor in several cancers.Methods: Real-time quantitative PCR, viability assays, and Western blotting analyzed MF and SUT/AX effects in RCC4 and 786-O cells. A tetracycline-inducible overexpression model was used to study the role of miR-205 and its known target gene, VEGFA. We analyzed miR-205 and VEGFA within a public and an in-house ccRCC cohort. Human umbilical vein endothelial cell (HUVEC) sprouting assays examined miR-205 effects on angiogenesis initiation. To determine the influence of the von Hippel-Lindau tumor suppressor (VHL), we examined VHLwt reexpressing RCC4 and 786-O cells.Results: Viability assays confirmed a sensitizing effect of MF toward SUT/AX in RCC4 and 786-O cells. Overexpression of miR-205 diminished VEGFA expression - as did treatment with MF. Tumor tissue displayed a downregulation of miR-205 and an upregulation of VEGFA. Accordingly, miR-205 caused less and shorter vessel sprouts in HUVEC assays. Finally, VHLwt-expressing RCC4 and 786-O cells displayed higher miR-205 and lower VEGFA levels.Conclusion: Our results support the protective role of MF in ccRCC and offer functional insights into the clinical synergism with tyrosine kinase inhibitors.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"49-59"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified Ileal Conduit for Pelvic Lipomatosis: Technique Description and Outcome. 改良回肠导管治疗盆腔脂肪瘤病：技术描述与结果

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-03-21 DOI: 10.1159/000538369

Mancheng Xia, Chang Meng, Peng Zhang, Xiaohui Tan, Yuke Chen, Jian Fan, Zhihua Li, Bing Wang, Hongjian Zhu, Kunlin Yang, Liqun Zhou, Ninghan Feng, Kai Zhang, Xuesong Li

{"title":"Modified Ileal Conduit for Pelvic Lipomatosis: Technique Description and Outcome.","authors":"Mancheng Xia, Chang Meng, Peng Zhang, Xiaohui Tan, Yuke Chen, Jian Fan, Zhihua Li, Bing Wang, Hongjian Zhu, Kunlin Yang, Liqun Zhou, Ninghan Feng, Kai Zhang, Xuesong Li","doi":"10.1159/000538369","DOIUrl":"10.1159/000538369","url":null,"abstract":"Introduction: The aim of this study was to present the surgical technique and clinical outcomes of modified ileal conduit for pelvic lipomatosis (PL).Methods: From 2020 to 2022, we prospectively enrolled 9 patients with PL undergoing modified ileal conduit. The patient characteristics, perioperative variables, and follow-up outcomes as well as the description of surgical technique were reported.Results: All 9 patients successfully completed the operation. Two patients had perioperative complications of Clavien-Dindo grade I. The mean operation time and bleeding volumes were 253 ± 51.4 min and 238.9 ± 196.9 mL, with a mean postoperative follow-up time of 13.0 ± 5.6 months. The postoperative 3-month and 1-year creatinine values were significantly decreased versus the preoperative (p = 0.006 and p = 0.024). The postoperative 3-month and 1-year estimated glomerular filtration rate values were significantly increased compared with those before operation (p = 0.0002 and p = 0.018). The separation value of left renal pelvis collection system after operation was significantly reduced compared with preoperative evaluation (p = 0.023 at 3 months and p = 0.042 at 1 year) and so was the right side (p = 0.019 and p = 0.023).Conclusion: Modified ileal conduit is safe and feasible for PL. A large sample cohort with long-term follow-up is needed to evaluate the clinical outcomes of PL.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"314-321"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11305515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the Effect of Pre-Biopsy Rectal Cleaning Together with Biopsy Needle Disinfection to Each Technique Alone on Hospitalization Rates because of Post-Biopsy Infections. 比较活组织检查前直肠清洁和活组织检查针消毒对活组织检查后感染住院率的影响。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2023-11-08 DOI: 10.1159/000535033

Coşkun Bostancı, Salih Bürlukkara

{"title":"Comparing the Effect of Pre-Biopsy Rectal Cleaning Together with Biopsy Needle Disinfection to Each Technique Alone on Hospitalization Rates because of Post-Biopsy Infections.","authors":"Coşkun Bostancı, Salih Bürlukkara","doi":"10.1159/000535033","DOIUrl":"10.1159/000535033","url":null,"abstract":"Introduction: To compare the effects of three techniques: biopsy needle disinfection with 10% formalin solution, povidone-iodine rectal cleaning, and the use of both methods to decrease hospitalization due to infectious complications after transrectal prostate biopsy.Methods: A total of 827 patients were divided into 3 groups. Group 1 patient data were analyzed retrospectively, while patients of groups 2 and 3 were followed up prospectively. Group 1 included 361 patients who underwent biopsy needle disinfection with a 10% formalin solution. Group 2 included 235 patients who underwent biopsy needle disinfection and povidone-iodine rectal cleaning. Group 3 included 231 patients who underwent povidone-iodine rectal cleaning only. The outcome scale was the number of patients hospitalized for biopsy-related infection 30 days after the date of transrectal prostate biopsy.Results: The hospitalization rates due to biopsy-related infectious complications were 3.0%, 0%, and 1.7% in groups 1, 2, and 3, respectively. The only statistically significant difference was found between groups 1 and 2.Conclusion: Biopsy needle disinfection and rectal cleaning with povidone-iodine seem to have greater potential to reduce infectious complications when applied together. Further prospective studies are required to confirm these findings.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"60-64"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71522735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Much Do Altmetric Scores Correlate with Bibliometric Scores? Analysis of the Most-Cited 100 Articles about the Holmium Laser Enucleation Prostatectomy. 另类计量学分数与文献计量学分数有多大关联?100篇引用率最高的钬激光前列腺切除术文献分析。

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1159/000534603

Gokhan Sonmez, Abdullah Golbasi

{"title":"How Much Do Altmetric Scores Correlate with Bibliometric Scores? Analysis of the Most-Cited 100 Articles about the Holmium Laser Enucleation Prostatectomy.","authors":"Gokhan Sonmez, Abdullah Golbasi","doi":"10.1159/000534603","DOIUrl":"10.1159/000534603","url":null,"abstract":"Introduction: In addition to bibliometric scores, which are an indicator of academic popularity, it has become frequently used in altmetric scoring that shows the visibility of articles on social media and the internet. In this study, 100 most-cited studies on holmium laser enucleation prostatectomy (HoLEP) were examined, and it was investigated whether the number of citations per year of these studies was affected by altmetric and bibliometric scores.Methods: The 100 most-cited HoLEP articles between 2000 and 2020 were included in the study. Some bibliometric scores such as h-indexes, impact factors, Scientific Journal Rankings (SJR) scores of the journals and demographics of the articles (such as the number of the citations per year, total number of citations, and total altmetric scores) were recorded. The effects of altmetric and bibliometric scores on the number of citations per year were evaluated by correlation analysis.Results: The median number of citations per year of the articles was 5.88 (4.69-8.42). It was determined that altmetric scores were not an effective factor on the number of citations per year (p = 0.335). A moderate relationship was found between the journal impact factor and the number of citations per year (p < 0.001, r = 0.471, R2 = 0.251). Journal h-index (p < 0.001, r = 0.424, R2 = 0.084), the SJR score (p < 0.001, r = 0.374, R2 = 0.254), and the publication year of the article (p = 0.001, r = 0.326, R2 = 0.023) were significantly but weakly correlated with the median number of citations per year.Conclusion: It was seen that the number of citations per year, which is the most important academic quality indicator, is not related to the altmetric scores. In addition, traditional bibliometric parameters still maintain their effectiveness on the number of citations.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"28-34"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Neutral Alpha-Glucosidase on Semen Parameters. 中性α-葡萄糖苷酶对精液参数的影响

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-05-10 DOI: 10.1159/000539218

Han Zhang, Xiao-Pu Zhou

{"title":"The Effect of Neutral Alpha-Glucosidase on Semen Parameters.","authors":"Han Zhang, Xiao-Pu Zhou","doi":"10.1159/000539218","DOIUrl":"10.1159/000539218","url":null,"abstract":"Introduction: The objective of this study was to investigate the relationship between the activity of neutral α-glucosidase in seminal plasma and semen quality and to explore the effect of secretory capability of the epididymis on male fertility.Methods: A retrospective analysis of 542 men treated in the Center for Reproductive Medicine and Infertility from February to December 2022, the semen parameters and neutral α-glucosidase were tested and compared among different groups. These 542 men included normozoospermia, oligospermia, asthenospermia, and teratozoospermia.Results: There was statistical difference in neutral alpha-glucosidase (NAG) level among different groups with different sperm concentration, motility, and morphology (p < 0.001). The NAG activity in seminal plasma was positively correlated with ejaculate volume and sperm concentration; meanwhile, a very weak positive correlation was found between NAG level and sperm motility, sperm morphology, respectively.Conclusions: Our results indicated that the secretion of NAG affected the volume, concentration, motility, and morphology of sperm to a certain extent. Given that NAG is a specific and marker enzyme in epididymis, where is the site of sperm maturation, we can conclude that there is a close relationship between NAG and sperm quality. Therefore, seminal plasma NAG has a definite clinical value in helping diagnosis of male infertility.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"479-486"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Testicular Plasmacytoma: A Case Report. 单发性睾丸浆细胞瘤：病例报告。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-08-19 DOI: 10.1159/000540967

Masanori Nishimura, Takeshi Nomura, Masahiro Fujimoto, Yoshihito Hiura

{"title":"Solitary Testicular Plasmacytoma: A Case Report.","authors":"Masanori Nishimura, Takeshi Nomura, Masahiro Fujimoto, Yoshihito Hiura","doi":"10.1159/000540967","DOIUrl":"10.1159/000540967","url":null,"abstract":"Introduction: Plasmacytoma of the testis is an extremely rare malignancy that may occur as a solitary tumor, also known as solitary testicular plasmacytoma (STP), or in conjunction with multiple myeloma (MM). Previous studies have shown that STP has a good prognosis and can be cured with localized treatments like radiotherapy or surgery. We report a case of STP with dissemination to the ribs. The patient required systemic chemotherapy.Case presentation: A 69-year-old man was referred to our hospital due to swelling of the left scrotum. The patient underwent left inguinal high orchiectomy. Based on pathological examination, the specimen was diagnosed as testicular plasmacytoma. As the tests for MM were negative, the patient was followed up. Sixteen months later, multiple bone lesions were detected in the left rims, although serum protein electrophoresis did not show the presence of M protein. Therefore, the patient received 4 courses of chemotherapy, and no signs of recurrence have been detected so far.Conclusion: STP is an extremely rare disease, which obscures its true prognosis. Systemic chemotherapy should be considered for patients with STP in case of recurrence, and long-term follow-up is necessary to understand the nature of the disease.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"578-581"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy and Safety of Retrograde Intrarenal Surgery in Elderly Patients: A Propensity Score Matching Study by the RIRSearch Group. 逆行肾上腺内手术在老年患者中的有效性和安全性：RIRSearch小组的倾向得分匹配研究。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-07-16 DOI: 10.1159/000540073

Murat Akgül, Ridvan Özcan, Cenk Yazıcı, Cem Başataç, Oktay Özman, Duygu Sıddıkoğlu, Önder Çınar, Hakan Çakır, Mehmet Fatih Şahin, Eyüp Burak Sancak, Barbaros Başeskioğlu, Burak Elmaağaç, Bülent Önal, Haluk Akpınar

{"title":"The Efficacy and Safety of Retrograde Intrarenal Surgery in Elderly Patients: A Propensity Score Matching Study by the RIRSearch Group.","authors":"Murat Akgül, Ridvan Özcan, Cenk Yazıcı, Cem Başataç, Oktay Özman, Duygu Sıddıkoğlu, Önder Çınar, Hakan Çakır, Mehmet Fatih Şahin, Eyüp Burak Sancak, Barbaros Başeskioğlu, Burak Elmaağaç, Bülent Önal, Haluk Akpınar","doi":"10.1159/000540073","DOIUrl":"10.1159/000540073","url":null,"abstract":"Introduction: The aim of the study was to evaluate the efficacy and safety of retrograde intrarenal surgery (RIRS) in elderly patients by comparing them with propensity score-matched age-groups.Methods: Patients who underwent RIRS to treat upper urinary tract stone disease at seven centers were included in the study and were divided into four groups. The age intervals of the patients in group 1, group 2, group 3, and group 4 were 18-29 years old, 30-49 years old, 50-64 years old, and over 65 years old, respectively. Propensity score matching analysis was used to homogenize the groups in terms of demographic and clinical properties. Operative results, preoperative complications, perioperative complications, postoperative complications, duration of hospitalization time, and stone-free status were compared between groups.Results: A total of 1,017 patients were included in the study. There were 69 (9.9%) patients in group 1, 324 (46.5%) in group 2, 217 (31.1%) in group 3, and 87 (12.5%) in group 4 after propensity score matching. The operation time and postoperative complication rates were significantly different among groups, whereas the hospitalization time, perioperative complication rates, and stone-free status were similar. The operation time was significantly higher in patients over 65 years old (p = 0.001). The postoperative complication rates were significantly higher in group 1 with Clavien I-II complication predominance (p = 0.003).Conclusion: The efficacy and safety of RIRS did not change with aging, and RIRS was an effective option for the treatment of upper urinary system stones in elderly patients.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"517-524"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing Efficacies of Different Exercises on Androgen Deprivation Therapy Adverse Effects in Prostate Cancer Patients: A Network Meta-Analysis. 比较不同运动对前列腺癌患者雄激素剥夺疗法不良反应的疗效：一项网络荟萃分析。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-03-02 DOI: 10.1159/000538114

Siping Hu, Xingyu Xiong, Shi Qiu, Jiakun Li, Hang Xu, Xianghong Zhou, Sheng Wang, Qiang Wei, Lu Yang

{"title":"Comparing Efficacies of Different Exercises on Androgen Deprivation Therapy Adverse Effects in Prostate Cancer Patients: A Network Meta-Analysis.","authors":"Siping Hu, Xingyu Xiong, Shi Qiu, Jiakun Li, Hang Xu, Xianghong Zhou, Sheng Wang, Qiang Wei, Lu Yang","doi":"10.1159/000538114","DOIUrl":"10.1159/000538114","url":null,"abstract":"Introduction: Previous studies showed exercise have efficacies for androgen deprivation therapy (ADT) adverse effects. To compare the efficacies of different exercises on ADT adverse effects, we conducted the network meta-analysis (NMA).Methods: Literature retrieval was performed in PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). Nineteen studies (1,184 participants) were included. All analyses were performed in R 4.1.2 or RevMan 5.4.1.Results: NMA results showed that compared with the control group, both aerobic + resistance training (ART) (MD = 5.92, 95% CI: 0.38; 11.46) and resistance exercise (RE) (MD = 5.62, 95% CI: 2.70; 8.55) improved quality of life (QoL). ART (P score: 0.72) may have superiority over RE (P score: 0.7). ART (MD = -10.89, 95% CI: -17.67; -4.11) significantly improved the performance of 400-m test. RE could significantly improve leg strength (MD = 118, 95% CI: 78.75; 157.25) and chest strength (MD = 13.30, 95% CI: 4.07; 22.53). RE ranked first for strength improvements of leg and chest.Conclusion: ART showed better efficacy for the QoL and significantly improved the performance of 400-m test. RE might be superior for the strengths of leg and chest. ART may be appropriate for patients with less significant muscle strength decline but also other adverse effects of ADT, such as decreased cardiopulmonary function.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"298-313"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Retrospective Assessment of the Effectiveness and Risk Factors of Fluoroquinolones, Cephalosporines, and Selective Antibiotic Prophylaxis for Transrectal Prostate Biopsy. 对经直肠前列腺活检使用氟喹诺酮类、头孢菌素和选择性抗生素预防的有效性和风险因素进行比较性回顾评估。

IF 1.5 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1159/000539028

Maximilian Haack, Christian Ruckes, Robert Dotzauer, Anita Thomas, Maximilian P Sparwasser, Nikita D Fischer, Lisa J Frey, Gregor Duwe, Axel Haferkamp, Igor Tsaur, Maximilian P Brandt

{"title":"Comparative Retrospective Assessment of the Effectiveness and Risk Factors of Fluoroquinolones, Cephalosporines, and Selective Antibiotic Prophylaxis for Transrectal Prostate Biopsy.","authors":"Maximilian Haack, Christian Ruckes, Robert Dotzauer, Anita Thomas, Maximilian P Sparwasser, Nikita D Fischer, Lisa J Frey, Gregor Duwe, Axel Haferkamp, Igor Tsaur, Maximilian P Brandt","doi":"10.1159/000539028","DOIUrl":"10.1159/000539028","url":null,"abstract":"Introduction: Despite increasing resistance of enterobacteria against fluoroquinolones (FLU), they are still widely used during transrectal prostate biopsy (TRPB). This study was designed to analyse infectious complications and risk factors between FLU, cephalosporines (CEPH) and selective other antibiotics (O-AB) used during TRPB.Methods: 664 patients were included retrospectively (152 FLU, 452 CEPH and 60 O-AB). Infectious complications were defined as fever >38.0°C, the in-house definition of complicated urinary tract infection (cUTI) (if all applied: fever >38.0°C, leucocytosis >11.000/µL and positive urine dipstick) or postinterventional bacteriuria. Hospitalisation rate, duration and comorbidities were also assessed. χ2 and Fisher's exact test were used for group comparison. Multivariate regression analysis assessed the association of comorbidities with infectious complications.Results: FLU and CEPH were indifferent regarding infectious complications, however in the O-AB group significantly more common compared to FLU and CEPH (11.6, 13.3, 25%, p < 0.05). Duration of hospital stay in CEPH was significantly shorter compared to FLU and O-AB (4.1 vs. 6.3 vs. 8.2 days, p < 0.05). Arterial hypertension showed increased association with fever (OR 6.002 (1.178; 30.597) p = 0.031) and cUTI (OR 6.006 (1.207; 29.891) p = 0.029).Conclusion: Infectious complications were low and indifferent between FLU and CEPH but significantly more frequent in O-AB. Arterial hypertension was significantly associated with postinterventional fever and cUTI.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"406-413"},"PeriodicalIF":1.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upstaging after Transurethral Resection of the Bladder for Non-Muscle-Invasive Cancer of the Bladder: Who Is at Highest Risk? 经尿道前列腺电切术（TUR-BT）治疗非肌肉侵袭性膀胱癌症后出现症状-谁的风险最高？

IF 1.6 4区医学

Urologia Internationalis Pub Date : 2024-01-01 Epub Date: 2023-11-09 DOI: 10.1159/000535024

Yannic Volz, Rabea Trappmann, Benedikt Ebner, Lennert Eismann, Benazir Enzinger, Julian Hermans, Nikolaos Pyrgidis, Christian Stief, Gerald B Schulz

{"title":"Upstaging after Transurethral Resection of the Bladder for Non-Muscle-Invasive Cancer of the Bladder: Who Is at Highest Risk?","authors":"Yannic Volz, Rabea Trappmann, Benedikt Ebner, Lennert Eismann, Benazir Enzinger, Julian Hermans, Nikolaos Pyrgidis, Christian Stief, Gerald B Schulz","doi":"10.1159/000535024","DOIUrl":"10.1159/000535024","url":null,"abstract":"Introduction: Transurethral resection of the bladder (TUR-BT) is the standard initial treatment and diagnosis of bladder cancer (BC). Of note, upstaging into muscle-invasive disease (MIBC) during re-resection occurs in a significant proportion of patients. This study aimed to define risk factors at initial TUR-BT for upstaging.Methods: TUR-BT between 2009 and 2021 were retrospectively screened (n = 3,237). We included patients with visible tumors that received their primary and re-TUR-BT at our institution. Upstaging was defined as pathological tumor stage progression into MIBC at re-TUR-BT. Clinicopathological variables were analyzed for the impact on upstaging.Results: Two hundred and sixty-six patients/532 TUR-BTs were included in the final analysis. Upstaging occurred in 7.9% (21/266) patients. Patients with upstaging presented with stroma-invasive and papillary non-muscle-invasive BC at primary resection in 85.7% (18/21) and 14.3% (3/21), respectively. Detrusor muscle at primary TUR-BT was significantly less present in patients with upstaging (4.1 vs. 95.9%; p < 0.001). After multivariate analysis, solid tumor configuration (HR: 4.17; 95% CI: 1.23-14.15; p = 0.022) and missing detrusor muscle at initial TUR-BT (HR: 3.58; 95% CI: 1.05-12.24; p = 0.043) were significant risk factors for upstaging into MIBC.Conclusions: The current study defined two major risk factors for upstaging: missing detrusor muscle and solid tumor configuration. We propose that a second resection should be performed earlier if these risk factors apply.","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"42-48"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72015478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0