Turkish journal of urology最新文献

{"title":"Role of Rezum in the treatment of benign prostate hyperplasia: A review of the literature.","authors":"Andrea Cocci,&nbsp;Alessia Celeste Bocchino,&nbsp;Gianmartin Cito,&nbsp;Antonello De Lisa,&nbsp;Giorgio Ivan Russo,&nbsp;Arturo Lo Giudice,&nbsp;Francesco Sessa,&nbsp;Lorenzo Viola,&nbsp;Luca Cindolo,&nbsp;Bhaskar K Somani,&nbsp;Giampaolo Siena","doi":"10.5152/tud.2021.21128","DOIUrl":"https://doi.org/10.5152/tud.2021.21128","url":null,"abstract":"<p><p>The aim of this study was to review the available literature on the efficacy and safety of the Rezum system for the treatment of symptomatic benign prostatic hyperplasia (BPH). A revision of literature up to January 2021 was carried out. Medline, Scopus, Web of Science, and PubMed archives were screened to identify all the relevant studies investigating the role of Rezum in the treatment of BPH. Randomized controlled trial (RCT), retrospective, prospective, observational, and comparative studies were included. Finally, 17 studies were included, five of which reporting data of a double blind Rezum RCT. Overall, 1,451 patients underwent Rezum procedure. All the studies performed a minimum of 3 months follow-up. Preoperatively, the mean International Prostate Symptom Score (IPSS) score was 19.8, mean Qmax was 9.2mL s1, and mean PVR was 142 cc. At 3 months after surgery, the mean IPSS score was 1.5, mean Qmax was 13.7mL s1, and mean PVR was 74 cc. Six studies investigated sexual function, most of them using the International Index of Erectile Function (IIEF)-5 questionnaire and a few also the Male Sexual Health Questionnaire (MSHQ). Preoperative mean IIEF-5 score was 18.5, and the mean MSHQ score was 7.4. At the 3 months follow-up, the mean IIEF-5 score was 16.4, and the mean MSHQ score was 9.62. None of the studies reported intraoperative complications. Rezum system is a novel minimally invasive treatment for symptomatic BPH using transurethral water vapor thermal energy. It represents a cost-effective and safe procedure with durable relief of lower urinary tract symptom, preservation of sexual function, low complications rate, and short recovery time.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/51/tju-47-6-452.PMC9612750.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39586394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iTIND for BPH: Technique and procedural outcomes: A narrative review of current literature.","authors":"Cristian Fiori,&nbsp;Sabrina De Cillis,&nbsp;Gabriele Volpi,&nbsp;Enrico Checcucci,&nbsp;Giovanni Cattaneo,&nbsp;Juliette Meziere,&nbsp;Matteo Manfredi,&nbsp;Michele Di Dio,&nbsp;Daniele Amparore,&nbsp;Francesco Porpiglia","doi":"10.5152/tud.2021.21145","DOIUrl":"https://doi.org/10.5152/tud.2021.21145","url":null,"abstract":"<p><p>In the last few years, new technologies have been developed to treat benign prostatic hyperplasia (BPH) in order to offer valid surgical alternatives to transurethral resection of the prostate with lower complications and hospitalization while maintaining satisfactory functional results. Among these new approaches, transurethral implantation of first- and second-generation temporary implantable nitinol device (TIND and iTIND, respectively) (Medi-TateVR ; Medi-Tate Ltd., Or Akiva, Israel) has been proposed. The aim of this work is to describe the surgical technique and to perform a systematic review of the available literature on follow-up of functional outcomes. A systematic research of the available literature on this topic was performed via Medline, Embase, and Cochrane databases in April 2021. Current evidence regarding the implantation of iTIND to treat BPH-related lower urinary tract symptoms (LUTSs) is still limited. Seven studies have been found. Only one randomized controlled trial has been published reporting short-term follow-up of implantation of iTIND versus sham procedure. All the studies reported that both procedures are safe, effective, and well-tolerated. Moreover, such treatment seems to not affect patient's sexual and ejaculatory functions. In conclusions, current clinical evidence suggests that temporary implantation of iTIND is a valid option for the minimally invasive surgical treatment of BPH-related LUTS. Further studies are required in order to confirm the functional results, especially over a long-term follow-up.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/48/tju-47-6-470.PMC9612743.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation validity and reliability of the Indonesian version of the 5-item International Index of Erectile Function (IIEF-5).","authors":"Tetuka Bagus Laksita,&nbsp;Yudhistira Pradnyan Kloping,&nbsp;Lukman Hakim,&nbsp;Fikri Rizaldi","doi":"10.5152/tud.2021.21185","DOIUrl":"10.5152/tud.2021.21185","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to translate the IIEF-5 questionnaire into Indonesian and perform a validity and reliability assessment of the translated instrument.</p><p><strong>Material and methods: </strong>A methodological study on 106 male outpatients, recruited consecutively, was carried out in a tertiary hospital in Surabaya, East Java from January to March 2020. This study was conducted in two stages: translation and validation. Two independent sworn translators performed a forward and backward translation of the first draft. The final version was synthesized by a team of experts comprised two urologists and another sworn translator. The validity of the questionnaire is determined through a Pearson correlation analysis. Cronbach's a internal consistency measurement was used to assess its reliability. Interrater reliability between the patient and the physician was measured using the Cohen's j coefficient.</p><p><strong>Results: </strong>Pearson's \"r\" value is significantly higher than the critical value table and indicates a high to a very high level of validity based on Guilford's interpretation (r ¼ 0.70-1.00). A good internal consistency is shown by the Cronbach's a coefficient value (a ¼ 0.828). An almost perfect agreement between the patient's results and the assessment made by the physicians is shown by the Cohen's j coefficient value (j ¼ 0.879, P < .001).</p><p><strong>Conclusion: </strong>The Indonesian IIEF-5 is a valid and reliable patient-reported outcome measure for evaluating erectile dysfunction in the literate middle-aged and older adult male population in Indonesia.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/93/tju-47-6-489.PMC9612751.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in benign prostatic hyperplasia surgery over the years: A multicenter 14-year retrospective study.","authors":"Muhammed Arif İbis,&nbsp;Selahittin Cayan,&nbsp;Zafer Tokatli,&nbsp;İrfan Orhan,&nbsp;Ramazan Ascı,&nbsp;Fatih Kocamanoglu,&nbsp;Erdem Akbay,&nbsp;Onder Yaman","doi":"10.5152/tud.2021.21262","DOIUrl":"https://doi.org/10.5152/tud.2021.21262","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to show the surgical trend over the past 14 years using the data from five major centers in Turkey with accumulated experience in benign prostatic hyperplasia (BPH) surgery.</p><p><strong>Material and methods: </strong>This study included 94,954 patients with low urinary tract symptoms (LUTSs) secondary to BPH. By using electronic databases, we identified 7,163 patients who underwent BPH surgery, including monopolar transurethral prostate resection (M-TURP), bipolar transurethral prostate resection (BTURP), transurethral incision of the prostate (TUIP), open prostatectomy (OP), and holmium laser enucleation of the prostate (HoLEP) from 2006 to 2019. The years were grouped as 2006-2010, 2011-2015, and 2016-2019.</p><p><strong>Results: </strong>The total number of outpatient treatments for BPH increased by 72.9% from 5,379 in 2006 to 9,302 in 2019. Until 2019, the annual number of surgeries increased from 375 to 937 (increasing 150%). All surgical approaches for BPH, except TUIP, were most frequently performed between the ages of 60 and 69. The rate of surgery including M-TURP, B-TURP, and TUIP was statistically different between 2006 and 2010, 2011 and 2015, and 2016 and 2019 (P < .001), except OP (P ¼ .071). The highest increase was observed in HoLEP in the first half of the 2010s compared to the second half of the 2010s. The rate of M-TURP decreased from 77.9% to 17.9% from 2016 to 2019.</p><p><strong>Conclusion: </strong>With the aging population, the number of patients diagnosed and treated with BPH is increasing. B-TURP as a resection technique and HoLEP as an enucleation technique replace M-TURP. Healthcare services and government spending should be organized according to these data.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/5f/tju-47-6-501.PMC9612752.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial comment on comparison of the micro-percutaneous nephrolithotomy results between adult and pediatric cases: Is it safe and effective for pediatric cases? Seçkiner et al.","authors":"Patrick Juliebø-Jones,&nbsp;Bhaskar K Somani","doi":"10.5152/tud.2021.21235","DOIUrl":"https://doi.org/10.5152/tud.2021.21235","url":null,"abstract":"","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612769/pdf/tju-47-5-347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment for the paper entitled \"Robotic simple prostatectomy is safe and effective technique for benign prostatic hyperplasia: Our single center initial results for 42 patients\".","authors":"Ali Atan","doi":"10.5152/tud.2021.21231","DOIUrl":"https://doi.org/10.5152/tud.2021.21231","url":null,"abstract":"I congratulate the authors for their valuable study titled “Robotic simple prostatectomy is safe and effective technique for benign prostatic hyperplasia: Our single center initial results for 42 patients.” After technologic improvements and the development of new endoscopic systems, surgical approaches have changed dramatically in recent years. It has become an obligation to adapt to developing technologies for the surgeons. One of the branches of surgery in which this change and adaptation is the fastest and most prominent is urology. As urologists, we have been experiencing this change clearly in the last 20 years. After the introduction of robotic surgery into daily urology practice, there is an increasing trend in many countries to perform a robotassisted surgery in all of the cases. There is even an exaggerated incentive to conduct robotic surgery. Open simple prostatectomy (OSP) is one of those overly encouraged surgeries. Although robot-assisted surgery is suitable and reasonable for some urological surgeries, we should provide an answer to the question whether or not robotic surgery is really necessary for all types of urological surgery.","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/2f/tju-47-5-349.PMC9612777.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A hybrid technique of lap perineal pelvic lymphadenectomy after open radical perineal prostatectomy in localized carcinoma prostate: Our initial experience.","authors":"Pirzada Faisal Masood,&nbsp;Hemant Kumar Goel,&nbsp;Umesh Sharma,&nbsp;Sumit Gahlawat,&nbsp;Karandeep Guleria,&nbsp;Rajeev Sood","doi":"10.5152/tud.2021.21172","DOIUrl":"https://doi.org/10.5152/tud.2021.21172","url":null,"abstract":"<p><strong>Objective: </strong>The major disadvantage of radical perineal prostatectomy (RPP) is the difficulty to perform pelvic lymphadenectomy via the same incision. Open retropubic, mini laparotomy, and transperitoneal laparoscopic pelvic lymphadenectomy as an adjunct to open RPP have been tried but need change in patient position and separate incision, thereby decreasing the acceptability of this procedure. Open RPP followed by a lap perineal pelvic lymphadenectomy via the same perineal incision is a hybrid technique that is aimed to decrease morbidity of lymphadenectomy.</p><p><strong>Material and methods: </strong>Patients of low and intermediate risk localized carcinoma prostate with a Partin score of >5% were taken for this procedure. After completing prostatectomy part of RPP, lap perineal pelvic lymphadenectomy was performed via same incision using single incision laparoscopic surgery port.</p><p><strong>Results: </strong>We performed this new hybrid technique in eight patients. Bilateral lymph node dissection required an additional mean time of 35 minutes. A total of 68 nodes were retrieved from eight patients with a median number of eight nodes (range: 6-12). None of our cases had any complications related to lymphadenectomy. Bilateral lymph node dissection was feasible in seven patients, and in one patient, it could be done on one side only.</p><p><strong>Conclusion: </strong>Sandwiching lap perineal pelvic lymphadenectomy between prostatectomy part of RPP and urethra-vesical anastomosis (by open approach) is a safe, reproducible, and feasible approach to pelvic lymphadenectomy compared to lymphadenectomy from other routes with simultaneous reduction in the operative time, patient morbidity, and discomfort. Ease of doing lymphadenectomy from same incision can increase the acceptability of this excellent procedure.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/dd/tju-47-5-386.PMC9612773.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of AquablationVR-From innovation to establishment.","authors":"Johannes Stein,&nbsp;Alexander Cox,&nbsp;Stefan Hauser,&nbsp;Manuel Ritter,&nbsp;Thorsten Bach","doi":"10.5152/tud.2021.21126","DOIUrl":"https://doi.org/10.5152/tud.2021.21126","url":null,"abstract":"<p><p>Technological progress is continuously improving medical care. The urological profession is well-known for further development of technical innovations and quick transfer into daily practice. Robot-assisted surgery, for example, has been part of the clinical routine in modern urological clinics for many years. In the endourological field, the implementation and further evolution of laser-based procedures have dominated research in the last decade. Recently, in 2015, the presentation of a new robot-assisted technique of waterjet-based ablation of prostate tissue raised attention in the society-the AquablationVR therapy. Aquablation therapy has been investigated within several randomized and controlled clinical trials, and-with growing experience- the technique has been modified over recent years to improve the safety of the procedure. Due to the clinical outcome, the number of hospitals performing Aquablation therapy is increasing continuously. This article provides an overview of the technique, its modifications, and the current status of evidence.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612770/pdf/tju-47-5-351.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39888414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting outcome of adult hypospadias single stage repair: A prospective observational study.","authors":"Hemant Kumar Goel,&nbsp;Chaure Mayur Tirthraj,&nbsp;Sumit Kabra,&nbsp;Sumit Gahlawat,&nbsp;Umesh Sharma,&nbsp;Rajeev Sood","doi":"10.5152/tud.2021.21163","DOIUrl":"https://doi.org/10.5152/tud.2021.21163","url":null,"abstract":"<p><strong>Objective: </strong>In our part of the world, many patients present with hypospadias in adult age, where results are often poor and associated with increased complications. This study was conducted to assess the factors affecting outcome of single stage hypospadias surgery in adults.</p><p><strong>Material and methods: </strong>This study included patients (>12 years) undergoing hypospadias repair in single stage. Preoperative factors were assessed and outcome parameters including early complications (within 1 month) and late complications (after 1 month) were studied and statistically analyzed.</p><p><strong>Results: </strong>Of the 31 patients included (mean age 20.8 6 7.87 years), 38.7% had a history of previous surgery. Mean glans width was 17.54 6 1.78mm. Postoperatively, the median hospital stay was 5 days (range: 4- 10 days), and the median catheter duration was 21 days (range: 7-21 days). Overall complication rate was 54.83% at 6-month follow-up. Early complications comprised of infection, skin necrosis, and dehiscence of suture line. Late complications included urethrocutaneous fistula, glans dehiscence, and urethral stricture. On performing univariate logistic regression, glans width, urethral plate width and shape, and history of previous surgery were significant risk factors of postsurgery complications. On multivariate logistic regression, glans width was an independent significant risk factor (odds ratio: 0.197).</p><p><strong>Conclusion: </strong>Several factors are associated with significant complications in adult hypospadias single stage repair. Among the various risk factors, glans width is an independent significant risk factor affecting outcome.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/f2/tju-47-5-420.PMC9612767.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraurethral lidocaine use during urodynamics in female patients: A systematic review and meta-analysis.","authors":"Dian Paramita Oktaviani,&nbsp;Mohammad Ayodhia Soebadi,&nbsp;Yudhistira Pradnyan Kloping,&nbsp;Furqan Hidayatullah,&nbsp;Zakaria Aulia Rahman,&nbsp;Soetojo Soetojo","doi":"10.5152/tud.2021.21182","DOIUrl":"https://doi.org/10.5152/tud.2021.21182","url":null,"abstract":"<p><p>Pain and discomfort may occur in catheterization during a urodynamic examination. A lidocaine gel combined with a water-based lubricant is sometimes used to reduce pain during catheterization. Several studies claimed that intraurethral lidocaine administration could cause inaccurate urodynamic parameters results. However, its definite effects in urodynamics testing on humans are still not clear. We aimed to evaluate the effects of intraurethral lidocaine on pain and urodynamic study parameters in patients undergoing an invasive urodynamic examination. A systematic search adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol was performed in the MEDLINE, PubMed, and ScienceDirect databases for randomized controlled trials (RCTs). The bias of the studies is evaluated using the Cochrane risk of bias tool by two independent reviewers. The analyses of continuous outcomes were displayed as mean difference (MD), whereas odds ratio is used to analyze dichotomous data. Heterogeneity between studies is determined using the I2 value. A total of three RCTs out of 622 discovered that articles were eligible for analysis. Forest plot analysis of the mean visual analogue scale difference of the studies indicated an insignificant difference between the lidocaine and placebo group (MD -7.68; 95% CI -34.04 to -18.68, P ¼ .57). All urodynamic parameter results were also similar between the two groups (P > .05). Routine intraurethral lidocaine injection prior to a urodynamic study does not affect pain intensity and urodynamic parameters.</p>","PeriodicalId":23366,"journal":{"name":"Turkish journal of urology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9612774/pdf/tju-47-5-366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39889275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}