A systematic review of non-HPV prognostic biomarkers used in penile squamous cell carcinoma.

IF 1 Q4 UROLOGY & NEPHROLOGY
Jessica Bowie, Sobha Singh, Ciaran O'Hanlon, Vishal Shiatis, Oliver Brunckhorst, Asif Muneer, Kamran Ahmed
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Abstract

The presence of lymph node metastasis is the most important prognostic indicator for patients with penile cancer. However, predicting which clinically node negative patients will harbor lymph node metastases remains unclear. The aim of this systematic review is to provide an overview of biomarkers p53, Ki-67, and SCCAg in predicting lymph node metastasis (LNM) and cancer-specific survival (CSS) in penile squamous cell carcinoma (SCC). MEDLINE, EMBASE, Cochrane Library, Scopus, and ClinicalTrials.gov were searched from inception until 15 October 2020. Eligible studies were identified by three independent reviewers. Outcome measures included the presence of penile LNM and CSS. Extracted data were narratively synthesized with GRADE criteria utilized to evaluate the quality of evidence. In total, 999 articles were screened with 20 selected for inclusion. Studies reporting the use of p53 to predict LNM and CSS were rated as having the highest quality of evidence using the GRADE criteria, and the majority showed a positive association between p53 expression and LNM and CSS. All biomarkers and outcome combinations had at least one study showing a significant effect on predicting the outcome. However, studies were heterogeneous, and many reported nonsignificant effects. Identifying p53 overexpression may help one to identify patients at higher risks of LNM to be considered for early inguinal lymphadenectomy. There is contradictory and unreliable evidence for the prognostic value of Ki-67 and SCCAg in penile SCC for LNM and CSS. Larger studies are required with more rigorous methods and reports to improve the evidence base.

Abstract Image

Abstract Image

阴茎鳞状细胞癌中非hpv预后生物标志物的系统回顾。
有无淋巴结转移是阴茎癌患者最重要的预后指标。然而,预测哪些临床淋巴结阴性患者会有淋巴结转移仍不清楚。本系统综述的目的是提供生物标志物p53、Ki-67和SCCAg在预测阴茎鳞状细胞癌(SCC)淋巴结转移(LNM)和癌症特异性生存(CSS)方面的概述。检索自成立至2020年10月15日的MEDLINE、EMBASE、Cochrane Library、Scopus和ClinicalTrials.gov。符合条件的研究由三名独立审稿人确定。结果测量包括阴茎LNM和CSS的存在。提取的资料以GRADE标准进行叙述性综合,用于评价证据质量。共筛选了999篇文章,其中20篇入选。使用GRADE标准,报告使用p53预测LNM和CSS的研究被评为具有最高质量的证据,并且大多数研究显示p53表达与LNM和CSS之间存在正相关。所有生物标志物和结果组合至少有一项研究显示对预测结果有显著影响。然而,研究是异质的,许多报告的效果不显著。识别p53过表达可能有助于识别LNM风险较高的患者,考虑早期进行腹股沟淋巴结切除术。Ki-67和SCCAg在阴茎SCC对LNM和CSS的预后价值存在矛盾和不可靠的证据。需要更严格的方法和报告进行更大规模的研究,以改善证据基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Turkish journal of urology
Turkish journal of urology Medicine-Urology
CiteScore
2.10
自引率
0.00%
发文量
53
期刊介绍: The aim of the Turkish Journal of Urology is to contribute to the literature by publishing scientifically high-quality research articles as well as reviews, editorials, letters to the editor and case reports. The journal’s target audience includes, urology specialists, medical specialty fellows and other specialists and practitioners who are interested in the field of urology.
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