Turkish Journal of Hematology最新文献

{"title":"Epithelial Cells or Vascular Smooth Muscle Cells in a Peripheral Blood Smear?","authors":"Wei Yang, Yongliang Wang, Wei Pan","doi":"10.4274/tjh.galenos.2024.2023.0399","DOIUrl":"10.4274/tjh.galenos.2024.2023.0399","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"47-48"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Cutaneous Peripheral T-cell Lymphoma-Not Otherwise Specified with Extensive Ulceronecrotic Dyschromic Plaques and Poor Outcome","authors":"Vishnu Sharma, Vansh Bagrodia","doi":"10.4274/tjh.galenos.2023.2023.0222","DOIUrl":"10.4274/tjh.galenos.2023.2023.0222","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"43-44"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9766861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Intravascular Coagulation in Acute Promyelocytic Leukemia Patients: A Retrospective Analysis of Outcomes and Healthcare Burden in US Hospitals","authors":"Rushin Patel, Darshil Patel, Mrunal Patel, Jessica Ohemeng-Dapaah, Afoma Onyechi, Zalak Patel, Chieh Yang, Safia Shaikh","doi":"10.4274/tjh.galenos.2024.2023.0479","DOIUrl":"10.4274/tjh.galenos.2024.2023.0479","url":null,"abstract":"<p><strong>Objective: </strong>Acute promyelocytic leukemia (APL) is associated with an elevated risk of developing disseminated intravascular coagulation (DIC). The purpose of this study was to assess the outcomes of hospitalizations related to DIC in APL and their impact on healthcare.</p><p><strong>Materials and methods: </strong>This study entailed a cross-sectional and retrospective analysis of the US National Inpatient Sample database. We identified adults with APL and categorized them into groups of patients with and without DIC. Our focus areas included in-hospital mortality, length of stay, charges, and complications associated with DIC. Unadjusted odds ratios/coefficients were computed in univariate analysis, followed by adjusted odds ratios (aOR)/coefficients from multivariate analysis that accounted for confounding factors.</p><p><strong>Results: </strong>Our analysis revealed that APL patients with DIC had a substantially higher aOR for mortality (aOR: 6.68, 95% confidence interval [CI]: 4.76-9.37, p<0.001) and a prolonged length of stay (coefficient: 10.28 days, 95% CI: 8.48-12.09, p<0.001) accompanied by notably elevated total hospital charges (coefficient: $215,512 [95% CI: 177,368-253,656], p<0.001), thereby emphasizing the reality of extended medical care and economic burden. The presence of DIC was associated with increased odds of sepsis, vasopressor support, pneumonia, acute respiratory failure, intubation/mechanical ventilation, and acute kidney injury, reflecting heightened vulnerability to these complications. Patients with DIC demonstrated significantly higher odds ratios for major bleeding, intracranial hemorrhage, gastrointestinal bleeding, red blood cell transfusion, platelet transfusion, fresh frozen plasma transfusion, and cryoprecipitate transfusion, highlighting the pronounced hematological risks posed by DIC.</p><p><strong>Conclusion: </strong>This study has revealed the significant associations between DIC in APL and various outcomes, underscoring the clinical and economic implications of these conditions. The hematological risks further increase patients’ vulnerability to bleeding events and the need for transfusions.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Hereditary FXII Deficiency Caused by Three Mutations Including a Novel Mutation","authors":"Longying Ye, Meina Liu, Lihong Yang, Mingshan Wang, Yaosheng Xie","doi":"10.4274/tjh.galenos.2024.2024.0016","DOIUrl":"10.4274/tjh.galenos.2024.2024.0016","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"66-68"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Many Faces of Multiple Myeloma","authors":"Asya Tuğçe Bol, Güldane Cengiz Seval, Meral Beksaç, Işınsı Kuzu","doi":"10.4274/tjh.galenos.2023.2023.0183","DOIUrl":"10.4274/tjh.galenos.2023.2023.0183","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"41-42"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Monocytes Phagocytosing Lymphocytes in the Small-Cell Variant of T-Cell Prolymphocytic Leukemia","authors":"Shuai Zhang, Meng Ma, Yanping Liu, Ying Bu, Zhe Zhang, Yun Zhang","doi":"10.4274/tjh.galenos.2023.2023.0422","DOIUrl":"10.4274/tjh.galenos.2023.2023.0422","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"53-54"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin Replacement Therapy for Hypogammaglobulinemia in Multiple Myeloma Should Not Be Ignored","authors":"Qinggang Zhang, Yongliang Wang, Wei Pan","doi":"10.4274/tjh.galenos.2024.2023.0401","DOIUrl":"10.4274/tjh.galenos.2024.2023.0401","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"51-52"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of Rare Gene Alterations in the Prognosis of B-Cell Acute Lymphoblastic Leukemia","authors":"Li Xiang, Yongliang Wang, Wei Pan","doi":"10.4274/tjh.galenos.2024.2023.0400","DOIUrl":"10.4274/tjh.galenos.2024.2023.0400","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"49-50"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rifampicin-Induced Toxic Hepatitis in a Patient with Hemophilia After Chemical Synovectomy","authors":"Mehmet Can Uğur, Semih Aydoğdu, Elçil Kaya Biçer, Can Balkan, Kaan Kavaklı","doi":"10.4274/tjh.galenos.2024.2023.0420","DOIUrl":"10.4274/tjh.galenos.2024.2023.0420","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"64-65"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of <i>CALR</i> and <i>JAK2</i>V617F Mutations on Clinical Course and Disease Outcomes in Essential Thrombocythemia: A Multicenter Retrospective Study in Turkish Patients.","authors":"Zehra Narlı Özdemir, Yıldız İpek, Püsem Patır, Gözde Ermiş, Rafiye Çiftçiler, Deniz Özmen, Mehmet Baysal, Vildan Gürsoy, Esra Yıldızhan, Serkan Güven, Tarık Ercan, Tayfun Elibol, Sinan Mersin, Eylem Genç, Eren Arslan Davulcu, Volkan Karakuş, Nergiz Erkut, Gürsel Güneş, Reyhan Diz Küçükkaya, Ahmet Emre Eşkazan","doi":"10.4274/tjh.galenos.2024.2023.0430","DOIUrl":"10.4274/tjh.galenos.2024.2023.0430","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we investigated the effects of calreticulin (<i>CALR</i>) and <i>JAK2</i>V617F mutational status on clinical course and disease outcomes in Turkish patients with essential thrombocythemia (ET).</p><p><strong>Materials and methods: </strong>Seventeen centers from Türkiye participated in the study and <i>CALR</i>- and <i>JAK2</i>V617F-mutated ET patients were evaluated retrospectively.</p><p><strong>Results: </strong>A total of 302 patients were included, of whom 203 (67.2%) and 99 (32.8%) were <i>JAK2</i>V617F- and <i>CALR</i>-positive, respectively. <i>CALR</i>-mutated patients were significantly younger (51 years vs. 57.5 years, p=0.03), with higher median platelet counts (987x10⁹/L vs. 709x10⁹/L, p<0.001) and lower median hemoglobin levels (13.1 g/dL vs. 14.1 g/dL, p<0.001) compared to <i>JAK2</i>V617F-mutated patients. Thromboembolic events (TEEs) occurred in 54 patients (17.9%), 77.8% of which were arterial. Compared to <i>CALR</i> mutation, <i>JAK2</i>V617F was associated with a higher risk of thrombosis (8.1% vs. 22.7%, p=0.002). Rates of transformation to myelofibrosis (MF) and leukemia were 4% and 0.7%, respectively, and these rates were comparable between <i>JAK2</i>V617F- and <i>CALR</i>-mutated cases. The estimated overall survival (OS) and MF-free survival of the entire cohort were 265.1 months and 235.7 months, respectively. OS and MF-free survival durations were similar between <i>JAK2</i>V617F- and <i>CALR</i>-mutated patients. Thrombosis-free survival (TFS) was superior in <i>CALR</i>-mutated patients compared to <i>JAK2</i>V617F-positive patients (5-year TFS: 90% vs. 71%, respectively; p=0.001). Age at diagnosis was an independent factor affecting the incidence of TEEs.</p><p><strong>Conclusion: </strong>In our ET cohort, <i>CALR</i> mutations resulted in higher platelet counts and lower hemoglobin levels than <i>JAK2</i>V617F and were associated with younger age at diagnosis. <i>JAK2</i>V617F was strongly associated with thrombosis and worse TFS. Hydroxyurea was the most preferred cytoreductive agent for patients with high thrombosis risk.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"41 1","pages":"26-36"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}