Turkish Journal of Hematology最新文献

{"title":"Analysis of Hereditary FXII Deficiency Caused by Three Mutations Including a Novel Mutation","authors":"Longying Ye, Meina Liu, Lihong Yang, Mingshan Wang, Yaosheng Xie","doi":"10.4274/tjh.galenos.2024.2024.0016","DOIUrl":"10.4274/tjh.galenos.2024.2024.0016","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"66-68"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Many Faces of Multiple Myeloma","authors":"Asya Tuğçe Bol, Güldane Cengiz Seval, Meral Beksaç, Işınsı Kuzu","doi":"10.4274/tjh.galenos.2023.2023.0183","DOIUrl":"10.4274/tjh.galenos.2023.2023.0183","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"41-42"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Monocytes Phagocytosing Lymphocytes in the Small-Cell Variant of T-Cell Prolymphocytic Leukemia","authors":"Shuai Zhang, Meng Ma, Yanping Liu, Ying Bu, Zhe Zhang, Yun Zhang","doi":"10.4274/tjh.galenos.2023.2023.0422","DOIUrl":"10.4274/tjh.galenos.2023.2023.0422","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"53-54"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin Replacement Therapy for Hypogammaglobulinemia in Multiple Myeloma Should Not Be Ignored","authors":"Qinggang Zhang, Yongliang Wang, Wei Pan","doi":"10.4274/tjh.galenos.2024.2023.0401","DOIUrl":"10.4274/tjh.galenos.2024.2023.0401","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"51-52"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of Rare Gene Alterations in the Prognosis of B-Cell Acute Lymphoblastic Leukemia","authors":"Li Xiang, Yongliang Wang, Wei Pan","doi":"10.4274/tjh.galenos.2024.2023.0400","DOIUrl":"10.4274/tjh.galenos.2024.2023.0400","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"49-50"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139088741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rifampicin-Induced Toxic Hepatitis in a Patient with Hemophilia After Chemical Synovectomy","authors":"Mehmet Can Uğur, Semih Aydoğdu, Elçil Kaya Biçer, Can Balkan, Kaan Kavaklı","doi":"10.4274/tjh.galenos.2024.2023.0420","DOIUrl":"10.4274/tjh.galenos.2024.2023.0420","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"64-65"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139698356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of <i>CALR</i> and <i>JAK2</i>V617F Mutations on Clinical Course and Disease Outcomes in Essential Thrombocythemia: A Multicenter Retrospective Study in Turkish Patients.","authors":"Zehra Narlı Özdemir, Yıldız İpek, Püsem Patır, Gözde Ermiş, Rafiye Çiftçiler, Deniz Özmen, Mehmet Baysal, Vildan Gürsoy, Esra Yıldızhan, Serkan Güven, Tarık Ercan, Tayfun Elibol, Sinan Mersin, Eylem Genç, Eren Arslan Davulcu, Volkan Karakuş, Nergiz Erkut, Gürsel Güneş, Reyhan Diz Küçükkaya, Ahmet Emre Eşkazan","doi":"10.4274/tjh.galenos.2024.2023.0430","DOIUrl":"10.4274/tjh.galenos.2024.2023.0430","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we investigated the effects of calreticulin (<i>CALR</i>) and <i>JAK2</i>V617F mutational status on clinical course and disease outcomes in Turkish patients with essential thrombocythemia (ET).</p><p><strong>Materials and methods: </strong>Seventeen centers from Türkiye participated in the study and <i>CALR</i>- and <i>JAK2</i>V617F-mutated ET patients were evaluated retrospectively.</p><p><strong>Results: </strong>A total of 302 patients were included, of whom 203 (67.2%) and 99 (32.8%) were <i>JAK2</i>V617F- and <i>CALR</i>-positive, respectively. <i>CALR</i>-mutated patients were significantly younger (51 years vs. 57.5 years, p=0.03), with higher median platelet counts (987x10⁹/L vs. 709x10⁹/L, p<0.001) and lower median hemoglobin levels (13.1 g/dL vs. 14.1 g/dL, p<0.001) compared to <i>JAK2</i>V617F-mutated patients. Thromboembolic events (TEEs) occurred in 54 patients (17.9%), 77.8% of which were arterial. Compared to <i>CALR</i> mutation, <i>JAK2</i>V617F was associated with a higher risk of thrombosis (8.1% vs. 22.7%, p=0.002). Rates of transformation to myelofibrosis (MF) and leukemia were 4% and 0.7%, respectively, and these rates were comparable between <i>JAK2</i>V617F- and <i>CALR</i>-mutated cases. The estimated overall survival (OS) and MF-free survival of the entire cohort were 265.1 months and 235.7 months, respectively. OS and MF-free survival durations were similar between <i>JAK2</i>V617F- and <i>CALR</i>-mutated patients. Thrombosis-free survival (TFS) was superior in <i>CALR</i>-mutated patients compared to <i>JAK2</i>V617F-positive patients (5-year TFS: 90% vs. 71%, respectively; p=0.001). Age at diagnosis was an independent factor affecting the incidence of TEEs.</p><p><strong>Conclusion: </strong>In our ET cohort, <i>CALR</i> mutations resulted in higher platelet counts and lower hemoglobin levels than <i>JAK2</i>V617F and were associated with younger age at diagnosis. <i>JAK2</i>V617F was strongly associated with thrombosis and worse TFS. Hydroxyurea was the most preferred cytoreductive agent for patients with high thrombosis risk.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"41 1","pages":"26-36"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiphospholipid Syndrome: To Classify or Not to Classify?","authors":"Doruk Erkan","doi":"10.4274/tjh.galenos.2024.2024.0003","DOIUrl":"10.4274/tjh.galenos.2024.2024.0003","url":null,"abstract":"<p><p>Antiphospholipid syndrome (APS) is a systemic autoimmune disorder resulting in thrombosis, microvascular disease, morbidity in pregnancy, and/or non-thrombotic manifestations. The recently introduced 2023 American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology (EULAR) APS classification criteria, with significantly higher specificity compared to the revised Sapporo criteria, now reflect the current thinking about APS and provide a new foundation for future APS research. The purpose of this short commentary is to discuss the appropriate circumstances under which the 2023 ACR/EULAR classification criteria could be used and to demonstrate how the new criteria can be applied to simple case scenarios.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"37-40"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Ibrutinib-Induced Thrombocytopenia in a Patient with Chronic Lymphocytic Leukemia: No Interruption, Only Reduction","authors":"Simge Erdem, Meliha Nalçacı","doi":"10.4274/tjh.galenos.2023.2023.0426","DOIUrl":"10.4274/tjh.galenos.2023.2023.0426","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"55-56"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138831697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibrutinib-Associated Leukocytoclastic Vasculitis in a Patient with Chronic Lymphocytic Leukemia.","authors":"Ayşe Kaya, İbrahim Aras, Pervin Özkan Kurtgöz, Umut Çakıroğlu","doi":"10.4274/tjh.galenos.2023.2023.0368","DOIUrl":"10.4274/tjh.galenos.2023.2023.0368","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"41 1","pages":"57-58"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}