Trends in Medicine最新文献_第2页

Determinants of the implementation of hospital risk management: Case of the Provincial Hospital Center of El Jadida Morocco 实施医院风险管理的决定因素:以摩洛哥贾迪达省医院中心为例

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000273

Sakhr Ahizoune, R. Benkirane, Mina El Hiyani, A. Mdaghri Alaoui

{"title":"Determinants of the implementation of hospital risk management: Case of the Provincial Hospital Center of El Jadida Morocco","authors":"Sakhr Ahizoune, R. Benkirane, Mina El Hiyani, A. Mdaghri Alaoui","doi":"10.15761/tim.1000273","DOIUrl":"https://doi.org/10.15761/tim.1000273","url":null,"abstract":"Introduction: Describe the determinants of the implementation of the Hospital Risk Management (HRM) approach at the Provincial Hospital Center (PHC) of El Jadida. Methods: The study was conducted from July 2018 to December 2019 at the Provincial Hospital Center of El Jadida. It is a descriptive study, aims to describe the determinants of the implementation of the risk management approach at the PHC El Jadida through an interview with the heads of the HRM unit, a questionnaire for hospital managers and a questionnaire for professionals of the said PHC. Results: Among the 338 participants in the study, more than half of them said that training and awareness are the main determinants for the implementation of the HRM approach in addition to the commitment of the administration. All of the managers interviewed agreed that the existence of the HRM unit is the starting point for any implementation of the HRM approach, while 87.1% stated that there was no HRM policy. 87.6% of the professionals have not had any HRM training, while 97.6% of them have expressed their needs in terms of HRM training. 85% of the professionals are unaware of the HRM procedure and the obligation to declare risks, which has impacted the implementation of this approach. Discussion: The confrontation of our results allowed us to determine the determinants of the implementation of HRM, namely: (a) establishment of the HRM unit, (b) commitment of the administration, (c) awareness raising, (d) training, (e) design of an HRM policy, (f) institutionalization and regulation of the approach, (g) design of the HRM process. Conclusion: Hospital risk management is essential for any hospital organization, enabling managers to make appropriate decisions.","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85459063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compounds targeting multiple prostanoid receptors 靶向多种前列腺素受体的化合物

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000264

David F Woodward, Jenny W Wang

{"title":"Compounds targeting multiple prostanoid receptors","authors":"David F Woodward, Jenny W Wang","doi":"10.15761/tim.1000264","DOIUrl":"https://doi.org/10.15761/tim.1000264","url":null,"abstract":"The prostanoids are a large family of oxygenated fatty acids that mediate numerous biological effects. They are biosynthesized from arachidonic acid by the enzymes cyclo-oxygenase-1 and -2 and inhibitors of these enzymes are widely indicated as drugs for treating inflammation, pain, and fever. Following structural elucidation of the pharmacologically defined prostanoid receptors, drug design largely switched from COX inhibitors to pharmacology. Potent and selective antagonists for each of the prostanoid receptors (DP 1-2 , EP 1-4 , FP, IP, TP) were developed but these have not translated into widely used new drugs, despite the clear importance of prostanoids in disease. Responding to this situation, a new polypharmacological approach was adopted whereby multiple activities were embodied in a single molecule. The receptors selected for antagonism were selected based on known roles in mediating inflammation and fibrosis. Receptors opposing pro-inflammatory events, notably EP 2 , were left open so that PGE 2 may be converted from a pro-inflammatory to an endogenously released anti-inflammatory mediator. This resulted in compounds with greater anti-inflammatory efficacy than antagonists selective for a single prostanoid receptor and cyclo-oxygenase inhibitors. Next steps in the","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89637638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tele-health in the era of COVID-19 pandemic: Pros and cons COVID-19大流行时代的远程医疗:利与弊

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000269

Abu Bashar, Nazia Begam, Sachin Gupta

引用次数: 1

Complex treatment after pathohistological and immunohistochemical analysis in synchronous neoplasms - anorectal achromatic malignant melanoma and gastric extrapleural solitary fibrous tumor 同步肿瘤-肛肠消色差恶性黑色素瘤和胃胸膜外孤立性纤维性肿瘤的病理组织学和免疫组织化学分析后的综合治疗

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/TIM.1000258

L. Marinova, B. Yordanova, N. Evgeniev, K. Petrova

引用次数: 0

PVAT mediated immunomodulation in vasculo-adipose balance in atherosclerosis 动脉粥样硬化中PVAT介导的血管-脂肪平衡免疫调节

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000270

N. Kaur, A. Avasthi, S. Sharda, A. Misra

{"title":"PVAT mediated immunomodulation in vasculo-adipose balance in atherosclerosis","authors":"N. Kaur, A. Avasthi, S. Sharda, A. Misra","doi":"10.15761/tim.1000270","DOIUrl":"https://doi.org/10.15761/tim.1000270","url":null,"abstract":"Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction, lipid deposition and inflammatory infiltration [1]. Endothelial dysfunction/injury caused by high shear stress promotes initiation of atherosclerosis, followed by subsequent adhesion of circulating inflammatory cells to the dysfunctional endothelium. These processes are further aggravated by accumulation of cholesterol in the arterial wall and lead to atherosclerosis [2]. One of the identified features of endothelial cells in response to local inflammation is dedifferentiation and switching of endothelial-to-mesenchymal transition which may be involved in the loss of endothelial phenotypes towards unspecialized mesenchymal-like cells that could undergo redifferentiation into mesodermal cell types, including adipocytes, in response to local inflammation [3]. This process can be triggered by various inflammatory cytokines and TGF-β which are produced in inflamed adipose tissue [4]. Adipose tissues play a significant role in atherosclerosis progression and are broadly classified as white adipose tissue (WAT) and brown adipose tissue (BAT). Initial studies have supported the hypothesis that dysfunctional WAT might be positively associated with atherosclerosis development, whereas activation of BAT may protect against atherosclerosis development. A third type beige adipose tissue (BeAT), has also been identified which is characterized by high expression of the brown adipocyte marker uncoupling protein-1 (UCP-1) [5].","PeriodicalId":23337,"journal":{"name":"Trends in Medicine","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74422521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Place of Yoga in Radiotherapy 瑜伽在放射治疗中的地位

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000286

Cihan Yb

引用次数: 0

Observational study on the tolerability of cluster immunotherapy schedules in patients sensitized to house dust mites 簇免疫治疗方案对屋尘螨敏感患者耐受性的观察研究

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000285

Garriga-Baraut T, J. P., Hernandez Hr, Gonzalez Perez R, Melgar Perez J, E. D., Escudero Arias E, Rondon Segovia C, Pajaron Fernandez MJ, Figueroa Rivero J, Cancelliere N, S. B, T. M

引用次数: 0

Pharmacokinetics, safety, and tolerability of Pentoxifylline intravaginal gel for subfertile/ infertile couples with low sperm quality: phase I randomized controlled clinical trial in healthy women 己酮茶碱阴道内凝胶治疗低精子质量不育夫妇的药代动力学、安全性和耐受性:健康女性的I期随机对照临床试验

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000263

Maria Rosa Ballester, M. Puntes, Jimena Coimbra, J. Perelló, I. Gich, Rosa Maria Antonijoan

引用次数: 0

An opinion of why HIV is disproportionately high in sub-Saharan Africa 关于为什么艾滋病毒在撒哈拉以南非洲高得不成比例的观点

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000278

Jiman He

引用次数: 2

Extracts from dietary fern, Ceratopteris thalictroides enriched in alkaloids induce apoptosis and lead to tumor regression in mice without causing toxicity to normal cells 膳食蕨类植物角蕨提取物富含生物碱，可诱导小鼠细胞凋亡，导致肿瘤消退，而对正常细胞无毒性作用

Trends in Medicine Pub Date : 2021-01-01 DOI: 10.15761/tim.1000279

Varsha Kk, Savithri A, R. U, S. S, K. A, Raghavan Sc

引用次数: 0