Tremor and Other Hyperkinetic Movements最新文献

{"title":"Ultrasound-Guided Botulinum Toxin Infiltrations in Essential Tremor Patients: A 36-week Follow Up.","authors":"Gabriel Salazar, Iolanda Caballero","doi":"10.5334/tohm.957","DOIUrl":"10.5334/tohm.957","url":null,"abstract":"<p><strong>Background: </strong>Essential tremor (ET) presents therapeutic challenges as oral therapies, are often partially effective and carry adverse effects. Deep Brain Stimulation and High-intensity Focused Ultrasound targeting the ventral intermediate thalamic nucleus show efficacy in managing ET; however, their cost and invasiveness deter some patients. Botulinum toxin infiltrations for ET in the upper limbs have been limited by adverse effects. Most studies used manual or electromyography guidance, while ultrasound guidance has been less explored. The purpose of the present study was to investigate the potential long-term improvement in tremor and quality of life among ET patients following ultrasound-guided IncobotulinumtoxinA (IncoBoNT) infiltrations.</p><p><strong>Methods: </strong>We present 18 ET patients who received IncoBoNT injections guided by ultrasounds. We also propose an anatomo-physiological paradigm for targeting muscles in ET patients based on two different tremor patterns.</p><p><strong>Results: </strong>Eighteen ET patients (mean age 68.2 years) were followed over 12 months. After 36 weeks, patients with supination/pronation (SPP) and flexion/extension (FEP) patterns showed significant TETRAS score improvements: 46.4% in SPP (p = 0.0022) and 48.2% in FEP (p = 0.0021). The QUEST-QOL score also improved (65% in SPP, p = 0.0018; 62.7% in FEP, p = 0.0018). All patients presented notable improvements in mean scores on the self-evaluating spiral test and neurophysiological measures (p < 0.01 for all). Treatment effects lasted 8-12 weeks, with temporary numbness and pain reported, and no cumulative effects observed.</p><p><strong>Discussion: </strong>Ultrasound-guided IncoBoNT infiltrations show promise for oral treatment-resistant ET patients with minimal adverse effects. The anatomophysiological paradigm utilized proved beneficial for our patients, although tremor pattern variability remains a consideration.</p><p><strong>Highlights: </strong>Essential tremor patients often face limited options, as oral therapies often yield only partial efficacy, and invasive interventions, like Deep Brain Stimulation, may not always be viable. In this open-label study, 18 patients received ultrasound-guided IncobotulinumtoxinA injections, showing significant tremor improvement and enhanced quality of life, with minimal adverse events reported.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"8"},"PeriodicalIF":2.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Individual Upper-Limb Muscles to Contribute to Postural Tremor: Simulations From Neural Drive to Joint Rotation.","authors":"Spencer A Baker, Landon J Beutler, Daniel B Free, Dario Farina, Steven K Charles","doi":"10.5334/tohm.949","DOIUrl":"10.5334/tohm.949","url":null,"abstract":"<p><strong>Background: </strong>It is unclear which muscles contribute most to tremor and should therefore be targeted by tremor suppression methods. Previous studies used mathematical models to investigate how upper-limb biomechanics affect muscles' potential to generate tremor. These investigations yielded principles, but the models included at most only 15 muscles. Here we expand previous models to include 50 upper-limb muscles, simulate tremor propagation, and test the validity of the previously postulated principles.</p><p><strong>Methods: </strong>Tremor propagation was characterized using the gains between tremorogenic neural drive to the 50 muscles (inputs) and tremulous joint rotations in the 7 joint degrees-of-freedom (DOF) from shoulder to wrist (outputs). Each gain can be interpreted as the potential of a muscle to generate tremor in a DOF. Robustness and sensitivity analyses were performed to assess the effects of model parameter variability on gains.</p><p><strong>Results: </strong>Simulations of postural tremor using the expanded model confirmed the previously postulated principles and revealed new insights, including: 1) most of the muscles with the largest gains were among the 15 muscles in the original model; 2) some gains depended strongly on posture; 3) averaged across the postures included in this study, the largest gains belonged to input-output pairs involving biceps/forearm/wrist muscles and forearm/wrist DOF, 4) although some shoulder and extrinsic hand muscles also exhibited large gains, especially in select postures.</p><p><strong>Discussion: </strong>These observations suggest that in the absence of additional information (such as tremorogenic neural drive to muscles), peripheral tremor suppression efforts should start by targeting biceps/forearm/wrist muscles or forearm/wrist DOF.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"7"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Spine Correction Belt for Treatment of Diaphragmatic Flutter.","authors":"Yoshiaki Kazama, Yuichi Ando, Masashi Suzuki, Juichi Sato","doi":"10.5334/tohm.967","DOIUrl":"10.5334/tohm.967","url":null,"abstract":"<p><strong>Background: </strong>Diaphragmatic flutter is an unusual movement disorder characterized by involuntary and repetitive contractions of the diaphragm. The pathophysiology is unclear. Its treatment is very difficult and challenging.</p><p><strong>Case report: </strong>A 70-year-old man presented with diaphragmatic flutter associated with severe abdominal pain in a sitting position, which stopped in a supine position. Videofluoroscopy clearly depicted diaphragmatic movements on postural change. A spine correction belt was effective for stopping diaphragmatic flutter.</p><p><strong>Discussion: </strong>This is the first reported case of diaphragmatic flutter for which a spine correction belt was used as successful and safe treatment.</p><p><strong>Highlights: </strong>Diaphragmatic flutter is an unusual movement disorder of the diaphragm. We describe a 70-year-old man who presented with diaphragmatic flutter associated with severe pain in a sitting position, which stopped in a supine position. A spine correction belt was used as successful and safe treatment for diaphragmatic flutter.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"6"},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Choreiform Movements in a Child: Early Recognition and Management of Sydenham Chorea.","authors":"Jason M Jaronik, Nicholas A Scott, Bruce D Harley, Phillip L Marsh, Hassaan A Khan, Sufyan Zackariya, Anna M Tincher, Anthony V Thomas, Mahmoud D Al-Fadhl, John R Bales, Morgan C Lain, Uzma Rizvi, Randall J Bjork, Mark M Walsh","doi":"10.5334/tohm.988","DOIUrl":"10.5334/tohm.988","url":null,"abstract":"<p><strong>Background: </strong>Sydenham chorea, a rare neurological manifestation of acute rheumatic fever, persists in developed countries due to rheumatogenic strains of group A streptococcus.</p><p><strong>Phenomenology shown: </strong>This case demonstrates the evolution from subtle early symptoms to definitive severe choreiform movements in Sydenham chorea in a 10-year-old female.</p><p><strong>Educational value: </strong>This case highlights the importance of early recognition, multidisciplinary management, and vigilance in medication administration to optimize outcomes in rare conditions such as Sydenham chorea.</p><p><strong>Highlights: </strong>This case highlights the diagnostic and management challenges of Sydenham chorea, showcasing its progression from subtle early symptoms to definitive severe choreiform movements. It demonstrates the importance of early recognition, multidisciplinary care, and cautious medication administration to optimize outcomes in this rare neurological condition associated with rheumatic fever.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"5"},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Telangiectasia and Cerebellar Atrophy in Ataxia-Telangiectasia (Louis-Bar Syndrome).","authors":"Lukas Gattermeyer-Kell, Daniela Kern, Mariella Kögl, Petra Schwingenschuh","doi":"10.5334/tohm.992","DOIUrl":"10.5334/tohm.992","url":null,"abstract":"<p><strong>Background: </strong>Ataxia-telangiectasia (Louis-Bar syndrome) is a rare genetic disorder characterized by progressive ataxia, ocular telangiectasias, immunodeficiency and increased cancer risk due to impaired DNA repair.</p><p><strong>Phenomenology shown: </strong>Thorough clinical and subsequently radiological examination in a 19-year-old woman with a history of previously undiagnosed, progressive gait ataxia since early childhood, diffuse large B-cell lymphoma and severe combined immunodeficiency revealed the eponymous features of the disease, ocular telangiectasias and cerebellar atrophy, enabling targeted genetic testing.</p><p><strong>Educational value: </strong>Ocular telangiectasias represent an important clue for a diagnosis of ataxia-telangiectasia in young patients with progressive ataxia, implicating awareness of increased malignancy risk and treatment of immunodeficiency.</p><p><strong>Highlights: </strong>Ataxia-telangiectasia is a rare genetic disorder characterized by its eponymous features, progressive cerebellar ataxia and ocular telangiectasias. These signs can help in establishing an early diagnosis, hence preventing, or addressing secondary complications of the disease caused by impaired DNA repair, such as malignancies, immunodeficiency, and increased radiation sensitivity.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"4"},"PeriodicalIF":2.5,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Ultrasound in the Evaluation of Tardive Dyskinesia: A Case Series.","authors":"Ujjawal Roy, Ajay Panwar, Achal Kumar Srivastava, Michael S Cartwright","doi":"10.5334/tohm.966","DOIUrl":"https://doi.org/10.5334/tohm.966","url":null,"abstract":"<p><strong>Background: </strong>Despite efforts to visualize all the movements of tongue and oropharynx in individuals with focal movement disorders (specifically tardive dyskinesia (TD)), clinicians can miss the complete picture and additional tools may be required to reach an accurate diagnosis.</p><p><strong>Cases: </strong>We present three cases with TD where ultrasound assisted in diagnoses. These individuals had difficulty swallowing and abnormal sensations in the tongue, which remained undiagnosed until we performed ultrasound of oropharynx which allowed for characterization of these movements.</p><p><strong>Discussion: </strong>Ultrasound is an ideal modality for imaging the tongue and oropharynx in TD. Further research should include large case series and standardized protocols for evaluation of these disorders.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"3"},"PeriodicalIF":2.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-Onset Myoclonus in a Large Urban Inpatient Setting: A Retrospective Cohort Study.","authors":"Karin Oh, Moath Hamed, Donna Zarandi, Moyosore Oluleye, Anas Zaher, Jude Elsayegh, Shaheen-Ahmed Rizly, Xiaoyue Ma, Hwai Yin Ooi, Harini Sarva, Miran Salgado, Daryl Victor","doi":"10.5334/tohm.977","DOIUrl":"10.5334/tohm.977","url":null,"abstract":"<p><strong>Background: </strong>Myoclonus is a hyperkinetic movement with various attributable etiologies, semiologies, and treatment outcomes. To our knowledge, few studies investigated adult-onset myoclonus in an inpatient setting.</p><p><strong>Methods: </strong>We retrospectively reviewed charts of adult inpatients with myoclonus at New York Presbyterian Brooklyn Methodist Hospital between 2011 and 2021. Data was analyzed with descriptive statistical methods to elucidate etiology-specific demographics and outcomes.</p><p><strong>Results: </strong>279 individuals, 56.63% female, were included in our study, aging at 70.61 + 15.76 years. More than 50% were not initially diagnosed with myoclonus by the admitting medical team, and more than 50% had 2 or more ascribable etiologies. Symptomatic myoclonus - mostly of toxic-metabolic or hypoxic-ischemic etiology - accounted for most cases. Hypoxic-ischemic etiologies had shorter durations prior to presentation and were also most resistant to treatment. Renal-associated myoclonus was most associated with asterixis, whereas stimulus-sensitive myoclonus was strongly associated with hypoxic-ischemic etiology. Mortality in-hospital was strongly associated with hypoxic-ischemic etiology and least associated with neurodegenerative and idiopathic etiologies. Treatment response rate diminished in patients who were tried on a second or third anti-seizure drug compared to those trialed on one.</p><p><strong>Discussion: </strong>Myoclonus remains an underdiagnosed hyperkinetic movement disorder with various ascribable etiologies of varying demographic characteristics and treatment outcomes.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"2"},"PeriodicalIF":2.5,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic Variant in the 5'-Untranslated Region of <i>GCH1</i> and Clinical Heterogeneity in a Chinese Family with Dopa-Responsive Dystonia.","authors":"Yanting Li, Mingqiang Li, Lanqing Liu, Qiying Sun, Guang Yang","doi":"10.5334/tohm.974","DOIUrl":"10.5334/tohm.974","url":null,"abstract":"<p><strong>Background: </strong>Variants in the <i>GCH1</i> gene, encoding guanosine triphosphate cyclohydrolase, are associated with dopa-responsive dystonia (DRD) and are considered risk factors for parkinson's disease.</p><p><strong>Methods: </strong>Comprehensive neurological assessments documented motor and non-motor symptoms in a Chinese family affected by DRD. Whole-exome sequencing (WES) was employed to identify potential mutations, with key variants confirmed by Sanger sequencing and analyzed for familial co-segregation.</p><p><strong>Results: </strong>The proband, a 50-year-old woman with a 10-year history of limb rigidity, abnormal posture, and a 23-year history of neck deviation, showed significant symptom improvement with levodopa treatment. Family evaluation revealed similar motor symptoms in four additional affected members, all responding well to levodopa. WES identified a <i>GCH1</i> variant (NM_000161.3: c.-22C > T) in the 5'-untranslated region (5' UTR) in four symptomatic individuals (excluding deceased II-3). This variant likely affects translation by introducing an upstream initiation codon and open reading frame (uORF), leading to decreased BH4 levels and disrupted dopamine synthesis.</p><p><strong>Discussion: </strong>This study reports a pathogenic variant in the 5' UTR of <i>GCH1</i> in a family with DRD, underscoring the phenotypic heterogeneity associated with this locus.</p><p><strong>Highlights: </strong>A non-coding variant (c.-22C > T) in the 5' UTR of the <i>GCH1</i> gene is identified in a Chinese family with DRD.The findings reveal significant clinical heterogeneity within the family, highlighting the complex genotype-phenotype relationship.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"15 ","pages":"1"},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ATP1A3</i>-Associated Paroxysmal Dystonia.","authors":"Mark S Ledoux","doi":"10.5334/tohm.975","DOIUrl":"10.5334/tohm.975","url":null,"abstract":"<p><strong>Background: </strong><i>ATP1A3</i> mutations are associated with a diverse set of distinct neurological syndromes and intermediate phenotypes that may include extra-neural features. Overall, genotype-phenotype correlations are weak. There are no consensus treatments.</p><p><strong>Case report: </strong>Video and clinical documentation is provided for a patient with a novel <i>ATP1A3</i> mutation (GRCh38:19:41982028:C:A;NM_152296.5:c.1072G>T;p.Gly358Cys). This highly deleterious variant (Combined Annotation Dependent Depletion [CADD] score-28.8, Rare Exome Variant Ensemble Learner [REVEL] score -0.992) is not present in gnomAD v.4.1.0. Clinical manifestations include recurrent stereotypical episodes of paroxysmal dyskinesias that include jaw-opening dystonia superimposed on a baseline of developmental delay with static cognitive impairment, mild ataxia, and hypotonia. Paroxysmal episodes are triggered by emotional excitement, heat, cold, exercise, chocolate, and menses. The paroxysmal events typically last 5 min. Oxcarbazepine and clonazepam have reduced the frequency of paroxysmal episodes.</p><p><strong>Discussion: </strong><i>ATP1A3</i> mutations are associated with protean manifestations that may include paroxysmal non-epileptic events such as ataxia, dystonia, and paresis. Accordingly, <i>ATP1A3</i> mutation screening, most commonly as a multi-gene panel, and assessment of variant deleteriousness and population frequency should be completed in individuals with non-classical phenotypes. Benzodiazepines and drugs that target voltage gaited sodium channels (e.g., oxcarbazepine) may be effective therapeutic options.</p><p><strong>Highlights: </strong><i>ATP1A3</i> mutations should be considered in patients with paroxysmal non-epileptic neurological events which may show clinical overlap with paroxysmal non-kinesigenic dyskinesias.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"14 ","pages":"61"},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Economic Correlates of Pharmacotherapy in Patients with Essential Tremor.","authors":"Rajesh Pahwa, Kalea Colletta, Donald Higgins, Bridgette Kanz Schroader, Brian M Davis, Liana Hennum, Elan D Louis","doi":"10.5334/tohm.973","DOIUrl":"10.5334/tohm.973","url":null,"abstract":"<p><strong>Background: </strong>Essential tremor (ET) is among the most common movement disorders, yet there are few treatment options. Medications have limited efficacy and adverse effects; thus, patients often discontinue pharmacotherapy or take several medications in combination. We evaluated the economic correlates (healthcare resource utilization [HCRU] and costs) and comorbidities among adults with and without ET and among subgroups of patients with ET prescribed 0 to ≥3 ET medications.</p><p><strong>Method: </strong>This was a retrospective cohort study using claims data from the Merative Market Scan Research Databases (1/1/2017-1/31/2022). Patients were categorized as commercially insured (22-<65 years) or Medicare (≥65 years) and stratified into 3 subgroups: patients with untreated ET, patients with treated ET, and non-ET patients. The index date was the date of first ET diagnosis or a random date (non-ET patients); post-index follow-up was 24 months.</p><p><strong>Results: </strong>There were 32,984 ET patients (n = 22,641 commercial; n = 10,343 Medicare) and 7,588,080 non-ET patients (n = 7,158,471 commercial; n = 429,609 Medicare). ET patients in both commercial and Medicare populations filled a numerically greater number of unique medications, had a higher numerical prevalence of comorbidities (ie, anxiety, depression, falls), and had numerically greater HCRU and costs than non-ET patients. Most of these numerical trends increased commensurately with increasing number of ET medications.</p><p><strong>Conclusions: </strong>Compared to non-ET patients, ET patients have higher healthcare costs and utilization, which positively correlated with the number of ET medications. ET patients often have numerically more comorbidities compared to non-ET patients. This analysis demonstrates the medical complexity of ET patients and calls attention to the need for additional therapeutic options.</p>","PeriodicalId":23317,"journal":{"name":"Tremor and Other Hyperkinetic Movements","volume":"14 ","pages":"60"},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}