Work and Activity Impairment in Individuals with Essential Tremor.

IF 2.1 Q2 CLINICAL NEUROLOGY
Tremor and Other Hyperkinetic Movements Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI:10.5334/tohm.1034
Margaret E Gerbasi, Rodger J Elble, Holly A Shill, Eddie Jones, Alexander Gillespie, John Jarvis, Elizabeth Chertavian, Zachary Smith, Ludy C Shih
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Abstract

Background: Essential tremor (ET) affects nearly 7 million people in the United States and consists of upper limb tremor that can affect activities of daily living, including activities related to work. Research examining the effect of ET on work productivity is limited and there are no studies using validated work productivity instruments.

Methods: Clinic-based data were collected between March 2021 and August 2021 from US physicians participating in the Adelphi ET Disease Specific Programme (DSP). Patients were evaluated with the Essential Tremor Rating Assessment Scale (TETRAS), Quality of Life in Essential Tremor (QUEST) questionnaire, and the Work Productivity and Activity Impairment (WPAI) questionnaire. Statistical associations between tremor severity and work productivity were examined.

Results: A total of 1,003 ET patients were identified, and 420 patients completed the WPAI questionnaire and were included in this study. Activity impairment was independently associated with tremor severity, adjusting for age, full-time vs. part-time employment, household income, depression, and anxiety. Of those who were employed (n = 165), 133 (80.6%) were employed full-time, and 141 (85.5%) had some level of work impairment. Work impairment was also independently associated with tremor severity, adjusting for the same covariates. Among those patients for whom QUEST responses were available, 47% (64/135) of patients with ET working full-time and 88% (36/41) of those working part-time reported that tremor interfered with work.

Discussion: Work impairment is significantly correlated with tremor severity. Although a minority of patients in this clinic-based cohort were identified as employed, nearly all reported a negative impact on work performance.

特发性震颤患者的工作和活动障碍。
背景:特发性震颤(ET)在美国影响近700万人,由上肢震颤组成,可影响日常生活活动,包括与工作相关的活动。研究ET对工作效率的影响是有限的,并且没有使用有效的工作效率工具的研究。方法:在2021年3月至2021年8月期间,从参与Adelphi ET疾病特异性计划(DSP)的美国医生那里收集临床数据。采用特发性震颤评分评定量表(TETRAS)、特发性震颤生活质量(QUEST)问卷、工作效率和活动障碍(WPAI)问卷对患者进行评估。研究了震颤严重程度与工作效率之间的统计学关联。结果:共发现1003例ET患者,420例患者完成WPAI问卷,纳入本研究。活动障碍与震颤严重程度、年龄、全职与兼职工作、家庭收入、抑郁和焦虑独立相关。在受雇者(n = 165)中,133人(80.6%)为全职雇员,141人(85.5%)有不同程度的工作障碍。在对相同协变量进行调整后,工作障碍也与震颤严重程度独立相关。在可获得QUEST应答的患者中,47%(64/135)的全职ET患者和88%(36/41)的兼职ET患者报告震颤干扰了工作。讨论:工作障碍与震颤严重程度显著相关。虽然在这个以诊所为基础的队列中,少数患者被确定为就业,但几乎所有患者都报告了对工作表现的负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
4.50%
发文量
31
审稿时长
6 weeks
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