Transplantation最新文献_第9页

Serine Glycine Restriction Aggravates Hepatic Ischemia-reperfusion Injury. 限制丝氨酸甘氨酸可加重肝缺血再灌注损伤。

IF 5 2区医学

Transplantation Pub Date : 2025-08-22 DOI: 10.1097/TP.0000000000005487

Moujie Yang, Junnan Wang, Chunmei Li, Zhi Yang, Wei Dong, Chong Zhang, Junfei Jin

{"title":"Serine Glycine Restriction Aggravates Hepatic Ischemia-reperfusion Injury.","authors":"Moujie Yang, Junnan Wang, Chunmei Li, Zhi Yang, Wei Dong, Chong Zhang, Junfei Jin","doi":"10.1097/TP.0000000000005487","DOIUrl":"https://doi.org/10.1097/TP.0000000000005487","url":null,"abstract":"Background: Hepatic ischemia-reperfusion injury (HIRI) significantly affects liver function in liver transplantation, primarily through dysregulated metabolism and inflammation. Although serine and glycine (SG) have been identified as potential therapeutic targets in various diseases, the mechanisms by which SG influences HIRI remain unclear. This study aimed to investigate the effects of SG deficient (-SG) dietary intervention on HIRI.Methods: We established an in vivo and in vitro HIRI model under the -SG condition. RNA sequencing, coupled with bioinformatics analysis, identified key targets modulated after -SG intervention. Biochemical and histological analyses were used to evaluate the effects of -SG on HIRI. Furthermore, plasmid-based transient overexpression of CYP2S1 and CYP26B1 was induced to explore the mechanistic role of -SG in regulating cell apoptosis and inflammatory responses.Results: Histological and liver enzyme analyses confirmed that SG deficiency worsened ischemia-reperfusion-induced liver necrosis and impaired liver function. Furthermore, SG deficiency exacerbated hepatocyte apoptosis, immune responses, and inflammatory responses caused by ischemia-reperfusion injury in vivo and in vitro experiments. RNA sequencing revealed a correlation between CYP family signaling pathway and liver injury resulting from SG deficiency.Conclusions: SG deficiency exacerbated apoptosis, as well as immune and inflammatory responses in a liver injury model. The lack of these amino acids can promote inflammation and worsen HIRI by downregulating CYP2S1 and CYP26B1 expression. Conversely, SG supplementation may exhibit a protective effect against liver injury after transplantation.","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does NRF2 Play a Double-edged Role in Acute GVHD Pathogenesis? NRF2在急性GVHD发病机制中起双刃剑作用吗？

IF 5 2区医学

Transplantation Pub Date : 2025-08-22 DOI: 10.1097/TP.0000000000005513

Kangyu Wang, Li Yang

引用次数: 0

Detection Is Protection: Adherence to Mandated HCV Testing After Liver Transplant. 检测即保护：肝移植后坚持强制性HCV检测。

IF 5 2区医学

Transplantation Pub Date : 2025-08-22 DOI: 10.1097/TP.0000000000005516

Eric M Przybyszewski, Camille N Kotton

引用次数: 0

National Trends in Machine Perfusion and Living Donor Liver Transplantation: Complement or Competition? 机器灌注和活体肝移植的全国趋势：互补还是竞争？

IF 5 2区医学

Transplantation Pub Date : 2025-08-22 DOI: 10.1097/TP.0000000000005509

Raphael P H Meier, Elizabeth A King, Andrew M Cameron, Saad Malik, Daniel G Maluf, Chandra S Bhati, Allison Kwong

引用次数: 0

Artificial Intelligence: Its Role in Clinical Medicine? 人工智能：它在临床医学中的作用？

IF 5 2区医学

Transplantation Pub Date : 2025-08-15 DOI: 10.1097/TP.0000000000005505

Jennifer Li, Harry Robertson

引用次数: 0

Auxiliary Liver Transplantation With Delayed Total Hepatectomy: Evolution From 2-stage APOLT to RAPID Following the ALPPS Principles. 辅助肝移植伴延迟全肝切除术：遵循ALPPS原则从2期APOLT到快速的演变。

IF 5 2区医学

Transplantation Pub Date : 2025-08-13 DOI: 10.1097/TP.0000000000005501

Shuai Wu, Guangyao Li, Bo Zhou, Shiran Zhang, Geng Chen

{"title":"Auxiliary Liver Transplantation With Delayed Total Hepatectomy: Evolution From 2-stage APOLT to RAPID Following the ALPPS Principles.","authors":"Shuai Wu, Guangyao Li, Bo Zhou, Shiran Zhang, Geng Chen","doi":"10.1097/TP.0000000000005501","DOIUrl":"https://doi.org/10.1097/TP.0000000000005501","url":null,"abstract":"The resection and partial liver segment 2/3 transplantation with delayed total hepatectomy (RAPID) represents an innovative fusion of 2 of the most challenging procedures of modern liver surgery: auxiliary partial orthotopic liver transplantation and associating liver partition and portal vein ligation for staged hepatectomy. By combining the principles of auxiliary partial orthotopic liver transplantation of partial graft implantation with staged parenchymal modulation of associating liver partition and portal vein ligation for staged hepatectomy, RAPID enables sequential hypertrophy of the transplanted graft followed by complete native liver removal, addressing critical limitations in donor-recipient size matching. Current evidence highlights its primary application in treating unresectable hepatic malignancies, demonstrating advantages over conventional strategies in preserving functional liver volume, minimizing the risk of small-for-size syndrome, and accelerating graft regeneration. However, the procedure faces unresolved challenges, including ethical debates over living donor utilization in oncological contexts, necessity and feasibility of portal inflow modulation, optimal timing for delayed hepatectomy, insufficient long-term oncological outcome data and so on. This review provides an overview of the past and current status of RAPID, especially with respect to its evolution, indication, and technical details, as well as the potential challenges that have been discussed. Additionally, future directions of this surgical paradigm are outlined.","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ischemia/Reperfusion Injury and Outcomes in Liver Transplantation Assessed by Omics Technologies: Where Do We Stand? 用组学技术评估肝移植的缺血/再灌注损伤和预后：我们站在哪里？

IF 5 2区医学

Transplantation Pub Date : 2025-08-13 DOI: 10.1097/TP.0000000000005466

Pablo J Giraudi, Gabriele Codotto, Umberto Baccarani, Francisco Baralle, Gabriel Gondolesi, Danilo Licastro, Claudio Tiribelli

{"title":"Ischemia/Reperfusion Injury and Outcomes in Liver Transplantation Assessed by Omics Technologies: Where Do We Stand?","authors":"Pablo J Giraudi, Gabriele Codotto, Umberto Baccarani, Francisco Baralle, Gabriel Gondolesi, Danilo Licastro, Claudio Tiribelli","doi":"10.1097/TP.0000000000005466","DOIUrl":"https://doi.org/10.1097/TP.0000000000005466","url":null,"abstract":"Liver transplantation faces several biological challenges, including those related to ischemia/reperfusion injury, graft rejection or tolerance, and disease recurrence. These processes significantly impact posttransplant outcomes and highlight the need for a deeper understanding to improve patient care. The progress of omics sciences has been remarkable over the past decades, and omics techniques are widely used in clinical investigations. In this review, we have explored and briefly described investigations using omics technologies (epigenomics, transcriptomics, and proteomics) to better understand the processes affecting liver transplantation. Additionally, we have highlighted recent studies that use cutting-edge omics technologies, including single-cell RNA sequencing, spatial transcriptomics, and multiplex proteomics, often integrated into multiomics approaches, which enable a more detailed and holistic analysis of the produced data, paving the way for the discovery of precise biomarkers for liver transplant monitoring and the development of novel therapies to prevent allograft rejection.","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Feasibility of Early Extubation in Liver Transplantation: Experience in 1555 Patients. 1555例肝移植早期拔管的安全性和可行性

IF 5 2区医学

Transplantation Pub Date : 2025-08-01 Epub Date: 2025-02-14 DOI: 10.1097/TP.0000000000005356

Conrad Lacom, Rishi P Kothari, Nicholas V Mendez, Alessandro Galli, Garrett R Roll, Michael P Bokoch, Matthieu Legrand, Dieter Adelmann

{"title":"Safety and Feasibility of Early Extubation in Liver Transplantation: Experience in 1555 Patients.","authors":"Conrad Lacom, Rishi P Kothari, Nicholas V Mendez, Alessandro Galli, Garrett R Roll, Michael P Bokoch, Matthieu Legrand, Dieter Adelmann","doi":"10.1097/TP.0000000000005356","DOIUrl":"10.1097/TP.0000000000005356","url":null,"abstract":"Background: Early extubation after liver transplantation can decrease cost and intensive care unit lengths of stay, but its adoption remains limited because of safety concerns. We assessed the feasibility and safety of early extubation at a liver transplant center with a high early extubation rate. We analyzed subgroups of high-risk patients, including high model for end-stage liver disease-sodium (MELD-Na) score, high intraoperative blood loss, and patients undergoing simultaneous liver-kidney transplantation.Methods: We included all adult liver transplantations performed at a single center between June 2012 and July 2022. Patients were divided into 2 groups: (1) those extubated early (ie, in the operating room or within the first hour of intensive care unit admission) and (2) those who underwent delayed extubation. The primary outcome was reintubation within 48 h after early extubation. Rates of early extubation were analyzed separately for quartiles of MELD-Na score and intraoperative blood loss.Results: Of 1555 patients, 969 (62%) were extubated early. Of these, 31 patients (3.2%) required mechanical ventilation within 48 h postoperatively: 11 patients (1.1%) were reintubated for respiratory failure and 20 (2.1%) remained intubated after reoperation. There was no difference in postoperative pneumonia between the groups ( P = 0.059). Early extubation rates inversely correlated with the quartiles of MELD-Na score and estimated blood loss. In the highest quartile for MELD-Na (>34) and estimated blood loss (>5 L), 34% of patients were extubated early.Conclusions: Early extubation of properly selected patients after liver transplantation is safe and associated with a low rate of reintubation, even among select groups of high-risk patients.","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"1393-1401"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time to Expand Selection Criteria for MELD Exception Points in Liver Transplantation for Hepatocellular Carcinoma. 是时候扩大肝癌肝移植MELD异常点的选择标准了。

IF 5 2区医学

Transplantation Pub Date : 2025-08-01 Epub Date: 2025-03-25 DOI: 10.1097/TP.0000000000005396

Chase J Wehrle, Jiro Kusakabe, Toshihiro Nakayama, Charles Miller, Koji Hashimoto, Timothy M Pawlik, Kazunari Sasaki, Vincenzo Mazzaferro, Andrea Schlegel, Federico Aucejo

引用次数: 0

Summary Report of the CTS-TIREX Expert Meeting 2024 "Innovative Approaches to Immunogenetics and Organ Transplantation". CTS-TIREX专家会议2024“免疫遗传学和器官移植的创新方法”总结报告。

IF 5 2区医学

Transplantation Pub Date : 2025-08-01 Epub Date: 2025-05-20 DOI: 10.1097/TP.0000000000005430

Caner Süsal, Idil Orhon, Georg A Böhmig, Lionel Rostaing, Klemens Budde, Bariş Akin, Mehmet Kanbay, Burak Kocak, Thuong Hien Tran, Christian Morath

引用次数: 0