Tropical Medicine and Health最新文献

{"title":"Global status and trends of proteomics in obesity: a bibliometric analysis and knowledge graph study.","authors":"Xiaoying Wu, Yongming Chen, Tong Wu, Qi Pan, Lixin Guo","doi":"10.1186/s41182-025-00785-7","DOIUrl":"10.1186/s41182-025-00785-7","url":null,"abstract":"<p><strong>Aims: </strong>Proteomics plays an essential role in uncovering the molecular mechanisms of obesity. This study aimed to map global research trends, identify major contributors, and examine evolving themes in this field over the past two decades.</p><p><strong>Methods: </strong>A bibliometric analysis was performed using the Web of Science Core Collection (WoSCC) from 1999 to February 2025. Only English-language original articles and reviews were included. CiteSpace and VOSviewer were used to analyze publication volume, collaboration networks, core journals, citation patterns, and keyword co-occurrence.</p><p><strong>Results: </strong>A total of 1688 publications were analyzed. Research output increased steadily and peaked in 2022. The United States led in publication count and citations, followed by China and Germany. Keyword analysis revealed a clear thematic shift: early studies focused on adipose biology and hormonal regulation, while more recent work highlights topics such as gut microbiota, lipid metabolism, type 2 diabetes, and PCOS. These shifts reflect an increased focus on systemic mechanisms and a stronger link to clinical needs such as diagnosis and personalized treatment.</p><p><strong>Conclusion: </strong>Proteomics research in obesity has grown in both scale and complexity, with expanding global collaboration and evolving scientific priorities. This study provides a comprehensive overview of the field's development and offers direction for future translational and interdisciplinary efforts.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"117"},"PeriodicalIF":3.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging gaps in the elimination of deep mycoses: a comparative analysis of mycetoma and chromoblastomycosis control strategies in Rwanda and China.","authors":"Alieu Sam, Niyibizi Julius, Munawar Harun Koray","doi":"10.1186/s41182-025-00778-6","DOIUrl":"10.1186/s41182-025-00778-6","url":null,"abstract":"<p><p>Deep mycoses, largely caused by mycetoma and chromoblastomycosis, is a chronic fungal infection prevalent in tropics and subtropics regions. Deprived populations in these regions are disproportionately affected. However, control strategies for deep mycoses on a global scale remain limited even though these diseases are included in WHO's roadmap for 2021-2030 NTDs. China and Rwanda, with distinct climates, economic conditions and health systems and policies, are both burdened with this debilitating fungal infection. This review, therefore, focused on providing a cross-case evaluation of the control strategies for mycetoma and chromoblastomycosis in Rwanda and China by assessing their epidemiology, diagnostics, treatment accessibility and policy frameworks in an effort to find actionable strategies for elimination. Evidence in the control strategies in these different countries can help improve the management of deep mycoses. Rwanda can learn more about advanced diagnostic technologies from China, while China may benefit from adapting the community-based approach from Rwanda. Enhancing surveillance, declaring mycetoma as notifiable disease, and encouraging international cooperation are essential for meeting the WHO 2030 NTD elimination targets.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"115"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether-lumefantrine to supplement the clinical data from the CALINA study.","authors":"Helen Gu, Nada Abla, Vinay Kumar Venishetty, Birgit Schoeberl, Julia Zack, Heidi J Einolf","doi":"10.1186/s41182-025-00790-w","DOIUrl":"10.1186/s41182-025-00790-w","url":null,"abstract":"<p><strong>Background: </strong>Evidence-based recommendations for malaria treatment in patients weighing < 5 kg are lacking as a consequence of differences in pharmacokinetics due to age and/or body weight (BW), and recruitment challenges in conducting trials in this population. A physiologically based pharmacokinetic (PBPK) model was developed and validated to predict artemether and lumefantrine concentrations in patients < 5 kg BW aged 1-28 days. The model predictions supplemented data from a trial (CALINA; NCT04300309) with an optimized dose of artemether-lumefantrine (5 mg artemether: 60 mg lumefantrine) in patients < 5 kg with Plasmodium falciparum malaria.</p><p><strong>Methods: </strong>PBPK models of artemether and lumefantrine were developed using Simcyp (Version 22) and validation was performed using historical data from adults and paediatric patients. To compare model-predicted and observed values, populations were matched to clinical trial populations (ranging from adults to infants) for patient numbers and demographics. The models were applied to predict artemether maximal concentration (C_max) and lumefantrine C_max and Day 7 concentration (C_168h) in neonates of < 5 kg BW aged 1-28 days, and for subgroups aged 1-7, 8-14, and 15-28 days.</p><p><strong>Results: </strong>Validated models for artemether and lumefantrine were used to predict plasma concentrations in neonates and young infants with BW < 5 kg after 3-day administration of 5 mg artemether and 60 mg lumefantrine twice daily with high confidence. The PBPK model using Upreti hepatic cytochrome P450 (CYP)3A4 ontogeny predicted observed artemether and lumefantrine exposure in infants and neonates better than Salem ontogeny. The predicted variability in neonates was comparable to or larger than the variability of observed concentrations in infants and older neonates in the CALINA study.</p><p><strong>Conclusions: </strong>Based on the success of the PBPK models for artemether and lumefantrine in predicting drug concentrations in adults and children, including neonates, modelling and simulation results can be used with confidence to supplement the limited available data for neonates (1-28 days old) < 5 kg BW obtained from the CALINA study for this rarer and more difficult to recruit patient population.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"116"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic evidence links human dengue cases with undetermined serotypes to sylvatic lineages.","authors":"Jeyanthi Suppiah, Murni Maya Sari Zulkifli, Amir Hussin Adiee, Nur Ain Zahidah Zainudin, Mazrul Effendy Dukut Soeharto, Nuraisyah Ramli, Ming Keong Wan, Mohd Rahim Sulong, Zailiza Suli, Rozainanee Mohd Zain","doi":"10.1186/s41182-025-00795-5","DOIUrl":"10.1186/s41182-025-00795-5","url":null,"abstract":"<p><strong>Background: </strong>Sylvatic dengue viruses, typically maintained in non-human primate and forest mosquito cycles, have rarely been associated with human infections. However, sporadic spillovers have been reported in Southeast Asia, including Malaysia. These events are often under-detected due to the genetic divergence of sylvatic strains from endemic urban dengue viruses. During routine surveillance in Malaysia (2024-2025), a subset of clinically confirmed dengue cases yielded undetectable serotype results by commercial real-time reverse transcription polymerase chain reaction (RT-PCR) assays, prompting investigation into a possible sylvatic origin.</p><p><strong>Methods: </strong>We investigated 22 such cases through clinical, serological, molecular, and phylogenetic analyses. NS1 antigen and broad-range RT-PCR confirmed acute dengue infection. Selected samples underwent sequencing and lineage determination.</p><p><strong>Results: </strong>Most patients presented with severe dengue during early illness (mean day 3), with 95.5% NS1 positivity and predominantly primary infection profiles. Despite serotyping failure, sequencing revealed that eight of nine analyzed samples belonged to sylvatic DENV2, while one represented a divergent DENV3. Comparative amino acid analysis uncovered a unique signature in recent Malaysian sylvatic DENV2 strains, differentiating them from both urban and historical sylvatic lineages. This includes the V270 mutation in the M gene; R844, V884, and I898 in the NS1 gene; T1207 in the NS2A gene; A1597 in the NS3 gene; and D3048 and I3373 in the NS5 gene. Phylogenetic analysis clustered these strains into a distinct Malaysian clade, separate from the African sylvatic lineage.</p><p><strong>Conclusions: </strong>This study provides the first genomic evidence of a recent sylvatic DENV2 spillover into humans in Malaysia, likely undetected by standard diagnostics due to genetic divergence. These findings underscore the urgent need to enhance surveillance tools and explore the sylvatic transmission cycle's role in dengue epidemiology.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"114"},"PeriodicalIF":3.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bionomics of the primary arbovirus vectors Aedes aegypti and Aedes albopictus in southeastern Benin.","authors":"Alphonse Keller Konkon, David Mahouton Zoungbédji, Rock Aïkpon, Isidore Hoyochi, Albert Sourou Salako, Camus Konkon, Antoine Salomon Lokossou, Brice Dangnon, Lamine Baba-Moussa, Martin Codjo Akogbéto, Germain Gil Padonou","doi":"10.1186/s41182-025-00794-6","DOIUrl":"10.1186/s41182-025-00794-6","url":null,"abstract":"<p><strong>Background: </strong>The main vectors of arboviruses, such as Aedes aegypti and Aedes albopictus, are present in Benin and deserve special attention in dengue prevention policies. In this context, the current study was initiated to provide information on the biology, ecology, including feeding behavior and life expectancy of Aedes aegypti and Aedes albopictus in southern Benin.</p><p><strong>Method: </strong>A larval survey was conducted in conjunction with a human landing catch (HLC), a Prokopak aspirator catch, and a survey of Aedes spp. breeding sites. The ovary dissection method was used to determine the age of the vectors. This allowed to assess the biology, ecology, exophagy or endophagy, and age expectancy of both Aedes aegypti and Aedes albopictus in southeastern Benin.</p><p><strong>Results: </strong>A total of 11 mosquito species were collected, with Aedes aegypti and Aedes albopictus showing the highest relative abundances, ranging, respectively, from 29.57% to 43.99% and from 16.26% to 45.65%, depending on the sampling method employed. Used tires accounted for 48.03% [45.06; 50.99] of all deposits found and were the most infested with Aedes spp. larvae, followed by buckets (14.23%) and jars (15.24%). The two main Aedes species studied (Aedes aegypti and Aedes albopictus) are more aggressive outdoors than indoors. Two peaks of aggressiveness were generally observed for both species: a first cycle in the morning from 7 a.m. to 11 a.m. and a second cycle in the evening from 4 p.m. to 7 p.m. A total of 76.47% of the Aedes aegypti and 81.21% of the Aedes albopictus samples were parous.</p><p><strong>Conclusion: </strong>Used tires and household containers (jars, water buckets, etc.) are the main breeding sites for Aedes spp., underscoring the importance of educating people about good water management habits. Aedes aegypti and Aedes albopictus, the main vectors of arboviruses, are exophagous and highly aggressive outdoors, with critical periods for human exposure, particularly in the morning and at the end of the day. Most of the collected females have already laid eggs (parous) and therefore are potentially susceptible to transmitting pathogens.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"113"},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parasitic infections and the development of endomyocardial fibrosis: systematic review of case reports and case series.","authors":"Abel Aizeque, Alex Mwangi Kihunyu, Olamide Daniel Odusola, Sulymon A Saka, Abdinasir Mohamed Aray","doi":"10.1186/s41182-025-00793-7","DOIUrl":"10.1186/s41182-025-00793-7","url":null,"abstract":"<p><strong>Background: </strong>Endomyocardial fibrosis (EMF) is a chronic restrictive cardiomyopathy prevalent in tropical regions, often underdiagnosed and associated with poor outcomes. Although its etiology remains unclear, parasitic infections such as schistosomiasis, filariasis, and trypanosomiasis have been implicated in its development. This study conducted a systematic review of case reports and case series to assess the correlation between parasitic infections and the development of EMF, identifying clinical patterns, implicated parasites, diagnostic approaches, and clinical outcomes, aiming to improve strategies for prevention, diagnosis, and treatment.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines, we searched multiple databases for case reports and case series describing patients with confirmed EMF associated with parasitic infections. 12 studies met the inclusion criteria, comprising 8 case reports and 4 case series, encompassing a total of 16 patients diagnosed with EMF related to parasitic infections.</p><p><strong>Results: </strong>The pooled analysis demonstrated that parasitic infections were predominantly caused by Schistosoma mansoni (10/16; 62.5%), followed by Schistosoma haematobium (3/16; 18.75%), with rare cases of Trypanosoma cruzi and Wuchereria bancrofti (1/16 each; 6.25%). Common clinical manifestations included signs of fibrosis of the right ventricular endocardium (81%), dilated right atrium (75%), pericardial effusion (75%), edema of both lower limbs (63%), and ascites (63%) and symptoms included abdominal distention (63%) and dyspnea (63%. Diagnosis was primarily established by echocardiography (92%), with additional confirmation by other imaging techniques and histopathology. Treatment mainly consisted of antiparasitic therapy and diuretics, with a survival rate of 50%, while 19% (3/16) of patients died from multi-organ failure and thromboembolic complications.</p><p><strong>Conclusion: </strong>This systematic review suggests a potential association between parasitic infections, particularly Schistosoma mansoni, and the development of endomyocardial fibrosis. Despite the limited sample size, the findings highlight the importance of early diagnosis and antiparasitic treatment. The variability in diagnostic and therapeutic approaches underscores the need for standardized guidelines and prospective studies in endemic areas to enhance clinical recognition and improve patient outcomes.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"112"},"PeriodicalIF":3.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal dynamics and associated drivers of COVID-19 incidence in Nepal.","authors":"Bipin Kumar Acharya, Shristi Sharma, Laxman Khanal, Pramod Joshi, Meghnath Dhimal","doi":"10.1186/s41182-025-00741-5","DOIUrl":"10.1186/s41182-025-00741-5","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 has been a major global health concern, severely impacting Nepal with thousands of cases and deaths. The patterns of COVID-19 incidence in the country may have varied over time during the pandemic, with geographic factors playing different roles in the early, middle, and later phases of transmission.</p><p><strong>Methods: </strong>We utilized spatial statistics and GeoDetector methods to analyze district-level variations in COVID-19 incidence across Nepal from January 2020 to December 2022 using laboratory confirmed cases of the disease and a range of physical, biological and socioenvironmental explanatory variables. The analysis focused on identifying spatial patterns, hotspots, and key driving factors contributing to the uneven distribution of COVID-19 cases.</p><p><strong>Results: </strong>We found an uneven distribution of COVID-19 in Nepal, with persistent hotspots in major cities, such as Kathmandu and Pokhara, reaching up to 133 cases per 1000 population. GeoDetector analysis identified the key drivers, including road density (q = 0.59, p < 0.001), ICU bed distribution (q = 0.51, p < 0.001), and population density (q = 0.46, p < 0.001). While natural environmental factors such as temperature, precipitation, and NDVI had low and statistically insignificant independent explanatory power, their interaction with variables such as nighttime light, NDVI, and population density enhanced explanatory strength, highlighting the complex spatial distribution of COVID-19 incidence.</p><p><strong>Conclusions: </strong>We recommend that the Nepalese government implement more targeted and region-specific interventions to address COVID-19 outbreaks, especially in persistent hotspot areas, such as Kathmandu and other emerging cities.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"111"},"PeriodicalIF":3.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic structure of Bithynia snails and its implications for targeted control of opisthorchiasis in the Lower Mekong Subregion.","authors":"Nathkapach Kaewpitoon Rattanapitoon, Chutharat Thanchonnang, Schawanya Kaewpitoon Rattanapitoon","doi":"10.1186/s41182-025-00774-w","DOIUrl":"10.1186/s41182-025-00774-w","url":null,"abstract":"<p><p>Recent findings by Bunchom et al. reveal distinct mitochondrial lineages of Bithynia siamensis goniomphalos in Champasak, Laos, with important implications for Opisthorchis viverrini transmission. The identification of lineage II, with high haplotype diversity and habitat-specific distribution, underscores the role of snail genetics in shaping local disease dynamics. Drawing parallels from Thailand's successful One Health intervention, this correspondence advocates for integrating lineage-informed mapping and surveillance into regional control programs. Broader genetic monitoring of Bithynia snails across the Lower Mekong Subregion may enhance the precision and effectiveness of liver fluke elimination strategies.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"110"},"PeriodicalIF":3.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic and reactivated dengue infection in an immunocompromised host: insights from a case report.","authors":"Ludovic Di Ascia, Etienne Frumence, Nicolas Traversier, Cécile Saint-Pastou, Gilda Grard, Henri Vacher-Coponat, Xavier de Lamballerie, Marie-Christine Jaffar-Bandjee","doi":"10.1186/s41182-025-00779-5","DOIUrl":"10.1186/s41182-025-00779-5","url":null,"abstract":"<p><strong>Background: </strong>Dengue, a viral infection transmitted by mosquitoes, is a growing global health concern, particularly as its spread now puts half of the world's population at risk. While dengue usually resolves after the primary infection, persistent or chronic cases can occur in immunocompromised individuals.</p><p><strong>Case presentation: </strong>This case study reports a 43-year-old woman with lupus nephritis and end-stage kidney disease who experienced symptomatic dengue reactivation nearly three years after her initial infection. Despite low viral loads, dengue RNA was detectable in her blood multiple times between 32 and 34 months after the initial detection. Genomic analysis confirmed that the same DENV-1 strain persisted, suggesting chronic infection rather than reinfection. The patient's immunosuppressive treatments, including rituximab, likely impaired her immune response to the initial infection, contributing to viral persistence. Additionally, her profound immunosuppressive state at the time of reactivation, potentially exacerbated by coinfections, may have triggered the virus to re-emerge.</p><p><strong>Conclusion: </strong>This case highlights the rare but clinically relevant possibility of chronic dengue infection in immunocompromised patients. The confirmed persistence of the same viral strain over nearly three years challenges the conventional view of dengue as a strictly acute infection. It raises concern about the potential for reintroduction and re-emergence of previously circulating strains, as well as the detrimental tissue consequences of chronic infection by the virus. These findings have important implications for clinical management, diagnostic strategies, and public health surveillance, and underscore the need for further research to better understand the mechanisms of dengue chronicity-particularly those involving viral immune evasion and host immune dysfunction.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"107"},"PeriodicalIF":3.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-COVID-19 pandemic identification of dengue hotspots and exploration of population and environmental determinants of dengue in Quezon City, Philippines.","authors":"John Robert Carabeo Medina, Shin'ya Kawamura, Rie Takeuchi, Rolando V Cruz, Johnedel Mendoza, Paul Michael R Hernandez, Fernando B Garcia, Ernesto R Gregorio, Jun Kobayashi","doi":"10.1186/s41182-025-00789-3","DOIUrl":"10.1186/s41182-025-00789-3","url":null,"abstract":"<p><p>In 2020, there were decreasing trends in reported dengue cases in several countries in the Western Pacific Region, including the Philippines, amid the COVID-19 pandemic. In this study, the spatial distribution of dengue incidence and the hotspots were described quarterly in Quezon City from 2019 to 2022, with the unit of analysis being the 142 barangays (small territorial and administrative villages) in Quezon City. The influence of selected environmental and demographic factors on the persistence of dengue was also explored. Surveillance data from the Quezon City Epidemiology and Surveillance Division, Normalized Difference Vegetation Index (NDVI), and satellite images of built environments, such as buildings, facilities, and transportation network hubs were processed and analyzed. The local Moran's I statistics performed with 95% confidence level was employed in the identification of local dengue hotspots. Dengue hotspot maps and maps of greenness, surrounding greenness, small building ratios, and the number of transportation network hubs in each barangay (village) of Quezon City were developed. The association of dengue cases with greenness, surrounding greenness, transportation network hubs, small building ratios, and population density was determined through a generalized linear model (GLM). Results revealed that incidence rates of dengue across barangays were spatially heterogeneous, and the dengue hotspots were unstable as they varied quarterly each year. Proximity to surrounding greenness (NDVI 1 km), small building ratio, and presence of transportation network hubs were found to be significantly associated with dengue hotspots. Dengue prevention strategies, such as search-and-destroy activities for breeding sites, are suggested to be implemented regularly in such areas. The study also recommends considering the anticipated increase in dengue hotspots and the significant environmental factors in the development of health promotion and education campaigns.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"53 1","pages":"109"},"PeriodicalIF":3.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}