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School health policies and their implementation during the COVID-19 pandemic in the Philippines.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-23 DOI: 10.1186/s41182-024-00659-4
Mikaela B Salanguit, Marian Danille C Santillan, Ernesto R Gregorio, Crystal Amiel M Estrada, Fumiko Shibuya, Akihiro Nishio, Jun Kobayashi
{"title":"School health policies and their implementation during the COVID-19 pandemic in the Philippines.","authors":"Mikaela B Salanguit, Marian Danille C Santillan, Ernesto R Gregorio, Crystal Amiel M Estrada, Fumiko Shibuya, Akihiro Nishio, Jun Kobayashi","doi":"10.1186/s41182-024-00659-4","DOIUrl":"https://doi.org/10.1186/s41182-024-00659-4","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has severely impacted the health and education of learners globally. However, there is a lack of information on enablers and barriers to the implementation of comprehensive school health policies during the pandemic.</p><p><strong>Methods: </strong>This study utilized a case study design, and was conducted in the Division of City Schools of Navotas. A desk review of relevant school health policies released at the national level by the Department of Education and Department of Health during the pandemic was performed. The collected policies were classified if they were related to the Preparedness/Prevention Phase, Early Phase Response, and Chronic Phase Response. Focus group discussions and key a informant interview were conducted to determine the enablers and barriers in implementing school health programs during the pandemic. The identified themes were created deductively by using categories from Whitman's Wheel of Factors influencing Implementation of Policy and Practice.</p><p><strong>Results: </strong>Policies under the Preparedness/Prevention Phase focused on providing a comprehensive healthy school environment for learners, including Water, Sanitation, and Hygiene (WASH) in Schools. Early Phase Response policies included school closures and public health guidelines to prevent further spread of disease. The policies under the Chronic Phase/Response notably included guidelines for implementation of vaccination days and reopening of classes. Most of the factors identified were categorized under Whitman's wheel of factors.</p><p><strong>Conclusions: </strong>Despite COVID-19 restrictions, health policy implementation continued because of the collaborations, innovations, and leadership of various stakeholders. The vaccination of the public, including the pediatric population was implemented through the collaboration of various agencies. WASH in Schools was evident in policies regarding the guidelines on prevention of the spread of disease. The data provided in this study will serve as a guide to address the barriers and further strengthen the implementation of these policies.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"98"},"PeriodicalIF":3.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Comment on: Fetal femur length and risk of diabetes in adolescence: a prospective cohort study.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-19 DOI: 10.1186/s41182-024-00667-4
Zainab Fatima, Arifa Inayatullah Kakar, Usama Idrees, Malik Olatunde Oduoye, Uzodinma Nwadinigwe
{"title":"Correction: Comment on: Fetal femur length and risk of diabetes in adolescence: a prospective cohort study.","authors":"Zainab Fatima, Arifa Inayatullah Kakar, Usama Idrees, Malik Olatunde Oduoye, Uzodinma Nwadinigwe","doi":"10.1186/s41182-024-00667-4","DOIUrl":"https://doi.org/10.1186/s41182-024-00667-4","url":null,"abstract":"","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"97"},"PeriodicalIF":3.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequential pulmonary functions in survivors of leptospirosis pulmonary haemorrhage syndrome: a prospective cohort study.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-19 DOI: 10.1186/s41182-024-00665-6
Dilshan Priyankara, Pramith Ruwanpathirana, Roshan Rambukwella, Nilanka Perera
{"title":"Sequential pulmonary functions in survivors of leptospirosis pulmonary haemorrhage syndrome: a prospective cohort study.","authors":"Dilshan Priyankara, Pramith Ruwanpathirana, Roshan Rambukwella, Nilanka Perera","doi":"10.1186/s41182-024-00665-6","DOIUrl":"https://doi.org/10.1186/s41182-024-00665-6","url":null,"abstract":"<p><strong>Background: </strong>Leptospirosis, a spirochaete infection, can lead to Leptospirosis Pulmonary Haemorrhage Syndrome (LPHS), which requires intensive care admission and has a high mortality. Although data on short-term outcomes are available, the long-term respiratory sequelae of LPHS survivors are not known. We aimed to identify the post-discharge pulmonary functions and functional limitations in survivors of LPHS.</p><p><strong>Methods: </strong>We conducted a prospective cohort study from January to December 2022 at the Medical Intensive Care Unit (ICU) of the National Hospital of Sri Lanka to assess the sequential changes in the spirometry parameters in patients who survived LPHS. The Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 s (FEV1) were measured on the day of discharge from the ICU (D0), 7th day after discharge (D7) and 28th day after discharge (D28). The predicted lung volume was calculated using the gender, age and height as per standard protocol. Physical and functional role limitations were assessed on D28 using the modified Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36).</p><p><strong>Results: </strong>Twenty-one patients with a mean age of 44 years (SD 16.07) were enrolled for the study. The majority were male patients (n = 19, 90.5%). Leptospirosis was serologically confirmed in all individuals. Seventeen (81%) patients had reduced FEV1 and FVC on D0, indicating a restrictive lung abnormality. FVC and FEV1 improved during the first 7 days (p < 0.01) but did not change significantly afterwards. Only seven individuals (33.3%) achieved a normal FVC (exceeding 80% of the predicted volume) at D28. However, 19 (90.5%) individuals achieved a normal FEV1 (exceeding 80% of predicted volume) by D28. In our study, administering corticosteroids during ICU stay did not impact lung recovery in FVC (p = 0.521) or FEV1 (p = 0.798). The participants did not have significant physical, functional, and role limitations at D28.</p><p><strong>Conclusions: </strong>The spirometry measurements of individuals diagnosed with LPHS significantly improved during the first 7 days. Most survivors did not have a functional impairment despite the FVC not recovering to normal by D28.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"96"},"PeriodicalIF":3.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-18 DOI: 10.1186/s41182-024-00664-7
Takatsugu Okai, Chim W Chan, Achyut Kc, Protus Omondi, Kelvin Musyoka, James Kongere, Wataru Kagaya, Gordon Okomo, Bernard N Kanoi, Yasutoshi Kido, Jesse Gitaka, Akira Kaneko
{"title":"Plasmodium falciparum with pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria infections in the Lake Victoria region, Kenya.","authors":"Takatsugu Okai, Chim W Chan, Achyut Kc, Protus Omondi, Kelvin Musyoka, James Kongere, Wataru Kagaya, Gordon Okomo, Bernard N Kanoi, Yasutoshi Kido, Jesse Gitaka, Akira Kaneko","doi":"10.1186/s41182-024-00664-7","DOIUrl":"https://doi.org/10.1186/s41182-024-00664-7","url":null,"abstract":"<p><p>Malaria rapid diagnostic tests (RDTs) targeting the Plasmodium falciparum histidine-rich protein 2 (PfHRP2) are widely used to diagnose P. falciparum infection. However, reports of P. falciparum strains lacking PfHRP2 and the structurally similar PfHRP3 have raised concerns about the utility and reliability of PfHRP2-based RDTs. This study investigated the presence of P. falciparum with pfhrp2 and/or pfhrp3 gene deletions among infected residents in the Lake Victoria region, Kenya. Four cross-sectional malaria, surveys were conducted in four sites (Suba South, Mfangano, Kibuogi, and Ngodhe) from September 2018 to January 2020. P. falciparum infections were detected using a PfHRP2-based RDT, microscopy, and PCR on 9120 finger-prick blood samples. Samples negative by RDT but positive by PCR were selected for PCR amplification of pfmsp1 and pfmsp2 to confirm the quality and quantity of P. falciparum DNA. Samples positive for both pfmsp1 and pfmsp2 were included for detection of deletions of exons 1 and 2 in pfhrp2 and pfhrp3 PCR. The multiplicity of infection (MOI) was determined as the higher allele count between pfmsp1 and pfmsp2. Logistic regression analysis was performed to analyze the association between pfhrp2 and/or pfhrp3 deletions and demographic and infection variables. Of the 445 RDT-negative and PCR-positive samples, 125 (28.1%) were analyzed for pfhrp2 and pfhrp3 deletions. Single pfhrp2 deletion, single pfhrp3 deletion, and pfhrp2/3 double deletions were detected in 13 (10.4%), 19 (15.2%), and 36 (28.8%) samples, respectively. Single pfhrp2 deletion was found in all sites while single pfhrp3 deletion was found in all sites except Kibuogi. The majority of samples with pfhrp2 and/or pfhrp3 deletions were submicroscopic (73.5%), asymptomatic (80.9%), and monoclonal (80.9%). Polyclonal infection was significantly (p = 0.022) associated with a lower odds of pfhrp2/3 double deletion, suggesting detection of intact pfhrp2/3 in mixed infections. We report the presence of P. falciparum with pfhrp2/pfhrp3 double deletions among asymptomatic and submicroscopic infections in Kenya. Our findings highlight the need for active monitoring of pfhrp2 and pfhrp3 deletions at the community level to improve malaria detection and control in the region.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"94"},"PeriodicalIF":3.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of dengue larvae of Aedes aegypti and Aedes albopictus using the larvicidal bioactive compounds in different plant extracts and plant extract-mediated nanoparticles.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-18 DOI: 10.1186/s41182-024-00654-9
Madhawa Pradeepa Nawarathne, Chathuranga Dharmarathne
{"title":"Control of dengue larvae of Aedes aegypti and Aedes albopictus using the larvicidal bioactive compounds in different plant extracts and plant extract-mediated nanoparticles.","authors":"Madhawa Pradeepa Nawarathne, Chathuranga Dharmarathne","doi":"10.1186/s41182-024-00654-9","DOIUrl":"https://doi.org/10.1186/s41182-024-00654-9","url":null,"abstract":"<p><strong>Background: </strong>Dengue is a devastating viral disease transmitted by mosquito vectors of Aedes aegypti and Aedes albopictus. Mosquito populations thrive in favourable breeding conditions, making mosquito control vital. Eliminating larval populations is the most effective method compared with other mosquito control methods. Synthetic chemicals such as organochlorine, organophosphate, carbamate and growth regulators are available for mosquito control, but their use is limited due to health and environmental concerns. Biologically synthesized insecticides are preferable to synthetic insecticides as they are eco-friendly, low cost, target-specific and less toxic for non-target organisms.</p><p><strong>Mainbody: </strong>Plant-derived bioassays are commonly used to control virally transmitted vectors, as plants contain bioactive compounds such as phytochemicals and essential oils that have high larvicidal efficacy against various mosquito vectors. In addition, nanomaterials are garnering attention in mosquito control due to their eco-friendliness, cost-effectiveness and safety. Commonly used nanomaterials include metal nanoparticles, such as silver nanoparticles, known for their potent larvicidal effect. Nanomaterials can be biologically synthesized through the combination with plant materials and encapsulation of bioactive compounds to maintain their stability and efficacy.</p><p><strong>Conclusion: </strong>Various plant species and parts, as well as plant-derived nanoparticles, show diverse larvicidal activities against Aedes mosquitos. Among these, plant-mediated nanoparticles demonstrate excellent larvicidal properties against mosquito larvae, including Aedes species.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"95"},"PeriodicalIF":3.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variable effects of non-falciparum species infections on malaria disease severity in high transmission regions in Senegal.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-04 DOI: 10.1186/s41182-024-00655-8
Aissatou Diagne, Babacar Souleymane Sambe, Folly Mawulolo Gaba, Ibrahima Sarr, Arona Sabène Diatta, Ousmane Sadio, Serigne Ousmane Mbacké Diaw, Hélène Ataume Mawounge Diatta, Babacar Diouf, Inès Vigan-Womas, Babacar Mbengue, Makhtar Niang
{"title":"Variable effects of non-falciparum species infections on malaria disease severity in high transmission regions in Senegal.","authors":"Aissatou Diagne, Babacar Souleymane Sambe, Folly Mawulolo Gaba, Ibrahima Sarr, Arona Sabène Diatta, Ousmane Sadio, Serigne Ousmane Mbacké Diaw, Hélène Ataume Mawounge Diatta, Babacar Diouf, Inès Vigan-Womas, Babacar Mbengue, Makhtar Niang","doi":"10.1186/s41182-024-00655-8","DOIUrl":"10.1186/s41182-024-00655-8","url":null,"abstract":"<p><p>In malaria endemic countries, non-falciparum species are often mixed with Plasmodium falciparum in patients with uncomplicated malaria, and their contribution to malaria severity and death is poorly studied. This study assesses the contribution of non-falciparum species to malaria severity in three regions of Senegal with the highest malaria incidence.We analysed 617 blood samples obtained between 2015 and 2021 from confirmed malaria patients at health facilities in Kedougou, Kolda and Tambacounda in Senegal. Plasmodium species composition was determined by PCR and their distribution were analysed according to age and disease severity, and the relative risk of developing severe malaria.Overall, 94.8% of samples contained P. falciparum either as single or mixed with other species. Non-falciparum P. ovale, P. vivax and P. malariae species were detected in 60.12, 13.61 and 1.62% of samples, respectively. Severe malaria was primarily due to P. falciparum, but co-infection with P. vivax led to a 1.63-fold significant (p = 0.05) increased risk of developing severe malaria, contrasting with the non-significant reduced risk (OR = 0.78; CI 95: 0.55-1.11; p = 0.16) associated with P. ovale infections. Children aged < 15 years old significantly suffered of SM than adults patients, whereas no significant association was found in relation to patient' sex.This study reports the first association of non-falciparum species infections with clinical malaria phenotypes in patients from the three most malaria-affected regions in Senegal. Non-falciparum P. ovale and P. vivax species in combination with P. falciparum had a protective and worsening effect, respectively. The findings suggest that interventions targeting only P. falciparum might not be sufficient to eliminate the overall malaria burden, and should take into account the neglected non-falciparum species.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"93"},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational risk of SARS-CoV-2 infection among healthcare workers in Bangladesh: a multicenter hospital-based study and lessons for future epidemics.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-03 DOI: 10.1186/s41182-024-00663-8
Ahamed Khairul Basher, Md Abdullah Al Jubayer Biswas, Aninda Rahman, Mahmudur Rahman, Fahmida Chowdhury, Md Zakiul Hassan
{"title":"Occupational risk of SARS-CoV-2 infection among healthcare workers in Bangladesh: a multicenter hospital-based study and lessons for future epidemics.","authors":"Ahamed Khairul Basher, Md Abdullah Al Jubayer Biswas, Aninda Rahman, Mahmudur Rahman, Fahmida Chowdhury, Md Zakiul Hassan","doi":"10.1186/s41182-024-00663-8","DOIUrl":"10.1186/s41182-024-00663-8","url":null,"abstract":"<p><strong>Background: </strong>Frontline healthcare workers (HCWs) were particularly vulnerable to contracting SARS-CoV-2 infection as a result of occupational exposure. There is a scarcity of data characterizing the risk of SARS-CoV-2 infection among HCWs, particularly in low-income hospital settings. This study aimed to assess the prevalence of COVID-19 among HCWs and identify associated risk factors.</p><p><strong>Methods: </strong>From July 2021 to July 2023, we enrolled HCWs from 13 primary, 2 secondary, and five tertiary care hospitals in four selected districts of Bangladesh. We collected information on demography and risk exposure in a face-to-face interview. We calculated the odds ratio to measure the risk using multivariable logistic regression.</p><p><strong>Results: </strong>We enrolled 3436 HCWs: 22% (747) physicians, 47% (1632) nurses, and 31% (1057) support staff. Most of the HCWs were female 67% (2292), and the mean age was 38.1, IQR = 29-44 years. Overall, 26% (889) of HCWs had lab-confirmed SARS-CoV-2 infection. Among HCWs, nurses accounted for the highest proportion of COVID-19 infections at 53% (473/1632). Physicians had a significantly higher risk of infection with an aOR of 3.08 (95% CI 2.42-3.93; p < .001) compared to support staff. HCWs who had direct exposure to COVID-19 patients were also at a higher risk, with a 1.93 times higher likelihood of infection ([aOR] = 1.93, 95% CI 1.50-2.47; p < .001), compared to HCWs who were not exposed.</p><p><strong>Conclusions: </strong>This study highlights the heightened vulnerability of HCWs to SARS-CoV-2 infection due to occupational exposure and indicates the risk of nosocomial transmission to patients and emphasizes the importance of implementing targeted infection control measures, such as improved workplace safety protocols and comprehensive training to tackle future pandemics of similar traits.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"92"},"PeriodicalIF":3.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial analysis of malaria cases and Anopheles species in East Java region, Indonesia.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-12-02 DOI: 10.1186/s41182-024-00662-9
Ngadino, Winarko, Demes Nurmayanti, Marlik, Slamet Wardoyo, Syarifah Nurhayati, Desya Wuryaningtyas
{"title":"Spatial analysis of malaria cases and Anopheles species in East Java region, Indonesia.","authors":"Ngadino, Winarko, Demes Nurmayanti, Marlik, Slamet Wardoyo, Syarifah Nurhayati, Desya Wuryaningtyas","doi":"10.1186/s41182-024-00662-9","DOIUrl":"https://doi.org/10.1186/s41182-024-00662-9","url":null,"abstract":"<p><p>Malaria remains a significant public health challenge worldwide, including in Indonesia, particularly in the East Java region. This study aimed to analyse the spatial distribution of malaria cases and Anopheles species that act as vectors in the area. Using an observational design with a cross-sectional approach, data on malaria cases were collected from tiers from the Community Health Centre, District Health Office and Province, all of which were documented on the Ministry of Health's malaria information system for the period 2021-2023. Malaria Vector Distribution Data from the East Java Health Office and the research team directly. Sampling of mosquitoes and larvae was carried out by researchers using a purposive sampling method, which prioritised locations with districts that have a high risk factor for the presence of breeding Anopheles sp., namely, Treggalek District, Malang District and Pacitan District with diverse topography, such as coastal (lagoon), rice fields and hills. The results of the analysis show that the distribution of imported malaria cases in East Java is uneven, with hotspots identified in several areas that have working population mobility from outside the East Java region. The presence of Anopheles species, particularly An. sundaicus and An. maculatus, contributes to their potential as vectors of malaria transmission, with An. sundaicus being more common in coastal areas and An. maculatus in valley and paddy fields. Environmental factors, such as topography of the region, temperature, humidity, and rainfall, influence the variation of Anopheles species. This study emphasises the importance of an ecosystem-based approach to malaria control, as well as the need to improve access to health services and community education. The findings provide important insights for the development of more effective and sustainable health policies in an effort to maintain malaria elimination areas in East Java.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"91"},"PeriodicalIF":3.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nine fatal cases of dengue: a case series from an intensive care unit in Sri Lanka.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-11-29 DOI: 10.1186/s41182-024-00661-w
Pramith Ruwanpathirana, Harindri Athukorala, Thamalee Palliyaguru, Praveen Weeratunga, Dilshan Priyankara
{"title":"Nine fatal cases of dengue: a case series from an intensive care unit in Sri Lanka.","authors":"Pramith Ruwanpathirana, Harindri Athukorala, Thamalee Palliyaguru, Praveen Weeratunga, Dilshan Priyankara","doi":"10.1186/s41182-024-00661-w","DOIUrl":"10.1186/s41182-024-00661-w","url":null,"abstract":"<p><strong>Background: </strong>The case fatality rate of untreated dengue is 20%; it can be reduced to less than 1% with optimal management. The leading causes of death in dengue patients are shock, bleeding, and acute liver injury. We describe the clinical features of patients who died of dengue and discuss the therapeutic challenges and pitfalls of complicated dengue.</p><p><strong>Methods: </strong>This retrospective study was done in the intensive care unit (MICU) of the National Hospital of Sri Lanka over 30 months between 2021 and 2023. All patients who died of serologically confirmed dengue were incorporated.</p><p><strong>Results: </strong>Of the 1722 ICU admissions, 44 (2.6%) patients were treated for dengue-of them, 11 (25.0%) died. Two patients were excluded as their deaths were not directly linked to dengue. Six were females. The average age was 40.2 years. The leading causes of death included shock (n = 5), acute liver failure (n = 6), intracranial bleeding (n = 2), and pulmonary embolism (n = 1). Patient 1 had concomitant leakage and bleeding, which did not respond to fluids or blood products. He developed fluid overload and acute liver failure (ALF) and died of multiorgan dysfunction. Patients 2-5 were in shock for a prolonged period due to leakage ± bleeding. Patients 2-5 developed ALF and lactic acidosis followed by multiorgan dysfunction. Patient 8 developed acute hepatitis and ALF without preceding shock. The patient was treated with immunosuppressants for myasthenia gravis. Patients 6 and 7 experienced intracranial bleeding. Patient 9 died of pulmonary embolism after prolonged ventilation for dengue encephalitis.</p><p><strong>Conclusions: </strong>Prolonged shock, fluid overload and acute liver failure were common causes of dengue related deaths, in our study. Fluid overload occurred when vigorous crystalloid resuscitation was continued in patients who were poorly responding. A prompt switch to colloids or blood could have prevented overload. Patients who were in shock for a prolonged period become unresponsive to fluid resuscitation. How to manage dengue in patients who take anti-inflammatory drugs, immunomodulators, or antiplatelets is not known. Balancing the bleeding risk of dengue in patients predisposed to bleeding or thrombosis is a challenge.</p>","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"90"},"PeriodicalIF":3.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Knowledge, attitude and practice towards intestinal schistosomiasis among school-aged children and adults in Amhara Regional State, northwest Ethiopia. A cross-sectional study.
IF 3.6
Tropical Medicine and Health Pub Date : 2024-11-29 DOI: 10.1186/s41182-024-00648-7
Getaneh Alemu, Endalkachew Nibret, Arancha Amor, Abaineh Munshea, Melaku Anegagrie
{"title":"Correction: Knowledge, attitude and practice towards intestinal schistosomiasis among school-aged children and adults in Amhara Regional State, northwest Ethiopia. A cross-sectional study.","authors":"Getaneh Alemu, Endalkachew Nibret, Arancha Amor, Abaineh Munshea, Melaku Anegagrie","doi":"10.1186/s41182-024-00648-7","DOIUrl":"10.1186/s41182-024-00648-7","url":null,"abstract":"","PeriodicalId":23311,"journal":{"name":"Tropical Medicine and Health","volume":"52 1","pages":"89"},"PeriodicalIF":3.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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