Tropical Diseases, Travel Medicine and Vaccines最新文献

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Impact of COVID-19 on a medium-sized travel medicine clinic in eastern Pennsylvania, USA.
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2025-03-01 DOI: 10.1186/s40794-024-00239-8
Pravallika Palwai, Marcelo Gareca, Sowmya R Rao, Mark C Knouse
{"title":"Impact of COVID-19 on a medium-sized travel medicine clinic in eastern Pennsylvania, USA.","authors":"Pravallika Palwai, Marcelo Gareca, Sowmya R Rao, Mark C Knouse","doi":"10.1186/s40794-024-00239-8","DOIUrl":"https://doi.org/10.1186/s40794-024-00239-8","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic (COVID) disrupted international travel. We sought to determine the impact of the COVID-19 pandemic on patient volume, traveler demographics, and income of our medium-sized travel clinic in Pennsylvania, USA.</p><p><strong>Methods: </strong>We extracted de-identified pre-travel data on 3,510 pre-travel consultations for adults during: Pre-COVID-19 (January 2018-December 2019), Early COVID-19 (April 2020-March 2022) and Late COVID-19 (April 2022-March 2023). We compared traveler demographics, destinations, purpose of travel, medical conditions, and number of vaccinations administered over time, and our clinic's revenue obtained from our financial database (TruSource) for the Pre, Early and Late COVID-19 periods.</p><p><strong>Results: </strong>We observed 84% and 85% relative decreases in traveler volume and revenue respectively from the Pre-COVID-19 to the Early COVID-19 period. The decrease (16-11%) in volume was highest for travelers over 65 years of age. Of those that sought care during Early COVID-19, a fewer proportion of travelers had multiple co-morbid conditions and were taking chronic medications. Trip length increased and there was a significant increase in travel to Africa. Travel to visit friends or family and for service work also increased during Early-COVID-19 (32.9%) versus Pre-COVID-19 (19.8%). Clinic volume and revenue began to increase in Late COVID-19 but did not return to Pre-COVID levels.</p><p><strong>Conclusions: </strong>The COVID pandemic resulted in a large reduction in patient volume and revenue in our academic-based Pennsylvania travel clinic. We saw substantial changes in our traveler demographics, destinations, as well as reasons and durations of travel. Smaller travel clinics will need to have plans in place in order to survive the next pandemic and better serve their pre-travel populations.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"11 1","pages":"5"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ear, nose and throat disorders and international travel.
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2025-02-15 DOI: 10.1186/s40794-024-00238-9
Nathaniel McHugh, Robert E Lyons, Ivan Keogh, Gerard T Flaherty
{"title":"Ear, nose and throat disorders and international travel.","authors":"Nathaniel McHugh, Robert E Lyons, Ivan Keogh, Gerard T Flaherty","doi":"10.1186/s40794-024-00238-9","DOIUrl":"10.1186/s40794-024-00238-9","url":null,"abstract":"<p><strong>Background: </strong>Disorders of the ear, nose and throat may be the most commonly occurring pre-existing health condition in international travellers. Despite their high incidence, there is limited guidance for travellers and their clinicians on their prevention and management. This narrative review addresses this deficit by compiling and discussing available evidence on this neglected subject.</p><p><strong>Methods: </strong>A comprehensive review of the literature was undertaken using Medine and Scopus databases and multiple combinations of relevant MeSH search terms. Further references were obtained from focused searches on specific issues and manual review of the reference lists of articles obtained from the primary search.</p><p><strong>Results: </strong>Nasal congestion or discharge are among the most common complaints amongst travellers and various causes are reviewed. Changes in elevation result in a pressure differential between the atmospheric pressure and the middle ear and paranasal sinuses. The effects of air travel, recreational high-altitude exposure and diving are considered. Various causes of epistaxis in travellers such as cold air exposure and recreational cocaine use are discussed. The aetiology of a discharging ear in travellers includes otitis externa. The most frequently described travel-specific aetiology of dizziness is motion sickness while mal de debarquement is a specific subtype which affects travellers and is most commonly associated with sea travel. Surgical tourism for treatment of ear, nose and throat pathology is well established and various precautions are presented for post-operative travel. Obstructive sleep apnoea is discussed from the perspective of international travel. The challenges facing travellers with hearing impairment are explored.</p><p><strong>Conclusions: </strong>This review critically discusses the prevention, diagnosis, and management of acute and chronic ENT conditions in the travelling population. Several areas of inquiry are highlighted that require further investigation. Close communication between ENT specialists and travel medicine practitioners is recommended in the preparation of selected patients for international travel.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"11 1","pages":"3"},"PeriodicalIF":2.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring primary care physicians' role in travel medicine: a scoping review of knowledge, practices, and training.
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2025-02-01 DOI: 10.1186/s40794-024-00233-0
Ayman Al-Dahshan, Salma Ahmed, Anwar Joudeh, Vahe Kehyayan
{"title":"Exploring primary care physicians' role in travel medicine: a scoping review of knowledge, practices, and training.","authors":"Ayman Al-Dahshan, Salma Ahmed, Anwar Joudeh, Vahe Kehyayan","doi":"10.1186/s40794-024-00233-0","DOIUrl":"10.1186/s40794-024-00233-0","url":null,"abstract":"<p><strong>Background: </strong>With the surge in international travel, primary care physicians (PCPs) play a critical role in managing travel medicine (TM) challenges. This scoping review aims to comprehensively synthesize literature on PCPs' involvement in TM, covering their knowledge, practices, and training.</p><p><strong>Methods: </strong>Systematic searches across various electronic databases identified empirical studies in English language peer-reviewed journals up to July 2023. Data synthesis involved charting evidence on PCPs' TM knowledge, practices, and training.</p><p><strong>Results: </strong>Sixteen articles met inclusion criteria, offering insights into PCPs' engagement with TM in primary care. The findings reveal a general deficiency in PCPs' TM knowledge, with factors like prior TM experience, formal training, high traveler exposure, and multilingual abilities predicting higher knowledge scores. TM consultation duration and documentation were frequently reported as insufficient. Barriers to effective TM provision included physician-related factors such as lack of formal training, traveler-related factors like delayed presentation and low-risk perception, and practice-related factors such as low traveler exposure and resource constraints.</p><p><strong>Conclusion: </strong>This review underscores the crucial role of PCPs in TM and the need for targeted interventions to enhance their expertise and practices. Overcoming barriers through tailored training and support is essential for optimizing TM delivery in primary care.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"11 1","pages":"4"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monkeypox: a re-emergent virus with global health implications - a comprehensive review. 猴痘:一种具有全球卫生影响的重新出现的病毒——一项全面审查。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2025-01-15 DOI: 10.1186/s40794-024-00237-w
Nourhan G Naga, Enas A Nawar, A'laa A Mobarak, Aya G Faramawy, Hend M H Al-Kordy
{"title":"Monkeypox: a re-emergent virus with global health implications - a comprehensive review.","authors":"Nourhan G Naga, Enas A Nawar, A'laa A Mobarak, Aya G Faramawy, Hend M H Al-Kordy","doi":"10.1186/s40794-024-00237-w","DOIUrl":"10.1186/s40794-024-00237-w","url":null,"abstract":"<p><p>Monkeypox virus (MPXV) is an enclosed, double-stranded DNA virus from the Orthopoxvirus genus, which also contains variola, vaccinia, and cowpox. MPXV, which was once confined to West and Central Africa, has recently had a rebound, spreading beyond its original range since 2017. The virus is distinguished by its unique morphology, which includes an oval or brick-shaped structure and a complex lipid and protein makeup. The current multi-country outbreak designated a public health emergency in 2022, has highlighted MPXV's shifting epidemiology and ability to spread rapidly over the globe. 'No one is safe until everyone is safe' is a slogan we often heard during the COVID-19 pandemic, which is now also required for the growing global and regional mpox outbreaks. The epidemic is divided into two clades: Clade I and Clade II, which have distinct pathogenic characteristics. Diagnostic approaches have developed with advances in molecular techniques, yet problems persist in resource-constrained situations. This overview summarizes the virus's history, epidemiology, morphology, and clinical characteristics, offering insights into its recent comeback and current global response efforts.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"11 1","pages":"2"},"PeriodicalIF":2.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the emerging threat of Oropouche virus: implications and public health responses for healthcare systems. 应对新出现的Oropouche病毒威胁:对卫生保健系统的影响和公共卫生应对。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2025-01-02 DOI: 10.1186/s40794-024-00236-x
Olalekan John Okesanya, Blessing Olawumi Amisu, Olaniyi Abideen Adigun, Mohamed Mustaf Ahmed, Abdulmajeed Opeyemi Agboola, Tolga Kab, Gilbert Eshun, Bonaventure Michael Ukoaka, Tolutope Adebimpe Oso, Jerico Bautista Ogaya, Don Eliseo Lucero-Prisno
{"title":"Addressing the emerging threat of Oropouche virus: implications and public health responses for healthcare systems.","authors":"Olalekan John Okesanya, Blessing Olawumi Amisu, Olaniyi Abideen Adigun, Mohamed Mustaf Ahmed, Abdulmajeed Opeyemi Agboola, Tolga Kab, Gilbert Eshun, Bonaventure Michael Ukoaka, Tolutope Adebimpe Oso, Jerico Bautista Ogaya, Don Eliseo Lucero-Prisno","doi":"10.1186/s40794-024-00236-x","DOIUrl":"10.1186/s40794-024-00236-x","url":null,"abstract":"<p><p>Oropouche fever is an increasingly significant health concern in tropical and subtropical areas of South and Central America, and is primarily spread by midge vectors. The Oropouche virus (OROV) was first identified in 1955 and has been responsible for numerous outbreaks, particularly in urban environments. Despite its prevalence, the disease is often under-reported, making it difficult to fully understand its impact. OROV typically causes febrile illness characterized by symptoms such as headaches, muscle pain, and, occasionally, neurological issues such as meningitis. The ability of the virus to thrive in both forested and urban areas has raised concerns regarding its potential spread to new regions, particularly in the context of climate change. This paper delves into the epidemiology, clinical features, and transmission patterns of OROV, shedding light on the difficulties in diagnosing and managing the disease. The absence of specific treatments and vaccines highlights the urgent need for continued research and development of targeted public health strategies. Advancements in molecular diagnostics and vector control strategies can mitigate Oropouche fever's impact. However, a comprehensive public health approach involving increased surveillance, public education, and cross-border collaboration is needed, especially as the global climate crisis may expand vector habitats, posing risks to previously unaffected regions.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"11 1","pages":"1"},"PeriodicalIF":2.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application of aptamer in tuberculosis diagnosis: a systematic review. 在结核病诊断中应用适配体:系统综述。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2024-12-15 DOI: 10.1186/s40794-024-00235-y
Elham Isaei, Mohammad Hossein Sobhanipoor, Mehran Rahimlou, Nima Firouzeh
{"title":"The application of aptamer in tuberculosis diagnosis: a systematic review.","authors":"Elham Isaei, Mohammad Hossein Sobhanipoor, Mehran Rahimlou, Nima Firouzeh","doi":"10.1186/s40794-024-00235-y","DOIUrl":"10.1186/s40794-024-00235-y","url":null,"abstract":"<p><p>Tuberculosis represents a significant menace to health, leading to millions of cases and fatalities each year. Traditional diagnostic methods, while effective, have limitations, necessitating improved tools. Aptamers possessing remarkable specificity single-stranded DNA or RNA molecules promising in TB diagnosis due to their adaptability and precise biomarker detection capabilities. In this study, we aimed to evaluate the research on aptamer applications in TB diagnosis, evaluating the efficacy, limitations, and future prospects. The present systematic review study followed PRISMA guidelines, including peer-reviewed studies on aptamer efficacy in TB diagnosis. Eligibility criteria covered experimental and human studies on TB diagnosis, prognosis, progression, and treatment response. Of 1165 identified studies, 35 met inclusion criteria. Aptamers were utilized for MTB and mycobacterial antigen detection, showcasing notable sensitivity and specificity. Targeted antigens included ESAT-6, HspX, MPT 64, and IFN-γ. Various aptamer-based assays, such as electrochemical, fluorescent, and immunosensors, demonstrated effectiveness. Multiplex assays, particularly for IFN-γ, showed enhanced diagnostic accuracy. Aptamer-based assays exhibited discrimination between active TB and other conditions, showcasing their diagnostic value. Aptamers, especially in conjunction with nanomaterials, show promise in developing advanced TB biosensors with superior detection capabilities. Cost-effective devices with heightened sensitivity for clinical and screening use are crucial for TB control, emphasizing the need for ongoing research in this field.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"10 1","pages":"25"},"PeriodicalIF":2.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of climate change in the emergence of human fascioliasis in Upper Egypt. 气候变化在上埃及人类片形吸虫病出现中的意义。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2024-12-01 DOI: 10.1186/s40794-024-00234-z
Naglaa Zanaty, Nagat Ibrahim, Haidi Karam-Allah Ramadan, Alzahraa Abdelraouf Ahmad, Amal Saad-Hussein
{"title":"Significance of climate change in the emergence of human fascioliasis in Upper Egypt.","authors":"Naglaa Zanaty, Nagat Ibrahim, Haidi Karam-Allah Ramadan, Alzahraa Abdelraouf Ahmad, Amal Saad-Hussein","doi":"10.1186/s40794-024-00234-z","DOIUrl":"https://doi.org/10.1186/s40794-024-00234-z","url":null,"abstract":"<p><strong>Background: </strong>Climate change in the upcoming years will raise the health burden of zoonotic parasites. As a liver fluke, Fasciola depends on certain climate conditions to complete its life cycle and is significantly influenced by climate changes. We aimed to investigate the relationship between the increasing prevalence of human fascioliasis and climate changes in Upper Egypt.</p><p><strong>Methods: </strong>Records of Fasciola cases in Assiut Governorate in Upper Egypt were evaluated between September 2018 and March 2023. The annual and monthly climate parameters of the region's temperature and humidity acquired from ERA5 and FLDAS were investigated between 2000 and 2023.</p><p><strong>Results: </strong>A total of 303 patients were included. The mean age was 33.9 ± 17.4 years; 57.1% were females, and the majority were rural residents. Positive correlations were found between temperature and the recorded cases in 2018, 2020, 2021, and 2022 (r = 0.92, 0.41, 0.61, and 0.60, respectively). In 2018 and 2022, humidity and Fasciola frequency had a significant positive correlation (r = 0.97 and 0.49, respectively). An outbreak of fascioliasis was recorded in September 2018, coinciding with the peak temperature and high humidity levels, exceeding the average climatology range from 2000 to 2017. The recorded cases exhibited a seasonal pattern, with peaks in hot, humid summer and autumn.</p><p><strong>Conclusion: </strong>The rise of human fascioliasis in Upper Egypt is influenced by local climate characteristics. A climate-based map of Fasciola distribution using forecast risk models is needed to predict future outbreaks and for better control.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"10 1","pages":"24"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring plant-based dengue therapeutics: from laboratory to clinic. 探索基于植物的登革热疗法:从实验室到临床。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2024-11-15 DOI: 10.1186/s40794-024-00232-1
Bisma Rehman, Akhlaq Ahmed, Saeed Khan, Nida Saleem, Faiza Naseer, Sagheer Ahmad
{"title":"Exploring plant-based dengue therapeutics: from laboratory to clinic.","authors":"Bisma Rehman, Akhlaq Ahmed, Saeed Khan, Nida Saleem, Faiza Naseer, Sagheer Ahmad","doi":"10.1186/s40794-024-00232-1","DOIUrl":"10.1186/s40794-024-00232-1","url":null,"abstract":"<p><p>Dengue virus (DENV) is a mosquito-borne virus that causes dengue fever, a significant public health concern in many tropical and subtropical regions. Dengue is endemic in more than 100 countries, primarily in tropical and subtropical regions of the world. Each year, up to 400 million people get infected with dengue. Approximately 100 million people get sick from infection, and 40,000 die from severe dengue. Unfortunately, dengue vaccine development is also marred with various complicating factors, as the forefront candidate vaccine performed unsatisfactorily. Moreover, the only licensed vaccine (Dengvaxia) for children 9 through 16 years of age is available in just a few countries. The treatment difficulties are compounded by the absence of an effective antiviral agent. Exploring plant-based therapeutics for dengue from the laboratory to clinical application involves a multi-stage process, encompassing various scientific disciplines. Individual investigators have screened a wide range of plant extracts or compounds for potential antiviral activity against DENV. In vitro studies help identify candidates that exhibit inhibitory effects on viral replication. Some of the most promising medicinal plants showing in vitro activity against DENV include Andrographis paniculate, Acorus calamus, and Cladogynos orientalis. Further laboratory studies, both in vitro and in animal models (in vivo), elucidate the mechanisms of action by which the identified compounds exert antiviral effects. Medicinal plants such as Carica papaya, Cissampelos pareira, and Ipomea batata exhibited potent platelet-enhancing activities while Azadirachta indica and Curcuma longa showed promising effects in both in vitro and in vivo studies. Based on positive preclinical results, researchers design clinical trials. This involves careful planning of trial phases, patient recruitment criteria, ethical considerations, and endpoints. The most important medicinal plants showing efficacy and safety in clinical trials include Carica papaya and Cissampelos pareira. This review suggests that several promising medicinal plants exist that have the potential to be turned into clinical drugs to treat dengue infection. However, in addition to developing synthetic and plant-based therapies against dengue infection, vector management strategies should be made robust, emphasizing the need to focus on reducing disease incidence.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"10 1","pages":"23"},"PeriodicalIF":2.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of antibody-dependent enhancement in dengue vaccination. 抗体依赖性增强在登革热疫苗接种中的作用。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2024-11-01 DOI: 10.1186/s40794-024-00231-2
D G Aynekulu Mersha, I van der Sterren, L P M van Leeuwen, T Langerak, M S Hakim, B Martina, S F L van Lelyveld, E C M van Gorp
{"title":"The role of antibody-dependent enhancement in dengue vaccination.","authors":"D G Aynekulu Mersha, I van der Sterren, L P M van Leeuwen, T Langerak, M S Hakim, B Martina, S F L van Lelyveld, E C M van Gorp","doi":"10.1186/s40794-024-00231-2","DOIUrl":"10.1186/s40794-024-00231-2","url":null,"abstract":"<p><p>Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. Two dengue vaccines are approved momentarily, with more in development. The increasing use of vaccines against dengue, combined with the development of more, makes a thorough understanding of the processes behind ADE more important than ever. Above that, due to the lack of treatment options, this method of prevention is of great importance. This review aims to explore the impact of ADE in dengue vaccinations, with the goal of enhancing potential vaccination strategies in the fight against dengue.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"10 1","pages":"22"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secreted protein NFA47630 from Nocardia farcinica IFM10152 induces immunoprotective effects in mice. 远古诺卡氏菌 IFM10152 的分泌蛋白 NFA47630 可诱导小鼠产生免疫保护作用。
IF 2.4
Tropical Diseases, Travel Medicine and Vaccines Pub Date : 2024-10-15 DOI: 10.1186/s40794-024-00229-w
Lichao Han, Xingzhao Ji, Shihong Fan, Jirao Shen, Bin Liang, Zhenjun Li
{"title":"Secreted protein NFA47630 from Nocardia farcinica IFM10152 induces immunoprotective effects in mice.","authors":"Lichao Han, Xingzhao Ji, Shihong Fan, Jirao Shen, Bin Liang, Zhenjun Li","doi":"10.1186/s40794-024-00229-w","DOIUrl":"https://doi.org/10.1186/s40794-024-00229-w","url":null,"abstract":"<p><strong>Purpose: </strong>Nocardia is emerging as a common and easily neglected cause of both healthcare- and occupation-associated infections worldwide, however, human vaccines for Nocardia prevention are not yet available. In this study, we aimed to evaluate the immunoprotective effect of the NFA47630 protein, a secreted protein abundant in the N. farcinica IFM10152 supernatant.</p><p><strong>Methods: </strong>Conservation and characteristics of nfa47630 were analyzed by PCR and bioinformatics. Then recombinant NFA47630 protein was cloned, expressed and purified for further antigenicity analysis. Subsequently, the ability to activate innate immunity was evaluated by examining the phosphorylation status of the MAPK signaling pathway and cytokine levels. Finally, the protective effect was evaluated on rNFA47630-immunized mice.</p><p><strong>Results: </strong>nfa47630 was conserved in N. farcinica strains with good antigenicity. The rNFA47630 protein was expressed under the optimal conditions of 0.2 mM IPTG, 28 °C, and it can be recognized by anti-N. farcinica and anti-N. cyriacigeorgica sera, but not anti-N. asteroids, anti-N. brasiliensis, anti-N. nova and anti-Mycobacterium bovis sera. It can upregulate the phosphorylation status of ERK, JNK, P38 and the cytokine levels of TNF-α, IL-10, IL-12, and IFN-γ. In addition, mice immunized with rNFA47630 protein exhibited higher antibody titers, greater bacterial clearance ability, milder organ infection, and higher survival rates than PBS-immunized mice.</p><p><strong>Conclusions: </strong>Our data demonstrate that NFA47630 is a potential vaccine candidate for defending against N. farcinica infection.</p>","PeriodicalId":23303,"journal":{"name":"Tropical Diseases, Travel Medicine and Vaccines","volume":"10 1","pages":"21"},"PeriodicalIF":2.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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