Microtechnologies for the New Millennium最新文献_第3页

Spectral and dielectric properties of nematic liquid crystal doped semiconductor quantum dots CdSe/ZnS 向列液晶掺杂半导体量子点CdSe/ZnS的光谱和介电性能

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2179024

M. Kurachkina, D. Shcherbinin, E. A. Konshina

引用次数: 2

Miniaturized devices towards an integrated lab-on-a-chip platform for DNA diagnostics 迈向DNA诊断集成芯片实验室平台的小型化设备

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2181953

G. Kaprou, G. Papadakis, G. Kokkoris, V. Papadopoulos, I. Kefala, D. Papageorgiou, E. Gizeli, A. Tserepi

{"title":"Miniaturized devices towards an integrated lab-on-a-chip platform for DNA diagnostics","authors":"G. Kaprou, G. Papadakis, G. Kokkoris, V. Papadopoulos, I. Kefala, D. Papageorgiou, E. Gizeli, A. Tserepi","doi":"10.1117/12.2181953","DOIUrl":"https://doi.org/10.1117/12.2181953","url":null,"abstract":"Microfluidics is an emerging technology enabling the development of Lab-on-a-chip (LOC) systems for clinical diagnostics, drug discovery and screening, food safety and environmental analysis. LOC systems integrate and scale down one or several laboratory functions on a single chip of a few mm2 to cm2 in size, and account for many advantages on biochemical analyses, such as low sample and reagent consumption, low cost, reduced analysis time, portability and point-of-need compatibility. Currently, available nucleic acid diagnostic tests take advantage of Polymerase Chain Reaction (PCR) that allows exponential amplification of portions of nucleic acid sequences that can be used as indicators for the identification of various diseases. Here, we present a comparison between static chamber and continuous flow miniaturized PCR devices, in terms of energy consumption for devices fabricated on the same material stack, with identical sample volume and channel dimensions. The comparison is implemented by a computational study coupling heat transfer in both solid and fluid, mass conservation of species, and joule heating. Based on the conclusions of this study, we develop low-cost and fast DNA amplification devices for both PCR and isothermal amplification, and we implement them in the detection of mutations related to breast cancer. The devices are fabricated by mass production amenable technologies on printed circuit board (PCB) substrates, where copper facilitates the incorporation of on-chip microheaters, defining the thermal zones necessary for PCR or isothermal amplification methods.","PeriodicalId":232941,"journal":{"name":"Microtechnologies for the New Millennium","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114810304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Novel nanoplasmonic biosensor integrated in a microfluidic channel 集成在微流体通道中的新型纳米等离子体生物传感器

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2178990

V. Solís-Tinoco, B. Sepúlveda, L. Lechuga

{"title":"Novel nanoplasmonic biosensor integrated in a microfluidic channel","authors":"V. Solís-Tinoco, B. Sepúlveda, L. Lechuga","doi":"10.1117/12.2178990","DOIUrl":"https://doi.org/10.1117/12.2178990","url":null,"abstract":"An important motivation of the actual biosensor research is to develop a multiplexed sensing platform of high sensitivity fabricated with large-scale and low-cost technologies for applications such as diagnosis and monitoring of diseases, drug discovery and environmental control. Biosensors based on localized plasmon resonance (LSPR) have demonstrated to be a novel and effective platform for quantitative detection of biological and chemical analytes. Here, we describe a novel label-free nanobiosensor consisting of an array of closely spaced, vertical, elastomeric nanopillars capped with plasmonic gold nanodisks in a SU-8 channel. The principle is based on the refractive index sensing using the LSPR of gold nanodisks. The fabrication of the nanobiosensor is based on replica molding technique and gold nanodisks are incorporated on the polymer structures by e-beam evaporation. In this work, we provide the strategies for controlling the silicon nanostructure replication using thermal polymers and photopolymers with different Young's modulus, in order to minimize the common distortions in the process and to obtain a reliable replica of the Si master. The master mold of the biosensor consists of a hexagonal array of silicon nanopillars, whose diameter is ~200 nm, and whose height can range from 250 nm to 1.300 μm, separated 400 nm from the center to center, integrated in a SU-8 microfluidic channel.","PeriodicalId":232941,"journal":{"name":"Microtechnologies for the New Millennium","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128729903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Microfabrication of multi-layered electrodes for dielectrophoresis-based field flow fractionation 介电泳场流分馏用多层电极的微细加工

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2179007

B. Mathew, A. Alazzam, S. Khashan

引用次数: 0

Metal silicide/Si thin-film Schottky-diode bolometers 金属硅化物/硅薄膜肖特基二极管测热计

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2178487

V. Yuryev, K. Chizh, Valery V. Chapnin, V. P. Kalinushkin

引用次数: 6

Biological implications of lab-on-a-chip devices fabricated using multi-jet modelling and stereolithography processes 使用多射流建模和立体光刻工艺制造的芯片实验室设备的生物学意义

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2180743

F. Zhu, N. Macdonald, J. Skommer, D. Wlodkowic

{"title":"Biological implications of lab-on-a-chip devices fabricated using multi-jet modelling and stereolithography processes","authors":"F. Zhu, N. Macdonald, J. Skommer, D. Wlodkowic","doi":"10.1117/12.2180743","DOIUrl":"https://doi.org/10.1117/12.2180743","url":null,"abstract":"Current microfabrication methods are often restricted to two-dimensional (2D) or two and a half dimensional (2.5D) structures. Those fabrication issues can be potentially addressed by emerging additive manufacturing technologies. Despite rapid growth of additive manufacturing technologies in tissue engineering, microfluidics has seen relatively little developments with regards to adopting 3D printing for rapid fabrication of complex chip-based devices. This has been due to two major factors: lack of sufficient resolution of current rapid-prototyping methods (usually >100 μm ) and optical transparency of polymers to allow in vitro imaging of specimens. We postulate that adopting innovative fabrication processes can provide effective solutions for prototyping and manufacturing of chip-based devices with high-aspect ratios (i.e. above ration of 20:1). This work provides a comprehensive investigation of commercially available additive manufacturing technologies as an alternative for rapid prototyping of complex monolithic Lab-on-a-Chip devices for biological applications. We explored both multi-jet modelling (MJM) and several stereolithography (SLA) processes with five different 3D printing resins. Compared with other rapid prototyping technologies such as PDMS soft lithography and infrared laser micromachining, we demonstrated that selected SLA technologies had superior resolution and feature quality. We also for the first time optimised the post-processing protocols and demonstrated polymer features under scanning electronic microscope (SEM). Finally we demonstrate that selected SLA polymers have optical properties enabling high-resolution biological imaging. A caution should be, however, exercised as more work is needed to develop fully bio-compatible and non-toxic polymer chemistries.","PeriodicalId":232941,"journal":{"name":"Microtechnologies for the New Millennium","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123975012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

ALD-tuned titanium dioxide nanophotonics ald调谐二氧化钛纳米光子学

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2178132

M. Häyrinen, A. Bera, M. Roussey, M. Kuittinen, S. Honkanen

引用次数: 0

Creation of hydrophilic microfluidic devices for biomedical application through stereolithography 利用立体光刻技术制造生物医学应用的亲水微流控装置

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2179562

L. Brandhoff, S. van den Driesche, F. Lucklum, M. Vellekoop

引用次数: 8

Oxide-bioceramic coatings obtained on titanium items by the induction heat treatment and modified with hydroxyapatite nanoparticles 用羟基磷灰石纳米粒子对钛材料进行改性，通过感应热处理获得氧化生物陶瓷涂层

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2180134

A. Fomin, M. Fomina, I. Rodionov, V. Koshuro, N. Petrova, A. Skaptsov, V. Atkin

引用次数: 0

Generation-recombination processes in InGaAs/GaAs heterostructures with one-dimensional nanostructures 具有一维纳米结构的InGaAs/GaAs异质结构的生成-重组过程

Microtechnologies for the New Millennium Pub Date : 2015-06-01 DOI: 10.1117/12.2178684

M. Kovalova, S. Kondratenko, A. Yakovlev, C. Furrow, V. Kunets, M. Ware, G. Salamo

引用次数: 1