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IF 6.4 2区医学

Translational Research Pub Date : 2025-02-11 DOI: 10.1016/S1931-5244(25)00016-7

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Corrigendum to “Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics” [Translational Research 275 (2025) 32–47] “慢性肾脏疾病的早期血管衰老：关注微血管维持、衰老特征和潜在治疗方法”[Translational Research] 275(2025) 32-47]。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.003

Samsul Arefin , Neja Mudrovcic , Sam Hobson , Federico Pietrocola , Thomas Ebert , Liam J. Ward , Anna Witasp , Leah Hernandez , Lars Wennberg , Torbjörn Lundgren , Julia Steinmetz-Späh , Karin Larsson , Anders Thorell , Stefania Bruno , Marita Marengo , Vincenzo Cantaluppi , Peter Stenvinkel , Karolina Kublickiene

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Infectious agents in the pathogenesis of autoimmune rheumatic diseases 自身免疫性风湿病发病机制中的传染因子。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.004

Aleksandra Korzeniowska, Ewa Bryl

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Dissecting the cellular reprogramming and tumor microenvironment in left- and right-sided Colorectal Cancer by single cell RNA sequencing 通过单细胞 RNA 测序剖析左右侧结直肠癌的细胞重编程和肿瘤微环境

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.002

Congxue Hu, Xiaozhi Huang, Jing Chen, Weixin Liang, Kaiyue Yang, Hui Jiang, Kuan Yang, Qi Ou, Xia Li, Yunpeng Zhang

{"title":"Dissecting the cellular reprogramming and tumor microenvironment in left- and right-sided Colorectal Cancer by single cell RNA sequencing","authors":"Congxue Hu, Xiaozhi Huang, Jing Chen, Weixin Liang, Kaiyue Yang, Hui Jiang, Kuan Yang, Qi Ou, Xia Li, Yunpeng Zhang","doi":"10.1016/j.trsl.2024.12.002","DOIUrl":"10.1016/j.trsl.2024.12.002","url":null,"abstract":"<div><div>Sidedness and staging are major sources of tumor microenvironment (TME) differences in colorectal cancer (CRC). Subpopulation compositions of stromal cells and immune cells, and interactions between cells collectively constitute the immunosuppressive microenvironment of CRC. In this study, we comprehensively collected single-cell RNA sequencing data from public databases. We filtered out 126,279 cells from 55 CRC samples to characterize the differences in cellular composition, and to elucidate the transcriptional features and potential functions of cell types, temporally and positionally. We observed an increased degree of hypoxia in right side-specific cancer cells compared to left-sided cancer. Cancer-associated fibroblasts (CAFs) illustrated molecular signatures tremendously tended to be associated with functions that orchestrate extracellular matrix remodeling and angiogenesis, and right-sided CAFs characterized the stronger cancer invasion signals. Crosstalk between side-specific cancer cells and stromal together with immune cells characterized CRC via different sample groups, and was pertinent to worse prognosis. Our study captured immunosuppressive pattern exhibiting more intricate intercellular interactions in right-sided CRC. Additionally, during malignant progression of CRC, the transformation of CD8+ T cell cytotoxic and exhausted properties and macrophage pro-inflammatory and anti-inflammatory properties epitomized the cellular reprogramming phenomenon that the function of TME shifted from promoting immunity to suppressive immunity. Our study shed lights on refining personalized therapeutic regimens during malignant progression in left- and right-sided CRCs.</div></div>","PeriodicalId":23226,"journal":{"name":"Translational Research","volume":"276 ","pages":"Pages 22-37"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to “Tumor molecular landscape of Epstein-Barr virus (EBV) related nasopharyngeal carcinoma in EBV-endemic and non-endemic areas: Implications for improving treatment modalities” [Transl. Res. 265 (2024) 1-16] eb病毒（EBV）相关鼻咽癌在eb病毒流行地区和非流行地区的肿瘤分子格局：改善治疗方式的意义[译]。Res. 265(2024) 1-16]。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.001

Deborah Lenoci , Carlo Resteghini , Mara S. Serafini , Federico Pistore , Silvana Canevari , Brigette Ma , Stefano Cavalieri , Salvatore Alfieri , Annalisa Trama , Lisa Licitra , Loris De Cecco

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Author Guidelines

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/S1931-5244(25)00005-2

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Editorial Advisory Board

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/S1931-5244(25)00004-0

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Information for Readers

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/S1931-5244(25)00006-4

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Breaking new ground: Unraveling the USP1/ID3/E12/P21 axis in vascular calcification 开辟新天地：揭示血管钙化中的 USP1/ID3/E12/P21 轴。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.09.002

Aoran Huang , Jianyun Rao , Xin Feng , Xingru Li , Tianhua Xu , Li Yao

{"title":"Breaking new ground: Unraveling the USP1/ID3/E12/P21 axis in vascular calcification","authors":"Aoran Huang , Jianyun Rao , Xin Feng , Xingru Li , Tianhua Xu , Li Yao","doi":"10.1016/j.trsl.2024.09.002","DOIUrl":"10.1016/j.trsl.2024.09.002","url":null,"abstract":"<div><div>Vascular calcification (VC) poses significant challenges in cardiovascular health. This study employs single-cell transcriptome sequencing to dissect cellular dynamics in this process. We identify distinct cell subgroups, notably in vascular smooth muscle cells (VSMCs), and observe differences between calcified atherosclerotic cores and adjacent regions. Further exploration reveals ID3 as a key gene regulating VSMC function. In vitro experiments demonstrate ID3′s interaction with USP1 and E12, modulating cell proliferation and osteogenic differentiation. Animal models confirm the critical role of the USP1/ID3/E12/P21 axis in VC. This study sheds light on a novel regulatory mechanism, offering potential therapeutic targets.<ul><li><span>1.</span><span><div>This study uses single-cell transcriptome to investigate vascular calcification in depth.</div></span></li><li><span>2.</span><span><div>This study successfully identifies cellular heterogeneity related to vascular calcification.</div></span></li><li><span>3.</span><span><div>This study reveals the crucial role of ID3 in vascular smooth muscle cell osteogenic differentiation.</div></span></li><li><span>4.</span><span><div><em>In vivo</em> and <em>in vitro</em> experiments of this study demonstrate the regulatory role of the USP1/ID3/E12/P21 axis in calcification.</div></span></li><li><span>5.</span><span><div>This study provides potential molecular targets for the treatment of calcification-related diseases.</div></span></li></ul></div></div>","PeriodicalId":23226,"journal":{"name":"Translational Research","volume":"276 ","pages":"Pages 1-20"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine 在儿科猪中，体外循环与深度低温循环停止导致器官特异性转录组反应。

IF 6.4 2区医学

Translational Research Pub Date : 2025-01-17 DOI: 10.1016/j.trsl.2025.01.002

Jesse A. Davidson , John Iguidbashian , Ludmila Khailova , Tanner Lehmann , Alejandro Suarez-Pierre , Lindsay M. Thomson , Jack Zakrzewski , Eiman Ali , Schuyler Lee , Benjamin S. Frank , Richard J. Ing , Matthew L. Stone , Suzanne Osorio Lujan , Sierra Niemiec , Christopher A. Mancuso

{"title":"Cardiopulmonary bypass with deep hypothermic circulatory arrest results in organ-specific transcriptomic responses in pediatric swine","authors":"Jesse A. Davidson , John Iguidbashian , Ludmila Khailova , Tanner Lehmann , Alejandro Suarez-Pierre , Lindsay M. Thomson , Jack Zakrzewski , Eiman Ali , Schuyler Lee , Benjamin S. Frank , Richard J. Ing , Matthew L. Stone , Suzanne Osorio Lujan , Sierra Niemiec , Christopher A. Mancuso","doi":"10.1016/j.trsl.2025.01.002","DOIUrl":"10.1016/j.trsl.2025.01.002","url":null,"abstract":"<div><div>The organ-level molecular response to cardiac surgery with cardiopulmonary bypass (CPB) remains inadequately understood and may be heterogeneous. Here, we measured organ-specific gene expression in a piglet model of CPB with deep hypothermic circulatory arrest (DHCA). Infant piglets underwent peripheral CPB with 75 min of DHCA and 6 h of critical care after separation from CPB. Mechanically ventilated animals served as controls. Tissue was obtained from the lung, kidney, liver, heart, and ileum. RNA sequencing was performed using NovaSeq 6000 and evaluated via differentially expressed gene (DEG) and pathway/network analyses. CPB/DHCA induced significant transcriptomic alterations, with greater changes seen in liver (2,166 DEGs), heart (775 DEGs), and kidney (1,759 DEGs) compared to lung (401 DEGs) and ileum (11 DEGs), and little overlap across organs (<20 % differentially expressed in >1 organ). Key upregulated systems included ribosomal proliferation and mitochondrial assembly in the liver, oxidative stress response and proximal tubular repair in the kidney, myofilament structural genes and pro-hypertrophy pathways in the heart, and solute channels and arginine metabolism in the lung. Downregulation of adaptive immunity genes occurred in multiple organs. Transcriptomics could inform the investigation of targeted therapies and adverse event screening after cardiac surgery.</div></div>","PeriodicalId":23226,"journal":{"name":"Translational Research","volume":"277 ","pages":"Pages 64-74"},"PeriodicalIF":6.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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