Translational Research最新文献

Macrophage-driven inflammation in acute kidney injury: Therapeutic opportunities and challenges

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-13 DOI: 10.1016/j.trsl.2025.02.003

Ya-Fan Mu , Zi-Hui Mao , Shao-Kang Pan , Dong-Wei Liu , Zhang-Suo Liu , Peng Wu , Zhong-Xiuzi Gao

{"title":"Macrophage-driven inflammation in acute kidney injury: Therapeutic opportunities and challenges","authors":"Ya-Fan Mu , Zi-Hui Mao , Shao-Kang Pan , Dong-Wei Liu , Zhang-Suo Liu , Peng Wu , Zhong-Xiuzi Gao","doi":"10.1016/j.trsl.2025.02.003","DOIUrl":"10.1016/j.trsl.2025.02.003","url":null,"abstract":"<div><div>Acute kidney injury (AKI) is increasingly being recognized as a systemic disorder associated with significant morbidity and mortality. AKI manifests with extensive cellular damage, necrosis, and an intense inflammatory response, often leading to late-stage interstitial fibrosis. Although the mechanisms underlying renal injury and repair remain poorly understood, macrophages (pivotal inflammatory cells) play central roles in AKI. They undergo polarization into pro-inflammatory and anti-inflammatory phenotypes, contributing dynamically to both the injury and repair processes while maintaining homeostasis. Macrophages modulate microenvironmental inflammation by releasing extracellular vesicles (EVs) containing pro- or anti-inflammatory signaling molecules, thereby influencing the regulation of tissue injury. The injured tissue cells release EVs and activate local macrophages to initiate these responses. Our bibliometric analysis indicated that a shift has occurred in AKI macrophage research towards therapeutic strategies and clinical translation, focusing on macrophage-targeted therapies, including exosomes and nanoparticles. This review highlights the roles and mechanisms of macrophage activation, phenotypic polarization, and trans-differentiation in AKI and discusses macrophage-based approaches for AKI prevention and treatment. Understanding the involvement of macrophages in AKI contributes to the comprehension of related immune mechanisms and lays the groundwork for novel diagnostic and therapeutic avenues.</div></div>","PeriodicalId":23226,"journal":{"name":"Translational Research","volume":"278 ","pages":"Pages 1-9"},"PeriodicalIF":6.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-12 DOI: 10.1016/j.trsl.2025.02.002

Xiaoxia Li , Qiaojing Lin , Bingyue Guan , Minghuan Yang , Xingxin Huang , Lianhuang Li , Chun Chen , Jinsheng Hong , Mingwei Zhang

{"title":"Multi-Omics Analysis Links Mitochondrial-Related Genes to Idiopathic Pulmonary Fibrosis and In Vivo Transcriptome Validation","authors":"Xiaoxia Li , Qiaojing Lin , Bingyue Guan , Minghuan Yang , Xingxin Huang , Lianhuang Li , Chun Chen , Jinsheng Hong , Mingwei Zhang","doi":"10.1016/j.trsl.2025.02.002","DOIUrl":"10.1016/j.trsl.2025.02.002","url":null,"abstract":"<div><div>Mitochondrial dysfunction is closely associated with idiopathic pulmonary fibrosis (IPF). However, the causal association between mitochondria-related genes and IPF remains to be determined. We obtained gene expression, protein abundance, and methylation quantitative trait locus data for mitochondria-related genes from previous studies. Genome-wide association study data for patients with IPF were obtained from the FinnGen study. A two-sample Mendelian randomisation analysis was conducted to assess the association between mitochondria-related genes and IPF. Furthermore, we conducted validation of expression differences utilizing transcriptome data derived from the BLM-induced pulmonary fibrosis mouse model (n=15). Concurrently, multiphoton imaging was utilized to quantify collagen contents and structural assessment. The direction of causality was verified using the Steiger test, and colocalisation analysis was used to better validate causality. Single-cell data were used to explore the localisation and expression of positive genes across different cell types. The study identified significant associations between mitochondria-related genes and IPF, with <em>POLG</em> and <em>NDUFB10</em> classified as Grade 1; <em>LYRM4, NBR1</em>, and <em>ACSF3</em> as Grade 2; <em>MCL1, GFER, MFN2, IVD</em>, and <em>SLC25A35</em> as Grade 3; and <em>METAP1D</em> and <em>MTX1</em> as Grade 4. Single-cell analysis showed elevated expression of <em>NBR1, MCL1</em>, and <em>MTX1</em> in pulmonary myofibroblasts of IPF. This study elucidated the causal effects of mitochondria-related genes on IPF, underscoring their significance in pathogenesis. These findings contribute to an improved understanding of the mechanisms underlying IPF, offering new potential therapeutic targets for interventions.</div></div>","PeriodicalId":23226,"journal":{"name":"Translational Research","volume":"278 ","pages":"Pages 10-21"},"PeriodicalIF":6.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Author Guidelines

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-11 DOI: 10.1016/S1931-5244(25)00017-9

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Information for Readers

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-11 DOI: 10.1016/S1931-5244(25)00018-0

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Editorial Advisory Board

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-11 DOI: 10.1016/S1931-5244(25)00016-7

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Corrigendum to “Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics” [Translational Research 275 (2025) 32–47] “慢性肾脏疾病的早期血管衰老：关注微血管维持、衰老特征和潜在治疗方法”[Translational Research] 275(2025) 32-47]。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.003

Samsul Arefin , Neja Mudrovcic , Sam Hobson , Federico Pietrocola , Thomas Ebert , Liam J. Ward , Anna Witasp , Leah Hernandez , Lars Wennberg , Torbjörn Lundgren , Julia Steinmetz-Späh , Karin Larsson , Anders Thorell , Stefania Bruno , Marita Marengo , Vincenzo Cantaluppi , Peter Stenvinkel , Karolina Kublickiene

引用次数: 0

Infectious agents in the pathogenesis of autoimmune rheumatic diseases 自身免疫性风湿病发病机制中的传染因子。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.004

Aleksandra Korzeniowska, Ewa Bryl

引用次数: 0

Dissecting the cellular reprogramming and tumor microenvironment in left- and right-sided Colorectal Cancer by single cell RNA sequencing 通过单细胞 RNA 测序剖析左右侧结直肠癌的细胞重编程和肿瘤微环境

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.002

Congxue Hu, Xiaozhi Huang, Jing Chen, Weixin Liang, Kaiyue Yang, Hui Jiang, Kuan Yang, Qi Ou, Xia Li, Yunpeng Zhang

{"title":"Dissecting the cellular reprogramming and tumor microenvironment in left- and right-sided Colorectal Cancer by single cell RNA sequencing","authors":"Congxue Hu, Xiaozhi Huang, Jing Chen, Weixin Liang, Kaiyue Yang, Hui Jiang, Kuan Yang, Qi Ou, Xia Li, Yunpeng Zhang","doi":"10.1016/j.trsl.2024.12.002","DOIUrl":"10.1016/j.trsl.2024.12.002","url":null,"abstract":"<div><div>Sidedness and staging are major sources of tumor microenvironment (TME) differences in colorectal cancer (CRC). Subpopulation compositions of stromal cells and immune cells, and interactions between cells collectively constitute the immunosuppressive microenvironment of CRC. In this study, we comprehensively collected single-cell RNA sequencing data from public databases. We filtered out 126,279 cells from 55 CRC samples to characterize the differences in cellular composition, and to elucidate the transcriptional features and potential functions of cell types, temporally and positionally. We observed an increased degree of hypoxia in right side-specific cancer cells compared to left-sided cancer. Cancer-associated fibroblasts (CAFs) illustrated molecular signatures tremendously tended to be associated with functions that orchestrate extracellular matrix remodeling and angiogenesis, and right-sided CAFs characterized the stronger cancer invasion signals. Crosstalk between side-specific cancer cells and stromal together with immune cells characterized CRC via different sample groups, and was pertinent to worse prognosis. Our study captured immunosuppressive pattern exhibiting more intricate intercellular interactions in right-sided CRC. Additionally, during malignant progression of CRC, the transformation of CD8+ T cell cytotoxic and exhausted properties and macrophage pro-inflammatory and anti-inflammatory properties epitomized the cellular reprogramming phenomenon that the function of TME shifted from promoting immunity to suppressive immunity. Our study shed lights on refining personalized therapeutic regimens during malignant progression in left- and right-sided CRCs.</div></div>","PeriodicalId":23226,"journal":{"name":"Translational Research","volume":"276 ","pages":"Pages 22-37"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum to “Tumor molecular landscape of Epstein-Barr virus (EBV) related nasopharyngeal carcinoma in EBV-endemic and non-endemic areas: Implications for improving treatment modalities” [Transl. Res. 265 (2024) 1-16] eb病毒（EBV）相关鼻咽癌在eb病毒流行地区和非流行地区的肿瘤分子格局：改善治疗方式的意义[译]。Res. 265(2024) 1-16]。

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/j.trsl.2024.12.001

Deborah Lenoci , Carlo Resteghini , Mara S. Serafini , Federico Pistore , Silvana Canevari , Brigette Ma , Stefano Cavalieri , Salvatore Alfieri , Annalisa Trama , Lisa Licitra , Loris De Cecco

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Author Guidelines

IF 6.4 2区医学

Translational Research Pub Date : 2025-02-01 DOI: 10.1016/S1931-5244(25)00005-2

引用次数: 0