Translational cancer research最新文献

筛选
英文 中文
Current and evolving practices of carbohydrate antigens in gastric cancer: a narrative review. 目前和发展的做法碳水化合物抗原在胃癌:叙述性的回顾。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-18 DOI: 10.21037/tcr-2024-2361
Shujing Zhao, Kaixu Li, Haiyu Wang, Yumin Ding, Dehong Li
{"title":"Current and evolving practices of carbohydrate antigens in gastric cancer: a narrative review.","authors":"Shujing Zhao, Kaixu Li, Haiyu Wang, Yumin Ding, Dehong Li","doi":"10.21037/tcr-2024-2361","DOIUrl":"10.21037/tcr-2024-2361","url":null,"abstract":"<p><strong>Background and objective: </strong>Carbohydrate antigens (CAs) are of great significance in various aspects of gastric cancer (GC). As new members of the family of CAs continue to be discovered, there is a growing focus on their role as therapeutic targets. The comprehensive review aims to provide an in-depth analysis of the current and evolving utilization of CAs in GC, offering valuable insights on the role of CAs as therapeutic targets or biomarkers for GC patients.</p><p><strong>Methods: </strong>A detailed narrative review of the most recent literature was conducted to assess the current use and advancements of CAs in GC. PubMed database was being examined and the last run was on 8 June 2024.</p><p><strong>Key content and findings: </strong>This article traces the discovery and biological properties of CAs and their role in GC clinical practice. CAs not only serve a crucial clinical function in the diagnosis, therapy monitoring, metastatic evaluation, and prognosis of GC, but they also improve biological performance when paired with other biomarkers. New CAs, like truncated O-glycans, gangliosides, globo-series glycan, and Lewis antigens, significantly influence GC progression, metastatic infiltration, and individual susceptibility. Moreover, these antigens exhibit unique potential in GC treatment, offering new approaches and insights for GC treatment.</p><p><strong>Conclusions: </strong>The use of CAs in GC diagnosis, prognosis, monitoring, and targeting therapy is beneficial. With the ongoing advancement of detection methodologies and technologies, challenges related to the sensitivity and specificity of CAs detection are anticipated to be progressively and effectively addressed. This will make its application in GC more widespread and effective.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3860-3873"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in genomic biomarkers for lethal metastatic castration-resistant prostate cancer. 致死性转移性去势抵抗性前列腺癌基因组生物标志物研究进展。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-25 DOI: 10.21037/tcr-2025-232
Sandra A Frimpong, Benjamin A Teply
{"title":"Advances in genomic biomarkers for lethal metastatic castration-resistant prostate cancer.","authors":"Sandra A Frimpong, Benjamin A Teply","doi":"10.21037/tcr-2025-232","DOIUrl":"10.21037/tcr-2025-232","url":null,"abstract":"","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3281-3285"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guanine monophosphate synthase-mediated nuclear and mitochondrial communication in the progression of gastric cancer. 鸟嘌呤单磷酸合酶在胃癌进展中介导的核和线粒体通讯。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-27 DOI: 10.21037/tcr-2024-2244
Xiaoshu Guo, Keyuan Xiao, Jiping Gong, Yu Wang, Liang Zong, Jiaoping Pan, Fan Yang, Hui Mi, Yiqiang Zhang, Baolian Ma, Lei Sun, Qilong Li, Wenqing Hu
{"title":"Guanine monophosphate synthase-mediated nuclear and mitochondrial communication in the progression of gastric cancer.","authors":"Xiaoshu Guo, Keyuan Xiao, Jiping Gong, Yu Wang, Liang Zong, Jiaoping Pan, Fan Yang, Hui Mi, Yiqiang Zhang, Baolian Ma, Lei Sun, Qilong Li, Wenqing Hu","doi":"10.21037/tcr-2024-2244","DOIUrl":"10.21037/tcr-2024-2244","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Aberrant regulation of guanine monophosphate synthase (GMPS) and serine hydroxymethyltransferase 2 (SHMT2) has been associated with abnormal cell growth, survival, and death in cancer models. This research endeavors to elucidate how the interplay between GMPS and SHMT2 in the nucleus and mitochondria can affect the viability, programmed cell death, and mitochondrial self-degradation of neoplastic cells.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The study utilized bioinformatics analysis to investigate the interaction mechanism between GMPS and SHMT2. Subsequently, enzyme-linked immunosorbent assay was utilized to assess the levels of GMPS, SHMT2, and TP53 in serum samples obtained from both gastric cancer (GC) patients and control subjects. Furthermore, the study examined the impact of GMPS knockout on cell characteristics, cellular mitochondrial reactive oxygen species (ROS) and 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide (JC-1) levels, as well as the expression of SHMT2, CASP3, and TP53 in GC cell lines AGS, MGC-803, and HGC-27. Additionally, the study detected protein expression levels of TP53, CASP3, and PINK1.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The findings of the bioinformatics analysis revealed a significant upregulation of GMPS, SHMT2, TP53, and CASP3 expression levels in patients diagnosed with gastric carcinoma compared to those in healthy individuals. Additionally, a notable increase in GMPS and SHMT2 expression was observed in cancerous tissues in comparison to adjacent para-carcinoma tissues. Furthermore, the serum levels of GMPS and SHMT2 exhibited significant correlations with the extent of GC invasion, tumor-node-metastasis classification staging, and the administration of chemotherapy (P&lt;0.05); the serum level of TP53, however, was significantly correlated only with the extent of GC invasion and whether chemotherapy was administered (P&lt;0.05). Upon transfection with the pLenti-GMPS-sgRNA plasmid, a notable decrease in the proliferation and migration capabilities of AGS, MGC-803, and HGC-27 cells was observed (P&lt;0.05). Subsequent GMPS knockout resulted in elevated levels of mitochondrial ROS in AGS, MGC-803, and HGC-27 cells, with a particularly significant difference noted in HGC-27 cells. Furthermore, spatial interactions between GMPS and SHMT2, CASP3, and TP53 were identified. Following GMPS knockout, the population of double-positive cells for SHMT2, CASP3, and TP53 experienced a significant reduction (P&lt;0.001). Following GMPS knockout, the protein expression levels of TP53, P-TP53 (Ser15), CASP3, PINK1, and PARK2 were upregulated in AGS cells, while the expression levels of SHMT2, AKT1, and CASP9 proteins were downregulated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The study identifies GMPS as a novel target for the prognosis and chemotherapy sensitivity of GC patients. The interaction between GMPS and SHMT2 enhances the exchange of nuclear and mitochondrial information in GC cells","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3471-3489"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D-regulated miRNA expression in tumoral and normal adjacent tissue of localized gastric cancer patients: the impact on survival and time to relapse. 维生素d调控的miRNA在局部胃癌患者肿瘤和正常癌旁组织中的表达:对生存和复发时间的影响
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-27 DOI: 10.21037/tcr-24-2068
Antía Cousillas Castiñeiras, Elena Gallardo Martín, Ana Fernández Montes, Marta Carmona Campos, Marta Covela Rúa, Mercedes Salgado Fernández, María Luz Pellón Augusto, José Carlos Méndez Méndez, Elena Brozos Vázquez, Nieves Martínez Lago
{"title":"Vitamin D-regulated miRNA expression in tumoral and normal adjacent tissue of localized gastric cancer patients: the impact on survival and time to relapse.","authors":"Antía Cousillas Castiñeiras, Elena Gallardo Martín, Ana Fernández Montes, Marta Carmona Campos, Marta Covela Rúa, Mercedes Salgado Fernández, María Luz Pellón Augusto, José Carlos Méndez Méndez, Elena Brozos Vázquez, Nieves Martínez Lago","doi":"10.21037/tcr-24-2068","DOIUrl":"10.21037/tcr-24-2068","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer (GC) is driven by genetic, epigenetic, and environmental factors, with dysregulated microRNAs (miRNAs) influencing key biological processes and vitamin D signaling through vitamin D receptor modulation, impacting tumor prognosis. The aim of this study is to correlate the expression of vitamin D-related miRNAs in tumor tissue and normal adjacent tissue (NAT) in GC with patient survival.</p><p><strong>Methods: </strong>The study involved 77 patients with localized GC, with time to relapse (TTR) and overall survival (OS) as primary and secondary endpoints, respectively. The study investigated miRNA expression levels in NAT and tumor and their association with patient characteristics.</p><p><strong>Results: </strong>The analysis revealed that miR-106b, miR-181b-5p, miR-181a-5p and miR-181d-5p were upregulated in tumor tissue, whereas miR-143 and miR-145 were downregulated. Patients with vitamin D deficiency (levels <30 ng/mL) showed downregulation of miR-145 in the NAT (P=0.02). The study found that downregulation of miR-181b-5p, miR-106b, and miR-181c-5p in NAT correlated with higher relapse risk (P=0.02, P=0.003, P=0.03). Furthermore, lower OS rates were significantly linked to the downregulation of miR-106b and miR-99b-3p in NAT (P<0.001, P=0.004). These findings indicate that specific miRNA downregulation in NAT is associated with poorer prognosis and increased relapse likelihood in GC patients. Additionally, miRNA expression patterns in NAT may indicate a predisposition to tumor recurrence.</p><p><strong>Conclusions: </strong>The study concludes that miRNA dysregulation in non-neoplastic gastric mucosa suggests these tissues may be cancer-prone environments.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3702-3713"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of a prognostic model for lung adenocarcinoma based on disulfidptosis-related lncRNAs. 基于二硫肺相关lncrna的肺腺癌预后模型构建
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-27 DOI: 10.21037/tcr-2024-2256
Man Sun, Dan Zang, Chen-Guang Liu, Huan Zhou, Jun Chen
{"title":"Construction of a prognostic model for lung adenocarcinoma based on disulfidptosis-related lncRNAs.","authors":"Man Sun, Dan Zang, Chen-Guang Liu, Huan Zhou, Jun Chen","doi":"10.21037/tcr-2024-2256","DOIUrl":"10.21037/tcr-2024-2256","url":null,"abstract":"<p><strong>Background: </strong>Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, and it has a high incidence and poor prognosis. Disulfidptosis is a novel form of death induced by disulfide stress caused by excessive intracellular cystine accumulation under glucose starvation conditions. This study investigated the significance of disulfidptosis-related long non-coding RNAs (DRlncRNAs) in the risk assessment and prognosis prediction of LUAD.</p><p><strong>Methods: </strong>RNA sequencing data and clinical information of LUAD patients were obtained from The Cancer Genome Atlas database. Differentially expressed genes associated with disulfidptosis were screened using univariate Cox regression analysis. A prognostic model was constructed using the least absolute shrinkage and selection operator and the Cox regression analysis to classify patients into high- and low-risk groups. Time-dependent receiver operating characteristic, C-index, and Kaplan-Meier curves were plotted and compared to evaluate the predictive ability of the prognostic model. Functional gene set enrichment analysis (GSEA) and single-sample GSEA were used to explore the characteristics of enrichment pathways, immune-related functions, and treatment response in the high- and low-risk groups.</p><p><strong>Results: </strong>A risk prognostic model was constructed consisting of eight DRlncRNAs (<i>ATXN1-AS1, AC018645.3, AC096733.2, AL049836.1, LINC01711, AF131215.5, AC027288.1,</i> and <i>AL606489.1</i>). Univariate and multifactorial Cox analyses showed that the model was a prognostic factor independent of multiple clinicopathologic parameters.</p><p><strong>Conclusions: </strong>The developed 8-lncRNA prognostic model serves as a valid biomarker for predicting LUAD prognosis and provides potential therapeutic insights. Targeting DRlncRNAs may contribute to improved prognosis and guide future therapeutic strategies.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3420-3437"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a KRP-based pH-responsive drug delivery system for solid tumors. 基于krp的ph反应性实体肿瘤给药系统的开发。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-27 DOI: 10.21037/tcr-2025-1151
Yu Wu, Jiahong Pei, Hanzhuo Wang, Mei Yu, Dandan Wang
{"title":"Development of a KRP-based pH-responsive drug delivery system for solid tumors.","authors":"Yu Wu, Jiahong Pei, Hanzhuo Wang, Mei Yu, Dandan Wang","doi":"10.21037/tcr-2025-1151","DOIUrl":"10.21037/tcr-2025-1151","url":null,"abstract":"<p><strong>Background: </strong>Cell-penetrating peptides (CPPs) are considered ideal carriers for the delivery of drugs through the cell membrane barrier, with enhanced permeation and retention effects. These peptides can increase the bioavailability of drugs and reduce their side effects. In this study, we developed a polypeptide called \"cell-penetrating peptide (KRP)\", linked it with doxorubicin (DOX), and created a pH-responsive triggered drug delivery system called \"KRP-Hyd-DOX\".</p><p><strong>Methods: </strong>We generated KRP through the application of standard Fmoc solid-phase peptide synthesis (SPPS). We attached DOX through a stable amide bond, using 3-maleimidopropionic acid as a linker, yielding KRP-DOX. With 6-maleimidopropionic acid as a linker, we connected DOX via a pH-sensitive hydrazone bond, resulting in KRP-Hyd-DOX. The pH-responsive drug-release performance of KRP-Hyd-DOX was evaluated through the calculation of the cumulative release of DOX at various time intervals and under different pH conditions via the DOX standard curve in the corresponding buffer. The cell penetration and cytotoxicity of KRP-Hyd-DOX, KRP-DOX, and DOX-hydrochloride (HCL) were compared.</p><p><strong>Results: </strong>The efficiency of KRP-DOX and KRP-Hyd-DOX in releasing free DOX was approximately 30% after 24 hours under pH 7.4. Under pH 5.0, the efficiency of KRP-DOX in releasing free DOX did not change significantly as compared to that at pH 7.4, while the efficiency of KRP-Hyd-DOX in releasing free DOX increased to 65% after 24 hours. After 24-hour exposure to KRP-Hyd-DOX, KRP-DOX, and DOX-HCL across different concentrations, MG63 cell viability exhibited a dose-dependent decline. The half-maximal inhibitory concentration (IC50) of KRP-Hyd-DOX (MG63 cells/5.22 µM) was less than that of KRP-DOX (MG63 cells/7.41 µM).</p><p><strong>Conclusions: </strong>The system we created (KRP-Hyd-DOX) leverages the synergistic effect of KRP and DOX, enhancing efficacy while minimizing side effects.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3812-3821"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines. 勘误:CD276 (B7H3)促进宫颈癌细胞系中癌症干细胞的形成。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-13 DOI: 10.21037/tcr-2025b-8
{"title":"Erratum: CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines.","authors":"","doi":"10.21037/tcr-2025b-8","DOIUrl":"10.21037/tcr-2025b-8","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/tcr-19-2910.].</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3882"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential biomarker for screening nasopharyngeal carcinoma: three-microRNA panel in serum. 筛查鼻咽癌的潜在生物标志物:血清中3 - microrna面板。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-26 DOI: 10.21037/tcr-2024-2213
Xutai Li, Zhenjian Ge, Wenkang Chen, Yingqi Li, Shengjie Lin, Yutong Wu, Pengwu Zhang, Huimei Zhou, Yongqing Lai
{"title":"Potential biomarker for screening nasopharyngeal carcinoma: three-microRNA panel in serum.","authors":"Xutai Li, Zhenjian Ge, Wenkang Chen, Yingqi Li, Shengjie Lin, Yutong Wu, Pengwu Zhang, Huimei Zhou, Yongqing Lai","doi":"10.21037/tcr-2024-2213","DOIUrl":"10.21037/tcr-2024-2213","url":null,"abstract":"<p><strong>Background: </strong>Nasopharyngeal carcinoma (NPC) is a prevalent form of cancer in Southeast Asia, characterized by distinctive epidemiological attributes, and its occurrence is influenced by factors such as race, age, and gender. Prior research has highlighted the potential of serum microRNA (miRNA) profiling as a non-invasive biomarker for cancer detection. The objective of this study was to ascertain the miRNAs that are specifically linked to the diagnosis of NPC.</p><p><strong>Methods: </strong>A three-phase study was conducted, involving a total of 112 participants (56 NPC patients and 56 healthy controls). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was employed to measure the expression levels of miRNAs in NPCs and healthy controls (HCs). The diagnostic capability of serum miRNAs for NPCs was assessed using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC). Furthermore, a diagnostic panel consisting of three miRNAs with high efficiency was constructed using inverse stepwise logistic regression. In addition, we investigated the biological functions of candidate miRNAs.</p><p><strong>Results: </strong>When compared to healthy controls, the blood of NPC patients had significantly dysregulated levels of five miRNAs (hsa-miR-363-3p, hsa-miR-106a-5p, hsa-miR-20b-5p, hsa-miR-200a-3p, hsa-miR-200b-3p). In order to create the diagnostic panels, hsa-miR-20b-5p, hsa-miR-200b-3p and hsa-miR-106a-5p were used. The panel's AUC was 0.925 [95% confidence interval (CI): 0.858-0.967; P<0.001; sensitivity: 94.64%; specificity: 76.92%]. According to the Gene Expression Profiling Interactive Analysis (GEPIA) database results, the target genes <i>AFAP1L1</i>, <i>GPT2</i>, <i>PPP1R12B</i>, <i>PRNP</i> and <i>SGIP1</i> in the three-miRNA panel were good candidates.</p><p><strong>Conclusions: </strong>Our three-miRNA panel (hsa-miR-20b-5p, hsa-miR-200b-3p and hsa-miR-106a-5p) is anticipated to be a promising non-invasive biomarker for NPC screening and diagnosis.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3554-3564"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic factor analysis and nomogram construction for elderly patients with stages III and IV epithelial ovarian cancer: a study based on the SEER database. 基于SEER数据库的老年III期和IV期上皮性卵巢癌患者预后因素分析及nomogram构建
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-27 DOI: 10.21037/tcr-24-2129
Ye Jin, Zhu Cao, Shizhou Yang
{"title":"Prognostic factor analysis and nomogram construction for elderly patients with stages III and IV epithelial ovarian cancer: a study based on the SEER database.","authors":"Ye Jin, Zhu Cao, Shizhou Yang","doi":"10.21037/tcr-24-2129","DOIUrl":"10.21037/tcr-24-2129","url":null,"abstract":"<p><strong>Background: </strong>Epithelial ovarian cancer (EOC), one of the most fatal diseases affecting the elderly women. Advanced stages EOC (stage III and stage IV) presents significant challenges in prognosis and treatment due to factors such as poor treatment tolerance, comorbidities, and immune dysfunction. There is a lack of reliable prognostic tools for elderly EOC patients. This study aimed to develop two nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in elderly patients with advanced-stage EOC using Surveillance, Epidemiology, and End Results (SEER) database, providing a tool for more personalized treatment decisions.</p><p><strong>Methods: </strong>Data about patients diagnosed with ovarian cancer at stages III and IV from 2010 to 2015 were extracted from the SEER database. Participants were randomly assigned to a training set and a validation set in a 7:3 ratio with OS and CSS as outcome events. Independent prognostic indicators determined in the multivariable analysis were employed in nomograms for predicting 1-, 3-, and 5-year OS and CSS for elderly EOC patients. The predictive performance and clinical utility were assessed using the concordance index (C-index), receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The majority of included participants were in stage III (71.38%), while 28.62% were in stage IV. In the OS training set, identified independent prognostic factors included age, race, marital status, tumor grade, T stage, American Joint Committee on Cancer (AJCC) stage, laterality, surgical method, chemotherapy, and cancer antigen 125 (CA-125). In the CSS training set, all these factors were retained except for the variable 'race'. The area under the ROC curve (AUC) for OS in the training set was 0.77 (0.75, 0.80) for 1-year, 0.68 (0.66, 0.70) for 3-year, and 0.66 (0.63, 0.68) for 5-year; in the validation set, the AUCs were 0.74 (0.70, 0.79), 0.69 (0.66, 0.72), and 0.70 (0.67, 0.73), respectively. For CSS in the training set, the AUCs were 0.77 (0.74, 0.79), 0.68 (0.66, 0.70), and 0.67 (0.64, 0.69) for 1, 3, and 5 years; in the validation set, the AUCs were 0.76 (0.71, 0.81), 0.66 (0.63, 0.70), and 0.67 (0.63, 0.70). These results indicate that the developed nomograms possess robust discriminative ability in predicting patients' OS and CSS.</p><p><strong>Conclusions: </strong>This study establishes clinically relevant nomograms for elderly patients with advanced ovarian cancer, demonstrating significant diagnostic value in predicting OS and CSS.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3302-3318"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors analysis for percutaneous endoscopic gastrostomy in patients with oral cancer: a retrospective study. 口腔癌患者经皮内镜胃造口术的危险因素分析:一项回顾性研究。
IF 1.5 4区 医学
Translational cancer research Pub Date : 2025-06-30 Epub Date: 2025-06-24 DOI: 10.21037/tcr-24-1880
Bohan Long, Lidan Hou, Hang Yin, Bin Xu, Wei Cao, Xiangjun Meng, Lei Wang
{"title":"Risk factors analysis for percutaneous endoscopic gastrostomy in patients with oral cancer: a retrospective study.","authors":"Bohan Long, Lidan Hou, Hang Yin, Bin Xu, Wei Cao, Xiangjun Meng, Lei Wang","doi":"10.21037/tcr-24-1880","DOIUrl":"10.21037/tcr-24-1880","url":null,"abstract":"<p><strong>Background: </strong>The indications for percutaneous endoscopic gastrostomy (PEG) in oral cancer patients remain unclear. This study aimed to analyze the relevant clinical characteristics of oral cancer surgical patients undergoing PEG.</p><p><strong>Methods: </strong>Clinical data of oral cancer patients who underwent PEG from July 2020 to June 2021 at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were collected. Patients with PEG usage exceeding 1 month were assigned to the case group, while those with PEG usage equal to or less than 1 month were assigned to the control group. Univariate analysis and logistic regression analysis were employed to identify independent factors influencing the differential usage of PEG and the predictive value of relevant factors was assessed using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>A total of 104 cases of oral cancer surgical patients undergoing PEG were included. Univariate analysis revealed significant effects of tongue/pharyngeal resection during surgery (P=0.03), postoperative combined radiotherapy and chemotherapy (P=0.002), as well as advanced tumor stage (T stage) (P<0.001) and node stage (N stage) (P<0.001) of oral cancer on PEG usage. Logistic regression analysis identified postoperative combined radiotherapy and chemotherapy, T stage, and N stage as independent factors influencing PEG usage. The combined predictive model yielded an area under the ROC curve (AUC) of 0.832 (P<0.001), with sensitivity and specificity of 0.767 and 0.778, respectively.</p><p><strong>Conclusions: </strong>The results suggest that oral cancer patients with tongue/pharyngeal resection during surgery, postoperative combined radiotherapy and chemotherapy, and advanced T and N stages of oral cancer may have a stronger indication for PEG.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"14 6","pages":"3577-3586"},"PeriodicalIF":1.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信