Translational cancer research最新文献

{"title":"Development of prediction models for liver metastasis in colorectal cancer based on machine learning: a population-level study.","authors":"Yuncan Xing, Guanhua Yu, Zheng Jiang, Zheng Wang","doi":"10.21037/tcr-24-1194","DOIUrl":"10.21037/tcr-24-1194","url":null,"abstract":"<p><strong>Background: </strong>Liver metastasis (LM) is of vital importance in making treatment-related decisions in patients with colorectal cancer (CRC). The aim of our study was to develop and validate prediction models for LM in CRC by making use of machine learning.</p><p><strong>Methods: </strong>We selected patients diagnosed with CRC from 2010 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Four machine-learning methods, eXtreme gradient boost (XGB), decision tree (DT), random forest (RF), and support vector machine (SVM), were employed to develop a predictive model. The receiver operating characteristic (ROC) curves, decision curve analysis (DCA) curves and calibration curves were adopted to evaluate the model performance. The SHapley Additive exPlanation (SHAP) technique was chosen for visual analysis to enhance the interpretation of the outcomes of models.</p><p><strong>Results: </strong>A total of 51,632 patients suffering from CRC were selected from the SEER database. Excellent accuracy of machine learning models was showed from ROC curves. In both the training and validation cohorts, calibration curves for the likelihood of LM demonstrated a high degree of concordance between model prediction and actual observation. The DCA indicated that each machine learning model can yield net benefits for both treat-none and treat-all strategies. Carcinoembryonic antigen (CEA) and N stage were identified as the most significant risk factors for LM based on the SHAP summary plot of the RF and XGB models.</p><p><strong>Conclusions: </strong>The XGB and RF were the best machine learning models among the four algorithms, of which CEA and N stage were identified as the most important risk factors related to LM.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"5943-5952"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The next frontier in breast cancer: genomic co-alteration and its impact on biology and treatment planning.","authors":"Meredith Li, Eitan Amir","doi":"10.21037/tcr-24-952","DOIUrl":"10.21037/tcr-24-952","url":null,"abstract":"","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6594-6597"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between marital status and survival in primary bone cancer: a population-based study.","authors":"Xiaoxia Huang, Leilei Tian, Chuang Li, Jinling Liu, Rui Shi, Fang Lin, Yi Luo","doi":"10.21037/tcr-24-1215","DOIUrl":"10.21037/tcr-24-1215","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have demonstrated a significant impact of marital status on the prognosis of various cancers; however, its specific influence on the prognosis of primary bone cancer remains insufficiently investigated. In this study, we aimed to investigate the survival differences between male and female in patients diagnosed with primary bone cancer.</p><p><strong>Methods: </strong>Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify suitable patients. Patients were categorized into married and unmarried groups, with a 1:1 propensity score matching (PSM) method used to balance baseline characteristics between the two groups. Kaplan-Meier curves and Log-rank tests were then employed to ascertain differences in overall survival (OS) and cancer-specific survival (CSS) between the groups, followed by gender-based subgroup analyses. A multivariate Cox regression was finally conducted to adjust for the effects of covariates.</p><p><strong>Results: </strong>A total of 8,208 patients were included in this study, comprising 4,650 married and 3,558 unmarried individuals. Significant baseline characteristic differences were observed between the two groups before PSM. After PSM, 3,138 patients from each group were included, with balance maintained in all considered baseline characteristics. Before PSM, married patients had better OS [hazard ratio (HR) =0.93, 95% confidence interval (CI): 0.87-0.99, P=0.047] compared to unmarried patients, but no significant difference in CSS (HR =0.95, 95% CI: 0.88-1.03, P=0.21). Following PSM, married patients exhibited significantly better OS (HR =0.85, 95% CI: 0.79-0.92, P<0.001) and CSS (HR =0.92, 95% CI: 0.84-0.99, P=0.045) than unmarried patients. However, in subgroup analyses, the survival benefit attributed to marriage was observed only in females, not in males. In Cox regression, marriage was identified as an independent protective factor for OS (HR =0.86, 95% CI: 0.79-0.93, P<0.001) and CSS (HR =0.91, 95% CI: 0.82-0.97, P=0.04).</p><p><strong>Conclusions: </strong>In patients with primary malignant bone cancer, marriage is a protective factor for survival, but this effect appears to be limited to females.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"5898-5908"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>FLT3</i> mutation-related immune checkpoint molecule absent in melanoma 2 (<i>AIM2</i>) contributes to immune infiltration in pediatric and adult acute myeloid leukemia: evidence from bioinformatics analysis.","authors":"Jing Zhao, Yue Cui, Hua Zhou, Dongming Zhou, Zhiping Che, Ning Zhang, Qi Yun, João Agostinho Machado-Neto, Daniela Damiani, Lika'a Fasih Y Al-Kzayer, Rohan Kulkarni, Meng Gu","doi":"10.21037/tcr-24-1403","DOIUrl":"10.21037/tcr-24-1403","url":null,"abstract":"<p><strong>Background: </strong>The use of FMS-like tyrosine kinase 3 (<i>FLT3</i>) as a crucial target for kinase inhibitors is well established, but its association with immune infiltration remains unclear. This study aimed to explore the relationship between <i>FLT3</i> mutations and immune checkpoint molecules (ICMs) in patients with acute myeloid leukemia (AML).</p><p><strong>Methods: </strong>The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases were used to identify the ICMs associated with <i>FLT3</i> mutations. A Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and gene set enrichment analysis (GSEA) were conducted to analyze the signaling pathways related to the ICMs. The single-sample GSEA (ssGSEA), Cibersort, and estimate algorithms were used to assess immune cell infiltration in AML.</p><p><strong>Results: </strong>Absent in melanoma 2 (<i>AIM2</i>) exhibits elevated expression levels in AML patients harboring <i>FLT3</i> mutation, contributing significantly to the progress of AML and establishing of an immunosuppressive microenvironment. <i>AIM2</i> expression significantly correlated with sensitivity of clinically relevant drugs in <i>ex vivo</i> assays of AML. Additionally, <i>AIM2</i> demonstrates substantial prognostic value and holds promise as a prospective immunotherapeutic target for AML. Our findings indicate a significant correlation between <i>AIM2</i> and immune infiltration in AML cases, potentially affecting the presence of neutrophils, macrophages, effector memory T cells (Tem), and monocytes. Furthermore, <i>AIM2</i> is closely linked to various signaling pathways, such as immune cytokine release, immune antigen presentation, and inflammasome signaling, which could play a role in immune cell enrichment in AML.</p><p><strong>Conclusions: </strong>Our study identified <i>AMI2</i> as an ICM linked to <i>FLT3</i> mutations. <i>AMI2</i> may be involved in the activation of suppressive immune cell populations, such as macrophages, neutrophils, and monocytes. <i>AIM2</i> could serve as a promising immunotherapeutic target for combination therapy with FLT3 inhibitors in AML.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6255-6272"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel cuprotosis-related gene signature: a prognostic indicator and regulator of the glioma immune microenvironment.","authors":"Dongming Gao, Lin Zhou, Youyuan Bao, Wenyin Shi, Lei Li, Liang Gao","doi":"10.21037/tcr-24-1860","DOIUrl":"10.21037/tcr-24-1860","url":null,"abstract":"<p><strong>Background: </strong>Glioma is a primary malignant brain tumor with a poor prognosis. Glioma-related biomarkers need to be identified to enable the personalized treatment of and predict the prognosis of glioma patients. Cuproptosis is an unusual mechanism of cell death, and is closely associated with disease progression and the immune-microenvironment of the tumor. However, the function of cuproptosis in glioma is still unclear, therefore the aim of this study was to investigate the role of cuproptosis-related genes in gliomas.</p><p><strong>Methods: </strong>We examined the relationship between cuproptosis and glioma using the clinical and expression data of glioma tumors from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA).</p><p><strong>Results: </strong>First, we determined the rate of somatic mutations and copy number variations (CNVs) of 51 copper homeostasis-related genes and studied their correlation with prognosis. We then identified three molecular subgroups of copper homeostasis-related genes linked to prognosis. We discovered that different subgroups had distinct immune and biological features. We then developed a prognostic model by least absolute shrinkage and selection operator (LASSO) regression that comprised four cuproptosis-related genes; that is, a solute carrier family 31 member A1 (<i>SLC31A1</i>), microtubule-associated protein tau (<i>MAPT</i>), ATPase beta (<i>ATP7B</i>), and six-transmembrane epithelial antigen of prostate 3 (<i>STEAP3</i>). This model was found to have strong prognostic ability in the CGGA cohort (P<0.05).</p><p><strong>Conclusions: </strong>We investigated the function of copper homeostasis-related genes in neuroglioma and their relationship with tumor immunology. Our in-depth analyses revealed that these biomarkers are useful for diagnostic and prognostic purposes and could be used to guide our understanding of the progression of and treatment of glioma tumorigenesis.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6282-6297"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary surgical management of testicular seminoma.","authors":"Rachel Passarelli, John L Pfail, Thomas L Jang","doi":"10.21037/tcr-24-241","DOIUrl":"10.21037/tcr-24-241","url":null,"abstract":"<p><p>Testicular cancer is the most commonly diagnosed cancer among young men in the United States. Seminoma comprises a little over half of all testicular germ cell neoplasms. After radial inguinal orchiectomy, management of seminoma is dictated by tumor stage and risk stratification. Dissemination patterns for metastatic testicular cancer are predictable and reproducible, initially metastasizing to the retroperitoneum before disseminating to the lungs or other viscera. Seminomas are exquisitely sensitive to radiation therapy and platinum-based chemotherapy. Approximately 80-85% of men presenting with early stage (clinical stage I) seminoma will not experience a relapse after radical orchiectomy alone. Therefore, surveillance has been supported by the National Comprehensive Cancer Network (NCCN) guidelines as the preferred management strategy. For those at higher risk of relapse, one or two cycles of single-agent carboplatin or radiation therapy are alternative options to reduce the risk of relapse. For patients with early disseminated seminoma (clinical stage IIA and IIB), radiation therapy or chemotherapy with three cycles of bleomycin, etoposide, cisplatin (BEP) or four cycles of etoposide and cisplatin (EP) are well-established options with excellent cure rates. However, these therapies may be associated with significant long-term toxicities. Primary retroperitoneal lymph node dissection (RPLND) in patients with low-volume metastatic seminoma has recently been evaluated for safety and efficacy in prospective clinical trials. Finally, though the role of surgery in patients with advanced seminoma (clinical stage IIC and III) is limited, a subset of patients with a residual mass following chemotherapy >3 cm suggestive of viable germ cell tumor on imaging may benefit from surgical resection. Herein we review the contemporary indications for surgery and outcomes for men with testicular seminoma.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6463-6472"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating the molecular and immune interplay between head and neck squamous cell carcinoma and diffuse large B-cell lymphoma through bioinformatics and machine learning.","authors":"Jing Zheng, Xinxin Li, Xun Gong, Yuan Hu, Min Tang","doi":"10.21037/tcr-24-1064","DOIUrl":"10.21037/tcr-24-1064","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Head and neck squamous cell carcinoma (HNSCC) contributes significantly to global health challenges, presenting primarily in the oral cavity, pharynx, nasopharynx, and larynx. HNSCC has a high propensity for lymphatic metastasis. Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, exhibits significant heterogeneity and aggressive behavior, leading to high mortality rates. Epstein-Barr virus (EBV) is notably associated with DLBCL and certain types of HNSCC. The purpose of this study is to elucidate the molecular and immune interplay between HNSCC and DLBCL using bioinformatics and machine learning (ML) to identify shared biomarkers and potential therapeutic targets.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Differentially expressed genes (DEGs) were identified using the \"limma\" package in R from the HNSCC dataset in The Cancer Genome Atlas (TCGA) database, and relevant modules were selected through weighted gene co-expression network analysis (WGCNA) from a DLBCL dataset in the Gene Expression Omnibus (GEO) database. Based on their intersection genes, functional enrichment analyses were conducted using Gene Ontology (GO), Disease Ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Protein-protein interaction (PPI) networks and ML algorithms were employed to screen for biomarkers. The prognostic value of these biomarkers was evaluated using Kaplan-Meier (K-M) survival analysis and receiver operating characteristic (ROC) curve analyses. The Human Protein Atlas (HPA) database facilitated the examination of messenger RNA (mRNA) and protein expressions. Further analyses of mutations, immune infiltration, drug predictions, and pan-cancer impacts were performed. Additionally, single-cell RNA sequencing (scRNA-seq) data analysis at the cell type level was conducted to provide deeper insights into the tumor microenvironment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From 2,040 DEGs and 1,983 module-related genes, 85 shared genes were identified. PPI analysis with six algorithms proposed 21 prospective genes, followed ML examination yielded 16 candidates. Survival and ROC analyses pinpointed four hub genes-&lt;i&gt;ACACB&lt;/i&gt;, &lt;i&gt;MMP8&lt;/i&gt;, &lt;i&gt;PAX5&lt;/i&gt;, and &lt;i&gt;TNFAIP6&lt;/i&gt;-as significantly associated with patient outcomes, demonstrating high predictive capabilities. Evaluations of mutations and immune infiltration, coupled with drug prediction and a comprehensive cancer analysis, highlighted these biomarkers' roles in tumor immune response and treatment efficacy. The scRNA-seq data analysis revealed an increased abundance of fibroblasts, epithelial cells and mononuclear phagocyte system (MPs) in HNSCC tissues compared to lymphoid tissues. &lt;i&gt;MMP8&lt;/i&gt; showed higher expression in five cell types in HNSCC tissues, while &lt;i&gt;TNFAIP6&lt;/i&gt; and &lt;i&gt;PAX5&lt;/i&gt; exhibited higher expression in specific cell types.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Leveraging bioinformatics and ML, this study identified four pivot","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"5725-5750"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative systemic therapy in high-risk renal cell carcinoma following nephrectomy: a narrative review.","authors":"Adam Khorasanchi, Taylor Goodstein, Shawn Dason, Eric A Singer, Danielle Zimmerman, Yuanquan Yang","doi":"10.21037/tcr-24-16","DOIUrl":"10.21037/tcr-24-16","url":null,"abstract":"<p><strong>Background and objective: </strong>For patients with resectable renal cell carcinoma (RCC), extirpative surgery with curative intent remains the standard of care. Despite surgical resection, most patients with high-risk features experience disease recurrence. The role of perioperative systemic therapy in the management of these patients' disease remains unclear. Several studies have evaluated the efficacy and safety of tyrosine kinase inhibitors (TKIs); however, most trials have yielded negative results. Adjuvant pembrolizumab demonstrated a disease-free survival benefit in the KEYNOTE-564 trial; however, multiple studies of other immune checkpoint inhibitors (ICIs) in a similar patient population did not yield consistent results. This review summarizes the current evidence for perioperative systemic therapy studies in RCC.</p><p><strong>Methods: </strong>The PubMed, American Society of Clinical Oncology (ASCO), and clinicaltrials.gov databases were used to retrieve articles published from January 1, 2001 to December 31, 2023 using the following search terms: \"adjuvant\", \"neoadjuvant\", \"perioperative\", \"VEGF inhibitors\", \"immune checkpoint inhibitors\", and \"renal cell carcinoma\". The search was limited to articles published in English.</p><p><strong>Key content and findings: </strong>We summarize the major perioperative systemic therapy studies in RCC patients and provide an analysis of study outcomes, comparing differences in trial design and patient selection. We also discuss ongoing trials and the emergence of novel biomarkers designed to improve patient selection.</p><p><strong>Conclusions: </strong>The optimal use of perioperative systemic therapy in high-risk RCC is an area of active investigation. The use of adjuvant TKIs failed to demonstrate a survival benefit and was limited by high rates of toxicity. Several neoadjuvant and adjuvant ICI-based combination studies are being carried out to further improve clinical outcomes. Further studies will be needed to identify effective biomarkers to improve patient selection while avoiding overtreatment.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6511-6528"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Matrine reverses the drug resistance of K562/ADM cells to ADM and VCR via promoting autophagy.","authors":"Zhao Li, Ning Wang, Ting Yue, Lu Liu","doi":"10.21037/tcr-2024-9","DOIUrl":"10.21037/tcr-2024-9","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.21037/tcr.2019.12.11.].</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6598"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics of myxopapillary ependymoma and factors affecting overall survival: a SEER-based analysis.","authors":"Ge Huang, Zhengyuan Xie, Jinhong Li","doi":"10.21037/tcr-24-757","DOIUrl":"10.21037/tcr-24-757","url":null,"abstract":"<p><strong>Background: </strong>Myxopapillary ependymoma (MPE) is a rare tumor. Most studies have discussed the clinical symptoms and treatment of individual cases, but limited data are provided on overall survival and its influencing factors. Consequently, we aimed to further explore the epidemiological features of MPE and factors influencing overall survival.</p><p><strong>Methods: </strong>The cohort study extracted information about all patients diagnosed with intracranial MPE from the Surveillance, Epidemiology, and End Results (SEER) 2004-2015. Epidemiological characteristics and prognostic factors after adjustment for different variables were analyzed. Outcomes were 5- and 10-year overall survival. Univariate and multivariate analyses were conducted using the Cox proportional hazards model, with hazard ratios (HRs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 1,026 cases were identified in the SEER database. No significant difference was found between the incidence of total MPE and the incidence of non-malignant MPE from 2004 to 2015, and there was no incidence trend. The incidence of MPE was higher among people aged 30-34 and 45-49 years old. In 2005, 2007 and 2011, the incidence of men was greater than that of women (P<0.001). Blacks had a lower incidence than whites in years other than 2007, 2010, and 2013. The older age (older <i>vs.</i> younger: HR =1.081, 95% CI: 1.055-1.107), widowed status (widowed <i>vs.</i> single/unmarried: HR =3.058, 95% CI: 1.282-7.296), no surgery (surgery <i>vs.</i> no surgery: HR =0.283, 95% CI: 0.126-0.635), and radiotherapy (radiotherapy <i>vs.</i> no radiotherapy: HR =4.355, 95% CI: 2.211-8.578) were significantly adverse prognostic factors.</p><p><strong>Conclusions: </strong>Age, marital status, surgery and radiotherapy are factors influencing the overall survival of MPE patients. Surgery is still the main therapeutic choice, while radiotherapy plays a negative role in the management of MPE. Therefore, prospective research is required to verify and complement our findings for MPE control.</p>","PeriodicalId":23216,"journal":{"name":"Translational cancer research","volume":"13 11","pages":"6154-6164"},"PeriodicalIF":1.5,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}