Bohan Long, Lidan Hou, Hang Yin, Bin Xu, Wei Cao, Xiangjun Meng, Lei Wang
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引用次数: 0
Abstract
Background: The indications for percutaneous endoscopic gastrostomy (PEG) in oral cancer patients remain unclear. This study aimed to analyze the relevant clinical characteristics of oral cancer surgical patients undergoing PEG.
Methods: Clinical data of oral cancer patients who underwent PEG from July 2020 to June 2021 at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were collected. Patients with PEG usage exceeding 1 month were assigned to the case group, while those with PEG usage equal to or less than 1 month were assigned to the control group. Univariate analysis and logistic regression analysis were employed to identify independent factors influencing the differential usage of PEG and the predictive value of relevant factors was assessed using receiver operating characteristic (ROC) curve analysis.
Results: A total of 104 cases of oral cancer surgical patients undergoing PEG were included. Univariate analysis revealed significant effects of tongue/pharyngeal resection during surgery (P=0.03), postoperative combined radiotherapy and chemotherapy (P=0.002), as well as advanced tumor stage (T stage) (P<0.001) and node stage (N stage) (P<0.001) of oral cancer on PEG usage. Logistic regression analysis identified postoperative combined radiotherapy and chemotherapy, T stage, and N stage as independent factors influencing PEG usage. The combined predictive model yielded an area under the ROC curve (AUC) of 0.832 (P<0.001), with sensitivity and specificity of 0.767 and 0.778, respectively.
Conclusions: The results suggest that oral cancer patients with tongue/pharyngeal resection during surgery, postoperative combined radiotherapy and chemotherapy, and advanced T and N stages of oral cancer may have a stronger indication for PEG.
期刊介绍：
Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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