Toxicological Research最新文献_第6页

Methylmercury exposure at dosage conditions that do not affect growth can impair memory in adolescent mice. 在不影响生长的剂量条件下接触甲基汞会损害青春期小鼠的记忆力。

IF 1.6 4区医学

Toxicological Research Pub Date : 2024-04-27 eCollection Date: 2024-07-01 DOI: 10.1007/s43188-024-00239-y

Ryota Yamagata, Ai Saito, Ryoko Fukushima, Osamu Nakagawasai, Naoya Yamashita, Koichi Tan-No, Gi-Wook Hwang

{"title":"Methylmercury exposure at dosage conditions that do not affect growth can impair memory in adolescent mice.","authors":"Ryota Yamagata, Ai Saito, Ryoko Fukushima, Osamu Nakagawasai, Naoya Yamashita, Koichi Tan-No, Gi-Wook Hwang","doi":"10.1007/s43188-024-00239-y","DOIUrl":"10.1007/s43188-024-00239-y","url":null,"abstract":"Methylmercury is an environmental pollutant that can induce serious central nervous system damage. Its ubiquitous presence in the environment in trace amounts has raised concerns about potential adverse effects on human health. Although many studies have evaluated the effects of methylmercury on neural development in fetal and neonatal mice, there has been less focus on studies using adolescent mice. Therefore, in this study, the effects of methylmercury on brain neurodevelopment and maturation were evaluated by various neurobehavioral trials using adolescent mice exposed to 30 ppm methylmercuric chloride (approximately 24 ppm methylmercury) for up to 8 weeks. Under these administration conditions, weight gain in adolescent mice was unaffected by methylmercury exposure. Furthermore, methylmercury exposure in adolescent mice had no effect on sociability as assessed by the social interaction test, impulsivity as assessed by the cliff avoidance reaction test, depressive behavior as assessed by the tail-suspension test, or locomotor activity as assessed using the Supermex system. In contrast, short-term memory assessed by the Y-maze test, as well as long-term memory assessed by novel object recognition and passive avoidance tests, revealed impairments induced by methylmercury exposure in adolescent mice. These results suggest that long-term exposure to methylmercury during adolescence potentially impairs memory function, and the nervous pathway of brain areas involved in learning and memory are particularly vulnerable to the adverse effects of methylmercury.Supplementary information: The online version contains supplementary material available at 10.1007/s43188-024-00239-y.","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":"40 3","pages":"441-448"},"PeriodicalIF":1.6,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats. 正乙酰半胱氨酸可防止重氮酮诱导的大鼠肾组织病理损伤和细胞凋亡。

IF 1.6 4区医学

Toxicological Research Pub Date : 2024-03-07 eCollection Date: 2024-04-01 DOI: 10.1007/s43188-024-00226-3

Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong Li

{"title":"n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats.","authors":"Gaiqin Dong, Qingfeng Li, Chun Yu, Qing Wang, Danhua Zuo, Xiaozhong Li","doi":"10.1007/s43188-024-00226-3","DOIUrl":"10.1007/s43188-024-00226-3","url":null,"abstract":"Diazinon (DZN) is a member of organophosphorus insecticides that has cytotoxic effects on different organs. n-Acetyl cysteine (NAC) is a widely used antioxidant in clinical, in vivo and in vitro studies. We evaluated the protective role of NAC against DZN-induced toxicity in kidney tissue of Wistar rats. 30 male Wistar rats were divided into 5 groups of control, single dose of DZN, continuous dose of DZN, single doses of DZN + NAC and continuous doses of DZN + NAC. Kidney function test (blood urea nitrogen, creatinine and uric acid) was provided. Levels of malondialdehyde (MDA), total antioxidant capacity (TAC) and total sulfhydryl (T-SH) were determined in renal tissues. Renal cells apoptosis was detected using TUNEL assay. The mRNA expressions of apoptosis, oxidative stress and inflammatory mediators, including B-cell lymphoma-2 (Bcl2), Bcl-2-associated X protein (Bax), superoxide dismutase (SOD), catalase (CAT), Interleukin 10 (IL-10), Tumor necrosis factor-α (TNF-α), Caspase-3 and Caspase-8 were analyzed in kidney tissues using Real Time PCR method. Chronic exposure to DZN was associated with severe morphological changes in the kidney, as well as impairment of its function and decreased kidney weights. Continues treatment with DZN significantly decreased the percentage of renal apoptotic cells as compared to rats treated with continuous dose of DZN alone (17.69 ± 3.67% vs. 39.46% ± 2.44%; p < 0.001). Continuous exposure to DZN significantly decreased TAC and T-SH contents, as well as SOD and CAT expression, but increased MDA contents in the kidney tissues (p < 0.001). A significant increase was observed in mRNA expression of Bax, Caspase-3, Caspase-8, as well as TNF-α following exposure to DZN, but the expression of IL-10 and Bcl2 was significantly decreased. NAC can protect kidney tissue against DZN-induced toxicity by elevating antioxidants capacity, mitigating oxidative stress, inflammation and apoptosis.","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":"40 2","pages":"285-295"},"PeriodicalIF":1.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological changes in various organs in HLA-B*57:01 transgenic mice with abacavir-induced skin eruption 阿巴卡韦诱发皮肤糜烂的 HLA-B*57:01 转基因小鼠各器官的病理变化

IF 2.3 4区医学

Toxicological Research Pub Date : 2024-01-06 DOI: 10.1007/s43188-023-00220-1

Akira Kazaoka, Kazuyoshi Kumagai, Junya Matsushita, Tetsuo Aida, Saki Kuwahara, Shigeki Aoki, Kousei Ito

引用次数: 0

Efficiency of pharmaceutical toxicity prediction in computational toxicology 计算毒理学中药物毒性预测的效率

IF 2.3 4区医学

Toxicological Research Pub Date : 2024-01-04 DOI: 10.1007/s43188-023-00215-y

Y. Uesawa

引用次数: 0

Catalytic enhancements in cytochrome P450 2C19 by cytochrome b_5 细胞色素 b_5 对细胞色素 P450 2C19 的催化增强作用

IF 2.3 4区医学

Toxicological Research Pub Date : 2024-01-02 DOI: 10.1007/s43188-023-00219-8

Gyu-Hyeong Lee, V. Kim, Sung-Gyu Lee, Eunseo Jeong, Changmin Kim, Yoo-Bin Lee, Donghak Kim

引用次数: 0

A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico 利用与谷胱甘肽在化学反应中的反应性筛选皮肤过敏化学物质的便捷分光光度检测法

IF 2.3 4区医学

Toxicological Research Pub Date : 2023-12-13 DOI: 10.1007/s43188-023-00218-9

D. H. Cha, G. Kim, Rahul U. Nepal, M. Nepal, Tae Cheon Jeong

引用次数: 0

Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure 西洛他唑对急性缺血性中风并发慢性肾功能衰竭大鼠血管损伤的保护作用

IF 2.3 4区医学

Toxicological Research Pub Date : 2023-12-13 DOI: 10.1007/s43188-023-00217-w

Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Min

引用次数: 0

Association between urinary arsenic concentration and genetic polymorphisms in Korean adults 韩国成年人尿砷浓度与基因多态性之间的关系

IF 2.3 4区医学

Toxicological Research Pub Date : 2023-11-23 DOI: 10.1007/s43188-023-00216-x

S. Lee, Sang-Yong Eom, Ji-Ae Lim, Byung-Sun Choi, Ho-Jang Kwon, Young-Seoub Hong, Yong-Dae Kim, Heon Kim, J. Park

引用次数: 0

Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles 经气管内注射硫化钼纳米和微粒后大鼠软组织和血液中钼的分布

4区医学

Toxicological Research Pub Date : 2023-11-14 DOI: 10.1007/s43188-023-00213-0

Renata Kuraś, Maciej Stępnik, Jarosław Grobelny, Emilia Tomaszewska, Magdalena Stanisławska, Katarzyna Domeradzka-Gajda, Wojciech Wąsowicz, Beata Janasik

{"title":"Distribution of molybdenum in soft tissues and blood of rats after intratracheal instillation of molybdenum(IV) sulfide nano- and microparticles","authors":"Renata Kuraś, Maciej Stępnik, Jarosław Grobelny, Emilia Tomaszewska, Magdalena Stanisławska, Katarzyna Domeradzka-Gajda, Wojciech Wąsowicz, Beata Janasik","doi":"10.1007/s43188-023-00213-0","DOIUrl":"https://doi.org/10.1007/s43188-023-00213-0","url":null,"abstract":"Abstract There is still little literature data on the toxicity and safety of the commonly used molybdenum (Mo) disulfide which is present in the working as well as living environments. Thus, an experiment was carried out involving rats, with single and repeated intratracheal exposure (in the latter case, 7 administrations at 2-week intervals with the analysis performed after 90 days) to lower (1.5 mg Mo kg −1 b.w.) and higher (5 mg Mo kg −1 b.w.) doses of molybdenum(IV) sulfide nanoparticles (MoS 2 -NPs) and microparticles (MoS 2 -MPs). The analysis of Mo concentrations in the tail and heart blood as well as in soft tissues (lung, liver, spleen, brain), after mineralization and bioimaging, was meant to facilitate an assessment of its accumulation and potential effects on the body following short- and long-term exposure. The multi-compartment model with an exponential curve of Mo concentration over time with different half-lives for the distribution and elimination phases of MoS 2 -MPs and MoS 2 -NPs was observed. After 24 h of exposure, a slight increase in Mo concentration in blood was observed. Next, Mo concentration indicated a decrease in blood concentration from 24 h to day 14 (the Mo concentration before the second administration), below the pre-exposure concentration. The next phase was linear, less abrupt and practically flat, but with an increasing trend towards the end of the experiment. Significantly higher Mo concentrations in MoS 2 -NPs and MoS 2 -MPs was found in the lungs of repeatedly exposed rats compared to those exposed to a single dose. The analysis of Mo content in the liver and the spleen tissue showed a slightly higher concentration for MoS 2 -NPs compared to MoS 2 -MPs. The results for the brain were below the calculated detection limit. Results were consistent with results obtained by bioimaging technique.","PeriodicalId":23181,"journal":{"name":"Toxicological Research","volume":"25 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens 对羟基苯甲酸酯雌激素受体α二聚化及转录活性的比较研究

4区医学

Toxicological Research Pub Date : 2023-10-05 DOI: 10.1007/s43188-023-00212-1

Jong-Yeon Kim, Yooheon Park, Seok-Hee Lee, Eun‐Jung Park, Hae‐Jeung Lee

引用次数: 0