Topics in companion animal medicine最新文献

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Effect of seminal plasma cholesterol and triacylglycerides concentrations and sperm morphology on semen freezability in domestic cats (Felis silvestris catus) 精浆胆固醇和三酰甘油浓度以及精子形态对家猫精液冷冻性的影响
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-08-20 DOI: 10.1016/j.tcam.2024.100907
María Florencia García , Romina Nuñez Favre , Ramiro Rearte , María Cecilia Stornelli , Susana Jurado , Luzbel de la Sota , María Alejandra Stornelli
{"title":"Effect of seminal plasma cholesterol and triacylglycerides concentrations and sperm morphology on semen freezability in domestic cats (Felis silvestris catus)","authors":"María Florencia García ,&nbsp;Romina Nuñez Favre ,&nbsp;Ramiro Rearte ,&nbsp;María Cecilia Stornelli ,&nbsp;Susana Jurado ,&nbsp;Luzbel de la Sota ,&nbsp;María Alejandra Stornelli","doi":"10.1016/j.tcam.2024.100907","DOIUrl":"10.1016/j.tcam.2024.100907","url":null,"abstract":"<div><p>There is scarce information about the effect of sperm morphology and seminal plasma composition on cat semen freezability. Thus, this study aims to assess the effect of cat sperm morphology and seminal plasma cholesterol (CHOL) and triacylglyceride (TAG) concentrations on sperm post-thaw survival. Ejaculates (n = 49) were evaluated, and seminal plasma was separated and frozen until CHOL and TAG concentrations were measured. The sperm pellet was diluted in a tris-based egg yolk extender, frozen (n = 38), or processed for sperm ultrastructure study (n = 11). Abnormalities recorded were abnormal head shape and size, detached heads, knobbed or ruffled acrosomes, eccentric mid-piece insertion, proximal and distal cytoplasmic droplets, folded and coiled tails, and Dag defect. Ultramicroscopic evaluation detected several sperm abnormalities in fresh semen and some sperm damage in frozen semen. Seminal plasma lipids components were positively correlated with post-thaw motility and acrosome integrity. Higher freezability indices for motility and acrosome integrity were observed in frozen-thawed semen with high seminal plasma CHOL and TAG concentrations. No freezability differences were observed between teratozoospermic and normozoospermic ejaculates. Our results showed that even when seminal plasma was removed before cryopreservation, sperm survival after thawing was significantly higher in samples with high seminal plasma CHOL and TAG concentrations, indicating a rapid adherence to these compounds to the sperm plasma membrane, protecting sperm cells from temperature changes. Nevertheless, there were no differences in sperm freezability by sperm morphology.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"62 ","pages":"Article 100907"},"PeriodicalIF":1.3,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of two haemostasis techniques on procedural duration, postoperative pain and gastrointestinal function in pet rabbits undergoing ovariohysterectomy 比较两种止血技术对接受卵巢切除术的宠物兔的手术时间、术后疼痛和胃肠功能的影响。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-08-08 DOI: 10.1016/j.tcam.2024.100906
Dario d'Ovidio , Chiara Adami
{"title":"Comparison of two haemostasis techniques on procedural duration, postoperative pain and gastrointestinal function in pet rabbits undergoing ovariohysterectomy","authors":"Dario d'Ovidio ,&nbsp;Chiara Adami","doi":"10.1016/j.tcam.2024.100906","DOIUrl":"10.1016/j.tcam.2024.100906","url":null,"abstract":"<div><p>Ovariohysterectomy is a common surgical procedure in pet rabbits and one of its potential complications is postoperative gastrointestinal stasis, possibly exacerbated by prolonged surgery time. The objective of this prospective clinical study was to compare two techniques for surgical haemostasis with respect to procedural duration, postoperative pain, and return of gastrointestinal function, in 22 female rabbits undergoing ovariohysterectomy. Rabbits were assigned to one of two groups: conventional vessel ligation (CVL) and haemostasis with a vessel sealing device (VSD). The outcome variables for comparison between the two groups, recorded at 60-, 120-, 180-, and 360-minutes post anaesthesia, were duration of anaesthesia and surgery, postoperative Rabbit Grimace Scale scores, and measured food intake and faecal output. The vessel sealing device caused no appreciable blood loss. The duration of both surgery and anaesthesia was shorter in group VSD (20 ± 4 and 31 ± 6 minutes, respectively) than in group CVL (43 ± 9 and 54 ± 9 minutes, respectively) (p &lt; 0.001). There were no differences between groups in time elapsed from the end of anaesthesia to both first food intake and first defecation. In both groups, the score of the Rabbit Grimace Scale decreased over time with statistically significant differences between 60 minutes and all the subsequent time points (p &lt; 0.001). Vessel sealing devices may be recommended over conventional haemostasis for rabbit ovariohysterectomy to decrease the duration of surgery and anaesthesia, with potential beneficial effects on sustainability and practice workflow.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"62 ","pages":"Article 100906"},"PeriodicalIF":1.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1938973624000618/pdfft?md5=4be62bc709fec3f6d85a1ad30f3693fc&pid=1-s2.0-S1938973624000618-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of forelimb osteochondroma in a ferret (Mustela putorius furo) 成功治疗雪貂(Mustela putorius furo)前肢骨软骨瘤。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-08-08 DOI: 10.1016/j.tcam.2024.100904
Alyssa Ungemach , Nicholas Dannemiller , Brittany Rasche , Esther Farber , Chris Griffin , Sarah Ozawa
{"title":"Successful treatment of forelimb osteochondroma in a ferret (Mustela putorius furo)","authors":"Alyssa Ungemach ,&nbsp;Nicholas Dannemiller ,&nbsp;Brittany Rasche ,&nbsp;Esther Farber ,&nbsp;Chris Griffin ,&nbsp;Sarah Ozawa","doi":"10.1016/j.tcam.2024.100904","DOIUrl":"10.1016/j.tcam.2024.100904","url":null,"abstract":"<div><p>A 1-year-old male neutered ferret <em>(Mustela putorius furo)</em> was evaluated for an abnormal left cubital joint. Radiographs demonstrated a proliferative osseous lesion of the left proximal antebrachium. Computed tomography confirmed a large thin-walled expansile osseous lesion of the left proximal radius and identified multifocal proliferative lesions of the axial spine, two of which caused spinal cord compression. A left forelimb amputation with total scapulectomy was performed. Histopathology revealed a well-demarcated mass with a thin rim of mature lamellar bone and a discontinuous cartilage cap covered by a perichondrial/periosteal membrane continuous with the adjacent bone. Findings were most consistent with an osteochondroma or osteochondromatosis (i.e., multiple cartilaginous exostoses, hereditary multiple exostoses). No evidence of malignant transformation was observed within this specimen. Three months post-surgery, verbal correspondence with the owner confirmed return to normal activity level and no emergence of neurological signs. Repeat examination and imaging were recommended.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"62 ","pages":"Article 100904"},"PeriodicalIF":1.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stifle arthrodesis in dogs using semi-circular saw: Cadaveric study 使用半圆锯在狗身上进行跗关节固定术:尸体研究。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-08-08 DOI: 10.1016/j.tcam.2024.100905
Rafael Kretzer Carneiro , Mariana Matos Brose , Mariana de Jesus de Souza , Thayse Meyer , Francine Hergemoller , Augusto Amadori , Amanda Junqueira , Renato Otaviando do Rego , Márcio Poletto Ferreira
{"title":"Stifle arthrodesis in dogs using semi-circular saw: Cadaveric study","authors":"Rafael Kretzer Carneiro ,&nbsp;Mariana Matos Brose ,&nbsp;Mariana de Jesus de Souza ,&nbsp;Thayse Meyer ,&nbsp;Francine Hergemoller ,&nbsp;Augusto Amadori ,&nbsp;Amanda Junqueira ,&nbsp;Renato Otaviando do Rego ,&nbsp;Márcio Poletto Ferreira","doi":"10.1016/j.tcam.2024.100905","DOIUrl":"10.1016/j.tcam.2024.100905","url":null,"abstract":"<div><p>The aim of this study was to develop a novel surgical technique for stifle arthrodesis in dogs using a semicircular saw for tibial and femoral ostectomies through a medial approach. Ten pelvic limbs from five canine cadavers underwent stifle arthrodesis. Prior to the surgical procedure, the limbs were radiographed to rule out musculoskeletal abnormalities. Additionally, the radiographs were used for surgical planning. For the tibial ostectomy, the center of the intercondylar eminences, the cranial limit of the tibial plateau, and the caudal cortex of the tibia were used as landmarks. In the femur, the groove of the insertion of the long digital extensor tendon and the caudal portion of the femoral cortex served as references. The most significant iatrogenic injury during the surgical procedures was the complete rupture of the long digital extensor tendon during the tibial cut in one of the stifles. Dome ostectomies facilitated interfragmentary contact, allowing for adjustment of the angulation between the fragments without the need for additional ostectomies or osteotomies. The medial approach provided a clear view of intra-articular structures without causing extensive damage to surrounding tissues. After the procedures, the limbs were radiographed to calculate angular measurements, and the final angulation (mean) of the knee joints was 134.7 ± 11°.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"62 ","pages":"Article 100905"},"PeriodicalIF":1.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycoplasma spp. pneumonia and subsequent pulmonary hypertension in a domestic ferret (Mustela putorius furo) 家养雪貂(Mustela putorius furo)的支原体肺炎和随后的肺动脉高压。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcam.2024.100891
{"title":"Mycoplasma spp. pneumonia and subsequent pulmonary hypertension in a domestic ferret (Mustela putorius furo)","authors":"","doi":"10.1016/j.tcam.2024.100891","DOIUrl":"10.1016/j.tcam.2024.100891","url":null,"abstract":"<div><p>Treatment of <em>Mycoplasma</em> spp. pneumonia has rarely been described in domestic ferrets (<em>Mustela putorius furo</em>). A 10-month-old, 0.53 kg, female spayed domestic ferret was presented for oxygen-dependent, chronic dyspnea of one-month's duration. Physical examination findings included dyspnea, tachypnea, increased bronchovesicular sounds bilaterally, and an intermittent non-productive cough. Bloodwork abnormalities included a mild leukocytosis (8.6×10<sup>3</sup>/µL), mild neutrophilia (4.0×10<sup>3</sup>/µL), mild hypoalbuminemia (2.7 g/dL), mild hyperglobulinemia (3.3 g/dL), mild hyponatremia (147 mEq/L), and mild hypochloremia (111.4 mEq/L). Radiographs revealed a marked diffuse bronchial pattern with peribronchial cuffing, a mild main pulmonary artery bulge, distended caudal lobar pulmonary arteries, and decreased serosal detail within the abdomen. An echocardiogram revealed indications of moderate pulmonary hypertension and systolic anterior motion of the mitral valve. Polymerase chain reaction testing for <em>Mycoplasma</em> spp. was positive, and treatment was initiated with doxycycline (10 mg/kg PO q 12 h for 16 weeks), prednisolone (0.4 mg/kg PO q 12 h for 13 weeks, tapered to 0.2 mg/kg PO q 12 h for two weeks, then eventually increased to 0.7 mg/kg PO q 12 h until further notice), sildenafil (0.3 mg/kg PO q 24 h for 13 weeks), and oxygen supplementation via an oxygen cage for six weeks. On repeat echocardiogram eleven weeks after initiation of doxycycline therapy, the pulmonary hypertension had resolved. At follow up six months later, the ferret was stable on previously prescribed medications and did not require oxygen supplementation. <em>Mycoplasma</em> spp. and pulmonary hypertension should be considered in cases of respiratory distress in ferrets.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"61 ","pages":"Article 100891"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical management of squamous cell carcinoma of the canine male external genitalia: 15 cases (1994-2020) 犬科雄性外生殖器鳞状细胞癌的手术治疗:15 例(1994-2020 年)。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcam.2024.100887
Pavlos Natsios , Kyriakos Chatzimisios , Vassiliki Tsioli , Dimitra Psalla , Vasileia Angelou , Ioannis Savvas , Lysimachos G Papazoglou
{"title":"Surgical management of squamous cell carcinoma of the canine male external genitalia: 15 cases (1994-2020)","authors":"Pavlos Natsios ,&nbsp;Kyriakos Chatzimisios ,&nbsp;Vassiliki Tsioli ,&nbsp;Dimitra Psalla ,&nbsp;Vasileia Angelou ,&nbsp;Ioannis Savvas ,&nbsp;Lysimachos G Papazoglou","doi":"10.1016/j.tcam.2024.100887","DOIUrl":"10.1016/j.tcam.2024.100887","url":null,"abstract":"<div><p>Fifteen male dogs with squamous cell carcinoma of the external genitalia were admitted for further investigation and surgical management between 1994 and 2020. The dogs belonged to various breeds. Thirteen dogs were intact and two were castrated with a median age of 8 years and a median weight of 28 kg. Seven dogs were white-coated and eight nonwhite coated. Scrotal ablation and orchiectomy were performed in four dogs, partial penile amputation in two, partial penile amputation plus partial preputial ablation in one, penile amputation, and scrotal urethrostomy in seven, and local preputial excision in one dog. Postoperative complications included hemorrhage in 10 dogs, bruising at the urethrostomy site in seven, and urethrostomy dehiscence in one dog. Tumor recurrence was recorded in six dogs. Dogs with poorly differentiated tumors that had tumor recurrence had shorter survival and worse prognosis compared to those with well and moderately differentiated tumors. The mean survival time was 48.132 months. After a median follow-up of 23 months (range: 8 to 72 months), eight dogs were alive, five were euthanized and two dogs died from unrelated causes. Surgical excision seems to be a treatment option for dogs with squamous cell carcinoma of the external genitalia.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"61 ","pages":"Article 100887"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhabdomyosarcoma in a Rabbit 兔子身上的横纹肌肉瘤
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcam.2024.100892
Logan Kopp , Michael Garner , Kara Priest
{"title":"Rhabdomyosarcoma in a Rabbit","authors":"Logan Kopp ,&nbsp;Michael Garner ,&nbsp;Kara Priest","doi":"10.1016/j.tcam.2024.100892","DOIUrl":"10.1016/j.tcam.2024.100892","url":null,"abstract":"<div><p>A geriatric Holland Lop rabbit presented for acute lameness. A pathologic fracture of the right distal femur associated with a pleomorphic rhabdomyosarcoma was diagnosed, and staging radiographs showed no overt metastasis upon initial presentation. The limb was amputated and submitted for microscopic examination. Immunohistochemical evaluation revealed the neoplastic cells were positive for desmin and MyoD1, and negative for cytokeratin AE1/AE3, CD204, IBA-1, and SMA. Gross, histologic, and immunohistochemical evaluation confirmed a diagnosis of pleomorphic rhabdomyosarcoma. The patient died 396 days after amputation, and a post-mortem examination showed metastatic sarcoma to multiple organs.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"61 ","pages":"Article 100892"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A retrospective study of Monteggia fractures in 8 dogs and 1 cat 对 8 条狗和 1 只猫的蒙氏骨折进行回顾性研究。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcam.2024.100889
A Anatolitou , AA Krystalli , KI Sideri , M Markou , G Kazakos , NN Prassinos
{"title":"A retrospective study of Monteggia fractures in 8 dogs and 1 cat","authors":"A Anatolitou ,&nbsp;AA Krystalli ,&nbsp;KI Sideri ,&nbsp;M Markou ,&nbsp;G Kazakos ,&nbsp;NN Prassinos","doi":"10.1016/j.tcam.2024.100889","DOIUrl":"10.1016/j.tcam.2024.100889","url":null,"abstract":"<div><p>Monteggia fractures (MFs) are proximal ulnar fractures with concurrent dislocation of the radial head. This retrospective study aims to report the clinical findings and discuss the treatments and outcomes in MFs cases of 9 cases. Previous medical records of the animals were reviewed for history, clinical features, radiographic findings and choice of treatment. Treatment follow-up was evaluated over the telephone by discussion with the owners. Six animals included in the study were presented 2 days after the initial trauma. Five dogs were presented after common road traffic accidents and two after unknown traumas. All dogs had type I MFs, while the cat had a type III MF. Radiographical findings showed that six animals had extra-articular ulnar fractures, while three animals had intra-articular ulnar fractures. All animals were treated with open reduction of the ulna and internal fixation surgical methods. Six ulnar fractures were stabilized with intramedullary pin(s) with cerclage wire. The clinical outcome was assessed by the owners as full function in 3 dogs, acceptable function in 2 dogs and unacceptable function in 2 dogs with intraarticular ulnar fractures. The cat case was rated as full function. One dog died from a pulmonary fat embolism. The findings presented here provide some support that cerclage wire placement could be a satisfactory method for annular ligament reconstruction as a simple and economical treatment option. Also, to the authors' knowledge, this is the third report of MFs with intraarticular ulnar fractures. In this series, comminuted, intraarticular fractures were related to major postoperative complications.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"61 ","pages":"Article 100889"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of subcutaneous maropitant at two dosages for pain management in domestic rabbits (Oryctolagus cuniculus) undergoing elective ovariohysterectomy or orchiectomy 在接受选择性卵巢切除术或睾丸切除术的家兔(Oryctolagus cuniculus)中使用两种剂量的皮下马洛比坦来止痛。
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcam.2024.100888
Maya Grayck , Michelle N. Sullivan , Pedro Boscan , Megan Gish , Laila Proença , William Guerrera , Sangeeta Rao , Miranda J. Sadar
{"title":"Use of subcutaneous maropitant at two dosages for pain management in domestic rabbits (Oryctolagus cuniculus) undergoing elective ovariohysterectomy or orchiectomy","authors":"Maya Grayck ,&nbsp;Michelle N. Sullivan ,&nbsp;Pedro Boscan ,&nbsp;Megan Gish ,&nbsp;Laila Proença ,&nbsp;William Guerrera ,&nbsp;Sangeeta Rao ,&nbsp;Miranda J. Sadar","doi":"10.1016/j.tcam.2024.100888","DOIUrl":"10.1016/j.tcam.2024.100888","url":null,"abstract":"<div><h3>Objective</h3><p>To describe the effect of two doses of maropitant on pain scores, food intake, and fecal output in domestic rabbits (<em>Oryctolagus cuniculus</em>) undergoing elective ovariohysterectomy or orchiectomy.</p></div><div><h3>Animals</h3><p>26 (11 female, 15 male) rabbits from three institutions.</p></div><div><h3>Procedures</h3><p>Rabbits were randomly assigned to one of three treatment groups: low-dose maropitant (LDM; 2 mg/kg SC once; n=8), moderate-dose maropitant (MDM; 4 mg/kg SC once; n=10), and control (saline equivalent to 4 mg/kg maropitant SC once; n=8), administered prior to surgery. Following surgery, all rabbits were provided buprenorphine (0.06 mg/kg q 8 hours) and meloxicam (1 mg/kg q 24 hours) intramuscularly. Rabbits were monitored using video surveillance postoperatively until 24 hours after surgery or discharge from the hospital, whichever came first. Pain scores were assessed by three blinded observers, and results were grouped into early (0-4 hours), mid (5-8 hours), and late (12-24 hours) time frames. Food intake and fecal output were compared between groups. Statistical analysis was performed using Chi square, Fisher's exact tests, and a mixed model approach.</p></div><div><h3>Results</h3><p>There were no adverse effects with maropitant administration. Rabbits that received MDM had significantly lower pain scores in the mid-time frame and behavior scores in the late-time frame compared to controls. Male rabbits consumed more food than females and rabbits hospitalized longer than 12 hours consumed more food than those that were discharged prior. No significant differences were detected in facial grimace scale scores, food intake, or fecal production among treatment groups.</p></div><div><h3>Conclusions and clinical relevance</h3><p>Moderate dose maropitant decreased pain related behaviors in the mid-time frame and behavior scores in the late-time frame after surgery. Further studies are necessary to better characterize the potential use of maropitant in postoperative analgesia.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"61 ","pages":"Article 100888"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios be used as markers for hypercortisolism in dogs? 中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率可用作狗皮质醇过多症的标记吗?
IF 1.3 3区 农林科学
Topics in companion animal medicine Pub Date : 2024-07-01 DOI: 10.1016/j.tcam.2024.100890
Sumin Yun , Taesik Yun , Sijin Cha , Jimin Oh , Dohee Lee , Yoonhoi Koo , Yeon Chae , Mhan-Pyo Yang , Byeong-Teck Kang , Hakhyun Kim
{"title":"Can neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios be used as markers for hypercortisolism in dogs?","authors":"Sumin Yun ,&nbsp;Taesik Yun ,&nbsp;Sijin Cha ,&nbsp;Jimin Oh ,&nbsp;Dohee Lee ,&nbsp;Yoonhoi Koo ,&nbsp;Yeon Chae ,&nbsp;Mhan-Pyo Yang ,&nbsp;Byeong-Teck Kang ,&nbsp;Hakhyun Kim","doi":"10.1016/j.tcam.2024.100890","DOIUrl":"10.1016/j.tcam.2024.100890","url":null,"abstract":"<div><p>Changes in neutrophil-to-lymphocite ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified in dogs with hypercortisolism (HC), but, no studies have investigated the changes in these inflammatory biomarkers as cost-effective and available parameters for the diagnosis and management of HC. This study was performed to evaluate whether NLR and PLR could be used as biomarkers for the diagnosis and treatment response in dogs with HC. This retrospective study included 67 dogs with HC, 58 dogs with non-adrenal illness (NAI), and 39 healthy dogs. NLR and PLR were compared among the three groups. Cut-off values of NLR and PLR for HC screening and percent change in biomarkers for assessing treatment response were evaluated. In addition, the NLR and PLR were compared before and after trilostane treatment. NLR and PLR were significantly higher in the HC group than in the NAI and healthy groups. The NLR cut-off value of 4.227 had a sensitivity of 67.16% and specificity of 65.52%, and the PLR cut-off value of 285.0 had a sensitivity of 56.72% and specificity of 70.69% for differentiating between dogs with HC and those with NAI, respectively. Furthermore, a significant decline in NLR was observed after treatment in the well-controlled HC group. The cutoff value of percent change in NLR to identify well-controlled HC was -7.570%; sensitivity and specificity were 100% and 63.64%, respectively. Therefore, NLR and PLR might be used cautiously as supportive biomarkers for HC diagnosis, and NLR could be a potential monitoring tool in assessing the treatment response of HC in dogs.</p></div>","PeriodicalId":23144,"journal":{"name":"Topics in companion animal medicine","volume":"61 ","pages":"Article 100890"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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