Journal of Multiscale Neuroscience最新文献

Search for potential Alzheimer’s disease therapeutics: Identification of inhibitors of amyloid oligomerization with high affinity for the zinc-binding site 寻找潜在的阿尔茨海默病治疗药物：鉴定对锌结合部位具有高亲和力的淀粉样蛋白寡聚化抑制剂

Journal of Multiscale Neuroscience Pub Date : 2024-08-11 DOI: 10.56280/1641424663

Elizaveta Lugovskaya, Giulia Codagnone, Ivan Sanavia, Silvia Rey, Vanessa Terranova, Marcello Miceli, M. Deriu, J. A. Tuszynski

引用次数: 0

Relationship between serum metabolic indexes and immune function in patients with insomnia and their mechanism 失眠患者血清代谢指标与免疫功能的关系及其机制

Journal of Multiscale Neuroscience Pub Date : 2024-08-11 DOI: 10.56280/1641482999

Zhang Sumei, Xiuhong Zhang, Xiaoli Wang, Xinxin Hao, Jiangyan Bai, Liqiao Zhao

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Relationship between serum metabolic indexes and immune function in patients with insomnia and their mechanism 失眠患者血清代谢指标与免疫功能的关系及其机制

Journal of Multiscale Neuroscience Pub Date : 2024-08-11 DOI: 10.56280/1641482999

Zhang Sumei, Xiuhong Zhang, Xiaoli Wang, Xinxin Hao, Jiangyan Bai, Liqiao Zhao

引用次数: 0

Search for potential Alzheimer’s disease therapeutics: Identification of inhibitors of amyloid oligomerization with high affinity for the zinc-binding site 寻找潜在的阿尔茨海默病治疗药物：鉴定对锌结合部位具有高亲和力的淀粉样蛋白寡聚化抑制剂

Journal of Multiscale Neuroscience Pub Date : 2024-08-11 DOI: 10.56280/1641424663

Elizaveta Lugovskaya, Giulia Codagnone, Ivan Sanavia, Silvia Rey, Vanessa Terranova, Marcello Miceli, M. Deriu, J. A. Tuszynski

引用次数: 0

Neurobehavioral perspectives on autistic spectrum disorder 从神经行为学角度看自闭症谱系障碍

Journal of Multiscale Neuroscience Pub Date : 2024-05-18 DOI: 10.56280/1628860368

Lleuvelyn A. Cacha

{"title":"Neurobehavioral perspectives on autistic spectrum disorder","authors":"Lleuvelyn A. Cacha","doi":"10.56280/1628860368","DOIUrl":"https://doi.org/10.56280/1628860368","url":null,"abstract":"Understanding genetics and environmental influences in autism has been explored in greater depth in recent decades. However, the mechanism by which they converge that leads to autism still needs to be explored further. An autism diagnosis in DSM-5 results from a neurodevelopmental disorder hurting normal brain function, affecting communication and social interaction combined with restricted or repetitive patterns of behavior and interests. This paper reviews current work investigating how the underlying mechanism of the brain structure and function relates to the complex and aberrant behavioral manifestations of autism. Mapping this connection can provide us with a better understanding of autism signs and symptoms, making the process of accurate diagnosis more straightforward. As a complex neurobehavioral condition, autistic individuals process the environment and their interactions with others differently from those without autism. So, they make different perceptions and connections between themselves and the environment. Consequently, they will have difficulty communicating, forming relationships, and responding appropriately to their environment. It is this lifelong neurobehavioral dysfunction that prevents autistic individuals from adequately understanding what they perceive and the emotional expression of others. There will be differences in their mental states, how their brains work, and how their thinking processes will be affected by a neurodevelopmental disability.","PeriodicalId":230864,"journal":{"name":"Journal of Multiscale Neuroscience","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consideration of intracranial venous thrombosis in cerebrovascular disease: a case study emphasizing diagnosis and treatment awareness 考虑脑血管疾病中的颅内静脉血栓形成：强调诊断和治疗意识的案例研究

Journal of Multiscale Neuroscience Pub Date : 2024-01-12 DOI: 10.56280/1605693152

S. S. Zhang, F. Jia, X. Wang, X. Chen

引用次数: 0

Molecular basis of dementia 痴呆症的分子基础

Journal of Multiscale Neuroscience Pub Date : 2024-01-10 DOI: 10.56280/1605703412

O. Szymanowicz, S. Pawlak, E. Potocka, U. Goutor, W. Kozubski, J. Dorszewska

{"title":"Molecular basis of dementia","authors":"O. Szymanowicz, S. Pawlak, E. Potocka, U. Goutor, W. Kozubski, J. Dorszewska","doi":"10.56280/1605703412","DOIUrl":"https://doi.org/10.56280/1605703412","url":null,"abstract":"Dementia is a set of symptoms characterized by deterioration of memory and cognitive functions. Dementia diseases include Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, and mixed dementia. This disease represents an escalating social issue, particularly in a society with an increasing elderly population. In 2019, 271,998 people succumbed to dementia, making Alzheimer's disease the sixth most prevalent cause of death. The pathophysiology of Alzheimer's disease is complex and not fully understood. It is a multifaceted disease, with its pathogenesis influenced by a combination of genetic, environmental, and lifestyle factors. One of the genes involved in the pathogenesis of the disease is the apolipoprotein E (APOE) gene, which is one of the most common risk factors for Alzheimer's disease. The significance of other genes, including presenilin genes (PSEN1 and PSEN2), the TREM2 gene, the MAPT gene, and the APP gene, linked to various forms of dementia, is also emphasized. Another issue is the growing number of identified genetic variants within genes implicated in the onset of dementia. Dementia diseases are also characterized by chemical alterations in the brain, including the accumulation of abnormal excitotoxic proteins, varying degrees of inflammation, and metabolic disorders. This review summarizes current research in the field of dementia and highlights the significance of molecular factors in its pathogenesis. Gaining insight into the pathogenic mechanisms of dementia may allow for faster diagnosis of the disease and facilitate the creation of more efficient patient care plans.","PeriodicalId":230864,"journal":{"name":"Journal of Multiscale Neuroscience","volume":"51 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive paradoxes and brain mechanisms 认知悖论与大脑机制

Journal of Multiscale Neuroscience Pub Date : 2024-01-08 DOI: 10.56280/1605522719

E. Brändas

{"title":"Cognitive paradoxes and brain mechanisms","authors":"E. Brändas","doi":"10.56280/1605522719","DOIUrl":"https://doi.org/10.56280/1605522719","url":null,"abstract":"It is generally agreed amongst philosophers and neuroscientists that the main obstacle between the science of the brain and the conscious nature of the mind is rooted in an objective-subjective dichotomy. It is further common to classify natural sciences in terms of their epistemological values and their ontological existential attributes. As a result, one concludes that a computer that is useful for studying nature, such as the conscious mind, is not itself part of nature, or as phrased differently by the noted philosopher, John Searle, ‘there are no Turing Machines in nature! However, the great physicist John Archibald Wheeler, by declaring the famous dictum, ‘it from bit’, did impart a somewhat different approach to the true nature of reality. To reconcile the two contrasting portraits, a different picture, based on the principle of self-reference, will be presented, and applied to the brain-mind problem. It is demonstrated how this principle imparts a thermo-qubit syntax, i.e., ‘bit from it’, for communication between increasingly more complex physical systems. Altogether, the steady state situation produces negentropic pockets for quantification and storage of information. The communication protocol entails cognition mechanisms that display unexpected equivalences that prompts fundamental interpretations of general optical illusions such as Necker’s cube, the Rubin vase, and the Spinning Dancer. The derived syntax also embodies an interesting deconstruction of the recently observed dodecanogram brain signal, experimentally elucidated by Anirban Bandyopadhyay and his team.","PeriodicalId":230864,"journal":{"name":"Journal of Multiscale Neuroscience","volume":"52 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putnam and Dennett on instrumentalism and the intentional 普特南和丹尼特论工具论与意向性

Journal of Multiscale Neuroscience Pub Date : 2023-12-18 DOI: 10.56280/1602242654

H.G. H.G. Callaway

{"title":"Putnam and Dennett on instrumentalism and the intentional","authors":"H.G. H.G. Callaway","doi":"10.56280/1602242654","DOIUrl":"https://doi.org/10.56280/1602242654","url":null,"abstract":"This paper examines Dennett’s conceptions of intentionality and consciousness—focused on his concept of the intentional stance (Dennett, 1987,1991b). It chiefly proceeds from a series of critical remarks due to Putnam (Putnam, 1999). Dennett has written extensively on the philosophy of mind; his work includes many scholarly and scientific contributions. He has attracted much attention to the philosophy of mind, cognitive psychology, and computer science; and he is an important critic of alternative views and theorists in related fields. The present paper draws on critical departures from Quine’s physicalism in publications of Putnam and Davidson (Davidson, 1963,1997); and it examines criticism brought against Dennett’s work on grounds of forms of instrumentalism and antirealism in the intentional stance. Evaluating Dennett’s posi¬tions and Putnam’s critical perspectives turn largely on understanding the relation of Dennett on intentionality, consciousness and the mental to formative and controversial theses of his acknowledged mentor, Quine (Quine, 1960). It will be argued that Dennett’s version of functionalism is best understood as a sophisticated physicalism, antirealism, and quasi-behaviorism in cognitive science.","PeriodicalId":230864,"journal":{"name":"Journal of Multiscale Neuroscience","volume":"141 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139175418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Approximate analytical solution of a (V,m,h) reduced system for backpropagating action potentials in sparsely excitable dendrites 稀疏可激发树突中反向传播动作电位的(V,m,h)约简系统的近似解析解

Journal of Multiscale Neuroscience Pub Date : 2023-07-25 DOI: 10.56280/1583164092

Nicolangelo Iannella, R. Poznanski

{"title":"Approximate analytical solution of a (V,m,h) reduced system for backpropagating action potentials in sparsely excitable dendrites","authors":"Nicolangelo Iannella, R. Poznanski","doi":"10.56280/1583164092","DOIUrl":"https://doi.org/10.56280/1583164092","url":null,"abstract":"We derive an approximate analytical solution of a nonlinear cable equation describing the backpropagation of action potentials in sparsely excitable dendrites with clusters of transiently activating, TTX-sensitive Na+ channels of low density, discretely distributed as point sources of transmembrane current along a continuous (non-segmented) passive cable structure. Each cluster or hot-spot, corresponding to a mesoscopic level description of Na+ ion channels, included known cumulative inactivation kinetics observed at the microscopic level. In such a reduced third-order system, the ‘recovery’ variable is an electrogenic sodium-pump and/or a Na+-Ca2+ exchanger imbedded in the passive membrane, and a high leakage conductance stabilizes the system. A nonlinear cable equation was used to investigate back-propagation and repetitive activity of action potentials, exhibiting characteristics of the modified Hodgkin-Huxley kinetics (in the presence of suprathreshold input). In particular, a time-dependent analytical solution was obtained through a perturbation expansion of the non-dimensional membrane potential (Φ) for all voltage dependent terms including the voltage dependent Na+ activation μ) and state-dependent inactivation (η) gating variables and then solving the resulting system of integral equations. It was shown that back-propagating action potentials attenuate in amplitude with the frequency following experimental findings and that the discrete and low-density distributions of transient Na+ channels along the cable structure contribute significantly to their discharge patterns. A major significance of integrative modelling is the provision of a continuous description of the non-dimensional membrane potential (Φ) as a function of position.","PeriodicalId":230864,"journal":{"name":"Journal of Multiscale Neuroscience","volume":"506 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115336999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0