Thrombosis research最新文献

{"title":"Comparison of rivaroxaban with warfarin for intracardiac thrombosis in the pediatric population at different cardiac sites: Early experience of anticoagulation approach and treatment outcomes","authors":"Deborah Cappelletti ,&nbsp;Francesco Bianco ,&nbsp;Valentina Bucciarelli ,&nbsp;Elena Raffaelli ,&nbsp;Linda Bordignon ,&nbsp;Gianluca Di Cesare ,&nbsp;Benedetta Bucciarelli ,&nbsp;Alessandro Bacchiocchi ,&nbsp;Camilla Manini ,&nbsp;Ettore Merlino ,&nbsp;Sergio Filippelli ,&nbsp;Maria Elena Lionetti","doi":"10.1016/j.thromres.2025.109397","DOIUrl":"10.1016/j.thromres.2025.109397","url":null,"abstract":"<div><h3>Aims</h3><div>To compare the rivaroxaban treatment with warfarin for intracardiac thrombi resolution in pediatric patients diagnosed with intracardiac thrombosis (ICT).</div></div><div><h3>Methods</h3><div>In 2020–24, we enrolled 18 [0.7 (0.3–12, Q1-Q3) years-old, 67 % males] consecutive ICT pediatric patients (&lt; 16 years old) treated in 2020–22 with warfarin (<em>n</em> = 9, 0.1 mg/Kg/day) and in 2023–24 with rivaroxaban (n = 9, dosage based on patient's body weight). ICT was suspected by echocardiography and confirmed with cardiac computed tomography (CCT) or magnetic resonance (CMR) imaging. All the participants were treated with enoxaparin for 7 days before the rivaroxaban implementation. CCT/CMR was repeated to confirm ICT resolution. <em>N</em> = 9/18 (50 %) patients presented with right atrial thrombosis, <em>n</em> = 5/18 (28 %) and <em>n</em> = 3/18 (17 %) with right/left ventricular thrombi, respectively, and <em>n</em> = 1/18 (5 %) with left atrial appendage thrombus.</div></div><div><h3>Results</h3><div>Compared with warfarin, treatment with rivaroxaban had a shorter duration (Log-rank <em>P</em> = 0.020); warfarin vs. rivaroxaban: 9.67 ± 3.6 vs. 6.6 ± 2.2 weeks (<em>P</em> = 0.0040). After rivaroxaban, all the thromboses were resolved and confirmed at the CCT/CMR imaging; no major bleeding event was documented during the treatment based on the BASIC bleeding assessment scale. Only minor bleedings were documented. In details: warfarin experienced <em>n</em> = 6/9 (67 %) gastrointestinal bleedings and <em>n</em> = 2/9 macroscopic hematuria, while 3 gingival bleedings were documented in the rivaroxaban group. After a follow-up period of 6 months, no recurrences were detected/suspected at the echocardiography evaluation.</div></div><div><h3>Conclusions</h3><div>Among pediatric patients with ICT, irrespective of the thrombosis site, rivaroxaban seemed effective in thrombus resolution.</div></div><div><h3>ClinicalTrials.gov ID</h3><div><span><span>NCT06371170</span><svg><path></path></svg></span></div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"253 ","pages":"Article 109397"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel Computable phENotype To Identify Pulmonary Embolism in chilDrEn: The CENTIPEDE Study","authors":"Hilary Whitworth ,&nbsp;Kristina Wagner ,&nbsp;Allison Zelinski ,&nbsp;Elana DiCocco ,&nbsp;Amy J. Goodwin Davies ,&nbsp;Rochelle Jordan ,&nbsp;Miranda Higginbotham ,&nbsp;Michael L. O'Byrne ,&nbsp;L. Charles Bailey ,&nbsp;Leslie Raffini ,&nbsp;Madhvi Rajpurkar","doi":"10.1016/j.thromres.2025.109385","DOIUrl":"10.1016/j.thromres.2025.109385","url":null,"abstract":"<div><h3>Background</h3><div>Pediatric pulmonary embolism (PE) is rare and requires multicenter research to generate meaningful results and improve care. PEDSnet is a multicenter learning health system including 10 pediatric institutions and a valuable tool to study rare diseases.</div></div><div><h3>Objectives</h3><div>We aimed to develop a computable phenotype (CP) to accurately identify pediatric PE in PEDSnet.</div></div><div><h3>Methods</h3><div>We developed an algorithm for identification of pediatric PE in Children's Hospital of Philadelphia data within PEDSnet and compared it to blinded chart review. We identified a cohort of patients from 1/1/2012–12/31/2022 who were predicted to have PE based on the CP and an equal number predicted to not have a PE. Manual chart review identified true positive and negative and false positive and negative PE. Subsequent adjustments were made to improve CP performance. In patients with a confirmed PE, we identified select outcomes in PEDSnet and compared them to chart review to evaluate the ability to assess outcomes in PEDSnet.</div></div><div><h3>Results</h3><div>There were 152 PE patients identified by the best performing CP which included: 1) Anticoagulant prescribed, dispensed, or administered in an inpatient or emergency department encounter, 2) SNOMED-CT code for PE, 3) Chest CT or perfusion study in the encounter. CP performance characteristics were as follows: sensitivity 96 %, specificity 88 %, positive predictive value 90 %, and negative predictive value 95 %. Preliminary outcome validation highlighted areas for improvement in identifying transfusions and thrombolysis.</div></div><div><h3>Conclusions</h3><div>We report the first pediatric PE CP. Future research will include multicenter CP validation and improved identification of interventions and outcomes.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"253 ","pages":"Article 109385"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent thrombosis in patients with mechanical prosthetic valves: 3-year follow-up of a randomized controlled trial","authors":"Yeganeh Pasebani ,&nbsp;Zahra Haghighi Fashi ,&nbsp;Arezo Hafezi Birgani ,&nbsp;Kasra Mehdizadeh ,&nbsp;Mozhgan Parsaee ,&nbsp;Melody Farrashi ,&nbsp;Ali Rafati ,&nbsp;Somayyeh Barati ,&nbsp;Erfan Kohansal ,&nbsp;Sedigheh Saedi ,&nbsp;Nasim Naderi ,&nbsp;Majid Maleki ,&nbsp;Zahra Khajali ,&nbsp;Raffaele De Caterina ,&nbsp;Parham Sadeghipour","doi":"10.1016/j.thromres.2025.109396","DOIUrl":"10.1016/j.thromres.2025.109396","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"253 ","pages":"Article 109396"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subject: Acknowledgement of letter regarding \"Leukadherin-1 mitigates disseminated intravascular coagulation in acute pancreatitis by suppressing necroptosis\".","authors":"Zhongjie Yi, Xueming Xu, Xingyu Xiang, Jinyuan Chang, Jie Shi, Yongjun Wang","doi":"10.1016/j.thromres.2025.109388","DOIUrl":"https://doi.org/10.1016/j.thromres.2025.109388","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":" ","pages":"109388"},"PeriodicalIF":3.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Leukadherin-1 mitigates disseminated intravascular coagulation in acute pancreatitis by suppressing necroptosis\".","authors":"Saraswati Sah, Rachana Mehta, Ranjana Sah","doi":"10.1016/j.thromres.2025.109387","DOIUrl":"https://doi.org/10.1016/j.thromres.2025.109387","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":" ","pages":"109387"},"PeriodicalIF":3.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term recurrence, bleeding, and mortality after first-time subsegmental pulmonary embolism compared to more proximal pulmonary embolism: Findings from the TROLL registry","authors":"Camilla Tøvik Jørgensen ,&nbsp;Mazdak Tavoly ,&nbsp;Heidi Hassel Pettersen ,&nbsp;Synne Frønæs ,&nbsp;Waleed Ghanima ,&nbsp;Jostein Gleditsch","doi":"10.1016/j.thromres.2025.109386","DOIUrl":"10.1016/j.thromres.2025.109386","url":null,"abstract":"<div><h3>Background</h3><div>Subsegmental pulmonary embolism (SSPE) refers to clots that exclusively obstruct the subsegmental arteries. Data on long-term recurrence and bleeding risks following SSPE remain limited.</div></div><div><h3>Objectives</h3><div>To determine the long-term incidence of venous thromboembolism (VTE) recurrence after cessation of anticoagulation in patients with SSPE compared to those with more proximal PE (non-SSPE), to assess major and clinically relevant non-major bleeding (CRNMB), and to evaluate 30-day and 31–365-day all-cause mortality.</div></div><div><h3>Methods</h3><div>Between January 2005 and May 2020, 1135 cancer-free patients with a first-time computed tomography-verified PE were identified from The Venous Thrombosis Registry in ØstfOLd HospitaL (TROLL), Norway.</div></div><div><h3>Results</h3><div>Among the 1135 patients, 72 (6.3 %) were diagnosed with SSPE, while 1063 (93.7 %) had more proximal PE. Median age was 70 years (IQR: 58–80), and 51.4 % were women. The 10-year cumulative incidence of VTE recurrence after discontinuation of anticoagulation was 16.5 % (95 % CI: 4.5–35.1) in the SSPE group compared to 28.4 % (95 % CI: 24.5–32.4) in the non-SSPE group (<em>p</em> = 0.08). The 6-month cumulative incidence of major bleeding was 1.4 % (95 % CI, 0.1–6.6) in SSPE cases and 4.6 % (95 % CI: 3.4–5.9) in non-SSPE cases (<em>p</em> = 0.23). The 30-day all-cause mortality rate was 9.7 % (95 % CI: 4.8–19.3) for SSPE and 4.4 % (95 % CI: 3.3–5.8) for non-SSPE (<em>p</em> = 0.04).</div></div><div><h3>Conclusion</h3><div>While the VTE recurrence rate following SSPE was lower than in non-SSPE cases, it remained high, with 16.5 % recurrence within 10 years. Major bleeding rate was lower for SSPE than non-SSPE (1.4 % vs. 4.6 %, <em>p</em> = 0.23). Unexpectedly, the 30-days mortality rate following SSPE was significantly higher compared to non-SSPE cases.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"252 ","pages":"Article 109386"},"PeriodicalIF":3.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High rate of immediate and early post-traumatic venous thromboembolism in combat soldiers","authors":"Ophir Freund ,&nbsp;David Pelcman ,&nbsp;Nimrod Orr Urtreger ,&nbsp;Amir Bar-Shai ,&nbsp;Cole Bendor ,&nbsp;Avishai M Tsur ,&nbsp;Ofer Almog ,&nbsp;Michael Katsev ,&nbsp;Dekel Golan ,&nbsp;Daniel Starobin ,&nbsp;Liran Levy ,&nbsp;Shai Moshe Amor ,&nbsp;Akiva Nachshon ,&nbsp;Ori Wand ,&nbsp;Michael Kassirer ,&nbsp;Evgeni Gershman","doi":"10.1016/j.thromres.2025.109382","DOIUrl":"10.1016/j.thromres.2025.109382","url":null,"abstract":"<div><h3>Objective</h3><div>Venous thromboembolism (VTE), which includes pulmonary embolism (PE) and deep vein thrombosis (DVT), is a known complication of trauma. Combat-related injuries have unique characteristics which might increase the rate of early VTE. For that reason, we aimed to evaluate the incidence and characteristics of immediate and early VTE among combat casualties during the Swords of Iron war.</div></div><div><h3>Methods</h3><div>A multicenter retrospective study including combat injured personnel evacuated to a trauma center between October 26 and December 31, 2023. PE and DVT were diagnosed based on imaging reports by screening all medical records. VTE cases were classified as immediate (&lt;6 h), early (6–72 h), or late (&gt;72 h). Pre- and in-hospital characteristics were compared to matched controls.</div></div><div><h3>Results</h3><div>Of 809 patients, 12 (1.5 %) had immediate or early PE and 4 (0.5 %) immediate or early DVT. Eleven PE cases involved chest and/or limb injuries, with 83 % diagnosed immediately by total body CT. Patients with immediate PE had higher rates of chest injuries, pre-hospital whole blood use, and tourniquet placement, though these differences were not statistically significant. DVT occurred in the injured limb in all cases. No VTE-related complications or interventions were reported.</div></div><div><h3>Conclusion</h3><div>Immediate and early VTE occurred at a higher rate than previously reported, highlighting the role of advanced diagnostic tools and rapid evacuation for early diagnosis. Further research is needed to assess the prognostic impact of immediate VTE diagnosis.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"252 ","pages":"Article 109382"},"PeriodicalIF":3.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombin generation assay in venous thromboembolism: A scoping review","authors":"Maria Eduarda Machado Souza ,&nbsp;Letícia Gonçalves Resende Ferreira ,&nbsp;Nádia Regina Oliveira Silva ,&nbsp;Livian Rabelo Lopes ,&nbsp;Maria das Graças Carvalho ,&nbsp;Danyelle Romana Alves Rios","doi":"10.1016/j.thromres.2025.109384","DOIUrl":"10.1016/j.thromres.2025.109384","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the relationship, through a scoping review, between thrombin generation assay (TGA) parameters and venous thromboembolism (VTE).</div></div><div><h3>Material and methods</h3><div>A systematic search was carried out in the PubMed/MEDLINE, Embase, Cochrane, Virtual Health Library, Web of Science, and Scopus databases using descriptors for VTE and thrombin generation. Human studies assessing the association between TGA parameters and the occurrence of VTE were included. Screening of the title/abstract and full text was carried out independently by two researchers and divergent classifications were resolved by a third examiner.</div></div><div><h3>Results</h3><div>5204 studies were found, of which 90 were included after screening and full reading. The articles were grouped according to the study population and the factors associated with VTE: unprovoked VTE [33], cancer [20], hereditary/acquired thrombophilias [12], trauma/hospitalization [11], use of hormone replacement therapy/combined oral contraceptives [6], pregnancy [4] and use of anticoagulants [4]. The studies included were predominantly conducted in European countries between 2001 and 2024. Most of the studies were prospective cohort studies and used the Calibrated Automated Thrombogram (CAT) method to perform the TGA. The TGA parameters evaluated were mainly ETP and peak, which were elevated in patients with VTE in all the subgroups assessed. The TGA was able to predict the risk of primary and recurrent VTE and proved to be a useful tool for managing therapeutic regimens with anticoagulants in patients who suffered VTE.</div></div><div><h3>Conclusion</h3><div>The included studies demonstrated that TGA is a promising test in the context of VTE.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"252 ","pages":"Article 109384"},"PeriodicalIF":3.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated intravascular coagulation with hyperfibrinolysis induced by a degenerating uterine leiomyoma: A rare case report","authors":"Furong Tang ,&nbsp;Ping Nie ,&nbsp;Hongjing Wang ,&nbsp;Jianguo Hu","doi":"10.1016/j.thromres.2025.109383","DOIUrl":"10.1016/j.thromres.2025.109383","url":null,"abstract":"<div><div>Disseminated intravascular coagulation (DIC) is typically associated with malignancy, sepsis, or obstetric complications. Its occurrence in benign tumors, particularly uterine leiomyomas, is extremely rare. We report a case of a 49-year-old woman with two months of menorrhagia. Laboratory tests revealed anemia, prolonged clotting times, hypofibrinogenemia, and markedly elevated D-dimer and fibrin degradation products (FDP) levels. Coagulation factor activities (V, VIII, XII) were reduced. Thrombin-antithrombin complex (TAT) and plasmin-α2-plasmin inhibitor complex (PIC) were elevated, and thromboelastography (TEG) indicated hypocoagulability with hyperfibrinolysis. Image revealed a large degenerating uterine fibroid. Comprehensive workup excluded autoimmune, neoplastic, and inherited causes. After perioperative antifibrinolytic and coagulation management, hysterectomy was performed. Pathology confirmed extensive intratumoral thrombosis. Coagulation parameters normalized postoperatively without requiring transfusion, and no thrombotic events were observed. This case highlights a rare but important cause of DIC with hyperfibrinolysis secondary to a benign uterine tumor. It underscores the value of TEG and molecular markers in diagnosis and management, and the need to consider benign tumors in the differential diagnosis of unexplained coagulopathy.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"252 ","pages":"Article 109383"},"PeriodicalIF":3.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of phenotypes and predictors for dyspnea, echocardiographic probability of pulmonary hypertension, and confirmed CTEPH in patients with acute pulmonary embolism: Analysis of two large patient cohorts","authors":"Elva Mendoza-Zambrano ,&nbsp;Aitor Ballaz-Quincoces ,&nbsp;Jose Luis Lobo ,&nbsp;Covadonga Gomez-Cuervo ,&nbsp;Raquel Lopez ,&nbsp;Pablo Javier Marchena-Yglesias ,&nbsp;Carmen Fernández ,&nbsp;Patricia Lopez-Miguel ,&nbsp;David Jimenez ,&nbsp;Iria Francisco-Albesa ,&nbsp;María Alfonso ,&nbsp;Jose Maria Pedrajas-Navas ,&nbsp;Marina Lumbierres-Burgues ,&nbsp;Ana Núñez-Ares ,&nbsp;Miguel Angel Aibar-Arregui ,&nbsp;Consolación Rodriguez-Matute ,&nbsp;Juan Bosco Lopez-Saez ,&nbsp;Javier de Miguel-Díez ,&nbsp;Montserrat Perez-Pinar ,&nbsp;Maria Barca-Hernando ,&nbsp;Luis Jara-Palomares","doi":"10.1016/j.thromres.2025.109379","DOIUrl":"10.1016/j.thromres.2025.109379","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"252 ","pages":"Article 109379"},"PeriodicalIF":3.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}