Thrombosis research最新文献

{"title":"Seasonality and territorial gradient of pulmonary embolism in France: an 8-year retrospective nationwide analysis","authors":"Antonia Perez Martin ,&nbsp;Lucas Léger ,&nbsp;Mathias Chéa ,&nbsp;Thierry Boudemaghe ,&nbsp;Jean-Christophe Gris","doi":"10.1016/j.thromres.2025.109492","DOIUrl":"10.1016/j.thromres.2025.109492","url":null,"abstract":"<div><h3>Introduction</h3><div>Seasonality of Pulmonary Embolism (PE) is increasingly described, suggesting the negative impact of cold meteorological conditions. Yet, little is known about geographical and climatic impact. With various climates, and large regional temperature ranges, France provides a model for highlighting climate-related differences in PE prevalence. We thus made a whole country, 8-year retrospective analysis of PE prevalence, per season and geographical area, using standardized sex and age strata.</div></div><div><h3>Methods</h3><div>The French Hospital Discharge Database provided data on in-hospital-managed PE, with sex, age and geographical codes to calculate the standardized prevalence of PE (PE-SP) and map its geographical distribution. Climatic conditions were estimated taking average regional temperatures. <strong><em>Results</em>:</strong> From 2012 to 2019, we identified 341,365 cases of PE (median age, 71y; 53.04 % female). PE-SP shows constant seasonality, with a higher incidence during the coldest months (globally +28.4 %), a peak in February and a trough in June (0.272 and 0.218 cases per 100,000 inhabitants respectively).</div><div>PE-SP also exhibits a marked territorial gradient, increasing from West to East and South to North, with a median magnitude of 86.9 %, (IQR 73.3 %–98.4 %, extreme values 50.1 %–133 %). This gradient remains whatever the sex or age, and over seasons and years. Finally, linear regression analysis, expressing PE-SP according to climatic conditions, found a significant association with TXQ10 (10th percentile of daily temperatures), highlighting higher PE-SP in geographical areas traditionally exposed to colder weather.</div></div><div><h3>Conclusions</h3><div>In France, PE occurrence is heterogeneously distributed, over seasons and also over territories. Geographical (seasonal and territorial) patient biotope should be considered regarding the thrombotic risk.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109492"},"PeriodicalIF":3.4,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated intravascular coagulation resolution as a surrogate outcome for mortality in sepsis-associated disseminated intravascular coagulation","authors":"Takeshi Wada ,&nbsp;Tomoki Tanigawa ,&nbsp;Yuki Shiko ,&nbsp;Kazuma Yamakawa ,&nbsp;Satoshi Gando","doi":"10.1016/j.thromres.2025.109485","DOIUrl":"10.1016/j.thromres.2025.109485","url":null,"abstract":"<div><div>Sepsis-associated disseminated intravascular coagulation (DIC) contributes to multiple organ dysfunction and increases mortality. Although DIC resolution is considered a therapeutic goal, its validity as a surrogate outcome remains unclear. Identifying key prognostic markers within the DIC score may improve treatment strategies. This study aimed to evaluate the association between DIC resolution and 28-d mortality in patients with sepsis-associated DIC treated with antithrombin and to assess the prognostic value of DIC score components. This study analyzed 2291 patients with sepsis-associated DIC using data from a nationwide post-marketing surveillance of antithrombin concentrates in Japan. Survival analysis and multivariate models were used to assess the associations among DIC resolution, DIC score components, and 28-d mortality. Patients with resolved DIC by day 6 had a significantly lower 28-d mortality rate than those with persistent DIC. Early resolution by day 3 correlated with better survival. Platelet count and prothrombin time-international normalized ratio (PT-INR) were the strongest predictors of mortality, whereas fibrin/fibrinogen degradation product had limited prognostic value. Even among patients with persistent DIC, improvements in the PT-INR and platelet count were associated with better survival. High-dose antithrombin increased DIC resolution rates and showed a trend toward reduced mortality, although the reduction was not statistically significant. DIC resolution is associated with improved survival and may serve as a surrogate outcome. Monitoring key coagulation markers, even in unresolved cases, may help refine the treatment strategies for sepsis-associated DIC. These findings may support future clinical trials targeting coagulopathy in patients with sepsis.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109485"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An international survey of clinician recommendations for physical activity after venous thromboembolism","authors":"Antonia Chan ,&nbsp;Pavlina Chrysafi ,&nbsp;Dana Angelini ,&nbsp;Jordan K. Schaefer ,&nbsp;Ang Li ,&nbsp;Shruti Chaturvedi ,&nbsp;Anjlee Mahajan ,&nbsp;Tefera Leben ,&nbsp;Jori May ,&nbsp;Leslie Lake ,&nbsp;Rushad Patell ,&nbsp;Alejandra Gutierrez Bernal ,&nbsp;Anna L. Parks","doi":"10.1016/j.thromres.2025.109478","DOIUrl":"10.1016/j.thromres.2025.109478","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109478"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in ischemic heart disease and thromboembolism-related mortality in the United States, 1999–2024: A population-based analysis using CDC WONDER Data","authors":"Muhammad Shaheer Bin Faheem ,&nbsp;Yumna Fatima ,&nbsp;Syeda Umbreen Munir ,&nbsp;Momina Khabir ,&nbsp;Nisha Khatri","doi":"10.1016/j.thromres.2025.109482","DOIUrl":"10.1016/j.thromres.2025.109482","url":null,"abstract":"<div><h3>Introduction</h3><div>Ischemic heart disease (IHD) and thromboembolism continue to contribute to significant cardiovascular mortality in the United States in spite of increased prevention and treatment. Underlying both arterial and venous events, such as stroke, pulmonary embolism (PE), and deep vein thrombosis (DVT), is thrombosis. With the aging of the population and increased risk factors such as obesity and diabetes, awareness of long-term trends in mortality is needed. In this article, CDC WONDER data are used to assess national trends in IHD- and thromboembolism-associated mortality from 1999 to 2024, with attention given to variation by age, sex, and race/ethnicity to inform future public health programs.</div></div><div><h3>Methods</h3><div>Mortality data for IHD-thromboembolism among those aged ≥45 in the US were extracted from the CDC WONDER (1999–2024), using ICD codes I20-I25 (IHD) and I74, I26, I80-I82 (thromboembolism). Age-adjusted mortality rates were calculated per 100,000 and stratified by age, sex, race/ethnicity, geographic region, and urban-rural classification. Joinpoint regression was used to evaluate average annual percentage change (AAPC) and annual percentage change (APC) with 95 % Confidence Intervals (CIs). A <em>p</em>-value of &lt;0.05 was considered significant.</div></div><div><h3>Results</h3><div>From 1999 to 2024, 70,339 deaths occurred due to IHD and thromboembolism. The AAMR decreased from 2.6 in 1999 to 2.3 in 2024 with an AAPC of −1.16 (95 % CI: −0.58 to −1.82). The AAMR initially inclined to 2.7 in 2001 with an APC of 1.95 (95 % CI: 5.40 to −1.94) followed by a drastic decline to 1.8 till 2018 with an APC of −2.40 (95 % CI: −2.18 to 4.90), afterward, the AAMR again incline to 2.3 in 2021 with an APC of 7.62 (95 % CI: −10.01 to −2.03). The stratified analysis revealed the highest AAMRs across the age group 85 years and older (16.03). Men consistently had higher AAMR than Women (AAMR: 2.7 vs. 1.9). By race, the highest AAMR was noted among NH Black or African American (3.4), followed by NH white (2.2). Regionally, the South showed the highest AAMR (2.4). Non-Metropolitan exhibited the highest AAMR than Metropolitan (AAMR: 12.6 vs. 10.8).</div></div><div><h3>Conclusion</h3><div>Despite an overall stable age-adjusted mortality trend of ischemic heart disease and thromboembolism between 1999 and 2024, the most recent years have witnessed a disturbing rise. The most notable disparities persist by age, sex, race, and geographic area, with the largest burden in older adults, men, racial minorities, non-metropolitan residents, and residents of the Midwestern U.S. These findings emphasize the need for targeted interventions and equitable public health interventions to reduce mortality among high-risk groups.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109482"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full vs. low-dose of direct oral anticoagulants as extended secondary prophylaxis of venous thromboembolism in the splanchnic venous thrombosis","authors":"Silvia Sorella,&nbsp;Mario Biglietto,&nbsp;Nadezda Zhdanovskaya,&nbsp;Manuela Merli,&nbsp;Alessandro Laganà,&nbsp;Antonio Chistolini","doi":"10.1016/j.thromres.2025.109481","DOIUrl":"10.1016/j.thromres.2025.109481","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109481"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter entitled “Point-of-care tests for hypofibrinogenemia in postpartum hemorrhage: Are we comparing apples and oranges?”","authors":"Eishin Nakamura ,&nbsp;Takahiro Mihara ,&nbsp;Yuriko Kondo ,&nbsp;Hisashi Noma ,&nbsp;Sayuri Shimizu","doi":"10.1016/j.thromres.2025.109483","DOIUrl":"10.1016/j.thromres.2025.109483","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109483"},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impacts of tranexamic acid on immune system during trauma","authors":"Shiva Abolhassani ,&nbsp;Mahsa Hajivalili ,&nbsp;Pooria Fazeli ,&nbsp;Morteza Jaafarinia ,&nbsp;Behzad Mansoori ,&nbsp;Shahram Paydar ,&nbsp;Maryam Hosseini","doi":"10.1016/j.thromres.2025.109458","DOIUrl":"10.1016/j.thromres.2025.109458","url":null,"abstract":"<div><div>Tranexamic acid (TXA) is a synthetic, reversible competitive inhibitor of the lysine receptor on plasminogen. It inhibits plasmin, the active form of plasminogen, from binding to and degrading the fibrin matrix. The mechanism not only effectively mitigates bleeding complications in various hemostatic challenges but also lowers mortality, with minimal adverse effects, including postoperative seizures in specific situations. Although the effectiveness of TXA in acute trauma is well-established, its impact on both the innate and adaptive immune systems underscore the need to address existing knowledge gaps. This review aims to shed light on both the pro- and anti-inflammatory effects of TXA in the context of traumatic injuries. Moreover, we will argue about TXA immunological effects through its anti-plasmin activity, stemming from its high affinity for lysine residues on plasmin and fibrin residues on plasminogen, leading to reduced vascular permeability, decreased allergic responses, and diminished inflammation. Furthermore, it will be disclosed that TXA administration significantly inhibited neutrophil extracellular trap (NETosis) formation during trauma injuries. More importantly, we will provide profound insights about the prominent factors orchestrating TXA immunomodulatory and prophylactic effects during trauma, including the type of trauma, presence of infection, TXA dosage, duration since trauma onset, the persistence of TXA treatment and genetic background.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109458"},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HemoDens: A global hemostasis analyzer for kinetic characterization of clot formation, retraction, and lysis","authors":"Mikael Lund ,&nbsp;Menikae K. Heenkenda ,&nbsp;Cia Laine ,&nbsp;Magnus Sethson ,&nbsp;Niklas Boknäs","doi":"10.1016/j.thromres.2025.109480","DOIUrl":"10.1016/j.thromres.2025.109480","url":null,"abstract":"<div><div>During clot retraction (CR), platelets use their actomyosin apparatus to contract the cross-linked fibrin-platelet meshwork of a nascent thrombus. As CR depends on thrombin generation, fibrin polymerization/cross-linking, platelet activation and fibrinolysis, measurements of CR can provide valuable information about global hemostatic function. However, a lack of standardized methods for simple and reproducible assessment of CR remains a major obstacle to a more widespread adoption of CR assays for clinical testing. Herein, we developed a whole-blood hemostasis analyzer (HemoDens) to enable rapid and reproducible kinetic characterization of clot formation (CF), CR, and exogenous clot lysis (eCL) from minute quantities of citrated whole blood. In our assay, double-end-anchored clots were formed inside hemitoroidal fluoropolymer sample chambers. This approach provided spatiotemporal standardization by focusing macroscale contractile forces on a geometrically defined region-of-interest (ROI) from which clots retracted uniformly. Fluorescence densitometry was used to monitor the redistribution of RBCs in this ROI during experiments. A set of analytical parameters provided a detailed kinetic characterization of CF, CR and eCL from a single experiment. The specific effects of CR on our assay were verified experimentally by inhibiting platelet fibrin(ogen) binding, actin polymerization, and non-muscle myosin II. We verified the sensitivity of our assay to variations in blood counts, and to the effects of unfractionated heparin (UFH), low molecular weight heparin (LMWH), dabigatran, and recombinant tissue plasminogen activator (rtPA). We also show that our assay could detect the reversal of heparins and rtPA with protamine and tranexamic acid.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109480"},"PeriodicalIF":3.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepsis-related coagulation-inflammation score: Development and validation for predicting 28-day mortality in patients with sepsis","authors":"Ji Jiang,&nbsp;Haicong Huang,&nbsp;Huiya Li,&nbsp;Jiasheng Shen","doi":"10.1016/j.thromres.2025.109479","DOIUrl":"10.1016/j.thromres.2025.109479","url":null,"abstract":"<div><h3>Background</h3><div>Sepsis remains a leading cause of mortality in intensive care units worldwide, characterized by dysregulated host response to infection involving complex interactions between coagulation and inflammatory pathways. Current prognostic tools have limitations in capturing this pathophysiological interplay. This study aimed to develop and validate a novel Sepsis-related Coagulation-Inflammation Score (SCIS) to predict 28-day mortality in sepsis patients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective observational study of adult patients diagnosed with sepsis according to Sepsis-3 criteria at a tertiary medical center between January 2017 and December 2022. Demographic data, clinical characteristics, coagulation parameters (platelet count, prothrombin time, activated partial thromboplastin time, D-dimer, fibrinogen), and inflammatory markers (C-reactive protein, procalcitonin, interleukin-6, white blood cell count, neutrophil-to-lymphocyte ratio) were collected. Univariate and multivariate logistic regression analyses identified significant predictors of 28-day mortality. The SCIS was developed by assigning weighted points to independent predictors. Receiver operating characteristic (ROC) curve analysis, calibration plots, and decision curve analysis evaluated the score's predictive performance and clinical utility. The score was compared with established sepsis severity scores including SOFA, APACHE II, and DIC scores.</div></div><div><h3>Results</h3><div>Among 578 sepsis patients, 28-day mortality was 32.7 %. The final SCIS incorporated five parameters: platelet count, D-dimer, prothrombin time, procalcitonin, and interleukin-6. The SCIS demonstrated excellent discriminative ability for predicting 28-day mortality (AUC 0.86, 95 % CI 0.83–0.89), superior to SOFA (AUC 0.79), APACHE II (AUC 0.77), and DIC score (AUC 0.74). The score maintained robust performance across subgroups stratified by infection site, comorbidities, and organ dysfunction. A SCIS ≥10 was associated with a 5.8-fold increased risk of 28-day mortality (95 % CI 4.2–7.9, <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The Sepsis-related Coagulation-Inflammation Score effectively integrates coagulation and inflammatory parameters to predict 28-day mortality in sepsis patients. This novel scoring system provides enhanced prognostic accuracy compared to established scores and may facilitate early risk stratification, therapeutic decision-making, and resource allocation in sepsis management.</div></div>","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109479"},"PeriodicalIF":3.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent mechanical prosthetic valve thrombosis: Another clinical challenge","authors":"Fidel Manuel Caceres-Loriga ,&nbsp;Humberto Morais ,&nbsp;Hilaryano Da Silva Ferreira","doi":"10.1016/j.thromres.2025.109477","DOIUrl":"10.1016/j.thromres.2025.109477","url":null,"abstract":"","PeriodicalId":23064,"journal":{"name":"Thrombosis research","volume":"255 ","pages":"Article 109477"},"PeriodicalIF":3.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}