Lorhayne Kerley Capuchinho Scalioni Galvao, Ana Clara Felix de Farias Santos, Nicole Pimenta Dos Santos, Fernanda Valeriano Zamora, Belisa Brunow Ventura Biavatti, João Pedro Costa Esteves Almuinha Salles, Horbert Soares Mendonca
{"title":"HTK solution cardioplegia in paediatric patients: a meta-analysis.","authors":"Lorhayne Kerley Capuchinho Scalioni Galvao, Ana Clara Felix de Farias Santos, Nicole Pimenta Dos Santos, Fernanda Valeriano Zamora, Belisa Brunow Ventura Biavatti, João Pedro Costa Esteves Almuinha Salles, Horbert Soares Mendonca","doi":"10.1055/a-2461-3147","DOIUrl":"https://doi.org/10.1055/a-2461-3147","url":null,"abstract":"<p><strong>Introduction: </strong>Cardioplegia, a therapy designed to induce reversible cardiac arrest, revolutionised cardiovascular surgery. Among the various pharmacological approaches is the histidine-tryptophan-ketoglutarate (HTK) solution. Despite numerous studies, no meta-analysis has investigated the efficacy of the HTK solution in the paediatric population. Therefore, we aim to conduct a meta-analysis comparing HTK and other cardioplegia solutions in paediatric patients undergoing cardiovascular surgery.</p><p><strong>Methods: </strong>PubMed, Embase and Cochrane databases were searched from inception through April 2024. Endpoints were computed in odds ratios (OR) with 95% Confidence Intervals (CI) for dichotomous variables, whereas continuous variables were compared using mean differences (MD) with 95% CI.</p><p><strong>Results: </strong>11 studies comprising 1,349 patients were included, of whom 677 (50.19%) received HTK cardioplegia. The results were similar between groups regarding mortality (OR 0.98; 95% CI 0.29, 3.29), length of hospital (MD 0.32 days; 95% CI -0.88, 1.51), MV (MD -17.72 hours; 95% IC -51.29, 15.85), arrhythmias (OR 1.27; 95% CI 0.83, 1.95;) and delayed sternal closure (OR 0.89; 95% 0.56, 1.43). However, transfusion volume was lower in the HTK group (MD -452.39; 95% CI -890.24, -14.53; p=0.04).</p><p><strong>Conclusion: </strong>The use of HTK solution was demonstrated to be similar regarding its clinical efficacy to other approaches for cardioplegia, and it may present advantages to patients prone to hypervolemia.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tim Berger, Albi Fagu, Martin Czerny, Tau Hartikainen, Constantin Von Zur Mühlen, Sami Kueri, Matthias Eschenhagen, Maximilian Kreibich, Friedhelm Beyersdorf, Bartosz Rylski
{"title":"Intraoperative Invasive Coronary Angiography after Coronary Artery Bypass Grafting.","authors":"Tim Berger, Albi Fagu, Martin Czerny, Tau Hartikainen, Constantin Von Zur Mühlen, Sami Kueri, Matthias Eschenhagen, Maximilian Kreibich, Friedhelm Beyersdorf, Bartosz Rylski","doi":"10.1055/s-0044-1791960","DOIUrl":"https://doi.org/10.1055/s-0044-1791960","url":null,"abstract":"<p><strong>Objective: </strong> The aim of this study was to prospectively evaluate the feasibility and safety of intraoperative invasive coronary angiography (ICA) following coronary artery bypass grafting using a mobile angiography C-arm.</p><p><strong>Methods: </strong> Between August 2020 and December 2021, 18 patients were enrolled for intraoperative ICA following coronary artery bypass grafting. After skin closure, ICA was performed including angiography of all established bypass grafts via a mobile angiography system by an interventional cardiologist. Data on graft patency, stenosis, and kinking were assessed. Grafts were rated on an ordinal scale ranging from very poor (1) to excellent (5). Furthermore, the impact of ICA compared with flow measurement was assessed using the ordinal Likert scale ranging from (I) worse to (V) much better.</p><p><strong>Results: </strong> The ICA was considered better (V) compared with transient flow measurement in 38 (93%) and comparable (III) in 3 (7%) distal anastomoses. ICA impacted clinical or surgical decision-making in three patients (17%). In one patient, dual antiplatelet therapy for 6 months was initiated and rethoracotomy was needed in two (11%) patients with bypass graft revision and additional bypass grafting for graft occlusion. There were no cerebral and distal embolic events or access vessel complications observed and no postoperative acute kidney injury occurred.</p><p><strong>Conclusion: </strong> Intraoperative angiography after coronary bypass grafting is safe. Using a mobile angiographic device, graft patency, and function assessment was superior to transit time flow measurement leading to further consequences in a relevant number of patients. Therefore, it has the potential to reduce postoperative myocardial injury and improve survival.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lactate Dehydrogenase Levels after aortic valve replacement: What do they tell us?","authors":"Laura Rings, Loreta Mavrova-Risteska, Achim Haeussler, Vasileios Ntinopoulos, Matteo Tanadini, Hector Rodriguez Cetina Biefer, Omer Dzemali","doi":"10.1055/a-2454-9020","DOIUrl":"https://doi.org/10.1055/a-2454-9020","url":null,"abstract":"<p><strong>Introduction: </strong>Lactate dehydrogenase (LDH) is a standard postoperative marker for hemolysis in the presence of paravalvular leakage (PVL) after aortic valve replacement (AVR). LDH is elevated in certain valves by a fluttering phenomenon. Previous studies suggested a correlation between microparticles (MP) and LDH elevation after AVR. We analyze the postoperative relevance of LDH after AVR with transapical transcatheter aortic valves (TA-TAV) or rapid deployment valves (RDV).</p><p><strong>Method: </strong>We retrospectively analyzed the data from patients who received an AVR with RDV and TA-TAV groups between 2015-2018. We compared PVL and LDH levels before and after surgery, transvalvular gradients, heart block that required pacemaker implantation, and 30-day mortality.</p><p><strong>Results: </strong>138 consecutive patients were selected: 79 patients in the RDV group (37 Sorin Perceval valve, 42 Edwards Intuity valves) and 59 in the TA-TAV group (Edwards Sapien valve). TA-TAV-group were older (median 10 years) and with higher incidence of PVL (Odds ratio 11, 95% CI from 2.5 - 73.2, p-value 0.04)). TA-TAV-Group showed lower levels of LDH despite higher rates of PVL while the Perceval valve trended towards higher LDH values. Additionally, the RDV group showed an increased arrhythmia profile (p=0.0041) although the results show lower incidence in pacemaker implantation (95 % CI 0.05 - 1.65, p=0.635). 30-day mortality was similar between groups.</p><p><strong>Conclusion: </strong>Our data do not support the association between hemolysis and PVL despite elevated LDH in suture-free valves. LDH could be a marker of extreme heart muscle output or fluttering phenomena and not a marker of hemolysis after sutureless AVR.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distal Events Following Emergent Operation for DeBakey Type I Aortic Dissection.","authors":"Shunsuke Miyahara, Gaku Uchino, Yoshukatsu Nomura, Hiroshi Tanaka, Hirohisa Murakami","doi":"10.1055/a-2454-8883","DOIUrl":"https://doi.org/10.1055/a-2454-8883","url":null,"abstract":"<p><strong>Objective: </strong>The goal of this study is to examine early and Mid-term results after surgical treatment of acute DeBakey type I aortic dissection (AIAD) and the effect of the range of aortic arch replacement on overall survival and prevention of distal aortic events.</p><p><strong>Methods: </strong>Between March 2002 and July 2020, a total of 374 AIAD aortic repairs were reviewed. One hundred fifty-four (41.2%) patients had total arch replacement (TAR), while 220 (58.8%) had hemi- or partial arch replacement (PAR).</p><p><strong>Results: </strong>Operative mortality did not show a significant difference (7.7% in PAR, 13.0 % in TAR, p = 0.096). Survival at 5 years showed no difference (77.8% in TAR, 72.6% in PAR, p = 0.14). Freedom from reoperations and re-interventions, as well as composite aortic events in the distal aorta, were comparable across groups (p=0.21, 0.84, and 0.91, respectively). The inverse provability of treatment weighting-adjusted model displayed higher 5-year freedom from reoperations and aortic events in the TAR group (p = 0.029 and 0.054, respectively) Conclusion: The extent of Arch replacement is determined based on the patient's background, making it difficult to compare the superiority of both surgical methods. However, TAR for appropriately selected patients may provide the benefit of avoiding aortic events in the long-term.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xun Zhang, Wenda Yu, Hanci Yang, Chao Fu, Bo Wang, Lu Wang, Qingguo Li
{"title":"Impact of Surgery Timing and Malperfusion on Acute Type A Aortic Dissection Outcomes.","authors":"Xun Zhang, Wenda Yu, Hanci Yang, Chao Fu, Bo Wang, Lu Wang, Qingguo Li","doi":"10.1055/a-2446-9886","DOIUrl":"https://doi.org/10.1055/a-2446-9886","url":null,"abstract":"<p><strong>Objective: </strong>To determine the impact of symptom-to-surgery time on mortality in acute type A aortic dissection (ATAAD) patients, with and without malperfusion.</p><p><strong>Methods: </strong>A retrospective analysis of 288 ATAAD patients was conducted. Patients were separated into the early (≤ 10 h) and late (> 10 h) groups by symptom-to-surgery time. Data on characteristics, surgery, and complications were compared, and multivariable logistic regression determined mortality risk factors.</p><p><strong>Results: </strong>Mortality rates did not significantly differ between early and late groups. Age (OR 1.09, 95% CI 1.05-1.13, p<0.001), ECMO use (OR 10.73, 95% CI 2.51-45.87, p=0.001), and malperfusion (OR 6.83, 95% CI 2.84-16.45, p<0.001) predicted operative death. Subgroup analysis showed cerebral (OR 3.20, 95% CI 1.11-9.26, p=0.031), cardiac (OR 5.89, 95% CI 1.32-26.31, p=0.020), and limb (OR 6.20, 95% CI 1.75-22.05, p=0.005) malperfusion as predictors of operative death. One (OR 6.30, 95% CI 2.39-16.61, p<0.001), two (OR 12.79, 95% CI 2.74-59.81, p=0.001), and three (OR 46.99, 95% CI 7.61-288.94, p<0.001) organs malperfusion, together with Penn B (OR 7.96, 95% CI 3.04-20.81, p<0.001) and Penn B-C (OR 12.50, 95% CI 2.65-58.87, p=0.001) classifications predict operative mortality. Survival analysis revealed significant differences between malperfusion and no malperfusion (34% vs. 9%, p<0.001) but not between late and early (14% vs. 21%, p=0.132) groups. Malperfusion remained an essential predictor of operative (OR 7.06 95% CI 3.11-17.19, p<0.001) and mid-term mortality (OR 3.38 95% CI 1.97-5.77, p<0.001) in subgroup analysis.</p><p><strong>Conclusions: </strong>Preoperative malperfusion status, rather than symptom-to-surgery time, significantly impacts both operative and mid-term mortality in ATAAD patients.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yeiwon Lee, Yoonjin Kang, Ji Seong Kim, Sue Hyun Kim, Suk Ho Sohn, Ho Young Hwang
{"title":"Impact of High-Intensity Statin on Atrial Fibrillation After Off-Pump Coronary Artery Bypass.","authors":"Yeiwon Lee, Yoonjin Kang, Ji Seong Kim, Sue Hyun Kim, Suk Ho Sohn, Ho Young Hwang","doi":"10.1055/a-2447-0020","DOIUrl":"https://doi.org/10.1055/a-2447-0020","url":null,"abstract":"<p><strong>Background: </strong>There is uncertainty regarding the impact of high-intensity statins on postoperative outcomes in patients undergoing surgical myocardial revascularization. This study was conducted to evaluate the impact of high-intensity statin treatment on the occurrence rate of new-onset postoperative atrial fibrillation (POAF) after off-pump coronary artery bypass grafting (OPCAB).</p><p><strong>Methods: </strong>Six hundred thirteen patients (66.8±9.8 years, male:female = 476:137) who underwent isolated OPCAB were retrospectively enrolled. Hypertension (n = 409, 66.7%), diabetes mellitus (n = 343, 59.6%) and chronic kidney disease (n = 138, 22.5%) were common comorbidities. Statins and beta-blockers were administered to all patients until the day of surgery and resumed within 6 hours after surgery. Risk factors associated with POAF were analyzed, including the use of high-intensity statins (atorvastatin 40 mg-80 mg or rosuvastatin 20 mg), as well as baseline characteristics and preoperative risk factors.</p><p><strong>Results: </strong>High-intensity statins were used in 158 patients (25.8%). POAF occurred in 184 patients (30.0%). The use of high-intensity statins was not correlated with preoperative levels of low-density lipoprotein (P = 0.135) or high sensitivity C-reactive protein (P = 0.365). Multivariate logistic regression analysis revealed that the use of high-intensity statins was significantly associated with a reduced occurrence of POAF (P = 0.022, odds ratio [95% confidence interval] = 0.592 [0.378-0.926]). Age, acute coronary syndrome, insulin-dependent diabetes mellitus and chronic kidney disease were also significantly associated with POAF.</p><p><strong>Conclusion: </strong>Preoperative administration of high-intensity statins was associated with a 41% reduction in the occurrence rate of POAF in patients who underwent OPCAB.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mary Bove, Giovanni Natale, Gaetana Messina, Matteo Tiracorrendo, Erino Angelo Rendina, Alfonso Fiorelli, Antonio D'Andrilli
{"title":"Erratum: Solitary Fibrous Tumor of the Pleura: Surgical Treatment and Recurrence.","authors":"Mary Bove, Giovanni Natale, Gaetana Messina, Matteo Tiracorrendo, Erino Angelo Rendina, Alfonso Fiorelli, Antonio D'Andrilli","doi":"10.1055/s-0044-1791983","DOIUrl":"https://doi.org/10.1055/s-0044-1791983","url":null,"abstract":"","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krzysztof Sanetra, Witold Gerber, Piotr Paweł Buszman, Marta Mazur, Krzysztof Milewski, Paweł Kaźmierczak, Andrzej Bochenek
{"title":"Determinants of Inadequate Cardioprotection in Adult Patients with Left Ventricular Dysfunction.","authors":"Krzysztof Sanetra, Witold Gerber, Piotr Paweł Buszman, Marta Mazur, Krzysztof Milewski, Paweł Kaźmierczak, Andrzej Bochenek","doi":"10.1055/a-2141-8105","DOIUrl":"10.1055/a-2141-8105","url":null,"abstract":"<p><strong>Background: </strong> Perioperative cardioprotection is essential for achieving satisfactory clinical outcomes in heart failure patients. It is important to understand the factors affecting perioperative cardioprotection.</p><p><strong>Methods: </strong> The institutional database was searched for patients with reduced ejection fraction (EF, < 40%) who underwent surgery with cardioplegia-induced arrest. Patients were divided into del Nido cardioplegia (DN) and cold blood cardioplegia (CB) groups. The relationships between age, preoperative blood parameters, creatinine, cross-clamp time (CCT), extracorporeal circulation time (ECT), and postoperative troponin values at 12 hours or deterioration of EF (≥5%) were evaluated. Baseline characteristics, operative parameters, and outcomes were analyzed.</p><p><strong>Results: </strong> There were 508 patients with reduced EF (331 DN and 177 CB). In the entire cohort, anemic patients had greater troponin values (<i>p</i> = 0.004) as well as in the DN group (<i>p</i> = 0.002). However, this was not detected in the CB group (flat regression line; <i>p</i> = 0.674). Patients with high leukocyte values had greater troponin release (entire cohort: <i>p</i> < 0.001; DN group: <i>p</i> < 0.001; CB group: steep regression line with <i>p</i> = 0.042). Longer CCT and ECT were associated with greater troponin release (entire cohort; both groups) and greater risk of fall in EF. In a direct comparison, fewer patients had significant deterioration of EF in the DN group than CB group (3.9 vs. 11.9%; <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong> The use of CB cardioplegia may be beneficial in anemic patients, whereas the use of DN cardioplegia may be beneficial for expected long CCT and high leukocytosis.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":"489-497"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10102430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingpeng Wu, Ye Tian, Jianli An, Zibo Zou, Yanchao Dong, Zhuo Chen, Hongtao Niu
{"title":"Outcomes of CT-Guided Deeper Localization Technique for Superficial Pulmonary Nodules.","authors":"Jingpeng Wu, Ye Tian, Jianli An, Zibo Zou, Yanchao Dong, Zhuo Chen, Hongtao Niu","doi":"10.1055/a-2168-9230","DOIUrl":"10.1055/a-2168-9230","url":null,"abstract":"<p><strong>Background: </strong> The possibility of coil dislocation in computed tomography (CT)-guided microcoil localization of superficial pulmonary nodules is relatively high. The aim of the study is to investigate the outcomes of deeper localization technique during CT-guided microcoil localization of superficial pulmonary nodules before video-assisted thoracoscopic surgery (VATS).</p><p><strong>Methods: </strong> Fifty-seven identified superficial pulmonary nodules (nodule-pleural distance ≤ 1 cm on CT image) from 51 consecutive patients underwent CT-guided microcoil localization, and subsequent VATSs were included. The rate of technical success, complications, and excised lung volume were compared between deeper localization technique group and conventional localization technique group.</p><p><strong>Results: </strong> The technical success rate of the localization procedure was 100% (25/25) in the deeper localization group and 81.3% (26/32) in the conventional localization group (<i>p</i> = 0.030). Excluding one case of lobectomy, the excised lung volume in the deeper localization group and the conventional localization group was 39.3 ± 23.5 and 37.2 ± 16.2 cm<sup>3</sup>, respectively (<i>p</i> = 0.684). The incidence of pneumothorax was similar between the deeper localization group and the conventional localization group (24.0 vs. 21.9%, respectively, <i>p</i> = 0.850). The incidence of intrapulmonary hemorrhage in the deeper localization group was higher (16.0%) than that in the conventional localization group (6.3%), but the difference was not statistically significant (<i>p</i> = 0.388).</p><p><strong>Conclusion: </strong> CT-guided microcoil localization of superficial pulmonary nodules prior to VATS using a deeper localization technique is feasible. Deeper localization technique reduced the occurrence of dislocation but did not increase excised lung volume.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":"550-556"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10169383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murat Mukharyamov, Hristo Kirov, Tulio Caldonazo, Torsten Doenst
{"title":"Impact of Age on the Relationship between Cross-Clamp Time and Mortality in Cardiac Surgery.","authors":"Murat Mukharyamov, Hristo Kirov, Tulio Caldonazo, Torsten Doenst","doi":"10.1055/a-2263-1933","DOIUrl":"10.1055/a-2263-1933","url":null,"abstract":"<p><p>Age is an independent risk factor for mortality even when all known comorbidities are considered. Thus, other factors may additionally contribute to the age-associated risk. We performed a systematic literature search and identified 161 manuscripts, of which 32 studies (18,256 patients) were analyzed. Cross-clamp time correlated with observed mortality. The increase in mortality risk with cross-clamp time was much greater in older patients than in younger patients. The log odds ratio (OR) for age and cross-clamp time was 0.07 and 0.01, respectively, which was highly significant for both independent risk factors. Age accelerates the increase in mortality risk with increasing aortic cross-clamp times.</p>","PeriodicalId":23057,"journal":{"name":"Thoracic and Cardiovascular Surgeon","volume":" ","pages":"539-541"},"PeriodicalIF":1.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}