Therapeutic Advances in Cardiovascular Disease最新文献

{"title":"Evaluating the implementation of guideline-directed medical therapy in the treatment of chronic heart failure at public hospitals in Ethiopia.","authors":"Akalu Fetene, Amsalu Degu, Chalelgn Kassaw, Chala Fekadu Oljira, Kale Gubae, Tariku Shimels, Getachew Alemkere","doi":"10.1177/17539447251411121","DOIUrl":"10.1177/17539447251411121","url":null,"abstract":"<p><strong>Background: </strong>Guideline-directed medical therapy (GDMT) prolongs survival in patients with heart failure with reduced ejection fraction (HFrEF). However, different countries implement GDMT differently, and many patients are still undertreated. Therefore, this study aimed to assess GDMT utilization in patients with chronic HFrEF at the adult cardiac clinics of three selected hospitals in Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>An explanatory sequential mixed-methods (quantitative cross-sectional followed by qualitative phenomenological) study design was used to assess GDMT usage in patients with HFrEF at the study settings from September 25 to November 25, 2022. Simple random and purposive sampling techniques were used to select participants for the quantitative and qualitative studies, respectively. Adherence level was defined as good (adherence score = 1), moderate (0.5 < score <1), and poor (score ⩽0.5). Quantitative data were analyzed using Statistical Package for the Social Sciences (SPSS) version 26.0. Logistic regression model was used to determine the association. Statistical significance was declared at <i>p</i> < 0.05. Qualitative data were analyzed with MAXQDA 2020.</p><p><strong>Results: </strong>Three hundred forty-one patients were included in the quantitative study. Adherence to GDMT was good in 128 (37.5%) of the patients. Patient parameters, including female gender (adjusted odds ratio (AOR) = 0.55, 95% CI: 0.32-0.93), unable to read and write (AOR = 0.31, 95% CI: 0.11-0.86), primary education (AOR = 0.27, 95% CI: 0.12-0.63), were negatively associated with Physicians' good adherence. Hypertension was associated with lower odds of physicians' good adherence (AOR = 0.41, 95% CI: 0.21-0.78). Absence of comorbidities (other than hypertension; AOR = 2.65, 95% CI: 1.36-5.15) were positive predictors. System, patient, and physician-related factors were reported as barriers to intensifying GDMT.</p><p><strong>Conclusion: </strong>Nearly one-fourth of eligible patients were on ⩽50% of guidelines-recommended drugs. Female gender, educational level, and comorbidities were the factors associated with adherence to GDMT. System, patient, and physician-related reasons for poor adherence were identified. Multipronged interventions are required to address those adherence barriers.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251411121"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATTR-CM: What do we know about blood levels of the TTR protein? A discussion with experts.","authors":"Mathew S Maurer, Adam Castaño","doi":"10.1177/17539447261434318","DOIUrl":"https://doi.org/10.1177/17539447261434318","url":null,"abstract":"<p><p>Transthyretin (TTR) amyloid cardiomyopathy occurs when stable TTR, normally a 4-protein tetramer, becomes misfolded and aggregates to form amyloid fibrils that accumulate in the heart. Progressive accumulation causes cardiomyopathy, leading to arrhythmia and heart failure. Acoramidis is a high-affinity TTR stabilizer (⩾90%) evaluated in the ATTRibute-CM clinical trial. In this podcast discussion, Dr Mathew Maurer and Dr Adam Castaño provide insights into their recent analysis of prognostic implications of acoramidis-mediated changes to serum TTR (sTTR) in 557 patients and the associated implications for all-cause mortality. For the patients included in this analysis, acoramidis fully mediated a sharp and significant early rise in sTTR levels (mean 9.1 mg/dL) by day 28, sustained through month 30. Incremental changes (+5 mg/dL) in sTTR were associated with a 31.6% lower odds of mortality through month 30. This evidence strongly supports a direct association between early, sustained sTTR increases with acoramidis treatment and survival.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447261434318"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare pair: two cases of clinically isolated pulmonary artery aneurysm.","authors":"Donovan Cassidy-Nolan, Claudia Cote, Dominique de Waard, Mathieu Castonguay, Volodko Bakowsky, Christine Herman","doi":"10.1177/17539447251410305","DOIUrl":"10.1177/17539447251410305","url":null,"abstract":"<p><p>Pulmonary artery aneurysms (PAAs) are a rare pathology with potentially devastating consequences. In this case series, we describe two cases of clinically isolated pulmonary arteritis and concisely review the literature surrounding this new clinical entity. Two Caucasian women, aged 65 and 73, were referred to our cardiovascular surgery center with incidental PAAs, both growing to over 65 mm in main pulmonary artery diameter. Both participants underwent serial thoracic CT-angiograms to monitor the pulmonary artery aneurysms. Both pulmonary artery aneurysms showed an interval increase in diameter, so they were repaired surgically. The main pulmonary artery was excised in both cases and replaced with a synthetic graft. No pre- or postoperative corticosteroids were administered. Neither of our patients had systemic symptoms of giant cell arteritis or elevated inflammatory markers. In both cases, only the main pulmonary artery was replaced to minimize surgical complexity and risk; however, the left pulmonary artery of one patient began to further dilate 5 years postoperatively. Currently, no reintervention is planned. These cases represent mounting evidence for the existence of clinically isolated pulmonary arteritis leading to a pulmonary artery aneurysm. This entity is analogous to clinically isolated aortitis and may represent a subclinical smoldering vasculitis. These rare aneurysms can progress over time and require surgical intervention. In the absence of guidelines for pulmonary artery aneurysm intervention, the present cases will serve to guide further management of this rare disease.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251410305"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systolic blood pressure range in patients with intermediate- to high-risk pulmonary embolism undergoing advanced treatment: a systematic review.","authors":"Hector Lopez-de la Garza, Carlos Jerjes-Sanchez, Victor E Lozano-Corres, Christian Camacho Mondragon, Maria Fernanda Reyes-Chavez, Ricardo J Estrada-Mendizabal, Jose Max Narvaez-Paliza, Victor Baylo Valdez, Cecilia Gocher Janet","doi":"10.1177/17539447251414584","DOIUrl":"10.1177/17539447251414584","url":null,"abstract":"<p><strong>Background: </strong>Despite continuous advances in management over the last two decades for pulmonary embolism (PE), treating intermediate- to high-risk PE remains challenging. There is a critical need to expand our understanding of the clinical spectrum beyond systolic blood pressure (SBP) to inform the intricate decision-making process for initiating advanced treatment in patients with intermediate- to high-risk PE.</p><p><strong>Objectives: </strong>We aimed to characterize the range of SBP values in patients with intermediate- to high-risk PE undergoing advanced therapy across different clinical settings. The secondary objective included the incidence of bleeding complications (intracranial, major, and minor).</p><p><strong>Design: </strong>We conducted a systematic review in alignment with PRISMA guidelines. The review involves a comprehensive, structured search of multiple electronic databases.</p><p><strong>Data sources and methods: </strong>We created two groups: Group 1, case reports and series, and Group 2, randomized control trials and cohorts with intermediate-risk PE who underwent advanced treatment. In addition, we performed an exploratory analysis in Group 1, created solely for descriptive purposes, to determine the frequency of the previously mentioned impending deterioration factors in the literature and further clarify their potential role in initiating advanced treatment.</p><p><strong>Results: </strong>We identified 1871 intermediate-high risk PE patients who received advanced therapy, divided into two groups: Group 1 for case reports and series, and Group 2 for randomized controlled trials and cohorts. In total, 77.1% reported SBP; the weighted average was 125.8 and 129.2 mmHg for Groups 1 and 2, respectively. The most common initial clinical presentations were dyspnea, syncope, and chest pain. In the exploratory analysis, we found that borderline SBP (110-120 mmHg), right ventricular dysfunction, and heart rate (⩾120 bpm) were the most frequent impending clinical deterioration factors.</p><p><strong>Conclusion: </strong>This systematic review shows that the SBP range for advanced treatment (129.2 and 125.8 mmHg) aligns with previous clinical models. However, it is important to recognize that while these SBP ranges may suggest practice variation, causality or definitive clinical instability cannot be inferred from aggregate data without patient-level outcomes. Outside of randomized controlled trials, clinical decision-making regarding advanced treatment may not fully align with international recommendations in real-world scenarios.</p><p><strong>Trial registration: </strong>Research Registry number: 2065.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251414584"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12891411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence for cardiology: from diagnosis to management.","authors":"Vasanthrie Naidoo, Lavanya Madamshetty, Suresh Babu Naidu Krishna","doi":"10.1177/17539447251406847","DOIUrl":"10.1177/17539447251406847","url":null,"abstract":"<p><p>Artificial intelligence (AI) and machine learning are rapidly transforming cardiac electrophysiology, offering new avenues for diagnosing, managing, and treating cardiac arrhythmias. These technologies leverage diverse data sources, including clinical records, imaging, and electrical waveforms, to support decision-making and optimize outcomes, particularly in procedures such as cardiac ablation. This scoping review explores the evolving role of AI in cardiology, emphasizing its applications in diagnostics, predictive analytics, and procedural innovations. It also examines the collaborative dynamics of interdisciplinary teams, highlighting how professionals, such as electrophysiologists, computer scientists, clinicians, nurses, perfusionists, and technologists, contribute to identifying and solving key challenges in the field. The integration of AI into cardiology is not only enhancing diagnostic precision and patient outcomes but also streamlining healthcare delivery. As technological capabilities expand, AI is poised to play an increasingly central role in preventive cardiology, enabling more accurate risk assessments, earlier interventions, and the promotion of healthier lifestyles. However, the successful implementation of AI requires thoughtful coordination across disciplines and a clear understanding of its limitations and ethical considerations. This review underscores the importance of fostering interdisciplinary collaboration and aligning AI innovations with clinical needs. It also identifies barriers to adoption and proposes strategies for integrating AI tools into routine practice. Ultimately, the findings aim to guide stakeholders, including researchers, clinicians, and policymakers, in advancing the development and application of AI systems in cardiology. By doing so, the healthcare community can move toward reducing the global burden of cardiovascular disease and improving population health. The insights presented here, after a review of 142 studies, offer a roadmap for future research and clinical integration, ensuring that AI continues to serve as a catalyst for innovation and excellence in cardiac care.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251406847"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing cardiovascular imaging in Iraq: infrastructure, gender diversity, and future perspectives.","authors":"Hasan Ali Farhan, May Saad Al-Jorani","doi":"10.1177/17539447261418111","DOIUrl":"10.1177/17539447261418111","url":null,"abstract":"<p><p>Cardiovascular imaging (CVI) provides an essential and accurate assessment of cardiac anatomy, function, and prognosis, thereby guiding management planning in long-term illnesses. It plays an essential role in modern cardiology in Iraq, where the adoption of advanced CVI technologies has enhanced diagnostic precision and patient care. However, there are some limitations that may interrupt the specialized improvement process, including a shortage of specialized personnel, limited infrastructure, and economic barriers. To address these challenges, the Iraqi Council of Cardiology established a nationally accredited CVI fellowship program in 2019. The key feature to initiate the program is the deliberate integration of diversity, particularly gender and geographic representation, into the training framework. This approach yielded a significantly high participation of women in CVI compared to other cardiology subspecialties in Iraq, which eventually reflected a special regional trend and productive response to workforce gaps. Also, geographic diversity has widened access to expertise across governorates, supporting equitable healthcare delivery. Regardless of these advances, marked progress needs continued investment in infrastructure and alignment with international standards. Furthermore, expanding and strengthening research capacity and fostering international collaborations will be critical to advance the whole process. The Iraqi CVI program has illustrated the framework of policy, training, and workforce planning that will overcome systemic limitations and contribute to the advancement of equitable cardiovascular care in resource-limited settings.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447261418111"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12936369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"35 Years of modern cardiothoracic surgery in Ghana: a legacy of excellence, a future of perfection.","authors":"Kow Entsua-Mensah, George Ekem-Ferguson, Mark Mawutor Tettey, Martin Tamatey, Innocent Adzamli","doi":"10.1177/17539447261445309","DOIUrl":"https://doi.org/10.1177/17539447261445309","url":null,"abstract":"<p><p>The National Cardiothoracic Centre at the Korle Bu Teaching Hospital stands as a premier institution for cardiothoracic surgery in Ghana and West Africa. Established in 1989 under the leadership of Prof. Kwabena Frimpong-Boateng, the Centre recently celebrated 35 years of advancing modern cardiothoracic surgery in Ghana. The Centre also serves as an accredited training hub for cardiothoracic surgeons, critical care nurses and other allied health professionals in the West African sub-region. Over the past 35 years, the Centre has undertaken 14,981 surgeries and other cardiac procedures for Ghanaians and other African countries. The centre has also locally trained a total of 30 cardiothoracic surgeons for Ghana, Nigeria and Ethiopia, and has recently commenced training its first surgeon for the Gambia. Among the Centres' challenges are infrastructural deficit, limited health financing, human resource deficit and technological gaps. This narrative review highlights the Centre's 35 years of existence, its contributions to the cardiothoracic surgical landscape in West Africa, challenges and its future directions.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447261445309"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pivotal role of echocardiography in structural heart interventions: from planning to success.","authors":"Tuğba Kemaloğlu Öz, Michael Hii, Deniz Kemaloglu, Ahmed Mohamed Fareed, Konstantinos Papadopoulos, Edoardo Zancanaro, Anosh Shane Sivashanmugarajah, Majo Joseph","doi":"10.1177/17539447251412630","DOIUrl":"10.1177/17539447251412630","url":null,"abstract":"<p><p>Structural heart disease (SHD) encompasses a wide range of congenital and acquired cardiac abnormalities, increasingly treated with transcatheter interventions. Echocardiography plays a crucial role in optimising these procedures, providing high-resolution imaging for pre-procedural planning, real-time guidance and post-intervention assessment. The shift from two-dimensional to advanced three/four-dimensional (3D/4D) echocardiography has significantly enhanced the visualisation of complex cardiac structures, improving procedural success and patient safety. The purpose of this review article is to provide an overview of the vital role of echocardiography in key structural heart interventions, including mitral transcatheter edge-to-edge repair, transcatheter aortic valve replacement, paravalvular leak closure, left atrial appendage occlusion and atrial septal defect closure. It highlights the integration of 3D/4D imaging and advanced Doppler techniques in refining procedural precision, optimising decision-making, and improving patient outcomes. The evolving field of interventional echocardiography continues to shape SHD management, making more minimally invasive treatments available to patients.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251412630"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel predictor of short-term prognosis in acute pulmonary embolism: inflammatory burden index.","authors":"Lingwei Huang, Dan Xiao, Meimei Yang, Zixing Wu, Fei He","doi":"10.1177/17539447251407467","DOIUrl":"10.1177/17539447251407467","url":null,"abstract":"<p><strong>Background: </strong>Inflammation significantly impacts disease progression and prognosis in acute pulmonary embolism (APE); however, the optimal method to quantify this inflammation for prognostic purposes remains unclear.</p><p><strong>Objectives: </strong>We aimed to identify the most effective blood-based inflammatory marker for predicting short-term mortality in patients with APE.</p><p><strong>Methods: </strong>We retrospectively analyzed 301 patients with APE. We compared the predictive performance of nine inflammatory markers for 30-day mortality, focusing on the inflammatory burden index (IBI), and contrasted it with the standard clinical score (sPESI).</p><p><strong>Results: </strong>After adjusting for potential confounders, a higher IBI was strongly and independently associated with an increased risk of 30-day mortality. IBI demonstrated superior predictive ability compared with all other inflammatory markers and the sPESI score. The relationship between IBI and mortality risk was linear; higher IBI values corresponded to greater mortality risk.</p><p><strong>Conclusion: </strong>IBI is a robust and independent predictor of short-term survival in patients with APE. Calculated from routine blood tests (C-reactive protein, neutrophil, and lymphocyte counts), it offers a simple, rapid, and cost-effective tool that may enhance early risk stratification and guide personalized treatment decisions in clinical practice. Further validation in independent cohorts is required to confirm its prognostic utility.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251407467"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12764757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Troponins and echocardiography: role in detecting myocardial injury in burn patients.","authors":"Mohammed AbuBaha, Samia Aldwaik, Ameer Awashra, Fathi Milhem, Anwar Zahran, Husam Hamshary, Hasan Fuqha, Mohammad Bdair, Bara Abubaha, Sarah Saife, Abdalhakim Shubietah","doi":"10.1177/17539447251414564","DOIUrl":"10.1177/17539447251414564","url":null,"abstract":"<p><p>Severe burn injuries result in a massive systemic inflammatory and hypermetabolic response, often disrupting multiple organ systems, including the cardiovascular system. Cardiac troponins are frequently elevated in burn patients, but the interpretation of these elevations is hardly straightforward. Sometimes, elevated troponin means type 1 myocardial infarction (MI) due to an acute coronary event, but it might also reflect type 2 MI due to an imbalance between body oxygen demand and supply, or even non-ischemic myocardial injury from things like overwhelming inflammation, sepsis, or direct thermal effects on the heart itself. This narrative review explores the prevalence, underlying pathophysiological mechanisms, diagnostic challenges, and prognostic implications of troponin elevation in burn patients. We discussed the limitations of applying conventional MI diagnostic criteria in this unique population. The role of electrocardiographic and echocardiographic assessment, as well as the potential utility of high-sensitivity troponin assays, is also discussed. Understanding of how burn pathophysiology relates to myocardial injury is essential for accurate diagnosis, improved management, and better outcomes in this highly vulnerable group of patients.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447251414564"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}