Therapeutic Advances in Cardiovascular Disease最新文献

{"title":"Real-world effectiveness and safety of torsemide and spironolactone fixed dose combination in Indian heart failure patients (RESTORE-HF study): a prospective, multicenter, observational study.","authors":"Chandrashekhar K Ponde, Devanu Ghosh Roy, Uday Jadav, Arun Mohanty, Karan Dang, Febin Francis, Nitin Zalte, Amarnath Sugumaran, Sandesh Sawant, Senthilnathan Mohanasundaram","doi":"10.1177/17539447261430243","DOIUrl":"10.1177/17539447261430243","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) remains a major public health challenge in India, with a need for effective and well-tolerated therapeutic strategies.</p><p><strong>Objective: </strong>The RESTORE-HF study evaluated the real-world effectiveness and safety of torsemide-spironolactone fixed-dose combination (FDC) in Indian patients with HF.</p><p><strong>Design: </strong>Prospective, multicenter, observational study.</p><p><strong>Methods: </strong>This study was conducted across 101 sites in India. Patients aged 18-75 years with HF with reduced ejection fraction and signs of congestion were enrolled and initiated on the torsemide-spironolactone FDC. Participants were followed over 3 weeks from baseline. The primary objective was the change in body weight. Secondary endpoints included changes in New York Heart Association (NYHA) functional class, edema, occurrence of adverse events (AEs), and physician and patient assessments of efficacy and tolerability.</p><p><strong>Results: </strong>Of the 1841 patients screened, 1752 were enrolled, and 1520 completed the study. The mean (SD) age of participants was 58.61 (9.45) years, of whom 61.05% were male. The study showed a significant reduction in mean body weight was observed from 75.54 kg at baseline to 73.13 kg at week 3 (mean difference: 2.41 kg; <i>p</i> < 0.0001). Additionally, an improvement in NYHA functional class and edema was observed over 3 weeks from baseline. Overall, 22.11% patients achieved no-edema stage. Only three mild AEs related to loose stools were reported, and no serious AEs or deaths occurred. Over 98% of physicians and patients rated the therapy favorably.</p><p><strong>Conclusion: </strong>The RESTORE-HF study demonstrated that the torsemide-spironolactone FDC may be associated with a mean body weight reduction of 2.41 kg and may be generally well-tolerated in Indian heart failure patients. Furthermore, the FDC may be linked to significant symptomatic improvement over 3 weeks in real-world clinical practice.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"20 ","pages":"17539447261430243"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies.","authors":"Andra Maria Ciutac, Tiberiu Pana, Dana Dawson, Phyo Kyaw Myint","doi":"10.1177/17539447241309673","DOIUrl":"10.1177/17539447241309673","url":null,"abstract":"<p><p>This review aims to describe the sex differences in heart failure (HF) patients, with a particular emphasis on the effect of cardiovascular ageing. Additionally, it takes into consideration the sex-related variation in cardiovascular health and physiology and the role ageing plays in HF and its implications in drug therapy. The pharmacokinetics and pharmacodynamics of the common HF medications, classified according to the established sub-types, are summarised with respect to sex-specific documented findings. Despite numerous studies confirming significant differences in HF outcomes according to sex, there are no current guidelines that consider patients' sex in medical therapy of HF. Moreover, females are significantly under-represented in research trials, as well as under-treated in clinical practice, which hinders our understanding of HF in this demographic. Most of the current knowledge on sex-specific HF therapies is driven by secondary analyses of studies not primarily undertaking sex-specific analyses. Therefore, we propose a multi-faceted approach, including increased awareness among healthcare providers and more inclusive research to create a personalised care plan accounting for sex differences in HF management. Given the highlighted knowledge gaps, it is paramount for new research efforts to account for the different sex phenotypes in HF.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447241309673"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thanks to reviewers.","authors":"","doi":"10.1177/17539447251316497","DOIUrl":"https://doi.org/10.1177/17539447251316497","url":null,"abstract":"","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251316497"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of anemia on the association between red cell distribution width and 1-year mortality in acute heart failure patients.","authors":"Sherelym Alessandra Maita-Arauco, Sthephanie María Quispe-Vasquez, Vicente Aleixandre Benites-Zapata, Pedro Antonio Segura-Saldaña","doi":"10.1177/17539447251366798","DOIUrl":"https://doi.org/10.1177/17539447251366798","url":null,"abstract":"<p><strong>Background: </strong>Different accessible and low-cost biomarkers have been investigated to stratify patients with acute heart failure (AHF). One of them is the red cell distribution width (RDW), which proved to be a greater prognostic marker of mortality than other conventional markers.</p><p><strong>Objective: </strong>Therefore, the objective of our study is to determine whether the anemic status modifies the magnitude of association between high RDW and 1-year mortality in patients with AHF.</p><p><strong>Design: </strong>Observational, analytical, retrospective cohort study.</p><p><strong>Methods: </strong>We included participants ⩾18 years old hospitalized with a diagnosis of AHF. As an association measure, a crude and adjusted generalized linear model of the Poisson family calculated the risk ratio (RR) with a 95% confidence interval (95% CI).</p><p><strong>Results: </strong>In all, 709 participants with an average age of 73.48 years were included. At 1 year, the risk of dying was three times higher with high RDW (RR = 3.05, 95% CI: 1.39-6.66; <i>p</i> < 0.01). In anemic participants, the risk of dying at 1 year is two times greater with high RDW (RR = 2.18, 95% CI: 0.91-5.22; <i>p</i> = 0.07), while in non-anemic participants, the risk of dying increased almost seven times (RR = 6.95, 95% CI: 1.65-29.23; <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>High RDW is a risk factor for mortality at 1 year in patients with AHF. A greater magnitude of association was found in non-anemic patients.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251366798"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practice on electrocardiography interpretation among nurses in emergency and intensive care units of selected public hospitals in Addis Ababa, Ethiopia.","authors":"Marta T/Mariam, Wagari Tuli Nora, Ousman Adal, Lemlem Beza Demisse","doi":"10.1177/17539447251403402","DOIUrl":"10.1177/17539447251403402","url":null,"abstract":"<p><strong>Background: </strong>Rapid interpretation of electrocardiography (ECGs) is essential for reducing patient mortality and morbidity associated with heart conditions. Despite its significance, many healthcare providers struggle to achieve proficiency in ECG interpretation.</p><p><strong>Objective: </strong>This study assessed nurses' knowledge, practices, and associated factors regarding ECG interpretation in the emergency and intensive care units of selected public hospitals in Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted to evaluate nurses' knowledge, practices, and factors related to ECG interpretation in selected public hospitals of emergency and intensive care units in Addis Ababa, Ethiopia. Data were collected using structured, self-administered questionnaires and analyzed using SPSS version 26. Binary logistic regression models were employed to identify associations between the dependent and independent variables.</p><p><strong>Results: </strong>Among 255 of the study participants, only 60 (23.5%) and 69 (27.1%) of them demonstrated good knowledge and practice in ECG strip interpretation, respectively. The most frequently recognized ECG strip was asystole. Factors associated with good knowledge and practice encompassed holding a master's degree, receiving ECG training, and working in intensive care units.</p><p><strong>Conclusion: </strong>This study identified the lack of knowledge and practice among nurses in ECG interpretation. The findings highlight the need for training programs and experience-sharing initiatives to enhance nurses' proficiency in ECG interpretation which might ultimately improve patient outcomes.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251403402"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Quantifying the 'distance to LDL-C goal' in patients at very high cardiovascular risk with hyperlipidaemia in Germany: a retrospective claims database analysis\".","authors":"","doi":"10.1177/17539447251333039","DOIUrl":"10.1177/17539447251333039","url":null,"abstract":"","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251333039"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of extent and localization of precordial ST-segment depression in acute inferior myocardial infarction as an indicator of infarct severity, coronary artery involvement, and cardiac outcomes.","authors":"Mahboobeh Gholipour, Sama Noruzi, Mani Moayerifar, Anita Khalili, Behrad Eftekhari, Fardin Mirbolouk, Jalal Kheirkhah, Arsalan Salari, Tolou Hassandokht, Golshan Ghasemzadeh","doi":"10.1177/17539447251326154","DOIUrl":"10.1177/17539447251326154","url":null,"abstract":"<p><strong>Background: </strong>It is crucial to timely recognize individuals presenting high-risk characteristics indicative of acute myocardial infarction.</p><p><strong>Objectives: </strong>Our study aimed to analyze the significance of evaluating ST-segment depression in patients with acute inferior myocardial infarction (MI). We assessed precordial ST-T changes as an indicator of ongoing ischemia, examined their correlation with the extent of coronary artery involvement, and potential association with both early and late cardiac outcomes.</p><p><strong>Methods: </strong>We enrolled 200 hospitalized patients with acute inferior MI who displayed ST depression in their precordial leads and underwent angiography. Individuals were divided into three groups based on the location of ST depression (V1-V3, V4-V6, and V1-V6). Demographic and echocardiographic data were extracted, and cardiac outcomes were assessed during hospitalization and follow-ups.</p><p><strong>Results: </strong>The findings revealed significant associations between ST depression in leads V1-V6 and V4-V6 with left ventricular systolic dysfunction, mitral regurgitation severity, and the extent of coronary artery stenosis in comparison with ST depression in V1-V3 (<i>p</i> < 0.05). Furthermore, a notable connection was found between the involved vessels and the degree of ST depression in precordial leads (<i>p</i> < 0.05). Moreover, individuals with prominent ST depression in V1-V6 and V1-V3 exhibited poorer outcomes (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Greater ST-segment depression in V1-V6 and V4-V6 in comparison with V1-V3 may signal multivessel disease, severe ischemia. Adverse outcomes like heart failure showed in V1-V6 especially V1-V3 versus V4-V6. This ST depression in acute inferior MI patients could indicate simultaneous ischemia or necrosis in other left ventricle regions, worsening cardiac function and prognosis. Thus, timely interventions are crucial.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251326154"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid blowout syndrome as a late complication of carotid stenting in irradiated neck: covered stent treatment using the \"No-Touch\" technique.","authors":"Yohei Takenobu, Noriko Nomura, Yoshito Sugita, Akihiro Okada, Takeshi Kawauchi, Yukinori Terada, Mizuha Toyama, Akihiro Furuta, Hiroomi Nishio, Atsushi Iwakura, Manabu Inoue, Kenji Hashimoto","doi":"10.1177/17539447251366781","DOIUrl":"10.1177/17539447251366781","url":null,"abstract":"<p><p>Carotid blowout syndrome (CBS) is a potentially fatal condition requiring prompt diagnosis and intervention. CBS primarily affects patients with a history of surgery or irradiation for head and neck malignancies. In this report, we describe a case of CBS in which the carotid artery ruptured 2 months after carotid artery stenting in a patient with a previous history of surgery and irradiation for pharyngeal cancer. Although the distance between the orifice of the common carotid artery and the ruptured site was short, <i>the \"no-touch\" technique</i>-using the Newton-shaped stiff inner catheter (Newton-T^®, Medikit) during the guiding catheter navigation-and snare fixation enabled a stable procedure. Two self-expanding covered stents (GORE^® VIABAHN^®, Gore) covered the ruptured site. Despite adverse conditions, the combination of these techniques led to effective management of impending CBS, a potentially fatal disease. This case report highlights the feasibility of covered stents for CBS and the techniques used for guiding catheter navigation and stabilization throughout the procedure.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251366781"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes among patients with coronary artery bypass grafts presenting with acute coronary syndrome: impact of revascularization.","authors":"Hilary J Bews, Brett Hiebert, Shuangbo Liu, John Ducas, Amir Ravandi, Kunal Minhas, Malek Kass, Michael P Love, Harindra C Wijeysundera, Ashish H Shah","doi":"10.1177/17539447241308047","DOIUrl":"10.1177/17539447241308047","url":null,"abstract":"<p><strong>Background: </strong>Patients post-coronary artery bypass graft (CABG) can re-present with acute coronary syndrome (ACS); however, culprit lesion identification, as well as revascularization, is often challenging. Furthermore, the impact of revascularization in this patient group is relatively unknown.</p><p><strong>Objectives: </strong>The purpose of our study was to evaluate the efficacy of percutaneous coronary intervention (PCI) in patients with previous CABG surgery presenting with ACS.</p><p><strong>Methods: </strong>Using data from the Manitoba Center for Health Policy, we identified patients treated with CABG between April 1979 and March 2018, who subsequently presented with the primary diagnosis of ACS. Patients were divided into four groups: (1) managed medically and not investigated by cardiac catheterization and (2) investigated by cardiac catheterization and treated (2a) medically, (2b) with PCI, and (2c) with redo-CABG. Inverse probability treatment-weighted survival analyses were performed. Ethical approval was obtained from the local research board.</p><p><strong>Results: </strong>Nearly 20% of patients treated with CABG presented with ACS at a median of 7.2 years (age at the time of CABG: 66 years (interquartile range: 58-73 years); 75.6% male). Patients treated with PCI (<i>N</i> = 929) demonstrated improved survival compared to the patients investigated by catheterization but treated medically (<i>N</i> = 952; hazard ratio 0.87, 95% confidence interval 0.77-0.97, <i>p</i> = 0.02). Patients who underwent redo CABG (<i>N</i> = 171) experienced 13% mortality within the first year, but subsequently, demonstrated a trend toward improved survival.</p><p><strong>Conclusion: </strong>ACS is not uncommon following CABG. Revascularization is associated with prognostic improvement; however, such could be accounted for by inherent group differences, including comorbidities and coronary anatomy These findings should be validated in a prospective randomized study.</p>","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447241308047"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor entitled \"Carotid artery atherosclerosis, low and high volumes of high-intensity interval training in patients after myocardial infarction: the precision of measurement embarks on a precise measurement protocol\".","authors":"Rodrigo Aispuru-Lanche, Sara Maldonado-Martín","doi":"10.1177/17539447251328169","DOIUrl":"10.1177/17539447251328169","url":null,"abstract":"","PeriodicalId":23035,"journal":{"name":"Therapeutic Advances in Cardiovascular Disease","volume":"19 ","pages":"17539447251328169"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}