The Open Biology Journal最新文献_第3页

Billions of Human Brains Immersed Within a Shared Geomagnetic Field: Quantitative Solutions and Implications for Future Adaptations 数十亿人脑沉浸在共同的地磁场中:定量解决方案和对未来适应的影响

The Open Biology Journal Pub Date : 2013-10-18 DOI: 10.2174/1874196701306010008

M. Persinger

引用次数: 13

Safety of Using Diapers Containing Copper Oxide in Chronic Care Elderly Patients 老年慢性护理患者使用含氧化铜纸尿裤的安全性

The Open Biology Journal Pub Date : 2013-02-22 DOI: 10.2174/1874196701306010001

I. Weinberg, A. Lazary, A. Jefidoff, Vatine J-J, G. Borkow, N. Ohana

{"title":"Safety of Using Diapers Containing Copper Oxide in Chronic Care Elderly Patients","authors":"I. Weinberg, A. Lazary, A. Jefidoff, Vatine J-J, G. Borkow, N. Ohana","doi":"10.2174/1874196701306010001","DOIUrl":"https://doi.org/10.2174/1874196701306010001","url":null,"abstract":"Copper has very potent antibacterial, antifungal, antiviral and acaricidal properties. Recently the use of copper alloys in hospital wards has been shown to reduce bioburden and nosocomial infection rates. We hypothesized that the use of copper oxide in textiles and other products that are in close contact with the patients may significantly reduce bioburden in clinical settings and consequently reduce the risk of nosocomial infections. In order to test this hypothesis we intend to conduct a trial in which we will examine if the nosocomial infection rates in a chronic care ward will be reduced when all the textile products will include copper oxide. The risk of adverse reactions due to dermal contact with copper are considered extremely low and medical devices containing copper, such as intrauterine devices and dental amalgams, are safely used for decades. Textile products containing copper oxide are being sold worldwide for several years and not even one adverse reaction was noted. However, in spite of all the above, and in preparation to the clinical trial we intend to conduct in a chronic care ward (long-term care facility), we conducted this preliminary study in which we examined the safety of using copper oxide impregnated diapers in 16 chronic care patients that used the diapers for 6 consecutive months. Importantly, not even one adverse reaction was recorded during the whole trial, indicating the high safety of the diapers. Therefore, this study allows us to examine the efficacy of textiles containing copper oxide in reducing nosocomial infections in larger populations, including in frail chronic care patients.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85747051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Computational Tools for Genome-Wide miRNA Prediction and Study 全基因组miRNA预测和研究的计算工具

The Open Biology Journal Pub Date : 2012-11-02 DOI: 10.2174/1874196701205010023

Tareq B. Malas, T. Ravasi

引用次数: 4

Analysis of the Effect of Wearing Copper Oxide Impregnated Socks on Tinea Pedis Based on "Before and After" Pictures - A Statistical Follow-up Tool 基于“前后对比”图片分析穿氧化铜浸渍袜子对足癣的影响——一个统计跟踪工具

The Open Biology Journal Pub Date : 2012-05-18 DOI: 10.2174/1874196701205010017

M. E. Gargiulo, A. Elias, G. Borkow

{"title":"Analysis of the Effect of Wearing Copper Oxide Impregnated Socks on Tinea Pedis Based on \"Before and After\" Pictures - A Statistical Follow-up Tool","authors":"M. E. Gargiulo, A. Elias, G. Borkow","doi":"10.2174/1874196701205010017","DOIUrl":"https://doi.org/10.2174/1874196701205010017","url":null,"abstract":"The assessment of skin conditions by digital images as part of the evaluation of treatment efficacy is not widely used in podiatry. The main objective of our study was to evaluate quantitative measuring of tinea pedis (athlete's foot) related medical endpoints via digital images of the affected feet areas before and after treatment as a supporting tool for podiatrists. In order to do so, we analyzed photographs taken of patients who had participated in a previous clinical study. During this already published study, the patient's fungal feet infections were treated only by wearing of antifungal socks containing copper oxide. The efficacy of the treatment was then determined solely by clinical observations of the podiatrist. In the current study, we randomly and blindly analyzed 282 digital images of patient's feet taken before and after using the socks in the pilot study. The affected feet areas, in which the tinea pedis infection was manifested by fissuring, scaling, erythema and/or vesicular eruptions, were determined before and after treatment by using ImageTool software. Statistical analysis of these determinations demonstrated a significant reduction in the severity of all 4 endpoints analyzed (p<0.05). This is in accordance with the results described in the published study, further establishing that using socks containing copper oxide is efficacious in treating tinea pedis. The present study thus demonstrates that statistical analysis of quantitative data obtained from digital images taken during treatment of tinea pedis is feasible and may serve as a tool for podiatrists in monitoring treatment.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80212466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

An Integrated Bioinformatics and Computational Biology Approach Identifies New BH3-Only Protein Candidates. 综合生物信息学和计算生物学方法鉴定新的BH3-Only候选蛋白。

The Open Biology Journal Pub Date : 2012-05-04 DOI: 10.2174/1874196701205010006

Robert G Hawley, Yuzhong Chen, Irene Riz, Chen Zeng

{"title":"An Integrated Bioinformatics and Computational Biology Approach Identifies New BH3-Only Protein Candidates.","authors":"Robert G Hawley, Yuzhong Chen, Irene Riz, Chen Zeng","doi":"10.2174/1874196701205010006","DOIUrl":"https://doi.org/10.2174/1874196701205010006","url":null,"abstract":"<p><p>In this study, we utilized an integrated bioinformatics and computational biology approach in search of new BH3-only proteins belonging to the BCL2 family of apoptotic regulators. The BH3 (BCL2 homology 3) domain mediates specific binding interactions among various BCL2 family members. It is composed of an amphipathic α-helical region of approximately 13 residues that has only a few amino acids that are highly conserved across all members. Using a generalized motif, we performed a genome-wide search for novel BH3-containing proteins in the NCBI Consensus Coding Sequence (CCDS) database. In addition to known pro-apoptotic BH3-only proteins, 197 proteins were recovered that satisfied the search criteria. These were categorized according to α-helical content and predictive binding to BCL-xL (encoded by BCL2L1) and MCL-1, two representative anti-apoptotic BCL2 family members, using position-specific scoring matrix models. Notably, the list is enriched for proteins associated with autophagy as well as a broad spectrum of cellular stress responses such as endoplasmic reticulum stress, oxidative stress, antiviral defense, and the DNA damage response. Several potential novel BH3-containing proteins are highlighted. In particular, the analysis strongly suggests that the apoptosis inhibitor and DNA damage response regulator, AVEN, which was originally isolated as a BCL-xL-interacting protein, is a functional BH3-only protein representing a distinct subclass of BCL2 family members.</p>","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384560/pdf/nihms-374801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30736415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Effects of n-Octyl-β-D-Glucopyranoside on Human and Rat Erythrocyte Membrane Stability Against Hemolysis 正辛基-β- d -葡萄糖吡喃苷对人和大鼠抗溶血红细胞膜稳定性的影响

The Open Biology Journal Pub Date : 2012-04-11 DOI: 10.2174/1874196701205010001

C. Sblano, S. Micelli, Daniela Meleleo

{"title":"Effects of n-Octyl-β-D-Glucopyranoside on Human and Rat Erythrocyte Membrane Stability Against Hemolysis","authors":"C. Sblano, S. Micelli, Daniela Meleleo","doi":"10.2174/1874196701205010001","DOIUrl":"https://doi.org/10.2174/1874196701205010001","url":null,"abstract":"The practical importance for the pharmaceutical and cosmetics industries of the interactions between biological membranes and surfactant molecules has led to intensive research within this area. The interactions of non-ionic surfactant n-octyl-β-D-glucopyranoside (OG) with the human and rat erythrocyte membranes were studied. The in vitro hemolytic and antihemolytic activities were determined by employing a method in which both erythrocytes were added to the hypotonic medium containing OG at different concentrations, and the amount of haemoglobin released was determined. n- octyl-β-D-glucopyranoside was found to have a biphasic effect on both types of erythrocyte membrane. We also investigated the interactions of OG with the erythrocyte membrane in isotonic medium; the dose-dependent curves show similar behaviour in both human and rat erythrocytes. Our results showed that OG has greater antihemolytic potency on rat than on human erythrocytes; furthermore, rat erythrocytes were more sensitive than human erythrocytes to hypotonic shock. How the different lipoprotein structure of these erythrocytes determines a difference in antihemolytic activity is discussed.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89843603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of Roundup ® Pesticide on the Stability of Human Erythrocyte Membranes and Micronuclei Frequency in Bone Marrow Cells of Swiss Mice 农达农药对瑞士小鼠红细胞膜稳定性及骨髓细胞微核频率的影响

The Open Biology Journal Pub Date : 2011-08-12 DOI: 10.2174/1874196701104010054

Humberto Gabriel Rodrigues, N. Penha-Silva, Mariana Ferreira Araujo, H. Nishijo, T. Aversi-Ferreira

{"title":"Effects of Roundup ® Pesticide on the Stability of Human Erythrocyte Membranes and Micronuclei Frequency in Bone Marrow Cells of Swiss Mice","authors":"Humberto Gabriel Rodrigues, N. Penha-Silva, Mariana Ferreira Araujo, H. Nishijo, T. Aversi-Ferreira","doi":"10.2174/1874196701104010054","DOIUrl":"https://doi.org/10.2174/1874196701104010054","url":null,"abstract":"Pesticides can affect the health of living organisms through different mechanisms such as membrane denaturation. The evaluation of the deleterious effects of chemical agents on biological membranes can be performed through the analysis of the stability of erythrocytes against a concentration gradient of certain chemical agent in physiologic saline solution. This work analyzed the effect of the herbicide Roundup ® on the membrane of human erythrocytes in blood samples collected with EDTA or heparin as anticoagulant agent. The results were analyzed through spectrophotometry at 540 nm and light microscopy. There was an agreement between spectrophometric and morphologic analyses. At the concentration limit recommended for agricultural purposes, Roundup ® promoted 100% of hemolysis. The D50Roundup ® values obtained for human blood samples collected with EDTA were not significantly different from those obtained for samples collected with heparin. However, the lysis curves presented lower absorbance values at 540 nm in the presence of blood collected with EDTA in relation to that collected with heparin, probably due to hemoglobin precipitation with EDTA. This work also analyzed the effects of three different Roundup ® doses (0.148, 0.754 and 1.28 mg/kg) on the micronuclei frequency in bone marrow cells of Swiss mice in relation to a positive control of cyclophosphamide (250 mg/kg). The two highest Roundup ® doses showed the same genotoxicity level as the positive control.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91501574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

On the Role of G Protein-Coupled Receptors Oligomerization G蛋白偶联受体寡聚化的作用研究

The Open Biology Journal Pub Date : 2011-05-26 DOI: 10.2174/1874196701104010047

Maricel Gómez-Soler, S. Ahern, V. Fernández-Dueñas, F. Ciruela

引用次数: 1

Comparative Physiology of the Respiratory System in the Animal Kingdom 动物王国呼吸系统的比较生理学

The Open Biology Journal Pub Date : 2011-03-16 DOI: 10.2174/1874196701104010035

O. Carvalho, C. Gonçalves

{"title":"Comparative Physiology of the Respiratory System in the Animal Kingdom","authors":"O. Carvalho, C. Gonçalves","doi":"10.2174/1874196701104010035","DOIUrl":"https://doi.org/10.2174/1874196701104010035","url":null,"abstract":"The inconstant environment in which animals lives and the variation of their metabolic states determined the gas exchangers system that must be able to operate efficiently across a spectrum of conditions that range from resting to exercise and even under hypoxia. The primordial respiratory organs that evolved for water breathing were the gills, evaginated gas exchangers, whereas for terrestrial air breathing developed a invaginated gas exchangers, the lungs. Specialized organs evolved for animals that can extract oxygen from water and air, consider as a transitional breathing (or bimodal). From amphibians to mammals, it is possible to verify that the dimensions of their respiratory units are being increasingly smaller and the number per unit of lung volume increases. The evolution of the vertebrate respiratory system achieved its most efficient state in birds, with their constant volume parabronchial lungs and their highly compliant air sacs with low pressure ventilation that, enabling them to sustained flapping flight. In contrast, the mammalian bronchoalveolar lungs, with their mandatory high-pressure ventilation and great volume changes, allowed the development of adaptations that favour, for example, a highly mobile trunk for high velocity running predators or to live in a deep-sea.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72812242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Fighting Nosocomial Infection Rates in the General Surgery Department of the Teaching Hospital Gabriel Toure in Bamako, Mali 马里巴马科加布里埃尔图雷教学医院普通外科的医院感染率

The Open Biology Journal Pub Date : 2010-09-08 DOI: 10.2174/18741967010030100087

T. A, Traore A, C. Y, Diallo S, Dembele B T, Diakite I, Diani N, S. B, Traore B A, Diallo G

{"title":"Fighting Nosocomial Infection Rates in the General Surgery Department of the Teaching Hospital Gabriel Toure in Bamako, Mali","authors":"T. A, Traore A, C. Y, Diallo S, Dembele B T, Diakite I, Diani N, S. B, Traore B A, Diallo G","doi":"10.2174/18741967010030100087","DOIUrl":"https://doi.org/10.2174/18741967010030100087","url":null,"abstract":"Nosocomial infections (NI) or hospital-acquired diseases are indicators of the quality of care. This study conducted in Mali aimed to determine the frequency of nosocomial infections, to recognize the risk factors, to identify the pathogens and their sensitivity to antibiotics and to determine the additional cost of care. The study lasted 6 months from January to June 2007, and the diagnosis of nosocomial infections was based on criteria from the USA C.D.C (Center for Disease Control). We identified 460 patients and 44 among them (9.6%) were affected by nosocomial infections, which included 31 cases of surgical site infections (57.4%), 9 cases of infections on burns (16.7%), 7 cases of lung infections (13%), and 7 cases of urinary tract infections (13%). The most frequently isolated bacteria were Escherichia coli (44%). All isolated bacteria were resistant to amoxicillin and 46% were sensitive to ciprofloxacin. The risk factors for infection were emergency surgery, ASA (American Society of Anaesthesiology) class and the type of surgery defined by Altemeir. The preoperative preparation of the patients, the strict respect of hygiene and asepsis to the operating room can reduce the frequency of NI in our country.","PeriodicalId":22949,"journal":{"name":"The Open Biology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80384411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11