The open prostate cancer journal最新文献_第8页

Signet Ring Cell Carcinoma of the Prostate: Case Report and Review of the Literature 前列腺印戒细胞癌:病例报告及文献复习

The open prostate cancer journal Pub Date : 1999-05-01 DOI: 10.1046/J.1525-1411.1999.09923.X

Ken‐ryu Han, A. Pantuck, N. Lobby, J. Marmar

引用次数: 0

Prostate Cancer Susceptibility Genes: A Current Update 前列腺癌易感基因:最新进展

The open prostate cancer journal Pub Date : 1999-05-01 DOI: 10.1046/J.1525-1411.1999.09928.X

H. Grönberg

引用次数: 1

Extended Follow-Up of Patients with Stage T2a Prostate Adenocarcinoma After Outpatient Conformal Brachytherapy: Risk Stratification for Treatment Optimization 门诊适形近距离放射治疗后T2a期前列腺癌患者的延长随访:优化治疗的风险分层

The open prostate cancer journal Pub Date : 1999-05-01 DOI: 10.1046/J.1525-1411.1999.09920.X

S. Sundararaman, D. Nori, S. Parikh, J. Moni, A. Osian, C. Wilson

{"title":"Extended Follow-Up of Patients with Stage T2a Prostate Adenocarcinoma After Outpatient Conformal Brachytherapy: Risk Stratification for Treatment Optimization","authors":"S. Sundararaman, D. Nori, S. Parikh, J. Moni, A. Osian, C. Wilson","doi":"10.1046/J.1525-1411.1999.09920.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.09920.X","url":null,"abstract":"Brachytherapy is an excellent definitive treatment modality for select patients with localized prostate cancer. Sixty-four patients with Stage T2a prostate adenocarcinoma were identified from the series of prostate patients receiving conformal outpatient brachytherapy between 1990 and 1997. Pretreatment Gleason scores and prostate specific antigen (PSA) values ranged from 2 to 10 and 1.5 to 100, respectively. Median follow-up was 48.5 months. The 5-year overall survival rate was 82.5%, whereas the cause-specific survival rate was 93.7%. The biochemical freedom-from-relapse (bFFR), defined as a PSA level of ≤ 1.0 for patients presenting with Gleason scores of ≤ 5, was 68%; 80% with Gleason scores of ≤ 5 and presenting PSA levels of ≤ 10. In patients with Gleason scores of 6 at presentation, the overall bFFrR was 67%; 87% with a Gleason scores of 6 and PSA levels of ≤ 10. The bFFR was maintained in more than half of patients with Gleason scores of 7 only if they presented with PSA levels of ≤ 10. All patients who presented with PSA levels of ≤ 10 had bFFRs of 75%, compared to 36% for those patients presenting with PSA levels of > 10. These data show that patients with Gleason scores of ≤ 5 can achieve very good PSA control with brachytherapy, especially if the presenting PSA level is ≤ 10. Consideration of PSA is of greater import when a Gleason score ≥ 6 is encountered at presentation. Our data show that durable bFFR can be achieved in patients presenting with Stage T2a disease, Gleason scores of 5–7, and PSA levels of ≤ 10. These results need to be confirmed with further follow-up and other prospective data.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"50 1","pages":"131-137"},"PeriodicalIF":0.0,"publicationDate":"1999-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80961948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Variations in Urethral Warming Temperatures During Cryosurgery: The Impact On Post‐Treatment PSA Levels 冷冻手术期间尿道升温温度的变化:对治疗后PSA水平的影响

The open prostate cancer journal Pub Date : 1999-05-01 DOI: 10.1046/J.1525-1411.1999.09929.X

R. S. Gould

引用次数: 0

Induction of Prostate Apoptosis in Response to α1-Adrenoceptor Antagonists: Therapeutic Significance in Benign Prostatic Hyperplasia and Prostate Cancer α -肾上腺素能受体拮抗剂诱导前列腺细胞凋亡:对良性前列腺增生和前列腺癌的治疗意义

The open prostate cancer journal Pub Date : 1999-03-01 DOI: 10.1046/J.1525-1411.1999.09918.X

N. Kyprianou

引用次数: 0

Prostate Specific Antigen Levels: Effect of Sexual Activity 前列腺特异性抗原水平:性活动的影响

The open prostate cancer journal Pub Date : 1999-03-01 DOI: 10.1046/J.1525-1411.1999.09915.X

M. Collins, K. Kleinman, M. Barry, J. Meigs, S. Yurgalevitch, J. Mckinlay

{"title":"Prostate Specific Antigen Levels: Effect of Sexual Activity","authors":"M. Collins, K. Kleinman, M. Barry, J. Meigs, S. Yurgalevitch, J. Mckinlay","doi":"10.1046/J.1525-1411.1999.09915.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.09915.X","url":null,"abstract":"Background: To determine whether six lifestyle factors (dietary fat, smoking, sleep, alcohol consumption, physical, and sexual activities) are associated with non-prostate cancer-related, elevated prostate specific antigen (PSA) levels. \u0000 \u0000Methods: PSA levels were measured on frozen serum that was collected at baseline (time T1, 1987–1989) and at follow-up (time T2, 1995–1996) in the Massachusetts Male Aging Study, a population-based random sample survey of 1709 men aged 39–70 years old. Men with a PSA level >4.0 ng/ml at time T2 were offered a biopsy. Excluding men who had ever had a diagnosis of prostate cancer (N = 82) left 892 men with both time T1 and time T2 PSA measurements. Lifestyle factors assessed at time T1 were used for the analysis. \u0000 \u0000Results: Of 866 men who had a time T1 PSA 4.0 ng/ml at time T2. In logistic regression models predicting crossing the threshold of 4.0 ng/ml, sexual activity was a significant predictor, but other lifestyle factors were not. Relative to little or no sexual activity, the age-adjusted odds ratio for sex 1–3 times/month was 4.18 (95% confidence interval (CI) = 1.4–12.3), and for sex ≥4 times/month was 2.54 (95% CI = 0.9–6.9). \u0000 \u0000Conclusions: Men who were more sexually active at time T1 were at higher risk of a falsely elevated PSA level >4.0 ng/ml at time T2. Although interim knowledge about lifestyle is lacking, this finding may reflect the effect of ejaculation on serum PSA. Other lifestyle factors had no effect on time T2 PSA levels.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"42 1","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86887300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acute and Chronic Prostatitis Syndromes: A Review of Microbiologic and Pathologic Issues 急性和慢性前列腺炎综合征:微生物学和病理学问题的综述

The open prostate cancer journal Pub Date : 1999-03-01 DOI: 10.1046/J.1525-1411.1999.09917.X

J. Zacks, S. Brecher

引用次数: 0

Prostate Apoptosis in Response to Castration in Wild‐Type and Nerve Growth Factor‐Induced Gene A‐Deficient Mice 野生型和神经生长因子诱导的基因A缺陷小鼠对去势的前列腺凋亡反应

The open prostate cancer journal Pub Date : 1999-03-01 DOI: 10.1046/J.1525-1411.1999.09911.X

C. Naughton, W. Tourtellotte, Deborah S. Smith, J. Milbrandt

{"title":"Prostate Apoptosis in Response to Castration in Wild‐Type and Nerve Growth Factor‐Induced Gene A‐Deficient Mice","authors":"C. Naughton, W. Tourtellotte, Deborah S. Smith, J. Milbrandt","doi":"10.1046/J.1525-1411.1999.09911.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.09911.X","url":null,"abstract":"Objective: Nerve growth factor-induced gene A (NGFIA) is a transcription factor implicated in androgen deprivation-induced apoptosis in an androgen-sensitive prostate cell line ( 1, 2). The objective of our study was to investigate the role of NGFIA in prostate apoptosis in response to androgen ablation in a mouse animal model lacking the gene. \u0000 \u0000 \u0000 \u0000Materials and Methods: Wild-type mice (n = 56) and NGFIA-deficient mice (“knock-out”) (n = 16) were surgically castrated. The animals were killed at 0 (noncastrated controls), 1, 3, 5, 7, 10, 14, and 21 days after castration, and the prostates were harvested. Tissue sections were stained for morphologic analysis and quantification of apoptosis using a terminal deoxynucleotidyl transferase biotinylated deoxyuridine triphosphate nick-end labeling (TUNEL) strategy. Apoptosis was quantitatively measured by counting the number of TUNEL-positive cells/100 epithelial cells by light microscopy. The percentage of apoptosis was compared for wild-type mice versus NGFIA-deficient mice after castration at the defined time points. \u0000 \u0000 \u0000 \u0000Results: We found a statistically significant increase in the mean percentage of prostate cell apoptosis within 7–21 days after castration in both wild-type and NGFIA-deficient mice (p 0.05). \u0000 \u0000 \u0000 \u0000Conclusion: NGFIA does not seem to play a critical role in prostate apoptosis induced by androgen ablation in this mouse model.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"9 1","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85006971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Critical Evaluation of Prostate Specific Antigen Parameter Responses to Manipulation According to Prostatic Histology 根据前列腺组织学对前列腺特异性抗原参数对操作反应的关键评价

The open prostate cancer journal Pub Date : 1999-03-01 DOI: 10.1046/J.1525-1411.1999.09919.X

K. Alexandrou, G. N. Collins, Alison Wynn-Davies, P. O’Reilly

{"title":"A Critical Evaluation of Prostate Specific Antigen Parameter Responses to Manipulation According to Prostatic Histology","authors":"K. Alexandrou, G. N. Collins, Alison Wynn-Davies, P. O’Reilly","doi":"10.1046/J.1525-1411.1999.09919.X","DOIUrl":"https://doi.org/10.1046/J.1525-1411.1999.09919.X","url":null,"abstract":"Introduction: The degree of increase in prostate specific antigen (PSA) forms after prostatic manipulation may differ depending on histology. We sought to critically evaluate this hypothesis and to examine possible clinical implications. \u0000 \u0000 \u0000 \u0000Methods: A series of 198 men referred for transrectal ultrasound-guided biopsy on clinical grounds had free (fPSA) and total PSA (tPSA) levels determined before undergoing biopsy and 30 min after biopsy. A subset of 100 men had the same analysis immediately before and 30 min after digital rectal examination (DRE). Geometric mean ratios and two-sample t tests compared the change in levels of fPSA, PSA, the ratio of fPSA to tPSA (f/t PSA), fPSA density, and PSA density after manipulation to prostatic histology. \u0000 \u0000 \u0000 \u0000Results: After undergoing biopsies, 57 men (29%) received a diagnosis of prostate cancer. The biopsy significantly altered all parameters. The degree of change was less in the malignant group for all parameters, although this only approached statistical significance for PSA and PSA density levles (p = 0.159 and p = 0.170, respectively). In the DRE group, the PSA changes were similar, although the cancer patients tended to release slightly less PSA forms (PSA, p = 0.376; fPSA, p = 0.657; f/t PSA, p = 0.396). \u0000 \u0000 \u0000 \u0000Conclusion: PSA release and PSA parameter alteration after manipulation differ in the neoplastic prostate. The subtlety of change after DRE currently limits clinical application.","PeriodicalId":22947,"journal":{"name":"The open prostate cancer journal","volume":"135 1","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"1999-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76904120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Meningeal Carcinomatosis in Metastatic Prostate Cancer: A Case Report 转移性前列腺癌伴脑膜癌1例报告

The open prostate cancer journal Pub Date : 1999-03-01 DOI: 10.1046/J.1525-1411.1999.09912.X

E. Reed, Douglas J Matthews, V. Dyer, W. Figg

引用次数: 1