根据前列腺组织学对前列腺特异性抗原参数对操作反应的关键评价

K. Alexandrou, G. N. Collins, Alison Wynn-Davies, P. O’Reilly
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引用次数: 2

摘要

前列腺操作后前列腺特异性抗原(PSA)形式的增加程度可能因组织学而异。我们试图批判性地评估这一假设,并检查可能的临床意义。方法:198例经直肠超声引导活检的男性患者在活检前和活检后30分钟分别测定游离PSA (fPSA)和总PSA (tPSA)水平。100名男性的一个子集在直肠指检(DRE)之前和之后30分钟进行了相同的分析。几何平均比和双样本t检验比较操作后fPSA水平、PSA、fPSA / tPSA之比(f/t PSA)、fPSA密度和PSA密度对前列腺组织学的变化。结果:接受活检后,57名男性(29%)被诊断为前列腺癌。活检明显改变了所有参数。在所有参数中,恶性组的变化程度较小,尽管这仅在PSA和PSA密度水平上接近统计学意义(p = 0.159和p = 0.170)。在DRE组中,PSA变化相似,尽管癌症患者倾向于释放略少的PSA形式(PSA, p = 0.376;fPSA, p = 0.657;f/t PSA, p = 0.396)。结论:在肿瘤前列腺中,手法治疗后PSA释放及PSA参数改变存在差异。DRE术后变化的微妙性目前限制了临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Critical Evaluation of Prostate Specific Antigen Parameter Responses to Manipulation According to Prostatic Histology
Introduction: The degree of increase in prostate specific antigen (PSA) forms after prostatic manipulation may differ depending on histology. We sought to critically evaluate this hypothesis and to examine possible clinical implications. Methods: A series of 198 men referred for transrectal ultrasound-guided biopsy on clinical grounds had free (fPSA) and total PSA (tPSA) levels determined before undergoing biopsy and 30 min after biopsy. A subset of 100 men had the same analysis immediately before and 30 min after digital rectal examination (DRE). Geometric mean ratios and two-sample t tests compared the change in levels of fPSA, PSA, the ratio of fPSA to tPSA (f/t PSA), fPSA density, and PSA density after manipulation to prostatic histology. Results: After undergoing biopsies, 57 men (29%) received a diagnosis of prostate cancer. The biopsy significantly altered all parameters. The degree of change was less in the malignant group for all parameters, although this only approached statistical significance for PSA and PSA density levles (p = 0.159 and p = 0.170, respectively). In the DRE group, the PSA changes were similar, although the cancer patients tended to release slightly less PSA forms (PSA, p = 0.376; fPSA, p = 0.657; f/t PSA, p = 0.396). Conclusion: PSA release and PSA parameter alteration after manipulation differ in the neoplastic prostate. The subtlety of change after DRE currently limits clinical application.
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