Journal of Bio Innovation最新文献_第10页

A CASE STUDY – MANAGEMENT OF YAVANA PIDIKA WITH MAHAMANJISTHADI KHADA & GANDHAKA MALAHARA 以玛哈曼吉萨迪·哈达和甘达卡·马拉哈拉为例，对雅瓦娜·皮蒂卡的管理

Journal of Bio Innovation Pub Date : 2021-02-15 DOI: 10.46344/JBINO.2021.V010I01.35

Seeta M.Biradar, Vijayalakshmi Hadimani, Renuka M. Tenahalli, Smitha Choudari

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REVISITING THE PAPER ON “PREDICTION OF HUMAN IMMUNODEFICIENCY VIRUS PROTEASE CLEAVAGE SITES IN PROTEINS” “人类免疫缺陷病毒蛋白酶在蛋白质中切割位点的预测”论文重述

Journal of Bio Innovation Pub Date : 2020-12-01 DOI: 10.46344/JBINO.2020.V09I06.24

K. Chou

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DESMOCOLLIN 3 GENE (DSC3) EXPRESSION AND CANCER - IN SILICO EVALUATION desmocolin 3基因(dsc3)表达及肿瘤计算机评价

Journal of Bio Innovation Pub Date : 2020-12-01 DOI: 10.46344/JBINO.2020.V09I06.11

Chandreshwar P. Shukla, N. Jain, R. Modi, A. Khamar, B. Khamar

{"title":"DESMOCOLLIN 3 GENE (DSC3) EXPRESSION AND CANCER - IN SILICO EVALUATION","authors":"Chandreshwar P. Shukla, N. Jain, R. Modi, A. Khamar, B. Khamar","doi":"10.46344/JBINO.2020.V09I06.11","DOIUrl":"https://doi.org/10.46344/JBINO.2020.V09I06.11","url":null,"abstract":"Desmocollin-3 (DSC3) is DSC3 protein coding gene, expressed in some epithelial cancers. DSC3 expression has prognostic value in some cancers. Using cBioportal and Kaplan– Meier plotter DSC3 gene was evaluated in 12 cancers using TCGA data and compared with Hallmark gene expression. Cancers were grouped to have low (Group I), intermediate (Group II) and high (Group III) DSC3 expression. Higher DSC3 expression in group III is associated with better survival and in group I with poor survival. DSC3 expression correlated with desmosomal genes DSG3, DSC1, DSG1, PKP1 in spite of its known reciprocal relationship with DSC1, DSG1 and PKP1 under physiological conditions. Of 10 Hallmarks evaluated, three hallmarks had no correlation with DSC3. Activating invasion and metastasis (AIM) (genes SERPINB5, PERP, SNAI2) and Evading Growth Suppressors (EGS) (gene TP63) were the key hallmarks associated with DSC3 expression. Gene expression correlation with DSC3 across various hallmark genes reveals no correlation in group I cancers. Our finding demonstrate that higher DSC3 expression level may be useful for prognostication and needs further evaluation. The finding of this analysis also suggests critical role of TP63 in DSC3 expressing cancers and potentially a different biological process unique to DSC3 expressing cancers.","PeriodicalId":228982,"journal":{"name":"Journal of Bio Innovation","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129330179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FCPD( FIBROCALCULUS PANCREATIC DIABETES) -ROLE OF MAHADADIMADI GHRUT Fcpd(纤维结石性胰腺糖尿病)- mahadadimadi ghut的作用

Journal of Bio Innovation Pub Date : 2020-10-25 DOI: 10.46344/jbino.2020.v09i5b.16

Swapnil C. Padte

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THE COURSE OF SUBCLINICAL SYSTEMIC LYMPHEDEMA OVER A SIX-YEAR PERIOD 亚临床全身性淋巴水肿的病程超过6年

Journal of Bio Innovation Pub Date : 2020-10-16 DOI: 10.46344/jbino.2020.v09i05.03

J. M. Godoy, L. D. S. Godoy, Glauco Veloso Rodarte de Melo, M. Godoy

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CONTACT DERMATITIS SECONDARY TO PHENYLEPHRINE EYE DROP: A CASE REPORT 苯肾上腺素滴眼液继发接触性皮炎1例

Journal of Bio Innovation Pub Date : 2020-10-16 DOI: 10.46344/jbino.2020.v09i05.08

Sunanda Biradar, Kartik Nuchhi, A. Kulkarni, Shivanand I. Lubadude, Kirankumar Awati, S. Badiger, R. Kattimani, Santosh R. Awasthi

引用次数: 0

INTERELATION OF PULSE RATE WITH THE LIKENESS OF FISH AS A PET 脉率与宠物鱼的相似性的相互作用

Journal of Bio Innovation Pub Date : 2020-10-16 DOI: 10.46344/jbino.2020.v09i05.34

Tayyaba Suleman, M. Qadir

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DOES THERE IS CONNECTION BETWEEN NITRITES IN URINE AND MOLES ON FACE? 尿中的亚硝酸盐和脸上的痣有关系吗?

Journal of Bio Innovation Pub Date : 2020-10-16 DOI: 10.46344/jbino.2020.v09i05.12

M. Qadir, Baber Saeed, I. Fatima

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MELKERSSON-ROSENTHAL SYNDROME COMPLICATED WITH FACIAL HEMIESPASM AND INTRACRANIAL HYPERTENSION Melkersson-rosenthal综合征并发面瘫和颅内高压

Journal of Bio Innovation Pub Date : 2020-10-09 DOI: 10.46344/JBINO.2021.V10I02.33

Elis Penteado Arantes, Giuliana Vieira Pretti, Soo Yang Lee, F. Leme

{"title":"MELKERSSON-ROSENTHAL SYNDROME COMPLICATED WITH FACIAL HEMIESPASM AND INTRACRANIAL HYPERTENSION","authors":"Elis Penteado Arantes, Giuliana Vieira Pretti, Soo Yang Lee, F. Leme","doi":"10.46344/JBINO.2021.V10I02.33","DOIUrl":"https://doi.org/10.46344/JBINO.2021.V10I02.33","url":null,"abstract":"Since it was first described in 1928 by neurologist Melkersson [1], and complemented in 1931 by Rosenthal C [2], the Melkersson [1] and Rosenthal [2] Syndrome (SMR) has been shown to be a rare disorder and still in need of specific treatment [3,4]. We describe the case of a young patient, who at 23 years old had the first episode of peripheral facial paralysis on the right. At the time, it was conducted in a protocol manner, with prednisone, paracetamol and eye care, as well as pertinent physiotherapy. There was an improvement in facial asymmetry, when in 2006 she presented a new peripheral facial paralysis, this time on the left, which was conducted in a similar way. Then, she presented 2 more episodes of facial paralysis in the interval of 3 years, already with aesthetic sequelae. In 2009, in the 5th episode of paralysis, she associated facial edema and cheilitis, when biopsy of the upper eyelid was requested, which was unspecific. In 2012, after the 8th facial paralysis, she underwent a new biopsy, in which an inflammatory infiltrate was demonstrated, consistent with clinical suspicion of SMR. Imaging exams (skull resonance and angioresonance), face electroneuromyography for prognosis, and CSF study, without abnormalities, were performed. That year she began to experience involuntary and rhythmic contractions of the orbicularis musculature of the eyes and mouth on the right, in addition to risory and platysma, featuring facial hemispasm, treated every 4 to 6 months with 100 IU Onabotulinum. Throughout the treatment period, alternating use of 10mg prednisone with deflazacort 6mg, and in 2019, due to persistent headache, she underwent a new resonance with arterial and venous cranial angioresonance, which brought elements suggestive of Intracranial Hypertension (IH). Currently, the patient is undergoing surgical programming for facial nerve decompression bilaterally and undergoing treatment for IH.","PeriodicalId":228982,"journal":{"name":"Journal of Bio Innovation","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129968186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTIDRUG RESISTANT ENTEROBACTERIACEAE FROM BLOOD STREAM INFECTIONS AT A TERTIARY CARE HOSPITAL OF EASTERN NEPAL 尼泊尔东部一家三级保健医院血流感染的多重耐药肠杆菌科

Journal of Bio Innovation Pub Date : 2020-07-28 DOI: 10.21203/rs.3.rs-44323/v1

A. Yadav, N. Bhattarai, B. Khanal

{"title":"MULTIDRUG RESISTANT ENTEROBACTERIACEAE FROM BLOOD STREAM INFECTIONS AT A TERTIARY CARE HOSPITAL OF EASTERN NEPAL","authors":"A. Yadav, N. Bhattarai, B. Khanal","doi":"10.21203/rs.3.rs-44323/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-44323/v1","url":null,"abstract":"\u0000 Background\u0000\u0000Blood stream infection (BSI) is one of the major causes of morbidity and mortality worldwide. It has poses significant challenge to the clinicians and clinical microbiologists alike. Therefore its accurate diagnosis, isolation and identification of causative agents with appropriate antibiotics is required. This study is aimed to find out resistance pattern, e.g. extended-spectrum-beta-lactamase (ESBL), AmpC, K1, carbapenemase and metallo-β-lactamase (MBL) among isolates obtained from BSI.\u0000Methods\u0000\u0000A cross-sectional study was conducted in the Department of Microbiology, BPKIHS from 1st September 2014 to 31st August 2015. Isolates were screened for ESBL, AmpC, K1, and carbapenemase production by ten disk method. Confirmation for ESBL was done phenotypically by using combined disk method recommended by CLSI, AmpC sterile disk method for AmpC and K1 by combined disk method. Metallo-beta-lactamase (MBL) production was detected by imipenem-ethylene-diamine-tetra acetic acid double disk synergy test.\u0000Results\u0000\u0000A total of 11,264 blood samples were collected from the patients suspected of Blood Stream Infection. Of these isolates, 192 (1.70%) were Enterobacteriaceae. Among them, 94 (49%) were ESBL, 51 (26.5%) were carbapenemase and 10 (5%) were AmpC producers. Of 51 carbapenemase producers, 22 (11.5%) were MBL producers. None of the isolates were found to produce K1 β-lactamase. A total of 64 (33.4%) isolates were MDR.\u0000Conclusion\u0000\u0000MDR Enterobacteriaceae is found to be prevalent in our set up as important cause of BSI.","PeriodicalId":228982,"journal":{"name":"Journal of Bio Innovation","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131185522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0