Nigerian Journal of Cardiology最新文献_第9页

Missing trees for the forest 为森林少树

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187742

R. Barik

引用次数: 5

Giant aneurysm of right coronary artery: A case report and review of literature 右冠状动脉巨动脉瘤1例并文献复习

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187732

B. Majumder, A. Misra, Viral Tandel, Ashfaque Ahmed

引用次数: 1

Cor triatriatum sinistrum in a Nigerian adult 尼日利亚成年人的三冠状核

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187729

A. Aje, O. Adebayo, Olugbenga Towoju, Opeyemi O. Oni, A. Adeoye, O. Ogah, A. Adebiyi, O. Oladapo

引用次数: 0

Isolated left ventricular noncompaction: Report of a case from Ibadan, Nigeria 孤立性左心室不压实:尼日利亚伊巴丹1例报告

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187741

O. Ogah, O. Adebayo, A. Aje, Funmilola K Koya, Olugbenga Towoju, J. Adesina, A. Adeoye, A. Adebiyi, O. Oladapo, A. Falase

引用次数: 3

Effect of change in body position on resting electrocardiogram in young healthy adults 体位变化对年轻健康成人静息心电图的影响

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187711

S. Khare, A. Chawala

{"title":"Effect of change in body position on resting electrocardiogram in young healthy adults","authors":"S. Khare, A. Chawala","doi":"10.4103/0189-7969.187711","DOIUrl":"https://doi.org/10.4103/0189-7969.187711","url":null,"abstract":"Background: The electrocardiogram (ECG) is recorded in the supine position and values of various parameters are based on calculations made from supine ECG recordings. In certain situations, such as exercise stress testing and evaluation of syncope by the head-up tilt test, the ECG is recorded in the upright position. Thus, it becomes equally important to study and quantify the nature and magnitude of changes seen in the ECG with a change of posture from supine to upright in healthy individuals. Aim: To study and investigate the effect of a change in body position on the frontal plane on ECG. Materials and Methods: Thirty healthy adult subjects (15 male and 15 female) in the age group of 18-25 years were included. The ECG was recorded in four body positions, supine, reclining with the trunk flexed at 70°, sitting upright, and standing. Results: The mean frontal plane QRS axis recorded in the supine and standing positions was comparable. The reclining and sitting ECG show a significant variation of the mean QRS axis as compared to the supine position. The T-wave axis was found to be comparable in the supine and standing positions. The corrected QT (QTc) interval showed a significant change with a change in the body position from supine to standing. Conclusion: All the subjects showed similar ECG changes, but differences in the magnitude of the changes with change in body position. The change in the QTc interval with standing needs to be explored.","PeriodicalId":228906,"journal":{"name":"Nigerian Journal of Cardiology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115324652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The spectrum of structural heart defects seen in children at the University College Hospital, Ibadan 伊巴丹大学学院医院的儿童结构性心脏缺陷谱

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187712

B. Adebayo, O. Ogunkunle, S. Omokhodion, R. Luke

{"title":"The spectrum of structural heart defects seen in children at the University College Hospital, Ibadan","authors":"B. Adebayo, O. Ogunkunle, S. Omokhodion, R. Luke","doi":"10.4103/0189-7969.187712","DOIUrl":"https://doi.org/10.4103/0189-7969.187712","url":null,"abstract":"Background: Structural heart defects constitute one of the commonest reasons for Paediatric Cardiology consultations. The availability of echocardiography has obviated the need for invasive procedures in providing an accurate diagnosis and description in such children. Objective: To describe the pattern of congenital and acquired heart diseases seen in children referred to the Paediatric Cardiology Clinic of the University College Hospital, Ibadan Methods: Consecutive cases referred to the Paediatric Cardiology Clinic over a twelve-month period were evaluated by clinical examination, chest x-ray, electrocardiography and echocardiography. Data were analysed using SPSS for Windows software, version 20.0. Frequency distributions were generated and the Wilcoxon signed rank test was used to test the association between the age at onset of symptoms and the age at presentation. Level of significance was set at P < 0.05 Results: Two hundred and forty children underwent echocardiography; 80.4% were aged 5 years and below. Structural heart defects were encountered in 210 (87.5%) children. Congenital defects comprised 80% of the cases, the commonest being VSD, occurring either singly (24.1%) or in combination with other defects in 18.7%. The commonest cyanotic lesion, Fallot′s Tetralogy (9.2%) occurred more commonly than other isolated acyanotic lesions. Acquired heart disease accounted for 7.5% of cases, dilated cardiomyopathy, rheumatic heart disease, and pericardial effusion (occurring in 2.9%, 2.5% and 2.1% respectively). The median age at presentation (13 months) was significantly higher than that at onset of symptoms (11 months) (P = <0.001). Conclusions: Ventricular septal defect remains the commonest structural defect seen in our centre. Fallot′s Tetralogy however is more common than isolated patent ductus arteriosus or atrial septal defect. Dilated cardiomyopathy and RHD are equally common.","PeriodicalId":228906,"journal":{"name":"Nigerian Journal of Cardiology","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123736819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cardiac biomarker changes with neoadjuvant epirubicin-based chemotherapy 新辅助表柔比星化疗后心脏生物标志物的变化

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187708

M. Kuti, A. Ogunleye, A. Ademola

{"title":"Cardiac biomarker changes with neoadjuvant epirubicin-based chemotherapy","authors":"M. Kuti, A. Ogunleye, A. Ademola","doi":"10.4103/0189-7969.187708","DOIUrl":"https://doi.org/10.4103/0189-7969.187708","url":null,"abstract":"Aim: A major concern with epirubicin-based neoadjuvant chemotherapy, a mainstay of neoadjuvant treatment for breast cancer in Nigeria, is their association with cardiotoxicity. We investigated for possible changes in the level of cardiac markers, troponin T, and N-terminal pro-brain natriuretic peptide (NT-ProBNP) detectable after least three cycles of epirubicin in the neoadjuvant setting. Methods: Thirty consenting female patients who had received at least three cycles of epirubicin-based neoadjuvant chemotherapy were recruited from the Surgical Oncology Unit of the University College Hospital. Patients who were eligible for neoadjuvant chemotherapy for breast cancer but who had not commenced the same were recruited to serve as controls. Samples for troponin T and NT-ProBNP were collected on the day of commencement of the next cycle, before the administration of the dose. Results: The mean troponin T and median NT-ProBNP values were significantly higher among the women on epirubicin-based chemotherapy (0.76 ng/ml vs. 0.68 ng/ml, P = 0.047 and 114.5 pg/ml vs. 103 pg/ml, P = 0.007), respectively. Values of NT-ProBNP exceeding 200 pg/ml were significantly more frequently observed in the same group (40% vs. 16.7%, P = 0.01). A significant relationship between the number of cycles received and level of NT-ProBNP was observed (P = 0.015). A similar relationship was not observed with troponin T. Conclusion: Epirubicin-based chemotherapy may be associated with increased elaboration of the cardiac markers, NT-ProBNP, and troponin T early during neoadjuvant chemotherapy. The potential clinical utility of these markers in predicting cardiotoxicity needs to be further evaluated in prospective studies.","PeriodicalId":228906,"journal":{"name":"Nigerian Journal of Cardiology","volume":"abs/2301.01819 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127610543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orchidectomy reduces blood pressure, but testosterone increases it in intact and orchidectomized normotensive rats 切除睾丸可降低血压，但睾酮会使正常血压的大鼠血压升高

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187705

F. Aliyu, A. Alagbonsi, A. Dikko

{"title":"Orchidectomy reduces blood pressure, but testosterone increases it in intact and orchidectomized normotensive rats","authors":"F. Aliyu, A. Alagbonsi, A. Dikko","doi":"10.4103/0189-7969.187705","DOIUrl":"https://doi.org/10.4103/0189-7969.187705","url":null,"abstract":"Background: The cardioprotective effect of estrogen has been well documented, and the effect of testosterone on blood pressure (BP) is controversial and remains inconclusive. Aim: The present study is aimed at investigating the effect of testosterone on BP in normotensive rats. Materials and Methods: In a blind study, 30 male albino rats (200-250 g) were divided into 5 oral treatment groups (n = 6 rats each) as follows: Groups I and II were intact rats that received 1 ml/kg normal saline (vehicle) and 25 mg/kg testosterone subcutaneously for 24 days. Group III was sham-operated and received normal saline for 24 days. Groups IV and V were bilaterally orchidectomized and received normal saline and 25 mg/kg testosterone subcutaneously for 24 days. Results: The systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP) of the sham-operated rats that received normal saline were not significantly different from the intact (control) rats that received normal saline (P > 0.05). Testosterone treatment in control rats caused a sustainably higher SBP (P < 0.001), DBP (P < 0.001), PP (P < 0.001), and MAP (P < 0.001) when compared to control that received normal saline. The SBP (P < 0.01), DBP (P < 0.001), MAP (P < 0.001), but not PP (P > 0.05) was significantly reduced in orchidectomized rats that received normal saline when compared to control. However, administration of testosterone in orchidectomized rats abolished orchidectomy-induced reduction in SBP, DBP, MAP, but not PP and further increased them above the control level (P < 0.05). Conclusion: This study shows that testosterone is prohypertensive in normotensive rats.","PeriodicalId":228906,"journal":{"name":"Nigerian Journal of Cardiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125874522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prenatal ultrasound diagnosis of ectopia cordis 心异位的产前超声诊断

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187743

D. Meena, Babita Jangid

引用次数: 1

Vitamin C alleviates surgical castration-induced dyslipidemia in male rats 维生素C减轻雄性大鼠手术去势引起的血脂异常

Nigerian Journal of Cardiology Pub Date : 2016-07-01 DOI: 10.4103/0189-7969.187706

L. Olayaki, A. Alagbonsi, M. Adamson, O. Ayodele, A. Oyewopo

{"title":"Vitamin C alleviates surgical castration-induced dyslipidemia in male rats","authors":"L. Olayaki, A. Alagbonsi, M. Adamson, O. Ayodele, A. Oyewopo","doi":"10.4103/0189-7969.187706","DOIUrl":"https://doi.org/10.4103/0189-7969.187706","url":null,"abstract":"Background and Aims: Androgen deprivation has been shown to be associated with dyslipidemia. Ameliorative effect of Vitamin C on dyslipidemia has also been reported. This study aimed at investigating the role of Vitamin C supplementation in castration-induced dyslipidemia. Materials and Methods: Twenty male rats were randomly divided in a blinded fashion into 4 groups (n = 5 each): Groups I and II were sham-castrated and received normal saline (1 ml/kg) and 1.25 g/kg Vitamin C, respectively, whereas Groups III and IV were rendered bilaterally castrated and received normal saline (1 ml/kg) and 1.25 g/kg Vitamin C for 4 weeks. Results and Conclusions: Castrated rats had reduced high-density lipoprotein, testosterone, estradiol, but increased low density lipoprotein, triglycerides, total cholesterol, and Castelli index and had no effect on follicle stimulating hormone when compared to sham-operated rats. Vitamin C supplements improved these parameters in normal and castrated rats. This study showed that castration-associated dyslipidemia and atherogenic risk in male rats is dependent on testosterone and estradiol. In addition, Vitamin C improves these parameters in normal and castrated rats by increasing testosterone and estradiol production, possibly from extra-testicular sites. However, there is a need for further study to ascertain the actual extra-testicular testosterone and estradiol production site.","PeriodicalId":228906,"journal":{"name":"Nigerian Journal of Cardiology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127064055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1