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Developmental Effects of 7 Hz, Square Wave Magnetic Fields and Nitric Oxide Modulation on Organ Systems 7赫兹方波磁场和一氧化氮调制对器官系统发育的影响

The Open Toxicology Journal Pub Date : 2008-06-23 DOI: 10.2174/1874340400802010007

P. Whissell, B. P. Mulligan, M. Hunter, H. P. Wu, G. Parker, M. Persinger

{"title":"Developmental Effects of 7 Hz, Square Wave Magnetic Fields and Nitric Oxide Modulation on Organ Systems","authors":"P. Whissell, B. P. Mulligan, M. Hunter, H. P. Wu, G. Parker, M. Persinger","doi":"10.2174/1874340400802010007","DOIUrl":"https://doi.org/10.2174/1874340400802010007","url":null,"abstract":"Prenatal or perinatal exposure to physiologically-patterned magnetic fields (MFs) affects behaviour in weanling (22d) and young adult (90d) rats. However, the long-term (120d-730d) biological effects of these MFs have not been ex- amined. In the current study, the long-term effects of developmental exposure to a physiologically-patterned MF, and their dependence on nitric oxide (NO) activity, were investigated. Pregnant dams were exposed from 2d before to 14d after par- turition to square wave, 7 Hz MF and to either water or nitric oxide (NO) modulation in tap water with NO precursor 1.0 g/L L-arginine or 0.5 g/L NO inhibitor n-methylarginine. To assess the possibility of intensity-windowing of any effects, MF intensities of <1, 1, 5, 10, 50 and 500 nT were employed. Male offspring were euthanized for post-mortem examina- tion and wet organ weights were then taken. Analysis showed increased brain weight in 10 and 50 nT-treated groups, in- creased bodyweight in 50 nT-treated groups and suggested increased testicular weight in 5, 10 and 50 nT-treated groups. Few effects of NO modulation were evident in these rats, reinforcing the idea that these are short-term and reversible. These findings suggest that subtle long-term changes in organ structure can arise from developmental exposure to physio- logically-patterned MFs.","PeriodicalId":22859,"journal":{"name":"The Open Toxicology Journal","volume":"56 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2008-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74626567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Therapeutic Alliance: Using N-(2,3,4,5,6-Pentahydroxylhex-1-yl)-NDithiocarbamate-L-Isoleucine Disodium to Improve the Toxicity and Survival of Cisplatin Receiving Mice 治疗联合:使用N-(2,3,4,5,6-五羟基己基-1-基)- n二硫代氨基甲酸酯- l -异亮氨酸二钠改善顺铂接受小鼠的毒性和生存

The Open Toxicology Journal Pub Date : 2008-05-23 DOI: 10.2174/1874340400802010001

Yuji Wang, Ming Zhao, Guohui Cui, Chunying Cui, J. Ju, Shiqi Peng

引用次数: 1

Methylmercury Neurotoxicity: Exploring Potential Novel Targets. 甲基汞神经毒性：探索潜在的新靶点。

The Open Toxicology Journal Pub Date : 2007-01-01 Epub Date: 2007-10-17 DOI: 10.2174/1874340400701010001

J L Aschner, M Aschner

{"title":"Methylmercury Neurotoxicity: Exploring Potential Novel Targets.","authors":"J L Aschner, M Aschner","doi":"10.2174/1874340400701010001","DOIUrl":"10.2174/1874340400701010001","url":null,"abstract":"Mechanistic studies on the effects of MeHg in the central nervous system (CNS) have been limited to morphology, substrate uptake and macromolecular synthesis, differentiation, and changes in gene expression during development and adulthood, but its primary site of action has yet to be identified. Proper functioning of the nitric oxide synthase (NOS)-cyclic GMP and the cyclooxygenase (COX)-prostaglandin (PG) signaling pathways in the CNS depend on post-translational modifications of key enzymes by chaperone proteins. The ability of MeHg to alter or inhibit chaperone-client protein interactions is hitherto unexplored, and potentially offers an upstream unifying mechanism for the plethora of MeHg effects, ranging from reactive species generation (ROS) generation, mitochondrial dysfunction, changes in redox potential, macromolecule synthesis, and cell swelling. In view of the prominent function of astrocytes in the maintenance of the extracellular milieu and their critical role in mediating MeHg neurotoxicity, they afford a relevant and well-established experimental model. The present review is predicated on (a) the remarkable affinity of mercurials for the anionic form of sulfhydryl (-SH) groups, (b) the essential role of thiols in protein biochemistry, and (c) the role of molecular chaperone proteins, such as heat shock protein 90 (Hsp90) in the regulation of protein redox status by facilitating the formation and breakage of disulfide bridges. We offer potential sites where MeHg may interfere with cellular homeostasis and advance a novel mechanistic model for MeHg-induced neurotoxicity.","PeriodicalId":22859,"journal":{"name":"The Open Toxicology Journal","volume":"1 ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c8/36/nihms-1001839.PMC6555406.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37312232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

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