The Journal of Qazvin University of Medical Sciences最新文献_第4页

Haplotype Effect of Two Human Leukocyte Antigen-G Polymorphisms of rs1736933 and rs2735022 on the Recurrent Pregnancy Loss rs1736933和rs2735022两种人类白细胞抗原- g多态性在复发性妊娠丢失中的单倍型效应

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-12-01 DOI: 10.32598/JQUMS.24.5.2

Z. Najafi, M. Khalaj-Kondori, M. feizi, Sh Abbasaliizadeh

{"title":"Haplotype Effect of Two Human Leukocyte Antigen-G Polymorphisms of rs1736933 and rs2735022 on the Recurrent Pregnancy Loss","authors":"Z. Najafi, M. Khalaj-Kondori, M. feizi, Sh Abbasaliizadeh","doi":"10.32598/JQUMS.24.5.2","DOIUrl":"https://doi.org/10.32598/JQUMS.24.5.2","url":null,"abstract":"Background: Recurrent Pregnancy Loss (RPL) is a multifactorial disease that affects 1-3% of couples. Since Human Leukocyte Antigen-G (HLA-G) gene is involved in fetal maternal immune tolerance, mutations in the HLA-G gene can affect the success rate of pregnancy. Objective: The present study aims to investigate the haplotype effect of rs1736933 and rs2735022 polymorphisms found in the HLA-G gene on the RPL. Methods In this case-control study, participants were 100 women with RPL and 80 women with normal fertility in northwestern Iran. The HLA-G gene promoter was amplified by Polymerase Chain Reaction (PCR) method and sequenced. The genotype and allele frequencies of the two polymorphisms were compared between the two groups by using t-test in SPSS software version 22. Haplotype analysis was performed using PHASE 2.1 and Haploview 4.2 applications Findings: C allele and CC genotype in rs2735022 polymorphism and the G allele and GG genotype in rs1736933 polymorphism showed a significant association with the RPL (P<0.05). Frequency of haplotypes AA, AC, GA, GC were 0.72, 0.23, 0.01, 0.03 in patients and 0.39, 0.01, 0.02, 0.59 in the control group (P<0.05). The linkage disequilibrium score was 94. Conclusion: Analysis of GC haplotype in rs2735022 and rs1736933 polymorphisms of the HLA-G gene can be helpful in genetic studies of women with RPL.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"398-409"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47660780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the General Health Indicators Predicting Marital Satisfaction in Older Couples 评估预测老年夫妇婚姻满意度的一般健康指标

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-12-01 DOI: 10.32598/JQUMS.24.5.4

Zahra Mahdikhani, Mitra Habibollah Pour, S. Motalebi, A. Salmani, F. Moafi

{"title":"Assessing the General Health Indicators Predicting Marital Satisfaction in Older Couples","authors":"Zahra Mahdikhani, Mitra Habibollah Pour, S. Motalebi, A. Salmani, F. Moafi","doi":"10.32598/JQUMS.24.5.4","DOIUrl":"https://doi.org/10.32598/JQUMS.24.5.4","url":null,"abstract":"Background: Due to the increasing life expectancy and aging population, attention to general health and marital satisfaction of older people can provide an opportunity to improve their living conditions. Objective: This study aims to assess the general health indicators of older couples to predict their marital satisfaction. Methods: This descriptive cross-sectional study was conducted on 110 older couples (men and women) living in Qazvin, Iran who were selected using two-stage cluster sampling technique. A demographic form, General Health Questionnaire (GHQ) and The ENRICH Marital Satisfaction Scale (EMSS) were used to collect data. Descriptive statistics and multivariate regression analysis were used for data analysis. Findings: The Mean±SD age of older women and men±SD was 64.15±5.46 years and 67.68±6.93 years, respectively. Their Mean±SD EMSS score was reported 109.72±12.58. Multivariate analysis showed that gender (β=0.169, P=0.050), age (β=0.097, P=0.567), age of marriage (β=0.214, P=0.002), somatic symptoms (β=0.233, P=0.013), anxiety/insomnia (β=0.227, P=0.008), social dysfunction (β=0.326, P<0.001), and depression (β=0.356, P<0.001) could significantly predict marital satisfaction. Conclusion: Different dimensions of general health can affect marital satisfaction of older couples. Therefore, interventions in these domains and the promotion of general health level can lead to increased marital satisfaction and, consequently, quality of life in the elderly.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"410-421"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41733306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of an Eight-week High-intensity Interval Training Program on Serum Cardiac Troponin I Level of Streptozotocin-induced Diabetic Rats 8周高强度间歇训练对链脲佐菌素诱导的糖尿病大鼠血清心肌肌钙蛋白I水平的影响

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-12-01 DOI: 10.32598/JQUMS.24.5.1

Najmeh Miraghaee, Navid Mohammadi

{"title":"Effect of an Eight-week High-intensity Interval Training Program on Serum Cardiac Troponin I Level of Streptozotocin-induced Diabetic Rats","authors":"Najmeh Miraghaee, Navid Mohammadi","doi":"10.32598/JQUMS.24.5.1","DOIUrl":"https://doi.org/10.32598/JQUMS.24.5.1","url":null,"abstract":"Background: One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. Methods: In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05. Findings: The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591). Conclusion: he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"386-397"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43983601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticonvulsive and Antioxidant Effects of Pioglitazone on Pentylenetetrazole-induced Seizures in Rats 吡格列酮对戊四唑致大鼠癫痫发作的抗惊厥和抗氧化作用

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-10-01 DOI: 10.32598/JQUMS.24.4.6

Y. Ghiasi, S. Rostamian, E. Aali, Y. Naderi

{"title":"Anticonvulsive and Antioxidant Effects of Pioglitazone on Pentylenetetrazole-induced Seizures in Rats","authors":"Y. Ghiasi, S. Rostamian, E. Aali, Y. Naderi","doi":"10.32598/JQUMS.24.4.6","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.6","url":null,"abstract":"Background: Epilepsy is a neurologic dysfunction caused by abnormal electrical activity in the brain. Oxidative stress is involved in the seizure-induced brain damage. Objective: This study aimed to evaluate the anticonvulsant and antioxidant effects of pioglitazone (a peroxisome proliferator-activated receptor gamma agonist used for treatment of type 2 diabetes) on Pentylenetetrazole (PTZ)-induced seizure in rats. Methods: In this experimental study, 28 rats weighing 20-30 g were divided into four groups of control, pioglitazone, PTZ, and treatment. For treatment, PTZ (85 mg/kg) or normal saline was injected intraperitoneally and 4 hours later, pioglitazone (80 mg/kg) was administrated orally. Carboxymethylcellulose was administered orally in the control and PTZ groups, instead of pioglitazone. One hour after PTZ injection, seizure severity was assessed using Racine scale. Then, the rats were decapitated and the Malondialdehyde (MDA) level and the activity of Catalase (CAT) and Superoxide Dismutase (SOD) in their hippocampus samples were measured by standard methods. Findings: Pioglitazone administration significantly increased the latency to the onset of seizure stages 1-4 and prevented the stage 5. It significantly reduced the lipid peroxidation caused by PTZ-induced seizure and increased the activity of CAT and SOD enzymes in the hippocampus of rats. Conclusion: Antioxidant effects of pioglitazone may play a role in preventing stable PTZ-induced seizures and protecting neurons from seizure-caused damage.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"320-331"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45481269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Eight Weeks of Endurance Training and Stevia Supplemention on Atrial Natriuretic Peptide and β-Myosin Heavy Chain Expression Levels in Heart Tissue of Rats With Type 1 Diabetes 8周耐力训练和添加甜菊糖对1型糖尿病大鼠心脏组织心房钠肽和β-肌球蛋白重链表达水平的影响

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-10-01 DOI: 10.32598/JQUMS.24.4.3

Kobra Soleymani, Asieh Abbassi Daloii, A. Barari, A. Saeidi

{"title":"Effect of Eight Weeks of Endurance Training and Stevia Supplemention on Atrial Natriuretic Peptide and β-Myosin Heavy Chain Expression Levels in Heart Tissue of Rats With Type 1 Diabetes","authors":"Kobra Soleymani, Asieh Abbassi Daloii, A. Barari, A. Saeidi","doi":"10.32598/JQUMS.24.4.3","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.3","url":null,"abstract":"Background: The effects of exercise and stevia extract on diabetes-related indicators have been already reported, but their cardiac benefits on Type 1 Diabetes (T1D) are unclear. Objective: This study aims to evaluate the effect of eight weeks of endurance training and stevia supplementation on gene expression levels of Atrial Natriuretic Peptide (ANP) and β-Myosin Heavy Chain (β-MHC) in the heart tissue of T1D rats. Methods: In this experimental study, 25 rats with the average weight of 250-300 g were divided into five groups; healthy control, diabetic control, diabetic+supplementation, diabetic+training, and diabetic+training+supplementation. T1D was induced by intraperitoneal injection of streptozotocin (55 mg/kg/ body weight). Endurance training was performed 5 days a week at a speed of 20-30 meters per minute on a surface with a zero slope for 8 weeks. Stevia was gavaged in a dose of 250 mg/kg/body weight. Rats were slaughtered 48 hours after the last training session. Cardiac tissue was used to measure the parameters. The gene expression of ANP and b-MHC in cardiac tissue was measured by real-time Polymerase Chain Reaction (PCR) method. Data were analyzed by using one-way ANOVA and Bonferroni post hoc test. Findings: The gene expression levels of ANP and β-MHC were significantly higher in the diabetic control group compared to the healthy control group (P=0.001), and significantly lower in the diabetic+training and diabetic+training+supplementation groups compared to the diabetic control group (P=0.001). Conclusion: Endurance training and stevia supplementation can have beneficial effects on the heart of T1D rats.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"308-319"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45329798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Menstrual Disorders and its Relationship With Quality of Life in Female High School Students 女高中生月经障碍的患病率及其与生活质量的关系

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-10-01 DOI: 10.32598/JQUMS.24.4.4

H. Pakniat, ezzat Hajiseyedjavadi, Hananeh Mirgaloybayat, Alireza Emami

{"title":"Prevalence of Menstrual Disorders and its Relationship With Quality of Life in Female High School Students","authors":"H. Pakniat, ezzat Hajiseyedjavadi, Hananeh Mirgaloybayat, Alireza Emami","doi":"10.32598/JQUMS.24.4.4","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.4","url":null,"abstract":"Background Menstrual disorders in female students in the early years after menarche affect their physical, \u0000emotional and social functions. \u0000Objective This study aimed to investigate the prevalence of menstrual disorders among female high \u0000school students and its relationship with their Quality of Life. \u0000Methods This cross-sectional study was conducted on 1000 high school girls in Qazvin, Iran during 2017- \u00002018. Their menstrual disorders and quality of life were evaluated by a demographic checklist and KIDSCREEN \u0000questionnaire, respectively. Data were analyzed using independent t-test. \u0000Findings The mean age of high school girls was 15.9±0.93 years. The most common disorder was Premenstrual \u0000Syndrome (PMS) with a prevalence of 60%. Their quality of life had a significant relationship \u0000with PMS, menorrhagia, metorrhagia, dysmenorrhea, spotting, hypermenorrhea (P<0.001), polymenorrhea \u0000(P=0.005), hypomnorrhea (P=0.002) and amenorrhea (P=0.025). The quality of life of girls with \u0000these disorders were poorer compared to the girls with no menstrual disorder. \u0000Conclusion Menstrual disorders are highly prevalent among female students, and have a considerable \u0000impact on their quality of life. Since this impact has the potential to have longer-term consequences, \u0000more efforts are needed to address and treat menstrual disorders in female students.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"346-355"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48525058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence and Risk Factors of Nosocomial Infections in the Intensive Care Unit of a Hospital in Iran 伊朗某医院重症监护室院内感染的流行率和危险因素

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-09-10 DOI: 10.32598/JQUMS.24.4.5

A. Kazemifar, A. Yahyaee, Mahyar Seddighi, Maryam Soleimannejad

{"title":"The Prevalence and Risk Factors of Nosocomial Infections in the Intensive Care Unit of a Hospital in Iran","authors":"A. Kazemifar, A. Yahyaee, Mahyar Seddighi, Maryam Soleimannejad","doi":"10.32598/JQUMS.24.4.5","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.5","url":null,"abstract":"Background Nosocomial infections account for about one third of deaths in hospitals. \u0000Objective In this study, we aim to determine the factors affecting the incidence of nosocomial infections \u0000in the Intensive Care Units (ICUs) to provide more information for helping improve the prevention and \u0000treatment of these infections in the hospitals located in Iran. \u0000Methods This is a comparative cross-sectional study conducted in 2017 on 86 patients admitted to the \u0000general ICU of \u0000Boo Ali Sina Hospital in Qazvin, Iran. We extracted the patients’ demographic and clinical information \u0000(e.g. blood and urine culture results) from their medical records. \u0000Findings The prevalence of nosocomial infections were reported 24.3; 38.4% of infections was related to \u0000Acinetobacter and 18.6% to Pseudomonas aeruginosa and other microorganisms. The highest antibiotic \u0000resistance in patients was to Cefepime (64%) and Ciprofloxacin (60%). \u0000Conclusion The prevalence of nosocomial infections in the general ICU of the study hospital is relatively \u0000high with different strains and varied patterns of antibiotic resistance indicating the need for more comprehensive \u0000studies and preventive measures in the country.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"356-365"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42215056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Core Stability Exercise and Vitamin D Intake on Liver Enzymes Activities in Women With Chronic Low Back Pain 核心稳定性运动和维生素D摄入对慢性腰痛女性肝酶活性的影响

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-09-10 DOI: 10.32598/JQUMS.24.4.2

Seyyed Javad Hashemi Sangatrashani, M. Habibian, S. J. Moosavi

{"title":"Effect of Core Stability Exercise and Vitamin D Intake on Liver Enzymes Activities in Women With Chronic Low Back Pain","authors":"Seyyed Javad Hashemi Sangatrashani, M. Habibian, S. J. Moosavi","doi":"10.32598/JQUMS.24.4.2","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.2","url":null,"abstract":"Background: Deficiency or insufficient level of vitamin D is very common in patients with liver disease, and is closely related to musculoskeletal pains, including low back pain. Objective: The current study aims to investigate of the activity of liver enzymes in women with chronic low back pain following core stability exercises and vitamin D intake. Methods: This clinical trial was conducted on 48 women (Mean±SD of age=36.59±5.50 years) in 2019 selected by using a convenience sampling method. They were randomly divided into four groups of control, vitamin D, exercise and combined (exercise +vitamin D). The last two exercise groups performed 8 weeks of core stability exercises with different intensities. The vitamin D and combined groups received 50,000 IU/week of vitamin D for 8 weeks. Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) activities were measured before and after the interventions. Data were analyzed by using paired t-test and one-way ANOVA. Findings: Eight weeks of core stability exercises, vitamin D intake, and the combined exercise and vitamin D supplementation caused a significant reduction in the activity of AST, ALT, and ALP enzymes. The combined intervention induced more reduction in the AST and ALP activities compared to other two groups received exercise and supplementation alone, and the decrease in ALT activity following the combined intervention was higher compared to the exercise group. Conclusion: It seems that the core stability exercises, vitamin D intake, and combination of exercise and vitamin D supplementation can improve liver function in women with chronic low back pain who have vitamin D deficiency by reducing the activity of liver enzymes. The combined intervention has greater effectiveness in improving liver function.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"332-345"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48559280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Chronic Administration of Pioglitazone on Learning and Memory in Rat Model of Streptozotocin-induced Alzheimer’s Disease 吡格列酮对链脲佐菌素诱导的阿尔茨海默病大鼠学习记忆的影响

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-09-10 DOI: 10.32598/JQUMS.24.4.1

E. Aali, M. Esmaeili, Sead Shima Mahmodi, Poriea Solimani

{"title":"Effects of Chronic Administration of Pioglitazone on Learning and Memory in Rat Model of Streptozotocin-induced Alzheimer’s Disease","authors":"E. Aali, M. Esmaeili, Sead Shima Mahmodi, Poriea Solimani","doi":"10.32598/JQUMS.24.4.1","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.1","url":null,"abstract":"Background: Alzheimer’s Disease (AD) is a chronic neurodegenerative disease characterized by abnormal protein accumulation, synaptic dysfunction, and cognitive impairment. Peroxisome Proliferator-Activated Receptor-γ (PPARγ) play a crucial role in regulating insulin sensitivity and may serve as potential therapeutic targets for AD. Pioglitazone (PIOG), as a PPARγ agonist, reduces β-amyloid and tau proteins, and inhibits neuroinflammation. Objective: This study aims to evaluate the effects of PIOG chronic administration on learning and memory in rat model of Streptozotocin (STZ)-induced AD Methods: Forty-two male Wistar rats were divided into two groups: A. Normal rats divided into three subgroups of Control, Dimethyl Sulfoxide (DMSO), and PIOG; and B. AD rats divided into four subgroups of Vehicle, STZ, STZ+DMSO and STZ+PIOG. The last two AD subgroups received 0.2 mL DMSO and PIOG (10 mg/kg per day) for 21 days. For induction of AD, STZ (3 mg/kg, 10 μl per injection site) were administered into lateral ventricles. All rates were trained under the Morris water maze task. Findings: PIOG impaired the spatial learning and memory in normal rats. Intracerebroventricular injection of STZ significantly increased escape latency and swimming time to find the hidden platform compared to the control group (P<0.05). The amnesic effect of STZ was prevented by PIOG administration such that the escape latency and swimming time to find the hidden platform in the STZ+PIOG group were significantly lower than in the STZ+DMSO group (P<0.05). Conversely, the percentage of time spent and distance swimming in the target quadrant in the probe test in the STZ+ PIOG group rats were significantly higher than those in the STZ + DMSO group. Conclusion: PIOG administration impaired spatial learning and memory in normal rats, but improved learning and memory in rats with STZ-induced AD. It can be useful for treatment of cognitive impairment in AD patients.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"294-307"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46870466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Role of Pre-hospital and Hospital Emergency Staff in Time Management of Acute Myocardial Infarction 院前和院内急救人员在急性心肌梗死时间管理中的作用

The Journal of Qazvin University of Medical Sciences Pub Date : 2020-09-10 DOI: 10.32598/JQUMS.24.4.9

P. Namdar, L. Yekefallah, Fatemeh Jalalian

{"title":"The Role of Pre-hospital and Hospital Emergency Staff in Time Management of Acute Myocardial Infarction","authors":"P. Namdar, L. Yekefallah, Fatemeh Jalalian","doi":"10.32598/JQUMS.24.4.9","DOIUrl":"https://doi.org/10.32598/JQUMS.24.4.9","url":null,"abstract":"According to the latest guidelines, in ST-segment elevation myocardial infarction (STEMI) cases, the best intervention to restore blood flow in the occluded coronary arteries is angioplasty at a time less than 90 minutes. Delay in timely implementation of reperfusion is one of the key problems in the management of STEMI. In this review study, the aim is to investigate the role of pre-hospital and hospital emergency staff in time management of STEMI. For this purpose, the articles published 1999-2019 with available full texts in ProQuest, SID, Science Direct, Google Scholar and Scopus databases were searched using the keywords: Pre-hospital Emergency, Hospital Emergency, Primary Angioplasty, Time Management, Ischemia, and Acute Myocardial Infarction. A total of 59 articles in Persian and English (from 10 different countries) covering both qualitative and quantitative studies were initially yielded. Those which were not a review paper and their full texts were unavailable were excluded from the review. Faster reperfusion reduces the cardiac necrosis area, resulting in reduced morbidity and mortality. Early ECG recording by the pre-hospital emergency team followed by the activation of the code STEMI by the emergency team can increase the speed of diagnosis, decision making, and transfer of the STEMI patient to receive the best treatment.","PeriodicalId":22748,"journal":{"name":"The Journal of Qazvin University of Medical Sciences","volume":"24 1","pages":"374-385"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48909419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0