The Journal of Prevention of Alzheimer's Disease最新文献

{"title":"Differential effects of soluble and plaque amyloid on late-life depression: The moderating role of tau pathology.","authors":"Gihwan Byeon, Suhyung Kim, Sunghwan Kim, Yoo Hyun Um, Sheng-Min Wang, Seunggyun Ha, Sonya Youngju Park, Yeong Sim Choe, Donghyeon Kim, Hyun Kook Lim, Chang Uk Lee, Dong Woo Kang","doi":"10.1016/j.tjpad.2025.100318","DOIUrl":"10.1016/j.tjpad.2025.100318","url":null,"abstract":"<p><strong>Background: </strong>Late-life depression frequently co-occurs with Alzheimer's disease (AD); however, the interactive effects of amyloid-beta (Aβ) species and tau pathology on depressive symptoms remain unclear. Soluble oligomeric Aβ (OAβ) and amyloid plaques may differentially influence depression depending on tau burden.</p><p><strong>Objectives: </strong>To examine how plasma OAβ and PET-measured amyloid plaque burden are associated with depressive symptoms across varying levels of tau pathology.</p><p><strong>Design: </strong>Cross-sectional analysis using generalized linear models with interaction terms, supported by stratified subgroup analyses and Johnson-Neyman procedures.</p><p><strong>Setting: </strong>Memory disorder clinic at a university-affiliated hospital.</p><p><strong>Participants: </strong>A total of 103 individuals, including cognitively normal controls (n = 24), patients with mild cognitive impairment (n = 54), and amyloid-positive dementia (n = 25), all of whom underwent plasma biomarker testing and tau and amyloid PET imaging.</p><p><strong>Measurements: </strong>Depression was evaluated using the Cornell Scale for Depression in Dementia (CSDD), Hamilton Depression Rating Scale (HAM-D), and Geriatric Depression Scale-Short Version (GDS-SV). Plasma OAβ was measured by Multimer Detection System (MDS), and PET quantified amyloid and tau burden.</p><p><strong>Results: </strong>MDS-OAβ showed a significant negative interaction with tau PET SUVR on depression scores (FDR-adjusted p < 0.05). Higher OAβ levels were linked to greater depression severity in low-tau individuals, but inversely related in high-tau individuals. Amyloid plaque burden was associated with depression only in those with advanced tau pathology.</p><p><strong>Conclusions: </strong>The association between amyloid pathology and depression differs depending on tau burden. Soluble OAβ may be a key contributor to depressive symptoms in early AD stages, while plaque effects become prominent later. These findings underscore the potential utility of OAβ as an early neuropsychiatric biomarker in AD and highlight the need to consider tau pathology when evaluating amyloid-related mood disturbances.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100318"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary economic evaluation of a potential program for the primary prevention of Alzheimer's disease.","authors":"Soeren Mattke, Jiahe Chen, Eric M Reiman","doi":"10.1016/j.tjpad.2025.100334","DOIUrl":"10.1016/j.tjpad.2025.100334","url":null,"abstract":"<p><strong>Introduction: </strong>We evaluated the potential cost-effectiveness of a hypothetical primary prevention screening and treatment program to avert the biological and clinical onset of Alzheimer's disease (AD) in cognitively unimpaired older adults.</p><p><strong>Methods: </strong>This hypothetical program would use an amyloid plaque-clearing antibody therapy monthly in the first six months and annually thereafter in cognitively unimpaired 55-79 year-old APOE4 carriers and 60-79 year-old non-carriers with a negative AD blood test (sensitivity and specificity of 0.9), averting the onset of moderately frequent neuritic amyloid plaques by 75 %. Lifetime hypothetical treatment outcomes were compared to natural history outcomes to estimate cost-effectiveness.</p><p><strong>Results: </strong>The program would be cost-effective up to a per-dose price of $1173 in APOE4 carriers and $307 in non-carriers or a lifetime cost of $20,167 and $5146, respectively.</p><p><strong>Discussion: </strong>Primary AD prevention could be cost-effective in older adults, especially in those at higher risk. Our findings and assumptions need to be confirmed with actual data.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100334"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144969866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor: \"Reevaluating the Neuroprotective promise of dietary nitrate: Commentary on Rajendra et al. (2025).","authors":"Catherine Bondonno","doi":"10.1016/j.tjpad.2025.100338","DOIUrl":"10.1016/j.tjpad.2025.100338","url":null,"abstract":"","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100338"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary sugar intake, genetic susceptibility, and risk of dementia: A prospective cohort study.","authors":"Yu An, Limin Cao, Gang Zheng, Yashu Liu, Honghao Yang, Liangkai Chen, Yuhong Zhao, Xiaopeng Zhang, Yang Xia","doi":"10.1016/j.tjpad.2025.100312","DOIUrl":"10.1016/j.tjpad.2025.100312","url":null,"abstract":"<p><strong>Background: </strong>Sugar intake has been identified as a risk factor for incident dementia; however, the role of genetic susceptibility in such association remains unclear.</p><p><strong>Methods: </strong>This cohort study involved 158,408 participants from the UK Biobank to explore the effect of genetic susceptibility on the association between dietary sugar intake and dementia risk. Data on sugar intake were evaluated using repeated web-based 24-hour dietary recalls. Polygenic risk scores (PRS) for sugar metabolism (Triglyceride Glucose, TyG), gut microbiota, and disease susceptibility (Alzheimer's disease) were generated based on genome-wide association studies.</p><p><strong>Results: </strong>Over a median follow-up period of 9.94 years, 1,219 dementia cases (0.7%) were documented. There were significant positive dose-response relationships between sugar intake and dementia risk (non-free sugar: HR, 95% CI, _{Quartile 4} vs. _{Quartile 1} = 1.26, 1.04-1.52; free sugar: 1.43, 1.20-1.70). Genetic susceptibility, including TyG-PRS, gut microbiota, and disease susceptibility, showed a combined effect on the association between sugar intake and dementia risk. Notably, significant interactions were observed between sugar intake, PRS for Ruminococcaceae UCG-014 and dementia, as well as between free sugar, PRS for Oscillospira and dementia. Participants with lower PRS of Ruminococcaceae UCG-014, or higher PRS of Oscillospira, posed a higher risk of dementia due to sugar intake.</p><p><strong>Conclusion: </strong>Both free and non-free sugar intake are independent risk factors for dementia incidence. The role of genetic susceptibility among such association cannot be ignored. These results underscore the importance of personalized nutritional interventions targeting both dietary habits and genetic risk profiles in dementia prevention strategies.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100312"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia risk prediction: A comparative analysis of the ANU-ADRI, CAIDE, CogDrisk, LIBRA, and LIBRA2 indices in the HUNT study.","authors":"Josephine Stubs, Ellen Melbye Langballe, Gill Livingston, Kaarin J Anstey, Kay Deckers, Fiona E Mathews, Mika Kivimäki, Bjørn Heine Strand, Anne-Marie Rokstad, Steinar Krokstad, Geir Selbæk","doi":"10.1016/j.tjpad.2025.100326","DOIUrl":"10.1016/j.tjpad.2025.100326","url":null,"abstract":"<p><strong>Background/objective: </strong>Dementia is a major global health concern, necessitating effective risk assessment tools and early intervention. This study compared the performance of five modifiable dementia risk indices - ANU-ADRI, CAIDE, CogDrisk, LIBRA, and LIBRA2 and a \"demographics-only\" (age, education) model.</p><p><strong>Methods: </strong>We analyzed data from 5247 Norwegian participants in the Trøndelag Health Study (HUNT4 70+, 2017-2019) and dementia risk indices from baseline data in HUNT3 (2006-2008). Logistic regression models assessed associations between standardized index scores and all-cause dementia and Alzheimer's disease (AD) across age group (<65 vs. ≥65 years), sex, and APOE4 status.</p><p><strong>Results: </strong>During the mean follow-up of 10.6 (9.3-12.3) years (SD=0.74), all indices significantly predicted dementia and AD, though none outperformed the demographics-only model. CogDrisk showed significantly better discriminative ability than all other indices (0.76, 95 % CI:0.74-0.78; DeLong p < 0.05), followed by LIBRA (0.75, 95 % CI:0.72-0.77) and ANU-ADRI (0.74, 95 % CI:0.72-0.76). LIBRA2 (0.69, 95 % CI:0.66-0.71) and CAIDE (0.59, 95 % CI:0.56-0.61) had significantly lower accuracy (DeLong p < 0.001). Removing demographics maintained rank order but reduced accuracy across all indices. Stratified analyses showed stronger performance in those ≥65 years and females at HUNT3, while APOE4 status did not affect performance.</p><p><strong>Conclusion: </strong>All indices were associated with dementia risk, with CogDrisk performing best across all conditions, and LIBRA2 and CAIDE performing weakest. No index outperformed a model including age and education only. Future research should refine risk indices for age- and sex-specific applications and assess whether simpler demographic models may suffice in some contexts.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100326"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal associations of neuropsychiatric symptoms, demographics and amyloid with subsequent tau burden in older adults.","authors":"Pablo Aguilar-Dominguez, Eleni Palpatzis, Muge Akinci, Anna Canal-Garcia, Joana B Pereira, Alexandre Bejanin, Eider M Arenaza-Urquijo","doi":"10.1016/j.tjpad.2025.100294","DOIUrl":"10.1016/j.tjpad.2025.100294","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric symptoms are increasingly recognized as early manifestations of Alzheimer's disease (AD). These symptoms may reflect or contribute to underlying neurobiological changes, including tau burden, which represents more advanced AD pathology. Understanding factors associated with tau burden may help identify individuals at elevated risk and improve early detection strategies.</p><p><strong>Objectives: </strong>To investigate the temporal relationships between neuropsychiatric symptoms, demographic factors, and tau burden, by examining amyloid (Aβ)-dependent, -independent, and interactive associations.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Alzheimer's Disease Neuroimaging Initiative.</p><p><strong>Participants: </strong>We included 681 participants without dementia (mean age = 71.2 years, 51.8 % female).</p><p><strong>Measurements: </strong>The participants underwent tau PET scanning with prior amyloid PET and Neuropsychiatric Inventory (NPI) interview assessments clustered around three time periods relative to tau PET: closest (0 - 2 years), mid (3 - 5 years), and furthest (6 - 8 years). Linear regression analyses, adjusting for age and APOE ε4 alleles, examined associations of NPI scores, sex, education, and their Aβ-status interactions with tau burden.</p><p><strong>Results: </strong>Higher total NPI scores up to 2 years prior to tau PET were associated with greater tau burden independently of Aβ status, whereas anxiety symptoms demonstrated an Aβ-dependent relationship with tau. (NPI: β=0.117, 95 % CI: 0.049 to 0.185, p=0.001, Anxiety: β=0.249, 95 % CI: 0.073 to 0.424, p=0.006). NPI measured up to 5 years prior to tau PET interacted with Aβ on tau burden (0-2 years: β=0.272, 95 % CI: 0.136 to 0.407, p<0.001, 3-5 years: β=0.336, 95 % CI: 0.127 to 0.544, p=0.002). Sex and education showed minimal associations with tau at uncorrected statistical levels.</p><p><strong>Conclusions: </strong>Neuropsychiatric symptoms were associated with tau burden up to two years before tau sampling, independently of Aβ, and interacted with Aβ status up to five years prior, suggesting that neuropsychiatric symptoms are related to tau in the short term and may represent manifestations of advancing AD pathology. Demographic factors showed minimal associations. These findings highlight the importance of evaluating neuropsychiatric and anxiety symptoms as potential indicators of increased tau pathology.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100294"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort.","authors":"Gurveen Kaur Sandhu, Ashwati Vipin, Jacklyn Leonardo, Fatin Zahra Zailan, Pricilia Tanoto, Faith Phemie Hui En Lee, Xin Ying Sim, Smriti Ghildiyal, Yi Jin Leow, Shan Yao Liew, Gursimar Bhalla, Rasyiqah Binte Shaik Mohamed Salim, Bocheng Qiu, Nagaendran Kandiah","doi":"10.1016/j.tjpad.2025.100300","DOIUrl":"10.1016/j.tjpad.2025.100300","url":null,"abstract":"<p><strong>Background: </strong>Elevated Glial Fibrillary Acidic Protein (GFAP) is associated with increased Phosphorylated Tau 181 (pTau181) induced neurodegeneration in Alzheimer's Disease.</p><p><strong>Objective: </strong>However, the role of GFAP and pTau181 in vascular/mixed dementias requires elucidation within the Southeast Asian context, where their burden is considerable.</p><p><strong>Design: </strong>Population based cross-sectional study.</p><p><strong>Setting: </strong>Biomarkers and Cognition Study, Singapore (BIOCIS).</p><p><strong>Participants: </strong>Baseline data from n = 583 (40.3 % male), non-demented but at risk, Southeast Asian community participants, were included in this analysis. All participants displayed cognitive symptoms on the Subjective Memory Complaints Questionnaire, although they may or may not have objective cognitive deficits and did not meet the criteria for dementia as per the DSM - 5.</p><p><strong>Methods: </strong>Neuropsychological assessments for executive function evaluation, volumetric White Matter Hyperintensities (WMH) measurement and plasma biomarker expression, were determined in non-demented but at risk, Southeast Asian research participants. Partial correlation analysis demonstrated variable associations. Simple moderation analysis revealed the ability for plasma biomarkers to influence the relationship between executive function and WMH.</p><p><strong>Results: </strong>WMH burden positively correlated to Neurofilament-Light (NfL) and pTau181. Executive function and processing speed negatively correlated to WMH burden. GFAP positively correlated to pTau181 and negatively correlated to executive function. NfL, GFAP, pTau181, and Amyloid beta 42/Amyloid beta 40 (Aβ42/Aβ40) ratio independently moderated, the relationship between executive function/processing speed and WMH burden.</p><p><strong>Conclusion: </strong>Inflammatory mechanisms represented by GFAP were linked to tau pathology and WMH and also moderated the association between WMH on cognitive performance.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100300"},"PeriodicalIF":7.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive decline among Chinese older adults: Findings from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).","authors":"Kaisy Xinhong Ye, Lei Feng, Tih-Shih Lee, Yi Zeng, Zhengliang Wang","doi":"10.1016/j.tjpad.2025.100393","DOIUrl":"https://doi.org/10.1016/j.tjpad.2025.100393","url":null,"abstract":"","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100393"},"PeriodicalIF":7.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Synergistic Effects of Multiple Pathological Processes on Alzheimer's Disease Risk: Evidence for Age-Dependent Stroke Interactions [The Journal of Prevention of Alzheimer's Disease (2025) 100268].","authors":"Fen Liu, Xuesong Xia, Chengjie Zheng, Feng Liu, Min Jiang","doi":"10.1016/j.tjpad.2025.100371","DOIUrl":"https://doi.org/10.1016/j.tjpad.2025.100371","url":null,"abstract":"","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100371"},"PeriodicalIF":7.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention.","authors":"Giulia Lorenzon, Anna Marseglia, Rosaleena Mohanty, Jenni Lehtisalo, Konstantinos Poulakis, Tiia Ngandu, Alina Solomon, Miia Kivipelto, Eric Westman","doi":"10.1016/j.tjpad.2025.100390","DOIUrl":"https://doi.org/10.1016/j.tjpad.2025.100390","url":null,"abstract":"<p><strong>Importance: </strong>Despite the emergence of anti-amyloid therapies for Alzheimer's disease, targeting modifiable risk factors remains the most effective primary prevention strategy for dementia. While cognitive benefits of multimodal lifestyle interventions have been demonstrated, the underlying effects on brain structure remain unclear, likely due to heterogeneity in brain structure among at-risk individuals.</p><p><strong>Objective: </strong>To investigate how distinct subgroups of at-risk individuals, defined by cortical and subcortical grey matter (GM) patterns, differ in their response to the FINGER intervention, as well as in their demographic, vascular, and lifestyle profiles.</p><p><strong>Design: </strong>Observational study employing unsupervised clustering of MRI-based cortical thickness and subcortical volume metrics, followed by longitudinal assessment of a lifestyle intervention.</p><p><strong>Setting: </strong>The FINGER randomized controlled trial (RCT), a population-based, multidomain lifestyle intervention targeting older adults (aged 60-77) with elevated cardiovascular risk (CAIDE score ≥ 6) and average to slightly below-average cognitive performance.</p><p><strong>Participants: </strong>A total of 120 participants (61 intervention, 59 control) with available baseline MRI data.</p><p><strong>Intervention: </strong>Participants were randomly assigned (1:1, double-blind) to a 2-year multidomain lifestyle intervention group - targeting diet, physical activity, cognitive training, social engagement, and metabolic and vascular risk management - or to a control group receiving standard health advice.</p><p><strong>Main outcomes and measures: </strong>Sociodemographic, vascular, and lifestyle factors, medical comorbidities, and cognitive performance, were assessed at baseline (pre-intervention). Additionally, brain structural outcomes (mean cortical thickness, Alzheimer's disease and resilience-related cortical signatures, hippocampal volume), and cognition (global, executive function, processing speed, memory) were analysed post-intervention using hierarchical linear models stratified by GM cluster.</p><p><strong>Results: </strong>Clusters with diffuse or frontal-predominant cortical thinning, but with more favourable vascular profiles, characterized by lower blood pressure and reduced obesity, showed significantly less cortical thinning (mean thickness, AD-signature, and resilience-signature regions; all p < 0.05) following the intervention.</p><p><strong>Conclusions and relevance: </strong>Stratifying at-risk individuals by GM patterns and vascular risk revealed differential brain responses to the FINGER intervention. These findings underscore the value of brain-based subtyping to optimize personalized dementia prevention strategies in heterogeneous at-risk populations.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT01041989.</p>","PeriodicalId":22711,"journal":{"name":"The Journal of Prevention of Alzheimer's Disease","volume":" ","pages":"100390"},"PeriodicalIF":7.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}