The Journal of Heart and Lung Transplantation最新文献_第3页

RAS in lung transplantation - Renin-Angiotensin System and mitochondrial protection with Angiotensin-1-7 during pulmonary preservation at 10°C. 肺移植中的RAS -肾素-血管紧张素系统和血管紧张素-1-7在10°C肺保存期间的线粒体保护。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-19 DOI: 10.1016/j.healun.2025.08.009

Ilker Iskender,Clemens Aigner

引用次数: 0

Donation after circulatory death heart transplantation in the United States continues to steadily increase but maintains unrealized potential to address the organ shortage. 在美国，循环死亡心脏移植后的捐赠继续稳步增加，但仍未实现解决器官短缺的潜力。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-19 DOI: 10.1016/j.healun.2025.08.006

A Cozette Killian,Rajamiyer Venkateswaran

引用次数: 0

Differential outcomes of ISHLT PGD 3 after ex-vivo lung perfusion compared to PGD 3 after direct transplantation. 与直接移植后PGD 3相比，ISHLT离体肺灌注后PGD 3的差异结果。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-19 DOI: 10.1016/j.healun.2025.08.002

Alberto Benazzo,John Peel,Andrea Mariscal,Jonathan Yeung,Meghan Aversa,Shaf Keshavjee,Marcelo Cypel

{"title":"Differential outcomes of ISHLT PGD 3 after ex-vivo lung perfusion compared to PGD 3 after direct transplantation.","authors":"Alberto Benazzo,John Peel,Andrea Mariscal,Jonathan Yeung,Meghan Aversa,Shaf Keshavjee,Marcelo Cypel","doi":"10.1016/j.healun.2025.08.002","DOIUrl":"https://doi.org/10.1016/j.healun.2025.08.002","url":null,"abstract":"BACKGROUNDPrimary graft dysfunction (PGD) remains the most feared complication in the early postoperative period after lung transplantation (LTx). Despite improved evaluation of marginal lungs with ex-vivo lung perfusion (EVLP), PGD 3 is still observed. We aimed to evaluate the outcomes of patients developing PGD 3 after EVLP.METHODSThis is a retrospective single-center study, including patients who received LTx between 2008 and 2021 in the Toronto Lung Transplant Program. The primary end-point was 90-day mortality. Propensity score weighting was applied to correct for possible confounders.RESULTSThe final analysis included 1,871 patients, of which 538 lungs were transplanted after EVLP assessment using the Toronto EVLP technique. The incidence of grade 3 PGD was 38.1% and 20.8% (p < 0.001) on intensive care unit (ICU) admission and 13.2% and 12.1% (p = 0.445) at 72 hours for EVLP LTx and standard transplantation, respectively. The EVLP LTx group developing PGD 3 on arrival to ICU had a shorter median length of mechanical ventilation (82 vs 124 hours, p < 0.001), shorter length of stay in ICU (6 vs 12 days, p < 0.001), and shorter length of hospital stay (23 vs 41 days, p < 0.001) compared to standard LTx PGD 3 group. A lower 90-day mortality rate in the EVLP LTx group was observed compared to standard LTx (6% vs 11%, p = 0.078). Mortality rate at 1 year post-transplant for PGD 3 patients was similar between the groups.CONCLUSIONSThe incidence of PGD 3 on admission to the ICU is higher after EVLP compared to standard transplantation. However, PGD 3 after acellular normothermic EVLP resolves within 24 hours and short-term outcomes are significantly improved compared to patients with PGD 3 after standard transplantation.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal membrane oxygenation in cardiogenic shock: A bridge in need of a destination. 心源性休克的体外膜氧合：需要目的地的桥梁。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-19 DOI: 10.1016/j.healun.2025.07.034

Jacob C Jentzer

引用次数: 0

The kidneys' effect on the survival of multi-organ transplant recipients. 肾脏对多器官移植受者生存的影响。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-18 DOI: 10.1016/j.healun.2025.07.031

Richard N Formica

引用次数: 0

Hemodynamic Effects of Sotatercept Administration in Pulmonary Hypertension- Insights from Remote Monitoring. 索特塞普给药对肺动脉高压的血流动力学影响——来自远程监测的见解。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-04 DOI: 10.1016/j.healun.2025.07.032

Suraj Nagaraj,Amy Suhotliv,Shreyas Yakkali,Kate Steinberg,Ulrich P Jorde,Harrison Farber,Sandhya Murthy

引用次数: 0

First Come, Second Served: Behind the Veil of Out-of-Sequence Donors in Adult Heart Transplant. 先到先得：成人心脏移植中不合顺序供体的背后。

The Journal of Heart and Lung Transplantation Pub Date : 2025-08-04 DOI: 10.1016/j.healun.2025.07.026

Yasbanoo Moayedi,Heather Ross

引用次数: 0

Donation after Circulatory Death Transplantation Alleviate Waitlist Time for Hard-to-Transplant Cardiac Recipients. 循环死亡移植后的捐赠减少了难以移植的心脏受者的等待时间。

The Journal of Heart and Lung Transplantation Pub Date : 2025-07-31 DOI: 10.1016/j.healun.2025.07.017

Elizabeth J Bashian,Sarah Y Park,Rocio Lopez,Jesse D Schold,Nicholas R Teman,Michael T Cain,Jordan R H Hoffman

{"title":"Donation after Circulatory Death Transplantation Alleviate Waitlist Time for Hard-to-Transplant Cardiac Recipients.","authors":"Elizabeth J Bashian,Sarah Y Park,Rocio Lopez,Jesse D Schold,Nicholas R Teman,Michael T Cain,Jordan R H Hoffman","doi":"10.1016/j.healun.2025.07.017","DOIUrl":"https://doi.org/10.1016/j.healun.2025.07.017","url":null,"abstract":"PURPOSEDonation after circulatory death (DCD) can increase the cardiac transplant donor pool and decrease waitlist time. Patients with certain characteristics may be more difficult to match with appropriate donors. This study aimed to evaluate the impact of DCD heart donations on these candidates.METHODSThis was a retrospective study using the Scientific Registry of Transplant Recipients database including adult patients listed for heart transplant between 11/1/2018 and 3/2/2024. The cohort was divided into pre-DCD era, early DCD era, and contemporary DCD era. The following factors were used to classify candidates as difficult to transplant: height or weight greater than 2 SD above the average, blood type O, congenital heart disease, LVAD, and status 4, 5, or 6.RESULTSFindings revealed a decrease in median waitlist time from 2.8 months in the pre-DCD era to 1.6 months in the contemporary era and an increase in the transplantation rate from 65% to 73%. However, factors such as type O blood, presence of durable left ventricular assist devices (LVAD), and listing status significantly correlated with lower transplant likelihood across eras. DCD transplant recipients faced longer waitlist times compared to donation after brain death (DBD) counterparts in the early DCD era, while this disparity diminished in the contemporary era.CONCLUSIONSEarly DCD utilization alleviated the prolonged waiting times seen by hard-to-transplant recipients. As experience with DCD hearts increased, DCD hearts augmented the donor pool, reducing waitlist time in across all cohorts.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transplanting Beyond Anatomy: When Congenital Heart Disease Challenges Persist Despite a New Heart. 超越解剖的移植：当先天性心脏病的挑战持续存在，尽管有一个新的心脏。

The Journal of Heart and Lung Transplantation Pub Date : 2025-07-30 DOI: 10.1016/j.healun.2025.07.025

Nicola Pradegan,Gino Gerosa

引用次数: 0

Angiotensin-(1-7) preconditioning during 10°C static preservation improves early post-transplant graft function in a rat lung transplantation model. 10°C静态保存期间血管紧张素-(1-7)预处理可改善大鼠肺移植模型移植后早期移植物功能。

The Journal of Heart and Lung Transplantation Pub Date : 2025-07-30 DOI: 10.1016/j.healun.2025.07.018

Paolo Oliveira,Aizhou Wang,Keiji Yamanashi,Yu Zhang,Prodipto Pal,Guillermo Garza,Juan Montagne,Gabriel Siebiger,Nadav Furie,Jenny Yune,Shaf Keshavjee,Paulo Manuel Pêgo-Fernandes,Marcelo Cypel

{"title":"Angiotensin-(1-7) preconditioning during 10°C static preservation improves early post-transplant graft function in a rat lung transplantation model.","authors":"Paolo Oliveira,Aizhou Wang,Keiji Yamanashi,Yu Zhang,Prodipto Pal,Guillermo Garza,Juan Montagne,Gabriel Siebiger,Nadav Furie,Jenny Yune,Shaf Keshavjee,Paulo Manuel Pêgo-Fernandes,Marcelo Cypel","doi":"10.1016/j.healun.2025.07.018","DOIUrl":"https://doi.org/10.1016/j.healun.2025.07.018","url":null,"abstract":"BACKGROUNDIschemia-reperfusion injury (IRI) plays an important role in early graft failure after lung transplantation. We hypothesized that treating injured donor lungs with Angiotensin-(1-7) [Ang-(1-7)], a biologically active product of the protective axis of the renin-angiotensin system, during 10°C preservation reduces IRI and improves lung transplant outcomes.METHODSIn Lewis rats, aspiration injury was induced through intratracheal instillation of hydrochloric acid (0.1N). Acid injured donor lungs (n = 5/group) were randomized to lungs flushed with low-potassium dextran-glucose solution (LPDG; Control) or LPDG plus Ang-(1-7) and stored for 12 hours at 10ºC. A third group included immediate transplantation (MinCIT). Left lungs were transplanted and reperfused for 2 hours.RESULTSAfter transplantation, lungs preconditioned with Ang-(1-7) showed significantly better oxygenation (p = 0.004) and lower IL-8 levels (p = 0.01) compared to other groups. Results of a panel of mitochondrial biogenesis markers showed higher fold regulations for MFN2 (p = 0.03), when lungs were flushed with Ang-(1-7) relative to Control. The improvement in lung function was dependent on MasR activation and specific to 10°C preservation.CONCLUSIONSWe demonstrate that the enrichment of lung preservation flush solution with Ang-(1-7) results in superior post-transplant graft function, amplifying the beneficial effects of hypothermic preservation on injured lungs. The maintenance of mitochondrial and cellular health through preconditioning with Ang-(1-7) may result in better clinical outcomes.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0