The Journal of Heart and Lung Transplantation最新文献_第3页

Corrigendum to ''Safety and efficacy of riociguat in patients with pulmonary arterial hypertension and cardiometabolic comorbidities: Data from interventional clinical trials'' [The Journal of Heart and Lung Transplantation, 44 (2025) 135-146]. 里奥西瓜特对肺动脉高压和心脏代谢合并症患者的安全性和有效性：来自介入性临床试验的数据"[《心肺移植杂志》，44 (2025) 135-146]。

The Journal of Heart and Lung Transplantation Pub Date : 2025-04-09 DOI: 10.1016/j.healun.2025.02.1679

Stephan Rosenkranz,Hossein-Ardeschir Ghofrani,Marius M Hoeper,David Langleben,Sara Hegab,Claudia Rahner,Jean-François Richard,Vallerie V McLaughlin

引用次数: 0

Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome. 儿童间质性肺疾病的儿科肺移植：适应症和结果。

The Journal of Heart and Lung Transplantation Pub Date : 2025-04-08 DOI: 10.1016/j.healun.2025.04.001

Hendrik Schneider,Fabio Ius,Carsten Müller,Jawad Salman,Katharina Schütz,Harald Köditz,Katja Nickel,Gesine Hansen,Dmitry Bobylev,Nicolaus Schwerk,Julia Carlens

{"title":"Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome.","authors":"Hendrik Schneider,Fabio Ius,Carsten Müller,Jawad Salman,Katharina Schütz,Harald Köditz,Katja Nickel,Gesine Hansen,Dmitry Bobylev,Nicolaus Schwerk,Julia Carlens","doi":"10.1016/j.healun.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.healun.2025.04.001","url":null,"abstract":"BACKGROUNDChildhood interstitial lung disease (chILD) is heterogeneous, associated with significant morbidity and can cause organ failure. In these cases, lung transplantation (LuTx) is a treatment option. Data on indications and outcome after LuTx for chILD is limited. We compared characteristics of LuTx for chILD to the indications cystic fibrosis (CF) and pulmonary hypertension (PH).METHODSchILD-patients <18 years who underwent LuTx at our center between Jan 1st, 2011 and Sep 30th, 2023, were retrospectively analysed and divided into two groups depending on their age at disease manifestation: Children in the chILD A group predominantly became ill during the first two years of life, chILD B patients thereafter. Outcomes were compared to patients with CF and PH.RESULTS101 children were included (chILD A 12; chILD B 19; CF 49; PH 21). Patients in the chILD A group were younger (mean age 1.5 vs., 12.9, 15.2, 10.9 years) and frequently required mechanical ventilation before LuTx (41.7%, vs. 10.5%, 2%, 9.5%, respectively). Their median ICU stay (23 vs. 4, 2, 13 days) and median hospital stay (48 vs. 27, 30, 42 days) after LuTx was longer. Patients with chILD B had the lowest pre-transplant ICU requirement (21.1% vs. 66.7% for chILD A, 30.6% for CF and 47.6% for PH) and short median hospital stay. Five year survival was comparable in all groups (80.2%, 86.5%, 80.4%, and 81.2%).CONCLUSIONLuTx for patients with chILD shows favourable outcome, although younger chILD A patients had a higher pre-transplant morbidity and longer ICU and hospital stay surrounding the transplantation.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sympathetic reinnervation in cardiac transplant recipients: Prevalence, time course and association with long-term survival. 心脏移植受者的交感神经再支配：发病率、时间过程以及与长期存活的关系。

The Journal of Heart and Lung Transplantation Pub Date : 2024-10-18 DOI: 10.1016/j.healun.2024.10.009

Oliver J F Weiner,Moloy Das,Richard H Clayton,Janet M McComb,Alan Murray,Gareth Parry,Stephen W Lord

{"title":"Sympathetic reinnervation in cardiac transplant recipients: Prevalence, time course and association with long-term survival.","authors":"Oliver J F Weiner,Moloy Das,Richard H Clayton,Janet M McComb,Alan Murray,Gareth Parry,Stephen W Lord","doi":"10.1016/j.healun.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.healun.2024.10.009","url":null,"abstract":"BACKGROUNDPartial cardiac sympathetic reinnervation after cardiac transplant has been extensively investigated and evidenced. However, there have been no large-scale, long-term studies evaluating the prevalence, time-course, and association with long-term survival of sympathetic reinnervation of the heart.METHODSCardiac transplant recipients (n=232) were recruited from outpatient clinic at a single transplant centre in the United Kingdom. Participants were each tested once for the presence of sympathetic reinnervation of the sinus node using the low frequency component of power spectral analysis of heart rate variability, with a cut-off defined as 2 standard deviations above the mean for denervated participants (those tested <56 days post-transplant). Time-course was calculated based on the timing of testing post-transplant. Patients were then followed-up over a period of up to 27 years after transplant for survival analysis.RESULTSThe overall prevalence of cardiac sympathetic reinnervation in the 225 patients tested >56 days post-transplant was 64.9%. Sympathetic reinnervation primarily occurred in the first 18 months after transplant, with a plateau thereafter. The prevalence in participants tested >18 months post-transplant was 69.6%. In Kaplan-Meier survival analysis, sympathetic reinnervation was associated with significantly improved survival (Log-rank P=0.019), with a median survival time for reinnervated patients of 19.9 years compared to 14.4 years for the denervated group.CONCLUSIONSSympathetic reinnervation of the sinus node occurs mostly within 18 months of transplant, is found in 70% of cardiac transplant recipients tested >18 months post-transplant, and is associated with significantly improved long-term survival.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Gaps in Lung Allocation: A Data-Driven Approach to Overcome Biological Disparities. 缩小肺分配差距：用数据驱动的方法克服生物差异。

The Journal of Heart and Lung Transplantation Pub Date : 2024-10-18 DOI: 10.1016/j.healun.2024.10.008

Ankit Bharat

引用次数: 0

Severe primary graft dysfunction after heart transplantation - Defining the Subtypes. 心脏移植后严重的原发性移植物功能障碍--亚型的定义。

The Journal of Heart and Lung Transplantation Pub Date : 2024-10-18 DOI: 10.1016/j.healun.2024.10.010

Sanjay Dutta,Peter S Macdonald

引用次数: 0

ISHLT consensus statement on the perioperative use of ECLS in lung transplantation: Part II: Intraoperative considerations. ISHLT 关于肺移植围手术期使用 ECLS 的共识声明：第二部分：术中注意事项。

The Journal of Heart and Lung Transplantation Pub Date : 2024-10-09 DOI: 10.1016/j.healun.2024.08.027

Archer Kilbourne Martin,Olaf Mercier,Ashley Virginia Fritz,Theresa A Gelzinis,Konrad Hoetzenecker,Sandra Lindstedt,Nandor Marczin,Barbara J Wilkey,Marc Schecter,Haifa Lyster,Melissa Sanchez,James Walsh,Orla Morrissey,Bronwyn Levvey,Caroline Landry,Siavosh Saatee,Sakhee Kotecha,Juergen Behr,Jasleen Kukreja,Göran Dellgren,Julien Fessler,Brandi Bottiger,Keith Wille,Kavita Dave,Basil S Nasir,David Gomez-De-Antonio,Marcelo Cypel,Anna K Reed

{"title":"ISHLT consensus statement on the perioperative use of ECLS in lung transplantation: Part II: Intraoperative considerations.","authors":"Archer Kilbourne Martin,Olaf Mercier,Ashley Virginia Fritz,Theresa A Gelzinis,Konrad Hoetzenecker,Sandra Lindstedt,Nandor Marczin,Barbara J Wilkey,Marc Schecter,Haifa Lyster,Melissa Sanchez,James Walsh,Orla Morrissey,Bronwyn Levvey,Caroline Landry,Siavosh Saatee,Sakhee Kotecha,Juergen Behr,Jasleen Kukreja,Göran Dellgren,Julien Fessler,Brandi Bottiger,Keith Wille,Kavita Dave,Basil S Nasir,David Gomez-De-Antonio,Marcelo Cypel,Anna K Reed","doi":"10.1016/j.healun.2024.08.027","DOIUrl":"https://doi.org/10.1016/j.healun.2024.08.027","url":null,"abstract":"The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in lung transplantation consensus statement was approved for development by the International Society for Heart and Lung Transplantation Standards and Guidelines Committee. International experts across multiple disciplines, including cardiothoracic surgery, anesthesiology, critical care, pediatric pulmonology, adult pulmonology, pharmacy, psychology, physical therapy, nursing, and perfusion, were selected based on expertise and divided into subgroups examining the preoperative, intraoperative, and postoperative periods. Following a comprehensive literature review, each subgroup developed recommendations to examine via a structured Delphi methodology. Following 2 rounds of Delphi consensus, a total of 39 recommendations regarding intraoperative considerations for ECLS in lung transplantation met consensus criteria. These recommendations focus on the planning, implementation, management, and monitoring of ECLS throughout the entire intraoperative period.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactivation of Chagas Disease 南美锥虫病复发

The Journal of Heart and Lung Transplantation Pub Date : 2024-04-01 DOI: 10.1016/j.healun.2024.02.1250

S. Moraes, M. Heringer, G. Campos, L. Xavier, S. Mangini, F. Bacal

引用次数: 0

Natural Outcome of Isolated Right Ventricular Dysfunction Immediately After Heart Transplantation 心脏移植术后即刻出现孤立性右心室功能障碍的自然结果

The Journal of Heart and Lung Transplantation Pub Date : 2024-04-01 DOI: 10.1016/j.healun.2024.02.687

M. Kittleson, J. Patel, A. Nikolova, M. White, N. Bhatnagar, A. Kanungo, M. Lee, E. Chow, J. Moriguchi, D. Geft, L. Czer, F. Esmailian, J. Kobashigawa

引用次数: 0

Histopathologic Changes of Primary Graft Dysfunction of the Heart 心脏原发性移植物功能障碍的组织病理学变化

The Journal of Heart and Lung Transplantation Pub Date : 2024-04-01 DOI: 10.1016/j.healun.2024.02.617

M. Ospina-Romero, J.J. Schulte

引用次数: 0

Associations of Outpatient Administration of Monoclonal Antibody Therapy for COVID-19 Infection in Orthotropic Thoracic Organ Transplant Recipients 矫形胸腔器官移植受者门诊使用单克隆抗体治疗 COVID-19 感染的相关性

The Journal of Heart and Lung Transplantation Pub Date : 2024-04-01 DOI: 10.1016/j.healun.2024.02.550

M.U. Ahmed, F. Wright, S. Munoz, A. Albrecht, P. Weber, S. Hassan, N. Manandhar Shrestha, C. Kerndt, J. McDermott, R. Hadley, M. Gonzalez, M. Tamae Kakazu, R. Loyaga-Rendon, B. Trethowan

引用次数: 0