The Journal of Heart and Lung Transplantation最新文献

{"title":"Molecular Insights into Allograft Rejection and the ISHLT Pulmonary AMR GAP Framework.","authors":"Andrew S Potter,Don Hayes","doi":"10.1016/j.healun.2026.07.017","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.017","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary-Abdominal Normothermic Regional Perfusion Enables In Situ Lung Evaluation in DCD: A Comparative Study with conventional A-NRP.","authors":"Masashi Umeda,Shin Tanaka,Kaoru Kondo,Tsuyoshi Ryuko,Hiroyuki Ujike,Haruki Choshi,Shinichi Kawana,Haruchika Yamamoto,Kumi Nakajima,Hidejiro Torigoe,Lucas Hoyos Mejía,Jose Luis Campo-Cañaveral de la Cruz,Kazuhiko Shien,Ken Suzawa,Kentaroh Miyoshi,Toshiaki Ohara,David Gómez-de-Antonio,Mikio Okazaki,Seiichiro Sugimoto,Akihiro Matsukawa,Shinichi Toyooka","doi":"10.1016/j.healun.2026.07.011","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.011","url":null,"abstract":"OBJECTIVEIn controlled donation after circulatory death (cDCD), normothermic regional perfusion (NRP) enables in situ assessment of abdominal organs, whereas donor lung evaluation remains limited and often relies on ex vivo lung perfusion. We developed a pulmonary-abdominal normothermic regional perfusion (PA-NRP) circuit that allows controlled pulmonary perfusion and ventilation during NRP. This study aimed to determine whether PA-NRP permits in situ lung assessment without compromising post-transplant lung function or abdominal organ integrity.METHODSUsing a porcine cDCD model, donor-recipient pairs were assigned to PA-NRP (n = 5) or conventional abdominal NRP (A-NRP; n = 4). After 30 minutes of warm ischemia, NRP was maintained for 2 hours. In the PA-NRP group, lungs were ventilated and perfused during NRP, whereas in the A-NRP group, lungs were retrieved without pulmonary reperfusion. Orthotopic single left lung transplantation was performed, followed by a 4-hour post-transplant evaluation. Hepatic and renal injury during NRP was evaluated histologically using Suzuki and EGTI scoring systems.RESULTSPost-transplant oxygenation, dynamic lung compliance, pulmonary vascular resistance, and wet-to-dry weight ratios were comparable between the PA-NRP and A-NRP groups. Histological lung injury scores did not differ between groups. Hepatic and renal histological injury scores were similar between groups.CONCLUSIONSPA-NRP enables controlled in situ lung perfusion and assessment while preserving abdominal organ integrity and achieving post-transplant lung outcomes comparable to conventional recovery. This integrated approach may provide an in situ lung evaluation platform during cDCD procurement, particularly in settings where ex vivo lung perfusion is unavailable or logistically impractical.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do we need consensus on Consensus?","authors":"Prof Gregory I Snell,Bronwyn J Levvey","doi":"10.1016/j.healun.2026.07.015","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.015","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"247 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148476290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Primary Graft Dysfunction Stratifies Risk After Heart Transplantation With Lower Mortality Among Recipients of Donation-After-Circulatory-Death Hearts.","authors":"Alexander R Berg,Aravind Krishnan,Elbert E Heng,Alice Zhou,Andreas Maskos,Vigasini Rajaram,Daniel I Alnasir,Kiran K Khush,Jeffrey Teuteberg,Y Joseph Woo,John W MacArthur","doi":"10.1016/j.healun.2026.07.007","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.007","url":null,"abstract":"BACKGROUNDDonation after circulatory death (DCD) heart transplantation expands the donor pool. Primary graft dysfunction (PGD) is more frequent after DCD than after donation after brain death (DBD), yet early survival is often similar, suggesting donor-type heterogeneity in PGD prognosis.METHODSUNOS STAR files were used to study adults undergoing isolated heart transplantation (September 14, 2023-October 1, 2025) with BI/LV PGD recorded at both 24 and 72 hours. PGD course was none, transient (24h only), or persistent (24/72h). Survival was left-truncated at postoperative day 3. Cox models estimated mortality hazard with center-clustered robust standard errors. Within persistent PGD, DCD vs DBD was evaluated with multivariable adjustment and 1:1 propensity-score matching, with pair-stratified Cox models used in the matched cohort.RESULTSAmong 6,629 recipients, 5,713 (86.2%) had no BI/LV PGD, 333 (5.0%) transient, and 583 (8.8%) persistent; DCD donors were overrepresented in transient and persistent courses. Persistent PGD tracked with higher stroke, dialysis, and mechanical circulatory support use, and survival separated stepwise by course. After adjustment including 72-hour severity, persistent PGD was associated with higher mortality hazard versus no PGD (aHR 2.25, 95% CI 1.63-3.10), whereas transient PGD was not. Within persistent PGD, DCD was associated with lower mortality hazard than DBD (aHR 0.59, 95% CI 0.38-0.92), with similar findings after matching.CONCLUSIONSBI/LV PGD course over 72 hours stratified early risk after transplantation. Among recipients with persistent BI/LV PGD, early survival was more favorable after DCD than DBD, supporting donor-type-specific PGD presentations, while persistent PGD remained high risk regardless of donor type.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148462614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation 2026 Adult Lung Transplantation Report: A Contemporary Analysis of Trends and Outcomes by Recipient Sex","authors":"Brian C. Keller, Michael Perch, Wida S. Cherikh, Don Hayes, Rossa Brugha, Alexandra Lewis, Dzhuliyana Handarova, Alan Hopkinson, Tajinder P. Singh, Kyung-Hee Kim, Estela Azeka, Eileen Hsich, Göran Dellgren, Rebecca Cogswell","doi":"10.1016/j.healun.2026.07.006","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.006","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148461767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Donor-Derived Cell-Free DNA Correlates with Donor-Specific Antibodies and Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Patients Without Rejection","authors":"Benjamin A. Olsen, Morgan L. MacBeth, Jason M. Cole, Scott R. Auerbach, Louise Helander, Christina L. Roark, Kathleen E. Simpson, Melanie D. Everitt","doi":"10.1016/j.healun.2026.07.010","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.010","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"293 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148461855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Immunogenicity of Live-Attenuated Measles-Mumps-Rubella Vaccination After Pediatric Heart Transplantation.","authors":"Lisa-Maria Rosenthal,Mirna Seifert-Hansen,Lauren Scavuzzo,Amelia Marrato,Anne I Dipchand","doi":"10.1016/j.healun.2026.07.013","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.013","url":null,"abstract":"BACKGROUNDIn recent years, global outbreaks of measles and mumps have re-emerged as herd immunity declines. Pediatric heart transplant recipients are at increased risk for severe vaccine-preventable infections, yet live vaccines have historically been avoided due to safety concerns. Data on post-transplant measles-mumps-rubella (MMR) vaccination remain limited.METHODSWe conducted a retrospective single-center cohort study of pediatric heart transplant recipients who received live-attenuated MMR vaccination between January 2022 and January 2026 under a structured post-transplant vaccination protocol. Eligibility required clinical stability, >6 months post-transplantation, no recent rejection, and predefined immune parameters. Safety, immunosuppressive status, and serologic response were assessed.RESULTSTwenty-nine recipients received 49 MMR doses at a median of 9.8 years post-transplant. Vaccination was well tolerated, with no vaccine-related adverse events, rejection episodes, or graft complications. Post-vaccination serologic data was available for 23 recipients. Overall seroconversion rates were 61% for measles, 65% for mumps, and 100% for rubella, with higher measles responses after two doses (68% vs. 43%). Seroconversion was not associated with age, time from transplantation, immunosuppression, or immune parameters. Most patients (65%) would not have met 2019 International Pediatric Transplantation Association criteria for standard live vaccination eligibility.CONCLUSIONIn carefully selected pediatric heart transplant recipients, MMR vaccination was safe and provided acceptable immunogenicity. These findings challenge the historical exclusion of this population from live vaccination and suggest current eligibility criteria may be overly restrictive.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric VADs in the ACTION Era: From Survival to Strategy.","authors":"Jondavid Menteer","doi":"10.1016/j.healun.2026.07.005","DOIUrl":"https://doi.org/10.1016/j.healun.2026.07.005","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could transbronchial biopsies tell us more? Searching for deeper meaning in the tissue.","authors":"Jussi M Tikkanen,Stephen C Juvet","doi":"10.1016/j.healun.2026.06.020","DOIUrl":"https://doi.org/10.1016/j.healun.2026.06.020","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Turn a Trifecta into a Superfecta?","authors":"Kevin Clerkin,Veli K Topkara","doi":"10.1016/j.healun.2026.06.019","DOIUrl":"https://doi.org/10.1016/j.healun.2026.06.019","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}