The Journal of Heart and Lung Transplantation最新文献

Evaluating the Influence of Atrial Fibrillation in Chronic Thromboembolic Pulmonary Hypertension.

The Journal of Heart and Lung Transplantation Pub Date : 2025-04-11 DOI: 10.1016/j.healun.2025.04.002

S A Reddy,J Pepke-Zaba

引用次数: 0

Corrigendum to ''Safety and efficacy of riociguat in patients with pulmonary arterial hypertension and cardiometabolic comorbidities: Data from interventional clinical trials'' [The Journal of Heart and Lung Transplantation, 44 (2025) 135-146]. 里奥西瓜特对肺动脉高压和心脏代谢合并症患者的安全性和有效性：来自介入性临床试验的数据"[《心肺移植杂志》，44 (2025) 135-146]。

The Journal of Heart and Lung Transplantation Pub Date : 2025-04-09 DOI: 10.1016/j.healun.2025.02.1679

Stephan Rosenkranz,Hossein-Ardeschir Ghofrani,Marius M Hoeper,David Langleben,Sara Hegab,Claudia Rahner,Jean-François Richard,Vallerie V McLaughlin

引用次数: 0

Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome.

The Journal of Heart and Lung Transplantation Pub Date : 2025-04-08 DOI: 10.1016/j.healun.2025.04.001

Hendrik Schneider,Fabio Ius,Carsten Müller,Jawad Salman,Katharina Schütz,Harald Köditz,Katja Nickel,Gesine Hansen,Dmitry Bobylev,Nicolaus Schwerk,Julia Carlens

{"title":"Paediatric Lung Transplantation for Childhood Interstitial Lung Disease: Indications and Outcome.","authors":"Hendrik Schneider,Fabio Ius,Carsten Müller,Jawad Salman,Katharina Schütz,Harald Köditz,Katja Nickel,Gesine Hansen,Dmitry Bobylev,Nicolaus Schwerk,Julia Carlens","doi":"10.1016/j.healun.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.healun.2025.04.001","url":null,"abstract":"BACKGROUNDChildhood interstitial lung disease (chILD) is heterogeneous, associated with significant morbidity and can cause organ failure. In these cases, lung transplantation (LuTx) is a treatment option. Data on indications and outcome after LuTx for chILD is limited. We compared characteristics of LuTx for chILD to the indications cystic fibrosis (CF) and pulmonary hypertension (PH).METHODSchILD-patients <18 years who underwent LuTx at our center between Jan 1st, 2011 and Sep 30th, 2023, were retrospectively analysed and divided into two groups depending on their age at disease manifestation: Children in the chILD A group predominantly became ill during the first two years of life, chILD B patients thereafter. Outcomes were compared to patients with CF and PH.RESULTS101 children were included (chILD A 12; chILD B 19; CF 49; PH 21). Patients in the chILD A group were younger (mean age 1.5 vs., 12.9, 15.2, 10.9 years) and frequently required mechanical ventilation before LuTx (41.7%, vs. 10.5%, 2%, 9.5%, respectively). Their median ICU stay (23 vs. 4, 2, 13 days) and median hospital stay (48 vs. 27, 30, 42 days) after LuTx was longer. Patients with chILD B had the lowest pre-transplant ICU requirement (21.1% vs. 66.7% for chILD A, 30.6% for CF and 47.6% for PH) and short median hospital stay. Five year survival was comparable in all groups (80.2%, 86.5%, 80.4%, and 81.2%).CONCLUSIONLuTx for patients with chILD shows favourable outcome, although younger chILD A patients had a higher pre-transplant morbidity and longer ICU and hospital stay surrounding the transplantation.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Outcomes in Cardiogenic Shock: A Focus on Reducing Complications. 改善心源性休克的预后：重点是减少并发症。

The Journal of Heart and Lung Transplantation Pub Date : 2025-01-17 DOI: 10.1016/j.healun.2025.01.009

Rachna Kataria,Claudius Mahr

引用次数: 0

Stressing the People's Ventricle: Exercise 3D Echocardiography to Evaluate Right Ventricular Reserve. 强调人的心室：运动三维超声心动图评价右心室储备。

The Journal of Heart and Lung Transplantation Pub Date : 2025-01-16 DOI: 10.1016/j.healun.2025.01.008

Cole J Buchanan,Ryan J Tedford

引用次数: 0

New Kidney-After-Heart Allocation Policy in the United States: Who would benefit from a rescue kidney? 美国新的心脏后肾分配政策：谁将从抢救肾中受益？

The Journal of Heart and Lung Transplantation Pub Date : 2025-01-16 DOI: 10.1016/j.healun.2025.01.002

Alice L Zhou,Armaan F Akbar,Alexandra A Rizaldi,Jessica M Ruck,Emily L Larson,Sorush Rokui,Dane C Paneitz,Elizabeth A King,Ahmet Kilic

{"title":"New Kidney-After-Heart Allocation Policy in the United States: Who would benefit from a rescue kidney?","authors":"Alice L Zhou,Armaan F Akbar,Alexandra A Rizaldi,Jessica M Ruck,Emily L Larson,Sorush Rokui,Dane C Paneitz,Elizabeth A King,Ahmet Kilic","doi":"10.1016/j.healun.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.002","url":null,"abstract":"PURPOSEThe new rescue kidney policy in the United States was implemented in June 2023. To estimate its potential impact, we investigated a historic cohort of heart transplant (HT) recipients who would have been eligible for a kidney-after-heart transplant under this policy.METHODSAdult heart-only recipients from 1/1/2000 to 3/31/2023 in the United Network for Organ Sharing database were categorized by retroactively applying eligibility criteria from the new policy: eGFR≤20mL/min, CrCl≤20mL/min, or dialysis 60-365 days post-HT. We evaluated outcomes of eligible recipients.RESULTSOf 45,833 HT recipients, 840 (1.8%) were eligible for a rescue kidney. Eligible recipients had higher median age (58 vs. 56 years, p<0.001) and serum creatinine (1.4 vs. 1.2, p<0.001), and were more likely to be status 1A in the pre-2018 allocation era (63.4% vs. 51.9%, p<0.001) and status 1 in the post-2018 allocation era (13.9% vs. 9.1%, p=0.003). Survival at 1 year conditional on 60-day survival was worse for eligible recipients (50.8% vs. 96.3%; HR 17.6 [95%CI: 15.8-19.6], p<0.001). Post-HT, 607 (72.3%) eligible recipients were never listed for kidney transplant (KT), of whom 486 (80.1%) died with a median time-to-death of 8.8 months. Among the 233 (27.7%) recipients listed for KT, 65 (27.9%) died/deteriorated on the waitlist and 99 (42.5%) received a KT (median 38.4 months post-HT).CONCLUSIONSHalf of recipients eligible for a rescue kidney did not survive to 1 year post-HT, and >70% were never listed for KT. The effects of the new policy on mitigating mortality in this challenging population will be paramount.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piwi-interacting RNAs (piRNAs), potential new liquid biopsy in the immune surveillance of heart transplant recipients. piwi相互作用rna (piRNAs)，心脏移植受者免疫监测中潜在的新型液体活检。

The Journal of Heart and Lung Transplantation Pub Date : 2025-01-15 DOI: 10.1016/j.healun.2025.01.006

J L Platt,M Cascalho

引用次数: 0

Right ventricular reserve in cardiopulmonary disease: a simultaneous hemodynamic and three-dimensional echocardiographic study. 心肺疾病的右心室储备：同时进行血流动力学和三维超声心动图研究。

The Journal of Heart and Lung Transplantation Pub Date : 2024-12-25 DOI: 10.1016/j.healun.2024.12.022

C Baratto,C Dewachter,K Forton,D Muraru,M F Gagliardi,M Tomaselli,M Gavazzoni,G B Perego,M Senni,A Bondue,L P Badano,G Parati,J L Vachiéry,S Caravita

{"title":"Right ventricular reserve in cardiopulmonary disease: a simultaneous hemodynamic and three-dimensional echocardiographic study.","authors":"C Baratto,C Dewachter,K Forton,D Muraru,M F Gagliardi,M Tomaselli,M Gavazzoni,G B Perego,M Senni,A Bondue,L P Badano,G Parati,J L Vachiéry,S Caravita","doi":"10.1016/j.healun.2024.12.022","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.022","url":null,"abstract":"BACKGROUNDRV reserve has been linked to exercise capacity and prognosis in cardiopulmonary diseases. However, evidence in this setting is limited, due to the complex shape and load dependency of the RV. We sought to study right ventricular (RV) adaptation to exercise by simultaneous three-dimensional echocardiography (3DE) and right heart catheterization (RHC).METHODSPatients with heart failure with preserved ejection fraction (HFpEF) or pulmonary vascular disease (PVD) underwent simultaneous supine rest/exercise RHC-3DE. They were subdivided based on RV ejection fraction (EF) changes: 1)exhausted RV reserve, RVEF-; 2)preserved RV reserve, RVEF+.RESULTSSixty percent of patients were RVEF-. Distribution of HFpEF/PVD, as well as RV volumes and RVEF at rest were similar in the two groups. Hemodynamic metrics of RV afterload, as well as their exercise-induced changes, were similar in the two groups. During exercise, RV end-diastolic volume increased more in RVEF- than in RVEF+ (29±29 vs 7±25 mL,p<0.05). RV end-systolic volume increased by 21[12;31]mL in RVEF- and decreased by 8[-15;1]mL in RVEF+ (p<0.001). RV-pulmonary artery coupling was lower in RVEF- at peak exercise(p<0.05). Peak RVEF was associated with left ventricular preload (R2=0.14,p=0.011). Cardiac output increased less in RVEF- than in RVEF+ (+2.3±2.0 vs +4.0±2.4 L/min,p<0.05). Peak RVEF was associated with oxygen consumption(p<0.01).CONCLUSIONSExhausted RV reserve, as evaluated by 3DE, was frequent in HFpEF and PVD, was relatively independent from classical afterload parameters, was associated with RV-pulmonary artery decoupling, RV dilation, enhanced ventricular interdependence, and cardiac limitation to exercise. Intrinsic RV dysfunction may contribute to exhausted RV reserve.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sympathetic reinnervation in cardiac transplant recipients: Prevalence, time course and association with long-term survival. 心脏移植受者的交感神经再支配：发病率、时间过程以及与长期存活的关系。

The Journal of Heart and Lung Transplantation Pub Date : 2024-10-18 DOI: 10.1016/j.healun.2024.10.009

Oliver J F Weiner,Moloy Das,Richard H Clayton,Janet M McComb,Alan Murray,Gareth Parry,Stephen W Lord

{"title":"Sympathetic reinnervation in cardiac transplant recipients: Prevalence, time course and association with long-term survival.","authors":"Oliver J F Weiner,Moloy Das,Richard H Clayton,Janet M McComb,Alan Murray,Gareth Parry,Stephen W Lord","doi":"10.1016/j.healun.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.healun.2024.10.009","url":null,"abstract":"BACKGROUNDPartial cardiac sympathetic reinnervation after cardiac transplant has been extensively investigated and evidenced. However, there have been no large-scale, long-term studies evaluating the prevalence, time-course, and association with long-term survival of sympathetic reinnervation of the heart.METHODSCardiac transplant recipients (n=232) were recruited from outpatient clinic at a single transplant centre in the United Kingdom. Participants were each tested once for the presence of sympathetic reinnervation of the sinus node using the low frequency component of power spectral analysis of heart rate variability, with a cut-off defined as 2 standard deviations above the mean for denervated participants (those tested <56 days post-transplant). Time-course was calculated based on the timing of testing post-transplant. Patients were then followed-up over a period of up to 27 years after transplant for survival analysis.RESULTSThe overall prevalence of cardiac sympathetic reinnervation in the 225 patients tested >56 days post-transplant was 64.9%. Sympathetic reinnervation primarily occurred in the first 18 months after transplant, with a plateau thereafter. The prevalence in participants tested >18 months post-transplant was 69.6%. In Kaplan-Meier survival analysis, sympathetic reinnervation was associated with significantly improved survival (Log-rank P=0.019), with a median survival time for reinnervated patients of 19.9 years compared to 14.4 years for the denervated group.CONCLUSIONSSympathetic reinnervation of the sinus node occurs mostly within 18 months of transplant, is found in 70% of cardiac transplant recipients tested >18 months post-transplant, and is associated with significantly improved long-term survival.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Gaps in Lung Allocation: A Data-Driven Approach to Overcome Biological Disparities. 缩小肺分配差距：用数据驱动的方法克服生物差异。

The Journal of Heart and Lung Transplantation Pub Date : 2024-10-18 DOI: 10.1016/j.healun.2024.10.008

Ankit Bharat

引用次数: 0