The Journal of Heart and Lung Transplantation最新文献

{"title":"Improving Outcomes in Cardiogenic Shock: A Focus on Reducing Complications.","authors":"Rachna Kataria,Claudius Mahr","doi":"10.1016/j.healun.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.009","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ACTION VAD Registry: A Collective Five-Year Experience.","authors":"Jonathan B Edelson,Alexander Raskin,Mohammed Absi,Iki Adachi,Othman Aljohani,Anaam Alzubi,Shahnawaz Amdani,Alfred Asante-Korang,Scott Auerbach,Neha Bansal,David Bearl,Katerina Boucek,Arene Butto,Ryan Butts,Jonathan Byrnes,Chesney Castleberry,Jennifer Conway,Nhue Do,John Dykes,Joshua Friedland-Little,Lawrence Greiten,Heather Henderson,Daphne Hsu,Aamir Jeewa,Anna Joong,Sairah Khan,Christopher Knoll,Jodie Lantz,Sabrina Law,Angela Lorts,Katsuhide Maeda,Hugo Martinez,Lindsay May,Mary Mehegan,Deepa Mokshagundam,Catherine Montgomery,Matthew O'Connor,John Jerry Parent,David Peng,David N Rosenthal,Aryaz Sheybani,Muhammad Shezad,Lana Shugh,Natalie Shwaish,Joseph Spinner,Jennifer Su,David Sutcliffe,Hari Tunuguntla,Christina VanderPluym,Gabrielle Vaughn,Gonzalo Wallis,Sarah Wilkens,Matthew Zinn,Robert Niebler,","doi":"10.1016/j.healun.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.007","url":null,"abstract":"BACKGROUNDThe Advanced Cardiac Therapies Improving Outcomes Network (ACTION) began in 2018 as a collaborative learning health system committed to improving outcomes in pediatric heart failure, including children and adults with congenital heart disease, supported with ventricular assist devices (VADs). This report describes patient and device characteristics, and outcomes through 1-year post-implant.METHODSThe ACTION VAD registry report was created from data submitted to the ACTION learning network from April 2018-June 2023. It includes 1,430 devices implanted in 1,220 pediatric patients (<18) from 57 sites across North America.RESULTSMales comprised 55% of the registry patients. The median age was 3.7 years with a median implant weight of 13.6 kg; 36% of the cohort was <10 kg. Nearly 40% of patients had a primary diagnosis of congenital heart disease (CHD). Patients with CHD represented 26% of VAD implants in 2018 which increased to 42% in 2023 (p=0.03). At implant, 25% of patients were supported with ECMO, 4.9% with dialysis, and 54% were mechanically ventilated. Paracorporeal pulsatile pumps comprised 40.2% of implants, followed in incidence by paracorporeal continuous flow (28.5%), and implantable continuous flow (24.1%). The number of patients in the VAD Registry patients increased from 102 in 2018 to 256 in 2022, partly reflecting increased center participation in ACTION. Overall survival on support at 1 year was 79.2%, and the incidence of stroke was 13.7%. Infants demonstrated the poorest outcomes, with a 1-year survival of 72.9% and a higher incidence of stroke (20.8%).CONCLUSIONThe five-year ACTION VAD experience highlights the growing collaboration in the pediatric VAD community and changes in clinical practice. More work is needed to improve survival and limit adverse outcomes, especially in younger patients.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoraco Abdominal Normothermic Regional Perfusion and Lung Transplantation - Is it a Safe Match?","authors":"Marius Berman","doi":"10.1016/j.healun.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.001","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What We Know We Don't Know: The Johari Window in DCD Heart Transplantation.","authors":"Scott C Silvestry","doi":"10.1016/j.healun.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.004","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stressing the People's Ventricle: Exercise 3D Echocardiography to Evaluate Right Ventricular Reserve.","authors":"Cole J Buchanan,Ryan J Tedford","doi":"10.1016/j.healun.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.008","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Kidney-After-Heart Allocation Policy in the United States: Who would benefit from a rescue kidney?","authors":"Alice L Zhou,Armaan F Akbar,Alexandra A Rizaldi,Jessica M Ruck,Emily L Larson,Sorush Rokui,Dane C Paneitz,Elizabeth A King,Ahmet Kilic","doi":"10.1016/j.healun.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.002","url":null,"abstract":"PURPOSEThe new rescue kidney policy in the United States was implemented in June 2023. To estimate its potential impact, we investigated a historic cohort of heart transplant (HT) recipients who would have been eligible for a kidney-after-heart transplant under this policy.METHODSAdult heart-only recipients from 1/1/2000 to 3/31/2023 in the United Network for Organ Sharing database were categorized by retroactively applying eligibility criteria from the new policy: eGFR≤20mL/min, CrCl≤20mL/min, or dialysis 60-365 days post-HT. We evaluated outcomes of eligible recipients.RESULTSOf 45,833 HT recipients, 840 (1.8%) were eligible for a rescue kidney. Eligible recipients had higher median age (58 vs. 56 years, p<0.001) and serum creatinine (1.4 vs. 1.2, p<0.001), and were more likely to be status 1A in the pre-2018 allocation era (63.4% vs. 51.9%, p<0.001) and status 1 in the post-2018 allocation era (13.9% vs. 9.1%, p=0.003). Survival at 1 year conditional on 60-day survival was worse for eligible recipients (50.8% vs. 96.3%; HR 17.6 [95%CI: 15.8-19.6], p<0.001). Post-HT, 607 (72.3%) eligible recipients were never listed for kidney transplant (KT), of whom 486 (80.1%) died with a median time-to-death of 8.8 months. Among the 233 (27.7%) recipients listed for KT, 65 (27.9%) died/deteriorated on the waitlist and 99 (42.5%) received a KT (median 38.4 months post-HT).CONCLUSIONSHalf of recipients eligible for a rescue kidney did not survive to 1 year post-HT, and >70% were never listed for KT. The effects of the new policy on mitigating mortality in this challenging population will be paramount.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piwi-interacting RNAs (piRNAs), potential new liquid biopsy in the immune surveillance of heart transplant recipients.","authors":"J L Platt,M Cascalho","doi":"10.1016/j.healun.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.006","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brick by Brick, BOLT by BOLT: Building the Case for DCD Lung Transplant.","authors":"Michael T Cain","doi":"10.1016/j.healun.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.003","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right ventricular reserve in cardiopulmonary disease: a simultaneous hemodynamic and three-dimensional echocardiographic study.","authors":"C Baratto,C Dewachter,K Forton,D Muraru,M F Gagliardi,M Tomaselli,M Gavazzoni,G B Perego,M Senni,A Bondue,L P Badano,G Parati,J L Vachiéry,S Caravita","doi":"10.1016/j.healun.2024.12.022","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.022","url":null,"abstract":"BACKGROUNDRV reserve has been linked to exercise capacity and prognosis in cardiopulmonary diseases. However, evidence in this setting is limited, due to the complex shape and load dependency of the RV. We sought to study right ventricular (RV) adaptation to exercise by simultaneous three-dimensional echocardiography (3DE) and right heart catheterization (RHC).METHODSPatients with heart failure with preserved ejection fraction (HFpEF) or pulmonary vascular disease (PVD) underwent simultaneous supine rest/exercise RHC-3DE. They were subdivided based on RV ejection fraction (EF) changes: 1)exhausted RV reserve, RVEF-; 2)preserved RV reserve, RVEF+.RESULTSSixty percent of patients were RVEF-. Distribution of HFpEF/PVD, as well as RV volumes and RVEF at rest were similar in the two groups. Hemodynamic metrics of RV afterload, as well as their exercise-induced changes, were similar in the two groups. During exercise, RV end-diastolic volume increased more in RVEF- than in RVEF+ (29±29 vs 7±25 mL,p<0.05). RV end-systolic volume increased by 21[12;31]mL in RVEF- and decreased by 8[-15;1]mL in RVEF+ (p<0.001). RV-pulmonary artery coupling was lower in RVEF- at peak exercise(p<0.05). Peak RVEF was associated with left ventricular preload (R2=0.14,p=0.011). Cardiac output increased less in RVEF- than in RVEF+ (+2.3±2.0 vs +4.0±2.4 L/min,p<0.05). Peak RVEF was associated with oxygen consumption(p<0.01).CONCLUSIONSExhausted RV reserve, as evaluated by 3DE, was frequent in HFpEF and PVD, was relatively independent from classical afterload parameters, was associated with RV-pulmonary artery decoupling, RV dilation, enhanced ventricular interdependence, and cardiac limitation to exercise. Intrinsic RV dysfunction may contribute to exhausted RV reserve.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Approaches to Optimize Donor Heart for Transplantation.","authors":"Amit H Alam,Candice Y Lee,Manreet K Kanwar,Yasbanoo Moayedi,Alexander M Bernhardt,Koji Takeda,Duc Thinh Pham,Christopher Salerno,Andreas Zuckermann,David D'Alessandro,Victor G Pretorius,John O Louca,Stephen Large,Dawn E Bowles,Scott C Silvestry,Nader Moazami","doi":"10.1016/j.healun.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.001","url":null,"abstract":"Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement and recent advancements in donor heart procurement technologies. This State-of-the-Art review will explore factors associated with bringing the \"ideal\" donor heart to the operating room in the contemporary era.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}