The Journal of Bone & Joint Surgery最新文献

{"title":"Predicting Post-Fracture Recovery with Smartphone Mobility Data: A Proof-of-Concept Study.","authors":"Brian M Shear,Dane J Brodke,Gregory R Hancock,Patrick McGlone,Haley Demyanovich,Vivian Li,Alice Bell,David Okhuereigbe,Gerard P Slobogean,Robert V O'Toole,Nathan N O'Hara","doi":"10.2106/jbjs.24.01305","DOIUrl":"https://doi.org/10.2106/jbjs.24.01305","url":null,"abstract":"BACKGROUNDAfter a lower-extremity fracture, the patient's priority is to regain function. To date, our ability to measure function has been limited. However, high-fidelity sensors in smartphones continuously measure mobility, providing an expansive pre- and post-injury gait history. We assessed whether pre-injury mobility data, combined with demographic and injury data, reliably predicted post-fracture mobility.METHODSWe enrolled 107 adult patients (mean age, 45 years; 43% female, 62% White, 36% Black, 1% Asian, 1% more than one race) ≥6 months after the surgical treatment of a lower-extremity fracture. Consenting patients exported their Apple iPhone mobility metrics, including step count, walking speed, step length, walking asymmetry, and double-support time. We integrated these mobility measures with demographic and injury data. Using nonlinear modeling, we assessed whether pre-injury mobility metrics combined with baseline data predicted post-fracture mobility.RESULTSAll models were well calibrated and had model fits ranging from an adjusted R2 of 0.18 (walking asymmetry) to 0.61 (double-support time). Pre-injury function strongly predicted post-injury mobility in all models. After the injury, the average daily step count increased by 65 steps each week (95% confidence interval [CI], 56 to 75). Weekly gains were significantly greater within 6 weeks after the injury (92 daily steps per week; 95% CI, 58 to 127) than 20 to 26 weeks post-injury (19 daily steps per week; 95% CI, 11 to 27; p < 0.001). Greater pre-injury steps were associated with increased post-injury mobility (301 daily steps post-injury per 1,000 steps pre-injury; 95% CI, 235 to 367). Mean walking speed declined by 0.200 m/s (95% CI, -0.257 to -0.143) from injury to 8 weeks post-injury. From 12 to 26 weeks post-injury, the average walking speed increased by 0.071 m/s (95% CI, 0.044 to 0.097).CONCLUSIONSThese proof-of-concept findings highlight the value of high-fidelity pre-injury mobility data in predicting recovery. Individualized recovery projections can provide patient-friendly counseling tools and useful clinical insight for surgeons.LEVEL OF EVIDENCEPrognostic Level III. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Double-Blinded Randomized Controlled Trial Comparing the Direct Superior Approach Versus the Posterior Approach for THA.","authors":"Babar Kayani,Sujith Konan,Jenni Tahmassebi,Dia Giebaly,Fares Sami Haddad","doi":"10.2106/jbjs.24.00830","DOIUrl":"https://doi.org/10.2106/jbjs.24.00830","url":null,"abstract":"BACKGROUNDThe direct superior approach (DSA) is a modification of the posterior approach (PA) that is intended to preserve the iliotibial band and short external rotators, except for the piriformis and conjoined tendon, during total hip arthroplasty (THA). The objective of this study was to compare postoperative pain scores between patients undergoing the DSA versus the PA for THA.METHODSThis study included 80 patients with symptomatic hip arthritis undergoing primary THA. Patients were prospectively randomized to receive either the DSA or PA for THA. Surgery was undertaken using identical implant designs in both groups, and all patients underwent a standardized postoperative rehabilitation program. Predefined study outcomes were recorded by blinded observers at regular intervals for 2 years after THA.RESULTSPatients in the PA and DSA groups had comparable baseline characteristics for age (mean and standard deviation, 67.3 ± 7.4 and 67.8 ± 7.8 years, respectively; p = 0.962), sex (26 male and 14 female patients, and 21 male and 19 female patients, respectively; p = 0.499) and body mass index (29.0 ± 4.3 and 29.1 ± 5.3 kg/m2; respectively; p = 0.298). There was no significant difference between the PA and DSA groups with respect to postoperative pain scores at 24 hours as assessed using the visual analogue scale (4.5 ± 1.2 and 4.2 ± 2.0, respectively; p = 0.312). The overall time to hospital discharge was 43.6 ± 9.7 hours in the PA group and 45.4 ± 8.9 hours in the DSA group. Two patients in the PA group and 1 in the DSA group developed superficial wound infections, which were successfully treated with oral antibiotics. There were no further complications or harm sustained by patients in either treatment group.CONCLUSIONSThis study showed that the intended benefits of the DSA in preserving the iliotibial band and the short external rotators, except for the piriformis and conjoined tendon, did not translate to any difference in postoperative pain scores when compared with the PA for THA.LEVEL OF EVIDENCETherapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the CT Scan in Preoperative Planning for Tillaux-Chaput Fractures in Adults.","authors":"Jafet Massri-Pugin,Gabriel Matamoros,Sergio Morales,Pablo Mery,María Jesús Lira,Jorge Filippi","doi":"10.2106/jbjs.24.01111","DOIUrl":"https://doi.org/10.2106/jbjs.24.01111","url":null,"abstract":"BACKGROUNDTillaux-Chaput fractures (TCFs) occur in the anterolateral rim of the distal tibia. TCFs are often overlooked on radiographic review, increasing the risk of chronic pain, instability, and ankle osteoarthritis. This study evaluated the effect of the computed tomography (CT) scan on preoperative planning for TCFs in adults.METHODSA retrospective review of ankle fractures evaluated from 2013 to 2023 at a university hospital was conducted. The inclusion criteria were patients ≥18 years of age who underwent radiographic and CT evaluation and had a TCF that was confirmed by CT. The exclusion criteria included pilon and distal tibial fractures and prior ankle surgery. Three orthopaedic surgeons assessed radiographs, classified TCFs using the Rammelt classification, formulated a treatment plan (conservative versus surgical), and, if a surgical treatment was indicated, determined the patient positioning, fixation type, and approach for the TCF. After evaluating CT images, changes in treatment strategy were recorded. Forward stepwise regression was utilized to analyze variables associated with modifications in preoperative planning.RESULTSA total of 481 fractures had ankle radiographs and CT scans; of these, 83 (17.3%) had a TCF. After the CT evaluation, the Rammelt classification and the surgical decision changed by 69.1% and 12.5%, respectively. Changes in patient positioning, the type of fixation, and the surgical approach for a TCF (when surgery was indicated) occurred in 32.1%, 43.8%, and 35.3% of all cases, respectively. Multivariable analysis showed that the detection of a TCF on CT predicted changes in the surgical decision and fixation type, while changes in the TCF classification predicted modifications in the fixation type and surgical approach. Posterior malleolar fractures were the unique predictor of changes in the patient positioning.CONCLUSIONSCT evaluation modified the surgical decision, type of fixation, and surgical approach for a TCF in 12.5%, 43.8%, and 35.3% of cases, respectively. Moreover, the detection of a TCF and a change in the classification after CT evaluation were predictors of a change in treatment strategy. These findings underscore the importance of the CT scan in the preoperative planning for TCFs in adults. Therefore, we strongly recommend conducting a CT scan when a TCF is suspected in adult patients.LEVEL OF EVIDENCEDiagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaphyseal Fixation in Revision Total Knee Arthroplasty.","authors":"Panayiotis D Megaloikonomos,Yasir AlShehri,Donald S Garbuz,Lisa C Howard,Michael E Neufeld,Bassam A Masri","doi":"10.2106/jbjs.24.01094","DOIUrl":"https://doi.org/10.2106/jbjs.24.01094","url":null,"abstract":"➢ Bone defect management is challenging, but essential, in revision total knee arthroplasty.➢ Appropriate metaphyseal fixation is crucial for stability and implant support.➢ Allografts have been traditionally used to address large defects, but the advent of highly porous metaphyseal cones and sleeves has attracted attention during the past years.➢ Metaphyseal implants are now available in a variety of shapes and sizes to meet various clinical needs.➢ These devices can successfully fill large defects, can better support revision implants, and can achieve long-term biologic fixation.➢ Very good intermediate-term outcomes have been reported with the available metaphyseal implants, using fully cemented or press-fit stems.➢ More research is warranted to further assess surgical indications and the strengths and weaknesses of the various implants used for metaphyseal fixation.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-Derived Mitochondria as a Novel Therapy for Muscle Degeneration After Rotator Cuff Tears.","authors":"Ding Xu,Qing Liu,Jingzeng Wang,Enzhi Yin,Biaohuan Zhou,Xiao Li,Yulong Shi","doi":"10.2106/jbjs.24.01322","DOIUrl":"https://doi.org/10.2106/jbjs.24.01322","url":null,"abstract":"BACKGROUNDRotator cuff tears (RCTs) commonly lead to muscle atrophy, fatty infiltration, and fibrosis, resulting in pain, weakness, and impaired shoulder mobility. These pathological changes are often irreversible and pose substantial treatment challenges. The aim of this study was to evaluate the therapeutic potential of muscle-derived mitochondria (Mito) in mitigating muscle degeneration and fibrosis following RCTs.METHODSSprague Dawley rats were assigned to 3 groups: sham surgery, RCTs treated with Mito, or RCTs treated with phosphate-buffered saline solution (PBS). Following RCTs, in vivo Mito or PBS treatments were administered to the supraspinatus muscles (SSPs) of the rats immediately and then biweekly for 12 weeks. Data were collected on muscle morphology, fibrosis, fatty infiltration, oxidative stress, mitochondrial function, macrophage phenotypes, and serum inflammatory cytokines. In vitro experiments included mitochondria tracking in bone marrow-derived macrophages (BMDMs), characterization of macrophage polarization, and inflammatory cytokine profiling.RESULTSIsolated mitochondria preserved their morphology and function. Mito treatment improved muscle wet weight (p < 0.0001) and fiber cross-sectional area (p < 0.0001) while reducing fibrosis (p < 0.0001) and fatty infiltration (p < 0.0001). It upregulated mitochondrial markers cytochrome c oxidase (COX IV) and translocase of outer mitochondrial membrane 20 (TOMM20) (p < 0.0001) and enhanced antioxidative activity, as shown by increased superoxide dismutase (SOD) activity (p < 0.0001), elevated glutathione peroxidase (GSH-PX) levels (p = 0.038), and decreased malondialdehyde (MDA) levels (p = 0.0002). Mitochondrial density and morphology were restored in SSPs after Mito treatment. Additionally, Mito treatment induced an anti-inflammatory macrophage phenotype and reduced pro-inflammatory cytokines in vivo and in vitro.CONCLUSIONSMito treatment mitigated muscle degeneration, improved mitochondrial function, and fostered an anti-inflammatory environment through macrophage modulation, demonstrating its potential as a cell-free therapeutic strategy for RCT-related muscle pathologies.CLINICAL RELEVANCEAlthough this is a preclinical study, its approach offers a novel avenue for improving RCT treatment outcomes. However, further validation in large animal models is needed to address the translational applicability of these findings, given the inherent regenerative capacity of rodent muscles.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Periprosthetic Joint Infection Following Total Joint Arthroplasty, as Defined by the Patient: A Qualitative Study.","authors":"Bahar Entezari,Johnathan R Lex,Joshua B Davis,Margaret S Juryn,Daniel C Gabriel,Antonia F Chen,Jesse I Wolfstadt","doi":"10.2106/jbjs.24.01057","DOIUrl":"https://doi.org/10.2106/jbjs.24.01057","url":null,"abstract":"BACKGROUNDThe literature on the subjective experience of patients undergoing treatment for periprosthetic joint infection (PJI) following total joint arthroplasty (TJA) is scarce, and treatment success is defined without consideration of patient values. The primary objective of this study was to characterize the experience of patients undergoing PJI management. The secondary and tertiary aims were to identify factors that patients associate with successful treatment and to assess alignment with a 2019 outcome-reporting tool (ORT) by the Musculoskeletal Infection Society (MSIS).METHODSPatients treated for PJI at 2 international tertiary arthroplasty centers and for whom no less than 1 year and no more than 5 years had elapsed since their most recent revision surgery were included. From August 2023 to April 2024, patients participated in semistructured interviews with a phenomenological approach-an approach that aims to provide detailed examinations of personal lived experiences and to identify themes regarding how a particular phenomenon is experienced. Interview topics included experiences with primary TJA, PJI diagnosis and management, and patient perceptions of the success of their PJI management. Interviews were transcribed, and a thematic analysis was performed. The concordance between patient-defined and MSIS ORT-defined treatment success was calculated.RESULTSOf 27 total patients, 21 (78%) reported considerable mental health impacts during the period from PJI onset to treatment conclusion. In defining successful PJI management, patients consistently emphasized the importance of function, pain relief, mobility, and independence. Nine (33%) of the patients (p < 0.001) did not agree with their MSIS ORT classification of success versus failure.CONCLUSIONSPJI is a devastating complication following TJA, and success as defined by patients does not align with success as defined by clinicians. As a result, there is insufficient support offered to patients throughout the PJI management process. Future avenues for research include the exploration of the feasibility and impact of implementing patient-centered care models that feature psychological support.LEVEL OF EVIDENCETherapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic Obliquity: A Possible Risk Factor for Curve Progression After Lumbosacral Hemivertebra Resection with Short Segmental Fusion.","authors":"Haoran Zhang,Yiqiao Zhang,Zhuosong Bai,Yuechuan Zhang,Tongyin Zhang,Xiangjie Yin,Yunze Han,Shengru Wang,Qianyu Zhuang,Jianguo Zhang","doi":"10.2106/jbjs.24.00331","DOIUrl":"https://doi.org/10.2106/jbjs.24.00331","url":null,"abstract":"BACKGROUNDA lumbosacral hemivertebra poses a unique problem, as it leads to a long compensatory curve above it and an obvious main curve. One-stage posterior hemivertebra resection with short segmental fusion is a standard surgery for patients with congenital scoliosis, but curve progression often occurs after surgery. The objective of this study was to investigate the risk factors for curve progression in patients who underwent 1-stage posterior hemivertebra resection with short segmental fusion.METHODSThis study included 58 Han Chinese patients with congenital scoliosis who underwent 1-stage posterior hemivertebra resection with short segmental fusion. Baseline information, radiographic parameters, and the Scoliosis Research Society-22r questionnaire were collected preoperatively, 3 months postoperatively, and at the last follow-up. Risk factors for curve progression were evaluated using logistic regression analysis and receiver operating characteristic (ROC) curve analysis.RESULTSThe mean age at surgery was 7.3 years, and the mean follow-up was 7.5 years. Nine patients (15.5%) were diagnosed with curve progression at the final follow-up. Compared with their preoperative condition, patients exhibited a significant reduction in the main curve (95% confidence interval [CI], 25.2° to 28.9° preoperatively versus 6.8° to 9.4° at 3 months; p < 0.001), compensatory curve (95% CI, 15.0° to 19.8° versus 5.5° to 8.1°; p < 0.001), and coronal balance (95% CI, 12.4 to 16.9 mm versus 7.0 to 10.5 mm; p < 0.001) at 3 months postoperatively. The progression group had larger preoperative pelvic obliquity values than the non-progression group (95% CI, 3.19° to 6.55° versus 2.01° to 2.63°; p = 0.008). The logistic regression analysis revealed that preoperative pelvic obliquity was a significant independent risk factor for curve progression (odds ratio, 1.653; 95% CI, 1.096 to 2.495; p = 0.017). The ROC analysis revealed that preoperative pelvic obliquity had good discriminatory capability (area under the ROC curve, 0.876; 95% CI, 0.677 to 1.000; p < 0.001).CONCLUSIONSIn summary, preoperative pelvic obliquity was an independent risk factor for curve progression, which means that preoperative measures should be taken to ensure minimal pelvic obliquity in patients in order to effectively prevent curve progression. The presence of pelvic obliquity should alert the surgeon and patients to the high risk of deformity progression and to the need for scheduling more frequent follow-ups as appropriate.LEVEL OF EVIDENCEPrognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"130 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Prevalence of Scoliosis in Female Professional Ballet Performers.","authors":"Bradley Lambert,Varan Haghshenas,Kevin Bondar,Takshi Hirase,Justin Aflatooni,Joshua Harris,Patrick McCulloch,Comron Saifi","doi":"10.2106/jbjs.24.00670","DOIUrl":"https://doi.org/10.2106/jbjs.24.00670","url":null,"abstract":"BACKGROUNDMusculoskeletal abnormalities have been reported among female professional ballet performers due, in part, to intrinsic predispositions related to joint and/or connective tissue laxity and extrinsic effectors such as reduced energy availability, low body mass, and high training volumes that may increase the risk of developing idiopathic scoliosis (IS). The purpose of this investigation was to characterize IS prevalence in this population. We hypothesized that there would be elevated prevalence in female performers and that those with IS would exhibit reduced bone mineral density (BMD), body mass, fat mass, and lean mass.METHODSA retrospective analysis of whole-body anteroposterior radiographs was performed on 98 professional ballet dancers (49 male performers [mean age, 25 ± 6 years] and 49 female performers [mean age, 27 ± 5 years]) from a single company. Body composition and BMD were assessed via dual x-ray absorptiometry. The criterion for IS was defined as a Cobb angle of >10°. The frequency of IS was plotted against general-population norms. A t test was used to compare demographic characteristics, anthropometrics, and BMD between performers with and without IS and to compare the Cobb angles between sexes. A Fisher exact test was used to compare the IS prevalence between sexes. The Type-I error was set at α = 0.05.RESULTSCompared with male performers, female performers had greater spinal asymmetry (mean Cobb angle, 7.98° [95% confidence interval (CI) width, 1.76°] for men and 4.02° [95% CI width, 1.00°] for women; p = 0.027). The prevalence of IS among male performers (3 [6.12%] of 49) was comparable with the general-population norms (0.31% to 5.60%). Women had an elevated prevalence of IS compared with men (10 [20.41%] of 49; p = 0.037) and with general-population norms (0.65% to 8.90%). Among women, performers with IS were observed to have a reduced percentage of body fat (p = 0.021) and reduced fat mass (p = 0.040) compared with performers without IS.CONCLUSIONSFemale professional ballet performers demonstrate a heightened prevalence of IS that, in addition to intrinsic predisposition, is associated with modifiable factors such as reduced fat mass commonly associated with reduced energy availability known to impact musculoskeletal health in athletes. Future investigations should seek to determine the prevalence of IS in other young female athlete populations commonly exposed to high degrees of activity and reduced energy availability.LEVEL OF EVIDENCEPrognostic Level III. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for and Prediction of Early Thromboembolic Disease Following Adult Spinal Deformity Surgery: An Analysis of >7,400 Patients with Spinal Deformity.","authors":"Daniel O Gallagher,Kevin Bondar,Takashi Hirase,Jacob Harris,Sree M Vemu,Philip K Louie,Arya Varthi,Bradley Lambert,Comron Saifi","doi":"10.2106/jbjs.23.01391","DOIUrl":"https://doi.org/10.2106/jbjs.23.01391","url":null,"abstract":"BACKGROUNDThe aim of this study was to determine the risk factors associated with deep vein thrombosis (DVT) or pulmonary embolism (PE) within 30 days after multilevel adult spinal deformity (ASD) surgery and to develop risk prediction models.METHODSA retrospective observational study was conducted using the American College of Surgeons National Surgical Quality Improvement Program database from 2010 to 2019. Current Procedural Terminology (CPT) codes 22843 and 22844 were used to query the database and to identify patients who underwent surgical correction of ASD with ≥7 levels of posterior instrumentation. The primary outcomes were the incidences of, and risk factors for, postoperative DVT and PE. Multiple logistic regression was utilized to identify variables associated with an elevated risk of DVT or PE within 30 days after surgery and to develop prediction models for assessing risk.RESULTSA total of 7,445 patients (56% female; 73% Caucasian; mean age, 61 years) met the inclusion criteria. Postoperatively, the rate of any venous thromboembolism (VTE; i.e., DVT or PE) was 3.4% (254 patients), the rate of DVT was 2.0% (151 patients), and the rate of PE was 1.7% (127 patients). The following independent predictors of any VTE were identified: weight (odds ratio [OR], 1.054; 95% confidence interval [CI]: 1.027 to 1.081), age per decade of life (OR, 1.106; 95% CI: 1.012 to 1.209), body mass index (BMI; OR, 1.032; 95% CI: 1.015 to 1.049), medicated hypertension (OR, 1.523; 95% CI: 1.168 to 1.987), chronic corticosteroid use (OR, 2.654; 95% CI: 1.848 to 3.812), American Society of Anesthesiologists (ASA) class (OR, 1.768; 95% CI: 1.426 to 2.192), and total operative time (OR, 1.002; 95% CI: 1.002 to 1.003) (p < 0.05 for all). When incorporated into a single model, total operative time, BMI, ASA class, and chronic corticosteroid use were associated with VTE risk.CONCLUSIONSFour major risk factors were identified as being associated with postoperative VTE risk in patients undergoing surgery for ASD. Corticosteroid use for a chronic medical condition was the strongest predictor of VTE risk, followed by ASA class, BMI, and operative time. Knowledge of these risk factors can aid in preoperative risk assessment, informed consent, and medical decision-making, such as in determining the clinical thresholds for VTE testing and chemoprophylaxis.LEVEL OF EVIDENCEPrognostic Level III. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"252 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delamination and Oxidation in Compression-Molded Polyethylene.","authors":"Brian T Nickel,Lydia Weitzler,Elexis B Padgett,Madeline Lang,Geoffrey H Westrich,Timothy M Wright,Douglas E Padgett","doi":"10.2106/jbjs.24.00857","DOIUrl":"https://doi.org/10.2106/jbjs.24.00857","url":null,"abstract":"BACKGROUNDAt our institution, surgeons were observing cases of failed total knee arthroplasties (TKAs) with surface delamination of the tibial insert fabricated by direct compression molding. The increase in unexpected failure led us to investigate the prevalence of delamination and its causes through the use of retrieval analysis and reviews of clinical, demographic, and radiographic data.METHODSBetween 2000 and 2019, a total of 519 Exactech Optetrak posterior-stabilized direct-compression-molded polyethylene inserts had been retrieved. To determine prevalence, we utilized institutional usage data, manufacturer sales to our institution, and hospital records to determine the delamination rate. Eighty-six retrieved specimens (16 with delamination) were assessed for oxidation with use of infrared spectroscopy.RESULTSSixty-four (12%) of the 519 inserts had delamination. The delamination rate was 0.36% across the 20-year period. Osteolysis was the reason for revision in 25% of delaminated cases, compared with 4% of non-delaminated cases. The mean oxidation index of the delaminated inserts was 2.67 ± 1.4 (range, 1.2 to 6.6). Delamination was not associated with surgical factors (cement viscosity and tibial insert thickness) or processes associated with manufacturing and implantation of the inserts into the patients (implantation year, shelf life, and packaging and sterilization dates).CONCLUSIONSThe lack of causative factors for the increase in delamination was perplexing. In 2021, following the completion of our study, the manufacturer determined that since 2004, polyethylene inserts were packaged in \"non-conforming\" vacuum bags that were missing a secondary barrier layer intended to markedly lessen oxygen permeation. The use of non-conforming bags apparently increased the risk of premature oxidation, delamination, and associated osteolysis.LEVEL OF EVIDENCEPrognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.","PeriodicalId":22625,"journal":{"name":"The Journal of Bone & Joint Surgery","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}