The Journal of Cancer Research最新文献_第8页

Biomarkers for Bladder Cancer: Present Challenges and Recent Developments 膀胱癌的生物标志物:目前的挑战和最新进展

The Journal of Cancer Research Pub Date : 2018-05-08 DOI: 10.12691/JCRT-6-2-2

Barnali Deb, Prashant Kumar

引用次数: 0

In Silico Molecular Docking Studies of Rutin Compound against Apoptotic Proteins (Tumor Necrosis Factor, Caspase-3, NF-Kappa-B, P53, Collagenase, Nitric Oxide Synthase and Cytochrome C) 芦丁化合物抗凋亡蛋白(肿瘤坏死因子、Caspase-3、NF-Kappa-B、P53、胶原酶、一氧化氮合酶、细胞色素C)的硅基分子对接研究

The Journal of Cancer Research Pub Date : 2018-04-27 DOI: 10.12691/jcrt-6-2-1

P. Jayameena, K. Sivakumari, K. Ashok, S. Rajesh

引用次数: 5

Indole-3-carbinol: A Promising Hope for Cancer Therapy 吲哚-3-甲醇:癌症治疗的希望

The Journal of Cancer Research Pub Date : 2018-04-17 DOI: 10.12691/JCRT-6-1-5

Ahmed M. Kabel, Eman A. Alharthi, Rana K. Alshehri, Afnan S. Alghamdi

引用次数: 1

LRRC超家族成员在肿瘤的研究进展The Progress of Research on LRRC Super Family Members in Cancer LRRC超家族成员在肿瘤的研究进展The Progress of Research on LRRC Super Family Members in Cancer

The Journal of Cancer Research Pub Date : 2018-04-11 DOI: 10.12677/WJCR.2018.82013

史婧怡, 陈妍珂

引用次数: 0

术中放射治疗应用于乳房保留手术——病例分析(2015~2018) 术中放射治疗应用于乳房保留手术——病例分析(2015~2018)

The Journal of Cancer Research Pub Date : 2018-04-11 DOI: 10.12677/WJCR.2018.82011

容菁霞, 郑翠芬, 柯卉玲

{"title":"术中放射治疗应用于乳房保留手术——病例分析(2015~2018)","authors":"容菁霞, 郑翠芬, 柯卉玲","doi":"10.12677/WJCR.2018.82011","DOIUrl":"https://doi.org/10.12677/WJCR.2018.82011","url":null,"abstract":"Regular mammography screening project for Taiwanese women aged 45~69 years has been administered for about 15 years which has achieved a good result in detection of early breast cancer and reduction in breast cancer mortality. According to NCCN (National Comprehensive Cancer Network) guideline, breast conserving surgery (BCS) is recommended for low grade breast cancer, because it provides better cosmetic effect and life quality compared to radical mastectomy. BCS combined with post-operative whole breast irradiation is a standard therapy for low grade breast cancer in previous practice because it provided same overall survival as traditional mastectomy. Inevitably, whole breast irradiation may yield some skin complications such as skin fibrosis, sclerosis, telangiectasia and even cause hyperpigmentation of nipple-areolar complex with lack of elasticity. Moreover, it may result in deformity of ipsilateral breast and alter psychological effect. FDA has approved the administration of intraoperative radiation therapy (IORT) in patients with breast cancer undergoing breast conserving surgery since 2012. It provided same level of safety as traditional post-operative whole breast irradiation and avoided aforementioned side effects [1]. Our institute started to perform IORT in low grade breast cancer since 2015. 60 patients received IORT and there were no apparent immediate or delay complication since then. Besides, no local recurrence or distant metastasis was detected during cancer surveillance. IORT is considered as a safe and feasible option in treatment of low grade breast cancer.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88671125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

高危复发胃癌术后予香菇多糖维持治疗的临床观察Clinical Observation of Immunization Maintenance Treatment with Lentinan on Postoperative Gastric Cancer with High Risk Recurrence 高危复发胃癌术后予香菇多糖维持治疗的临床观察Clinical Observation of Immunization Maintenance Treatment with Lentinan on Postoperative Gastric Cancer with High Risk Recurrence

The Journal of Cancer Research Pub Date : 2018-04-11 DOI: 10.12677/WJCR.2018.82010

陈苏娟, 李瑞中

引用次数: 0

The Antioxidant Glycolysis Inhibitor (Citric Acid) Induces a Dose-dependent Caspase-mediated Apoptosis and Necrosis in Glioma Cells 抗氧化糖酵解抑制剂(柠檬酸)诱导剂量依赖性caspase介导的胶质瘤细胞凋亡和坏死

The Journal of Cancer Research Pub Date : 2018-03-21 DOI: 10.12691/jcrt-6-1-4

S. Sayed, H. Baghdadi, Nassar Ayoub Abdellatif Omar, A. Allithy, N. Hablas, A. Fakhreldin, Reham A. Mariah, Momen El-shazley, M. Ayat, S. Mostafa, Mostafa Abu-el Naga, M. Abdel-Halim

{"title":"The Antioxidant Glycolysis Inhibitor (Citric Acid) Induces a Dose-dependent Caspase-mediated Apoptosis and Necrosis in Glioma Cells","authors":"S. Sayed, H. Baghdadi, Nassar Ayoub Abdellatif Omar, A. Allithy, N. Hablas, A. Fakhreldin, Reham A. Mariah, Momen El-shazley, M. Ayat, S. Mostafa, Mostafa Abu-el Naga, M. Abdel-Halim","doi":"10.12691/jcrt-6-1-4","DOIUrl":"https://doi.org/10.12691/jcrt-6-1-4","url":null,"abstract":"Background: Glioma tumors are still a big challenge being incurable with current chemotherapy and radiotherapy treatments. Surgical treatment of glioma needs adjuvant effective targeting therapy for better glioma cell treatment. Citrate is a well-known antioxidant organic acid abundant in citrus fruits and is an inhibitor of glycolysis through targeting the glycolytic enzyme phosphofructokinase, one of the key enzymes of glycolysis. Citrate is a natural product that is formed inside mitochondria during Krebs cycle to the extent that Krebs cycle is often referred to as citric acid cycle. It was reported that glioma cells are driven by glycolysis where glioma cells upregulates the expression of glycolysis genes and enzymes. Objectives: This aim is to investigate effect of citrate on glioma cells viability, morphology and moge of glioma-induced cell death. Methodology: In this study, citrate-induced glioma cell death was investigated using MTT assay, western blot analysis and flowcytometric evaluation was done to C6 glioma cells. Results: Citrate induced a potent anti-glioma effect by significantly decreasing viability of C6 glioma cells in a dose-dependent manner. Flow cytometric analysis revealed that at 5 mM, citrate induced a caspase-dependent apoptotic glioma cell death. Higher doses of citrate (9 mM) induced necro-apoptotic glioma cell death. Conclusion: citrate may be a promising therapeutic treatment for glioma and glioblastoma. Citrate-rich fruits are strongly recommended as a nutritional treatment for glioma patients.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"9 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2018-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88360100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

3-bromopyruvate as a Promising Treatment for Hematological Cancer 3-溴丙酮酸作为一种有希望治疗血液病的药物

The Journal of Cancer Research Pub Date : 2018-03-06 DOI: 10.12691/JCRT-6-1-3

M. Ayat

{"title":"3-bromopyruvate as a Promising Treatment for Hematological Cancer","authors":"M. Ayat","doi":"10.12691/JCRT-6-1-3","DOIUrl":"https://doi.org/10.12691/JCRT-6-1-3","url":null,"abstract":"Many biological differences exist between cancer cells and normal cells that can act as potential targets in targeted cancer therapy. Hematological cancers e.g. lymphoma, leukemia and myeloma exhibit drug-resistance that ultimately results in deteriorated patients' conditions and high mortality rates. Resistance of hematological malignancy to conventional chemotherapy is attributed in part to upregulation of glucose oxidation (glycolysis) genes evidenced by gaining a promising chemosensitization effect upon adding a glycolysis inhibitor to chemotherapeutics. The promising anticancer agent 3-bromopyruvate (3BP) is a structural analog of both pyruvate and lactate. 3BP was reported to antagonize the Warburg effect (malignant phenotype where cancer cells utilize cytoplasmic glucose oxidation to produce ATP and lactate even in the presence of oxygen without making benefit of the generous ATP provision from glucose oxidation via mitochondrial pathways). Warburg effect deprives cancer cells from the high energetic yield achieved through utilizing mitochondrial pathways. 3BP is a promising antiglycolytic agent that targets major glycolysis enzymes (hexokinase II and glyceraldehyde-3-phosphate dehydrogenase. In this article, 3BP promising anticancer effects in treating lymphoma, leukemia and myeloma are discussed in addition to the mode of inhibition of Warburg effect using 3BP. In conclusion, 3BP is a promising anticancer drug (that will be more powerful upon proper pharmaceutical formulations) for treating hematological malignancies. 3BP is advisable to be included in treatment protocols in hematological cancers as a chemosensitizer or as a sole anticancer agent.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"33 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2018-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76188393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of Premenopousal and Postmenopausal Breast Cancer Cases in Terms of Demographic and Prognostic Factor 绝经前和绝经后乳腺癌病例的人口学和预后因素比较

The Journal of Cancer Research Pub Date : 2018-02-27 DOI: 10.12691/JCRT-6-1-2

I. Kızıloglu, A. C. Acara, B. Bayar, S. Karaisli, E. Sari, E. Tarcan

{"title":"Comparison of Premenopousal and Postmenopausal Breast Cancer Cases in Terms of Demographic and Prognostic Factor","authors":"I. Kızıloglu, A. C. Acara, B. Bayar, S. Karaisli, E. Sari, E. Tarcan","doi":"10.12691/JCRT-6-1-2","DOIUrl":"https://doi.org/10.12691/JCRT-6-1-2","url":null,"abstract":"Breast cancer is the second most common type of cancer in the world and it is the most frequently seen cancer type in women. In early stages involving small and monocenter tumors, surgical treatment with breast conserving surgery followed by radiotherapy is the most preferred treatment regimen. Similar to the size of the tumor, several prognostic factors determine survival in breast cancer patients. This study was conducted to evaluate prognostic factors and their relationship to the menopausal status of the patients. University Ataturk Training and Research Hospital, Izmir, Turkey with 573 patients diagnosed with breast cancer between January 2006 and December 2012. Patient age, menopausal status, tumor location surgical treatment information, treatment regimen was gathered using the registry system of the hospital. Male breast cancer patients and patients with insufficient data were excluded. The mean (±SD) age of the study population was determined as 55.9 (±12.9). Most of the patients (65.3%) included in the study were identified as post-menopausal (n=199). Post-menopausal women were detected with larger tumors (p=0.048), at a later stage (p=0.037), with higher KI-67 index (p=0.015) and received more adjuvant hormone therapy (p=0.036) when compared to the pre-menopausal women. Multi-centered studies are needed to evaluate prognostic factors and their relationship to the menopausal status of the patients in order to plan more precise personal treatment regimens.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"41 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2018-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86394056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oleuropein is a Powerful Sensitizer of Doxorubicin-mediated Killing of Prostate Cancer Cells and Exerts Its Action via Induction of Autophagy 橄榄苦苷是阿霉素介导的前列腺癌细胞杀伤的强致敏剂，并通过诱导自噬发挥其作用

The Journal of Cancer Research Pub Date : 2018-02-26 DOI: 10.12691/JCRT-4-4-2

A. Papachristodoulou, M. Tsoukala, D. Benaki, S. Kostidis, K. Gioti, N. Aligiannis, H. Pratsinis, D. Kletsas, A. Skaltsounis, E. Mikros, R. Tenta

{"title":"Oleuropein is a Powerful Sensitizer of Doxorubicin-mediated Killing of Prostate Cancer Cells and Exerts Its Action via Induction of Autophagy","authors":"A. Papachristodoulou, M. Tsoukala, D. Benaki, S. Kostidis, K. Gioti, N. Aligiannis, H. Pratsinis, D. Kletsas, A. Skaltsounis, E. Mikros, R. Tenta","doi":"10.12691/JCRT-4-4-2","DOIUrl":"https://doi.org/10.12691/JCRT-4-4-2","url":null,"abstract":"The phenolic component Oleuropein (OLEU), a bioactive natural product, has recently shown antiproliferative properties. Doxorubicin (DXR) is an anthracycline present in many chemotherapeutic schemes, although limited due to its cardio-toxic effects. Important research effort has been devoted therefore, to reducing DXR toxicity without compromising its antitumor efficacy. The anticancer actions of DXR and OLEU were assessed, on PC-3 prostate cancer cells, while cell cycle distribution and rate of apoptosis were assessed by flow cytometry. The autophagic process was determined via immunoblotting and immunofluorescent staining. Finally, cell extracts were analyzed by NMR spectroscopy. The present study showed that both DXR and OLEU inhibited PC-3 cells proliferation, while the co-treatment with DXR and OLEU resulted in an additive inhibition. Although the addition of OLEU to DXR did not alter significantly the cell cycle distribution, exhibited by each treatment alone, and produced a marginal increase on the rate of apoptosis, both compounds produced a remarkable induction of autophagy. In addition, treated cells exhibited significant metabolite alterations. This study demonstrates that OLEU, a basic component of the everyday diet, is capable of lowering significantly the cytotoxic dose of DXR, while obtaining an important anti-proliferative effect in prostate cancer cells.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"23 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78730144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8