{"title":"术中放射治疗应用于乳房保留手术——病例分析(2015~2018)","authors":"容菁霞, 郑翠芬, 柯卉玲","doi":"10.12677/WJCR.2018.82011","DOIUrl":null,"url":null,"abstract":"Regular mammography screening project for Taiwanese women aged 45~69 years has been administered for about 15 years which has achieved a good result in detection of early breast cancer and reduction in breast cancer mortality. According to NCCN (National Comprehensive Cancer Network) guideline, breast conserving surgery (BCS) is recommended for low grade breast cancer, because it provides better cosmetic effect and life quality compared to radical mastectomy. BCS combined with post-operative whole breast irradiation is a standard therapy for low grade breast cancer in previous practice because it provided same overall survival as traditional mastectomy. Inevitably, whole breast irradiation may yield some skin complications such as skin fibrosis, sclerosis, telangiectasia and even cause hyperpigmentation of nipple-areolar complex with lack of elasticity. Moreover, it may result in deformity of ipsilateral breast and alter psychological effect. FDA has approved the administration of intraoperative radiation therapy (IORT) in patients with breast cancer undergoing breast conserving surgery since 2012. It provided same level of safety as traditional post-operative whole breast irradiation and avoided aforementioned side effects [1]. Our institute started to perform IORT in low grade breast cancer since 2015. 60 patients received IORT and there were no apparent immediate or delay complication since then. Besides, no local recurrence or distant metastasis was detected during cancer surveillance. IORT is considered as a safe and feasible option in treatment of low grade breast cancer.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"11 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"术中放射治疗应用于乳房保留手术——病例分析(2015~2018)\",\"authors\":\"容菁霞, 郑翠芬, 柯卉玲\",\"doi\":\"10.12677/WJCR.2018.82011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Regular mammography screening project for Taiwanese women aged 45~69 years has been administered for about 15 years which has achieved a good result in detection of early breast cancer and reduction in breast cancer mortality. According to NCCN (National Comprehensive Cancer Network) guideline, breast conserving surgery (BCS) is recommended for low grade breast cancer, because it provides better cosmetic effect and life quality compared to radical mastectomy. BCS combined with post-operative whole breast irradiation is a standard therapy for low grade breast cancer in previous practice because it provided same overall survival as traditional mastectomy. Inevitably, whole breast irradiation may yield some skin complications such as skin fibrosis, sclerosis, telangiectasia and even cause hyperpigmentation of nipple-areolar complex with lack of elasticity. Moreover, it may result in deformity of ipsilateral breast and alter psychological effect. FDA has approved the administration of intraoperative radiation therapy (IORT) in patients with breast cancer undergoing breast conserving surgery since 2012. It provided same level of safety as traditional post-operative whole breast irradiation and avoided aforementioned side effects [1]. Our institute started to perform IORT in low grade breast cancer since 2015. 60 patients received IORT and there were no apparent immediate or delay complication since then. Besides, no local recurrence or distant metastasis was detected during cancer surveillance. IORT is considered as a safe and feasible option in treatment of low grade breast cancer.\",\"PeriodicalId\":22619,\"journal\":{\"name\":\"The Journal of Cancer Research\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Cancer Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12677/WJCR.2018.82011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cancer Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12677/WJCR.2018.82011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
台湾45~69岁女性定期乳房x光检查项目已实施约15年,在早期乳腺癌的发现和降低乳腺癌死亡率方面取得了良好的效果。根据NCCN (National Comprehensive Cancer Network)指南,低级别乳腺癌推荐保乳手术(breast conservation surgery, BCS),因为与根治性乳房切除术相比,保乳手术能提供更好的美容效果和生活质量。在以前的实践中,BCS联合术后全乳照射是低级别乳腺癌的标准治疗方法,因为它提供了与传统乳房切除术相同的总生存率。全乳照射不可避免地会产生一些皮肤并发症,如皮肤纤维化、硬化、毛细血管扩张,甚至导致缺乏弹性的乳头-乳晕复合体色素沉着。此外,它可能导致同侧乳房畸形和改变心理效应。自2012年以来,FDA已批准对接受保乳手术的乳腺癌患者进行术中放疗(IORT)。其安全性与传统手术后全乳照射相同,且避免了上述副作用[1]。我院自2015年开始对低分级乳腺癌进行IORT治疗。60例患者接受IORT治疗,此后无明显的即时或延迟并发症。此外,在肿瘤监测期间未发现局部复发或远处转移。IORT被认为是治疗低级别乳腺癌的一种安全可行的选择。
Regular mammography screening project for Taiwanese women aged 45~69 years has been administered for about 15 years which has achieved a good result in detection of early breast cancer and reduction in breast cancer mortality. According to NCCN (National Comprehensive Cancer Network) guideline, breast conserving surgery (BCS) is recommended for low grade breast cancer, because it provides better cosmetic effect and life quality compared to radical mastectomy. BCS combined with post-operative whole breast irradiation is a standard therapy for low grade breast cancer in previous practice because it provided same overall survival as traditional mastectomy. Inevitably, whole breast irradiation may yield some skin complications such as skin fibrosis, sclerosis, telangiectasia and even cause hyperpigmentation of nipple-areolar complex with lack of elasticity. Moreover, it may result in deformity of ipsilateral breast and alter psychological effect. FDA has approved the administration of intraoperative radiation therapy (IORT) in patients with breast cancer undergoing breast conserving surgery since 2012. It provided same level of safety as traditional post-operative whole breast irradiation and avoided aforementioned side effects [1]. Our institute started to perform IORT in low grade breast cancer since 2015. 60 patients received IORT and there were no apparent immediate or delay complication since then. Besides, no local recurrence or distant metastasis was detected during cancer surveillance. IORT is considered as a safe and feasible option in treatment of low grade breast cancer.