The Indonesian Journal of Infectious Diseases最新文献_第8页

Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection 当在感染的早期阶段开始抗逆转录病毒治疗时，淋巴组织中HIV rna阳性细胞的矛盾性更强

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-11 DOI: 10.1093/infdis/jiac089

E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker

{"title":"Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection","authors":"E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker","doi":"10.1093/infdis/jiac089","DOIUrl":"https://doi.org/10.1093/infdis/jiac089","url":null,"abstract":"Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"15 4 1","pages":"2167 - 2175"},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80399423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evolution of resistance to antibiotics in Neisseria meningitidis: any reasons for concern? 脑膜炎奈瑟菌对抗生素耐药性的演变:有什么值得关注的理由吗?

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-10 DOI: 10.1093/infdis/jiac095

M. Taha, A. Deghmane

引用次数: 1

Reply to Kao and Liaw. 回复高和刘。

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-04 DOI: 10.1093/infdis/jiac081

Valeria Ochoa, F. Erra Díaz, E. Ramírez, María Clara Fentini, M. Carobene, J. Geffner, L. Arruvito, F. Remes Lenicov

引用次数: 0

Infants Younger Than 6 Months Infected With SARS-CoV-2 Show the Highest Respiratory Viral Loads 6个月以下感染SARS-CoV-2的婴儿呼吸道病毒载量最高

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-04 DOI: 10.1093/infdis/jiac080

Chih-Ching Kao, Y. Liaw

引用次数: 0

Group B Streptococcus invasive infections in women of childbearing age, France, 2012 - 2020 : GBS CC-17 hypervirulence in intrapartum infections. 2012 - 2020年法国育龄妇女B族链球菌侵袭性感染:产时感染中的GBS CC-17高毒力

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-02 DOI: 10.1093/infdis/jiac076

C. Plainvert, Yasmina de Saint Salvy-Tabet, N. Dmytruk, A. Frigo, C. Poyart, Asmaa Tazi

引用次数: 0

Novel Hepatic Schistosomula Antigens as Promising Targets for Immunodiagnosis and Immunoprotection of Schistosomiasis japonica. 新型肝血吸虫抗原在日本血吸虫病免疫诊断和免疫保护中的应用前景

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-02 DOI: 10.1093/infdis/jiac077

N. Hou, X. Piao, Ning Jiang, Shuai Liu, Pengfei Cai, Bing Liu, D. McManus, Qijun Chen

引用次数: 1

SARS-CoV-2 nucleocapsid urine antigen in hospitalized patients with Covid-19 新冠肺炎住院患者尿液中SARS-CoV-2核衣壳抗原的研究

The Indonesian Journal of Infectious Diseases Pub Date : 2022-03-01 DOI: 10.1093/infdis/jiac073

N. Veyrenche, A. Pisoni, S. Debiesse, K. Bollore, A. Bedin, A. Makinson, C. Niel, C. Alcocer-Cordellat, A. Mondain, V. Le Moing, P. Van de Perre, E. Tuaillon

{"title":"SARS-CoV-2 nucleocapsid urine antigen in hospitalized patients with Covid-19","authors":"N. Veyrenche, A. Pisoni, S. Debiesse, K. Bollore, A. Bedin, A. Makinson, C. Niel, C. Alcocer-Cordellat, A. Mondain, V. Le Moing, P. Van de Perre, E. Tuaillon","doi":"10.1093/infdis/jiac073","DOIUrl":"https://doi.org/10.1093/infdis/jiac073","url":null,"abstract":"Abstract Background SARS-CoV-2 nucleocapsid antigen (N-Ag) can be detected in the blood of patients with Covid-19. We used a highly sensitive and specific assay to explore the presence of N-Ag in urine during the course of Covid-19, and explore its relationship with the severity of the disease. Methods We studied urine and blood N-Ag using highly sensitive immunoassay in 82 patients with a SARS-CoV-2 infection proven by PCR. Results In the first and second weeks of Covid-19, hospitalized patients tested positive for urinary N-Ag (81.25% and 71.79%, respectively), and blood N-Ag (93.75% and 94.87%, respectively). High urinary N-Ag levels were associated with the absence of SARS-CoV-2 nucleocapsid antibodies, admission in intensive care units, high C-reactive protein levels, lymphopenia, eosinopenia, and high lactate dehydrogenase. A higher accuracy was observed for urine N-Ag as a predictor of severe Covid-19 compared to blood N-Ag. Conclusions Our study demonstrate that N-Ag is present in the urine of patients hospitalized in the early phase of Covid-19. As a direct marker of SARS-CoV-2, urinary N-Ag reflects the dissemination of viral compounds in the body. Urine N-Ag may be a useful marker for disease severity of SARS-CoV-2 infections.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87843622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Response to Cyktor Et Al. 对Cyktor等人的反应。

The Indonesian Journal of Infectious Diseases Pub Date : 2022-02-26 DOI: 10.1093/infdis/jiac070

Martina Bottanelli, D. Ceccarelli, L. Galli, A. Castagna, C. Muccini

引用次数: 0

Tofacitinib Treatment in Primary Herpes Simplex Encephalitis Interferes With Antiviral Response 托法替尼治疗原发性单纯疱疹脑炎干扰抗病毒反应

The Indonesian Journal of Infectious Diseases Pub Date : 2022-02-26 DOI: 10.1093/infdis/jiac040

M. Krzyżowska, Anders Jarneborn, Karolina Thorn, K. Eriksson, T. Jin

{"title":"Tofacitinib Treatment in Primary Herpes Simplex Encephalitis Interferes With Antiviral Response","authors":"M. Krzyżowska, Anders Jarneborn, Karolina Thorn, K. Eriksson, T. Jin","doi":"10.1093/infdis/jiac040","DOIUrl":"https://doi.org/10.1093/infdis/jiac040","url":null,"abstract":"Abstract Tofacitinib, a Janus kinase inhibitor, is a novel immunosuppressive drug for treatment of rheumatoid arthritis. Herpes simplex virus type 1 (HSV-1) may cause encephalitis during primary infection or following reactivation from a latent state. Long-term tofacitinib treatment may increase the risk of this life-threatening condition. The aim of this study was to investigate the effect of tofacitinib on HSV-1 primary infection using a mouse model. Mice pretreated with tofacitinib were intranasally infected with a clinical strain of HSV-1 and monitored for infection severity and antiviral response. Tofacitinib treatment of HSV-1 primary infection resulted in increased viral loads and worsened clinical outcome. Furthermore, tofacitinib promoted M2 anti-inflammatory phenotype of microglia and infiltrating monocytes, as well as inhibited production of inflammatory and antiviral cytokines by macrophages in vitro. Our findings show that treatment with tofacitinib increases severity of herpes simplex encephalitis in mice, by impairing antiviral response induced by monocytes and microglia.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"9 1","pages":"1545 - 1553"},"PeriodicalIF":0.0,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73867558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cross-neutralizing activity against Omicron could be obtained in SARS-CoV-2 convalescent patients who received two doses of mRNA vaccination 接种两剂mRNA疫苗的SARS-CoV-2恢复期患者可获得对Omicron的交叉中和活性

The Indonesian Journal of Infectious Diseases Pub Date : 2022-02-26 DOI: 10.1101/2022.02.24.22271262

Y. Kurahashi, K. Furukawa, S. Sutandhio, L. H. Tjan, S. Iwata, Shigeru Sano, Y. Tohma, Hiroyuki Ohkita, Sachiko Nakamura, M. Nishimura, J. Arii, T. Kiriu, M. Yamamoto, T. Nagano, Y. Nishimura, Y. Mori

引用次数: 5