The Indonesian Journal of Infectious Diseases最新文献

{"title":"Clinical Burden of Respiratory Syncytial Virus in Hospitalized Children Aged ≤5 Years (INSPIRE Study).","authors":"Katrin Hartmann, Johannes G Liese, Daniel Kemmling, Christiane Prifert, Benedikt Weißbrich, Pushpike Thilakarathne, Joris Diels, Karin Weber, Andrea Streng","doi":"10.1093/infdis/jiac137","DOIUrl":"10.1093/infdis/jiac137","url":null,"abstract":"<p><strong>Background: </strong>Respiratory syncytial virus (RSV) is a leading cause of hospitalizations in children (≤5 years of age); limited data compare burden by age.</p><p><strong>Methods: </strong>This single-center retrospective study included children (≤5 years of age) hospitalized for >24 hours with reverse-transcription polymerase chain reaction (RT-PCR)-confirmed RSV infection (2015-2018). Hospital length of stay (LOS), intensive care unit (ICU) admissions, ICU LOS, supplemental oxygen, and medication use were assessed. Multivariate logistic regression analyses identified predictors of hospital LOS >5 days.</p><p><strong>Results: </strong>Three hundred twelve patients had RSV infection (ages 0 to <6 months [35%], 6 to <12 months [15%], 1 to <2 years [25%], and 2-5 years [25%]); 16.3% had predefined comorbidities (excludes preterm infants). Median hospital LOS was 5.0 days and similar across age; 5.1% (16/312) were admitted to ICU (ICU LOS, 5.0 days), with those aged 0 to <6 months admitted most frequently (10/108 [9.3%]). Supplemental oxygen was administered in 57.7% of patients, with similar need across ages. Antibiotics were administered frequently during hospitalization (43.6%). Predictors of prolonged LOS included pneumonia (odds ratio [OR], 2.33), supplemental oxygen need (OR, 5.09), and preterm births (OR, 3.37). High viral load (RT-PCR RSV cycle threshold value <25) was associated with greater need for supplemental oxygen.</p><p><strong>Conclusions: </strong>RSV causes substantial burden in hospitalized children (≤5 years), particularly preterm infants and those aged <6 months.</p>","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"7 1","pages":"386-395"},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90320298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia.","authors":"Julia C Cutts, Katherine O'Flaherty, Sophie G Zaloumis, Elizabeth A Ashley, Jo Anne Chan, Marie A Onyamboko, Caterina Fanello, Arjen M Dondorp, Nicholas P Day, Aung Pyae Phyo, Mehul Dhorda, Mallika Imwong, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M Abdul Faiz, Eizo Takashima, Takafumi Tsuboi, James G Beeson, Francois Nosten, Julie A Simpson, Nicholas J White, Freya J I Fowkes","doi":"10.1093/infdis/jiac232","DOIUrl":"10.1093/infdis/jiac232","url":null,"abstract":"<p><strong>Background: </strong>Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibodies confound parasite clearance measures. However, variation in naturally acquired antibodies across Asian and sub-Saharan African epidemiological contexts and their impact on parasite clearance re yet to be quantified.</p><p><strong>Methods: </strong>In an artemisinin therapeutic efficacy study, antibodies to 12 pre-erythrocytic and erythrocytic P. falciparum antigens were measured in 118 children with uncomplicated P. falciparum malaria in the Democratic Republic of Congo (DRC) and compared with responses in patients from Asian sites, described elsewhere.</p><p><strong>Results: </strong>Parasite clearance half-life was shorter in DRC patients (median, 2 hours) compared with most Asian sites (median, 2-7 hours), but P. falciparum antibody levels and seroprevalences were similar. There was no evidence for an association between antibody seropositivity and parasite clearance half-life (mean difference between seronegative and seropositive, -0.14 to +0.40 hour) in DRC patients.</p><p><strong>Conclusions: </strong>In DRC, where artemisinin remains highly effective, the substantially shorter parasite clearance time compared with Asia was not explained by differences in the P. falciparum antibody responses studied.</p>","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"65 1","pages":"324-331"},"PeriodicalIF":0.0,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85800569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pneumococcal Conjugate Vaccines on Antibiotic-Nonsusceptible Invasive Pneumococcal Disease in the United States.","authors":"Kristina L Bajema, Ryan Gierke, Monica M Farley, William Schaffner, Ann Thomas, Arthur L Reingold, Lee H Harrison, Ruth Lynfield, Kari E Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M Snippes Vagnone, Bernard Beall, Tamara Pilishvili","doi":"10.1093/infdis/jiac154","DOIUrl":"10.1093/infdis/jiac154","url":null,"abstract":"<p><strong>Background: </strong>Antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) incidence declined dramatically in the United States after introduction of pneumococcal conjugate vaccines (PCVs) into the infant immunization schedule (7-valent PCV7 in 2000, replaced by the 13-valent PCV13 in 2010). We evaluated the long-term impact of PCVs on NS-IPD.</p><p><strong>Methods: </strong>We identified IPD cases through the Centers for Disease Control Active Bacterial Core surveillance during 1998-2018. Isolates intermediate or resistant to ≥1 antibiotic class were classified as nonsusceptible. We calculated annual rates of IPD (cases per 100 000 persons).</p><p><strong>Results: </strong>From 1998 through 2018, NS-IPD incidence decreased from 43.9 to 3.2 among children <5 years and from 19.8 to 9.4 among adults ≥65 years. Incidence of vaccine-type NS-IPD decreased in all age groups, whereas incidence of nonvaccine type (NVT) NS-IPD increased in all age groups; the greatest absolute increase in NVT NS-IPD occurred among adults ≥65 years (2.3 to 7.2). During 2014-2018, NVTs 35B, 33F, 22F, and 15A were the most common NS-IPD serotypes.</p><p><strong>Conclusions: </strong>Nonsusceptible IPD incidence decreased after PCV7 and PCV13 introduction in the United States. However, recent increases in NVT NS-IPD, most pronounced among older adults, have been observed. New higher valency PCVs containing the most common nonsusceptible serotypes, including 22F and 33F, could help further reduce NS-IPD.</p>","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"7 1","pages":"342-351"},"PeriodicalIF":0.0,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74948303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Disease Burden of Respiratory Syncytial Virus in Preterm Children in 2019: A Systematic Review and Individual Participant Data Meta-Analysis Protocol.","authors":"Xin Wang, You Li, Ting Shi, Yiming Ma, Bhanu Wahi-Singh, Richard D Riley, Harish Nair","doi":"10.1093/infdis/jiac078","DOIUrl":"10.1093/infdis/jiac078","url":null,"abstract":"<p><p>Existing guidelines on respiratory syncytial virus (RSV) prophylaxis differ greatly by gestational age (GA) and other underlying risk factors, highlighting the data gaps in RSV disease burden among preterm infants. We will conduct a systematic review and individual participant data (IPD) meta-analysis of RSV global disease burden among preterm-born children. Three databases, Medline, Embase, and Global Health, will be searched for relevant studies on RSV disease burden for 2019 or before in preterm-born children published between 1 January 1995 and 31 December 2021. IPD will be sought by contacting the investigators identified from published literature and from existing collaboration networks. One-stage and 2-stage random-effects meta-analyses will be used to combine information from IPD and non-IPD studies to produce summary RSV burden estimates of incidence rate, hospital admission rate, and in-hospital case fatality ratio. The framework will be extended to examine subgroup(s) with the most substantial RSV disease burden.</p>","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"5 1","pages":"S135-S141"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72788629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flipped Inflammatory Time and the Role of Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: Optimizing Tocilizumab Against Coronavirus Disease 2019.","authors":"Pablo Guisado-Vasco, José Aguarles Gorines, María M Carralón González, Gabriel Sotres Fernández, Daniel Carnevali Ruiz","doi":"10.1093/infdis/jiac090","DOIUrl":"10.1093/infdis/jiac090","url":null,"abstract":"<p><p>Use of interleukin (IL-6) inhibitors has become one of the most complicated clinical issues in treating coronavirus disease 2019 (COVID-19). Recently, randomized open-label platform trials have found that IL-6 inhibitors have a beneficial effect on mortality in severe COVID-19. However, several questions arise around their mechanism of action in this disease, as well as how, when, and at which dose they should be used. IL-6 has both proinflammatory and anti-inflammatory effects, which may modulate the course of COVID-19, whose immunopathogenesis is driven by the innate immune system, autoantibodies, and interferon. Given that patients with delayed seroconversion against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein would be at the highest risk of complications beyond the second week of disease, we propose that considering patient serostatus at admission could optimize the use of IL-6 inhibitors in COVID-19. We predict that the net treatment benefits could be higher in the subgroup of patients with delayed seroconversion as compared to those who seroconvert more rapidly after SARS-CoV-2 infection.</p>","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"254 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75936811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profil Tuberkulosis Paru Pada Anak di RSPI Prof. Dr. Sulianti Saroso","authors":"Agatha Nagrintya Ginting, Kriston Silitonga, Suliati Suliati, Farida Murtiani","doi":"10.32667/ijid.v8i1.134","DOIUrl":"https://doi.org/10.32667/ijid.v8i1.134","url":null,"abstract":"Latar belakang: Tuberkulosis (TB) adalah penyakit infeksi menular yang disebabkan oleh Mycobacterium tuberculosis (MTB) dan salah satu dari 10 penyebab kematian di dunia, 11% kasus diantaranya adalah anak-anak. Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui karakteristik, manifestasi klinis, gambaran riwayat kesehatan pasien, pengobatan, dan efek samping obat tuberculosis anak.  Metode: Penelitian deskriptif. Data bersumber dari rekam medik dan form TB 01 periode Januari-Desember 2018. Hasil: Mayoritas pasien adalah anak laki-laki berusia 1-4 tahun. Manifestasi klinis batuk ditemukan sebanyak 71,8%; demam 53,8%; pembesaran KGB 43,6%; dan penurunan berat badan 33,3%. Sebagian besar (84,6%) tidak ada riwayat kontak dengan penderita TB dan 30.8% sudah mendapatkan imunisasi BCG. Sebanyak 46.2% memiliki hasil uji tuberculin positif dan hasil foto gambaran khas TB pada foto thorax. Berdasarkan riwayat kesehatan, 46.2% di antaranya bergizi baik, 89.7% merupakan pasien baru dan hanya 15 anak dengan penyakit penyerta. Pada studi ini, sebagian besar (82,1%) mendapatkan Obat Anti Tuberkulosis (OAT) anak, dengan kombinasi obat HRZ pada tahap intensif 61,5% dengan lama pengobatan 6 bulan sebanyak 48,7%. Kesimpulan: Terdapat variasi spektrum klinis yang luas pada TB anak dengan pengobatan OAT.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81612116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Antara Kadar Vitamin D dengan Derajat Keparahan COVID-19","authors":"Handoko Handoko, Angki Purwanti, Dian Wahyu Tanjungsari, I. Pertiwi, Farida Murtiani","doi":"10.32667/ijid.v8i1.130","DOIUrl":"https://doi.org/10.32667/ijid.v8i1.130","url":null,"abstract":"Latar belakang: Vitamin D merupakan salah satu vitamin yang dapat melalui penghambatan respons sel T helper tipe 1 dan merangsang induksi sel T. Hal ini menunjukkan efek perlindungan vitamin D terhadap status infeksi virus pernapasan pada pasien COVID-19. Tujuan: mengetahui hubungan antara kadar Vitamin D dengan derajat penyakit COVID-19. Metode: rancangan penelitian deskriptif korelasional dengan metode analitik melalui pendekatan cross sectional. Total sampel 547 sampel pasien COVID-19 RSPI Sulianti Saroso periode Maret-Desember Tahun 2020. Hasil: Jumlah pasien rawat inap tahun 2020 sebanyak 547 pasien COVID-19, rata-rata usia 47,74 tahun, jenis kelamin laki-laki (55%), dengan komorbid (penyakit penyerta) (58,7%), rata-rata vitamin D 17.94 ng/ml dalam kategori defisiensi < 20 ng/ml (64,2%), derajat keparahan sedang (81,9%). Hasil uji chi square diperoleh nilai p value 0,518 (> 0,05) dengan menggunakan alpha 5% (0,05) berarti tidak ada hubungan antara Vitamin D dengan derajat keparahan pada pasien COVID-19 Kesimpulan: Kadar Vitamin D tidak berhubungan dengan derajat keparahan COVID-19","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81159628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kematian pada Pasien COVID-19 Berdasarkan Komorbid dan Tingkat Keparahan","authors":"H. Herlina, Anita Puspitasari Dyah Nugroho, Siti Maemun, Intansari Pertiwi, Andi Dala Intan Sapta Nanda, Farida Murtiani","doi":"10.32667/ijid.v8i1.135","DOIUrl":"https://doi.org/10.32667/ijid.v8i1.135","url":null,"abstract":"Latar Belakang:. Penyakit Coronavirus 2019 merupakan penyakit sistem pernapasan yang baru saja muncul dan menjadi pandemi. Indonesia mengalami peningkatan jumlah kasus yang cukup drastis.  Derajat keparahan yang dialami oleh pasien COVID-19 dapat dipengaruhi oleh berbagai hal seperti usia, penyakit komorbid, defisiensi vitamin D, dan obesitas. Penelitian ini bertujuan untuk mengetahui hubungan jumlah komorbid dan derajat keparahan terhadap kematian pada pasien COVID-19. Metode: Penelitian deskriptif analitik dengan rancangan cross sectional. Total sampel 1240 pasien COVID-19 RSPI Sulianti Saroso Tahun 2020 2021. Hasil: Komorbid terbanyak adalah hipertensi dan diabetes melitus, derajat keparahan kategori sedang dan outcome hidup. Hasil analisis ada hubungan antara jumlah komorbid dengan status kematian (OR=1,585). Ada hubungan diabetes melitus dengan status kematian pasien pada pasien COVID-19 (OR=1,927). Ada hubungan antara derajat keparahan dengan status kematian pada pasien COVID-19 (OR=12,699). Kesimpulan: Derajat keparahan, jumlah komorbid dan komorbid diabetes mellitus berhubungan merupakan faktor risiko kematian pada pasien COVID-19.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87532605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penerapan Posisi Pronasi Terhadap Peningkatan Oksigenasi Pada Pasien COVID-19 Dengan Pneumonia","authors":"D. Kurniasih, Fitrian Rayasari, Ahmad Zubairi, S. Suryati, Kunti Wijiarti, Farida Murtiani","doi":"10.32667/ijid.v8i1.133","DOIUrl":"https://doi.org/10.32667/ijid.v8i1.133","url":null,"abstract":"Latar Belakang: Penurunan saturasi pada pasien COVID-19 dengan pneumonia dapat dicegah dengan program pemberian posisi salah satunya posisi pronasi. Penelitian ini bertujuan mengetahui pengaruh posisi pronasi terhadap peningkatan saturasi oksigen pada pasien COVID-19 dengan pneumonia. Metode: Quasi eksperimen pretest tanpa kelompok kontrol. Penelitian dilakukan di 2 RS yaitu RSPI Prof Dr Sulianti Saroso dan RSUD Tarakan pada tanggal 8 Maret- 29 April 2021. Jumlah responden sebanyak 24 orang (RSPI SSS: 8 responden dan RS Tarakan: 16 responden). Hasil: Rata-rata pasien adalah laki-laki (19 orang) berusia 55,54 tahun, tidak ada riwayat DM (14 orang) dan memiliki riwayat hipertensi (17 orang). Sebelum intervensi rata-rata SpO2 96.53% dan RR 25.60 x/menit. Sesudah Intervensi rata – rata SpO2 97.36% dan RR 24.59 x/menit. Ada peningkatan nilai SpO2 sebesar 0.83% (Pvalue=0,000), dan ada penurunan RR 1.01 x/menit (Pvalue-0,000). Kesimpulan: ada pengaruh dari penerapan posisi pronasi terhadap peningkatan oksigenasi pada pasien COVID-19 dengan pneumonia.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"16 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78169743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Kadar Interleukin-6 (IL-6) Dengan Neutrophil Lymphocyte Ratio (NLR) Pada Pasien COVID- 19","authors":"Sriyanto Sriyato, Lyana Setiawan, Rizana Fajrunni’mah, Farida Murtiani","doi":"10.32667/ijid.v8i1.132","DOIUrl":"https://doi.org/10.32667/ijid.v8i1.132","url":null,"abstract":"Latar belakang: COVID-19 menjadi masalah kesehatan di dunia. Penanda inflamasi yang dapat digunakan sebagai predictor prognosis COVID-19 salah satunya Interlukin-6 (IL-6) dan Neutrofil Lymphocyte Ratio (NLR). Tujuan penelitian: mengetahui hubungan kadar IL-6 dengan NLR pada pasien COVID-19. Metode: Penelitian kuantitatif dengan desain cross sectional. Data yang dikumpulkan dari rekam medik pasien COVID-19 di RS Kanker Dharmais periode Januari-Juli 2021. Jumlah sampel sebanyak 70 pasien yang memenuhi kriteria inklusi dan eksklusi. Analisa data dilakukan secara univariat dan bivariat dengan korelasi spearman. Hasil: Dari 70 pasien COVID-19 sebagian besar berusia dalam kategori lansia akhir (56-65 Tahun) 17 (24,3%) dan jenis kelamin sebagian besar laki-laki yaitu 42 (60%). Rata-rata kadar IL-6 43,34 pg/ml dan rata-rata NLR 12,73. Ada korelasi antara kadar IL-6 dengan NLR pada pasien COVID-19 (P Value=0,000; nilai r 0.563). Kesimpulan:  Adanya korelasi positif IL-6 dengan NLR. IL-6 adalah salah satu biomarker yang digunakan untuk memprediksi prognosis COVID-19 karena pemeriksaannya yg kompleks, tidak dapat memprosesnya di lab yg sederhana. Sebagai gantinya, kami menyimpulkan pemeriksaan NLR dapat menjadi biomarker alternatif. ","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75892757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}