E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker
{"title":"当在感染的早期阶段开始抗逆转录病毒治疗时,淋巴组织中HIV rna阳性细胞的矛盾性更强","authors":"E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker","doi":"10.1093/infdis/jiac089","DOIUrl":null,"url":null,"abstract":"Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"15 4 1","pages":"2167 - 2175"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection\",\"authors\":\"E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker\",\"doi\":\"10.1093/infdis/jiac089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.\",\"PeriodicalId\":22572,\"journal\":{\"name\":\"The Indonesian Journal of Infectious Diseases\",\"volume\":\"15 4 1\",\"pages\":\"2167 - 2175\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Indonesian Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiac089\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indonesian Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiac089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection
Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.