当在感染的早期阶段开始抗逆转录病毒治疗时,淋巴组织中HIV rna阳性细胞的矛盾性更强

E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker
{"title":"当在感染的早期阶段开始抗逆转录病毒治疗时,淋巴组织中HIV rna阳性细胞的矛盾性更强","authors":"E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker","doi":"10.1093/infdis/jiac089","DOIUrl":null,"url":null,"abstract":"Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.","PeriodicalId":22572,"journal":{"name":"The Indonesian Journal of Infectious Diseases","volume":"15 4 1","pages":"2167 - 2175"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection\",\"authors\":\"E. Kroon, S. Chottanapund, S. Buranapraditkun, C. Sacdalan, D. Colby, N. Chomchey, P. Prueksakaew, S. Pinyakorn, R. Trichavaroj, S. Vasan, S. Manasnayakorn, C. Reilly, E. Helgeson, Jodi L Anderson, C. David, Jacob J. Zulk, M. de Souza, S. Tovanabutra, A. Schuetz, M. Robb, D. Douek, N. Phanuphak, A. Haase, J. Ananworanich, T. Schacker\",\"doi\":\"10.1093/infdis/jiac089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.\",\"PeriodicalId\":22572,\"journal\":{\"name\":\"The Indonesian Journal of Infectious Diseases\",\"volume\":\"15 4 1\",\"pages\":\"2167 - 2175\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Indonesian Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiac089\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indonesian Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/infdis/jiac089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

摘要

在Fiebig 1型急性HIV感染中开始抗逆转录病毒治疗(ART)限制了淋巴组织中病毒库的大小,但不影响治疗中断期间病毒反弹的时间。为了更好地理解为什么减少的储存库大小没有增加反弹时间,我们测量了RV254急性感染队列参与者淋巴结中HIV RNA+细胞的频率和位置。与Fiebig晚期相比,在Fiebig晚期开始抗逆转录病毒治疗时,在Fiebig 1期检测到更多的HIV RNA+细胞,并且与在Fiebig晚期治疗的b细胞卵泡相比,在t细胞区检测到更多的HIV RNA+细胞。在急性感染期间接受治疗的人群中病毒产生的变异性表明,在感染的早期阶段,病毒产生细胞和清除受感染细胞的免疫反应之间的平衡迅速演变。临床试验注册:NCT02919306。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection
Abstract Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信