The Egyptian Journal of Chemistry最新文献_第6页

In vitro Cytotoxicity, Antimicrobial, Antioxidant Activities and HPLC Finger Print Analyses of the Extracts of Ceiba insignis Leaves Growing in Egypt 埃及产木棉叶提取物体外细胞毒性、抗菌活性、抗氧化活性及HPLC指纹图谱分析

The Egyptian Journal of Chemistry Pub Date : 2021-04-27 DOI: 10.21608/EJCHEM.2021.73023.3618

A. Abdel-Aziz, Mona Abdel-Motagaly, M. A. Abdallah, Rasha Shaaban, N. S. Osman, N. Elwan

{"title":"In vitro Cytotoxicity, Antimicrobial, Antioxidant Activities and HPLC Finger Print Analyses of the Extracts of Ceiba insignis Leaves Growing in Egypt","authors":"A. Abdel-Aziz, Mona Abdel-Motagaly, M. A. Abdallah, Rasha Shaaban, N. S. Osman, N. Elwan","doi":"10.21608/EJCHEM.2021.73023.3618","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.73023.3618","url":null,"abstract":"Polyphenols rich plants can be used to reduce health disorder resulting from cancer and infectious diseases. Methodology: Different solvent extracts of Ceiba insignis leaves were evaluated for their in vitro cytotoxic, antimicrobial, and antioxidant activities, while their chemical profiles were investigated via high‐performance liquid-chromatography (HPLC) -fingerprint analyses. Results: Showed that methanol, butanol, and dichloromethane extracts of Ceiba insignis leaves exhibited a moderate cytotoxicity against HepG2 with IC50 values of 98.54, 75.38, 40.71 μg/ml respectiviely, while petroleum ether and water exhibited weak activity with IC50 values of 118.15 and 170.03 μg/ml respectively and very weak activity was recorded with ethyl acetate extract with IC50 value of 924.05μg. Moreover, methanol, dichloromethane, petroleum ether, and ethyl acetate exhibited strong antimicrobial activities with inhibition zones (20-25 mm), (15-30 mm), (14-16 mm), and (16-28 mm) respectively, while butanol and water exhibited low to moderate activity with inhibition zones (0-18 mm), and (0-16 mm) respectively. On the other side, strong DPPH antioxidant scavenging activity was recorded within petroleum ether extract with IC50 (24.72 μg/ml), while the least antioxidant activity was recorded within ethyl acetate with IC50 (97.50 μg/ml). HPLC fingerprint analyses revealed the presence of major compounds; syringic acid in dichloromethane extract, gallic acid, chlorogenic acid & syringic acid in ethyl acetate extract, and naringenin & gallic acid in methanol, butanol and water extracts, this finding provides an insight into the usage of the tested species as a source of naturally occurring antioxidant, cytotoxic and antimicrobial agents.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74667913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes 新型N2O2四齿希夫碱金属配合物的设计、光谱表征、热、三维分子建模、XRD及体外抗氧化和抗菌筛选

The Egyptian Journal of Chemistry Pub Date : 2021-04-27 DOI: 10.21608/EJCHEM.2021.69667.3539

O. El-Gammal, Hanna El-Boraey, Azza A. Serag El-Din

引用次数: 2

Synthesis, Spectral, Thermal and Biological Studies of Some Transition and Inner Transition Schiff base Metal Complexes 一些过渡和内过渡席夫碱金属配合物的合成、光谱、热及生物学研究

The Egyptian Journal of Chemistry Pub Date : 2021-04-27 DOI: 10.21608/EJCHEM.2021.71817.3578

Eman A. Khalil, W. Mahmoud, M. El-Dessouky, G. Mohamed

{"title":"Synthesis, Spectral, Thermal and Biological Studies of Some Transition and Inner Transition Schiff base Metal Complexes","authors":"Eman A. Khalil, W. Mahmoud, M. El-Dessouky, G. Mohamed","doi":"10.21608/EJCHEM.2021.71817.3578","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.71817.3578","url":null,"abstract":"The new bidentate Schiff base ligand (L) named N1-(diphenylmethylene)naphthalene-1,8-diamine was prepared by the condensation reaction of benzophenone and 1,8-naphthylenediamine. The complexes with Mn(II), Ni(II), Zn(II), La(III), Er(III), and Yb(III) metal ions were prepared and characterized by using elemental analyses (C, H, N and M), FT-IR, 1H NMR, molar conductivity, magnetic moment, UV-Vis, mass and scanning electron microscope (SEM). The temperatures of decomposition of the Schiff base ligand and metal complexes were investigated using thermal analyses. The metal complexes were found to have the formulae [M(L)(H2O)3Cl]Cl.nH2O (M = Mn(II) (n = 4); Ni(II) (n = 2))], [Zn(L)(H2O)2Cl2] and [M(L)(H2O)2Cl2]Cl (M = La(III), Er(III) and Yb(III)) according to the elemental analyses data. The geometrical structure of all complexes was found to be octahedral. The molar conductivity of the complexes in DMF indicated the electrolytic nature of all complexes except Zn(II) complex was non-electrolyte. From the spectroscopic data, the Schiff base ligand acts as NNbidentate ligand. The biological and anticancer activities of the Schiff base ligand and its complexes were investigated against two bacterial strains, two fungal strains and breast cancer cell line (MCF-7). Docking studies were performed to study the possible interaction between the Schiff base ligand with the active sites of the 3HB5 and 5JPE receptors.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80754962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Comparative study for physico - chemical characteristics of crude Moringa Peregrina , Terminalia bellerica and Tiger nut oils 辣木粗油、辣木粗油和虎坚果粗油理化特性的比较研究

The Egyptian Journal of Chemistry Pub Date : 2021-04-25 DOI: 10.21608/EJCHEM.2021.70105.3585

M. Mohamed, A. Soliman, Mohamed Abbas, Hisham Abd el-lateaf, A. Ismael

引用次数: 1

Comparative study of Oxalis L. species growing wild in Egypt: GC-MS analysis and chemosystematic significance 埃及野生酢浆草种的比较研究:GC-MS分析及其化学系统意义

The Egyptian Journal of Chemistry Pub Date : 2021-04-25 DOI: 10.21608/EJCHEM.2021.72328.3592

A. Draz, E. Shamso, H. Hosni, S. Kawashty, S. Hussein

引用次数: 1

Indirect spectrophotometric determination of Mebendazole using n-bromosuccinimide as an oxidant and tartarazine dye as analytical reagent 以n-溴丁二酰亚胺为氧化剂，酒石酸嗪染料为分析试剂，间接分光光度法测定甲苯咪唑的含量

The Egyptian Journal of Chemistry Pub Date : 2021-04-25 DOI: 10.21608/EJCHEM.2021.68614.3509

J. Jamur, S. Abbas, Takleef Sallal

引用次数: 3

Synthesis and characterization of chelating phenolic polymers containing Metoclopramide hydrochloride drugs 盐酸甲氧氯普胺类药物螯合酚醛聚合物的合成与表征

The Egyptian Journal of Chemistry Pub Date : 2021-04-25 DOI: 10.21608/EJCHEM.2021.44696.2908

Sameaa J. Khammas, S. Yosef, T. A. Mahmood, W. Mahmood, Shahad Taher, Muna Abass Hadi

引用次数: 0

Development of an Ecological-friendly Method for Dexamethasone Determination and Cloud Point Extraction in pharmaceutical formulations using Schiff Base Reaction 席夫碱反应中地塞米松测定及浊点萃取的生态友好型方法的建立

The Egyptian Journal of Chemistry Pub Date : 2021-04-23 DOI: 10.21608/EJCHEM.2021.64886.3390

S. A. Dadoosh, M. Thani, A. Abdullah, A. S. Fahad, Y. Fahad

引用次数: 1

Synthesis and antitumor potential of new 7-halocoumarin-4-acetic acid derivatives 新型7-卤代香豆素-4-乙酸衍生物的合成及其抗肿瘤潜力

The Egyptian Journal of Chemistry Pub Date : 2021-04-23 DOI: 10.21608/EJCHEM.2021.68873.3508

Yasser Fakri Mustafa, R. Khalil, E. Mohammed

{"title":"Synthesis and antitumor potential of new 7-halocoumarin-4-acetic acid derivatives","authors":"Yasser Fakri Mustafa, R. Khalil, E. Mohammed","doi":"10.21608/EJCHEM.2021.68873.3508","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.68873.3508","url":null,"abstract":"Compounds having their chemical structure based on coumarin framework have enticed much research concern not only because of the variance structural characteristic but also the pluralism of the bioactivities. In this report, four derivatives of 7halo-4-coumarinylacetic acid referred to as RY1-RY4 were synthesized, and their chemical backbones were confirmed via the employed spectrophotometers. The pharmacokinetic profiles of the synthesized halocoumarins were inspected in silico using a free online software named the pre-ADMET program. The potential of the synthesized halocoumarins as antitumor applicants was evaluated utilizing 5-fluorouracil as a reference drug and the well-authenticated protocol based on the MTT as a visible indicator against eight standard tumor-cell lines. The outcomes acquired from this assessment indicated that the synthesized halocoumarins, except RY1, have less impact as antitumor agents comparing with the standard drug. Also, the halocoumarins revealed roughly the same fashion of activity versus the test cell lines with the greatest inhibitory influence reported against MCF-7 and HeLa. From the calculated pharmacokinetic data and outcomes exhibited from antitumor assessment, the authors concluded that the synthesized halocoumarins, particularly RY1, offered potential applicants as antitumor agents with broad-ranged activity. Besides, the compounds RY1 and RY2 may provide highly valuable scaffolds for synthesizing agents with a powerful antitumor activity versus the breast and cervical cancer phenotypes.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84272890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Spectrophotometric Determination of carvedilol Via Oxidative Coupling Reaction 氧化偶联分光光度法测定卡维地洛的含量

The Egyptian Journal of Chemistry Pub Date : 2021-04-23 DOI: 10.21608/EJCHEM.2021.57506.3253

D. Mohammed, F. Omar

引用次数: 3