The clinical investigator最新文献_第7页

Plasma lipids and lipoproteins and essential hypertension. 血浆脂质和脂蛋白与原发性高血压。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577733

M Flesch, A Sachinidis, Y D Ko, K Kraft, H Vetter

{"title":"Plasma lipids and lipoproteins and essential hypertension.","authors":"M Flesch, A Sachinidis, Y D Ko, K Kraft, H Vetter","doi":"10.1007/BF00577733","DOIUrl":"https://doi.org/10.1007/BF00577733","url":null,"abstract":"In recent years there have been many studies demonstrating a correlation between increased arterial blood pressure and altered lipid profiles, and there has been an especially positive correlation between high cholesterol levels and blood pressure. There are differences between the various reports that are important. In our study the lipid distribution in 105 hypertensive patients with mild or moderate arterial hypertension according to WHO criteria without clinically or ultrasonographically apparent atherosclerosis was compared to the lipid distribution in 65 age-matched healthy persons. On the epidemiological level a significant, positive association was found between LDL serum levels (P < or = 0.001), Apo B serum levels (P < or = 0.001), serum triglyceride levels (P < or = 0.05) and VLDL serum levels (P < or = 0.01) and arterial hypertension. However, in contrast to recent reports, no significant difference was found between total serum cholesterol levels in normotensives and hypertensives, and there was no difference in HDL serum levels. No evidence could be found for a significant increase in lipoprotein (a) serum levels in hypertensives.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18713214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Limited trypsin proteolysis renders carnitine palmitoyltransferase insensitive to inhibition by malonyl-CoA in patients with muscle carnitine palmitoyltransferase deficiency. 有限的胰蛋白酶蛋白水解使肉毒碱棕榈酰基转移酶对肌性肉毒碱棕榈酰基转移酶缺乏症患者丙二酰辅酶a的抑制不敏感。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577735

S Zierz

引用次数: 7

Effects of captopril treatment versus placebo on renal function in type 2 diabetic patients with microalbuminuria: a long-term study. 卡托普利治疗与安慰剂对2型糖尿病伴微量白蛋白尿患者肾功能的影响:一项长期研究

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577736

M Capek, C Schnack, B Ludvik, A Kautzky-Willer, M Banyai, R Prager

{"title":"Effects of captopril treatment versus placebo on renal function in type 2 diabetic patients with microalbuminuria: a long-term study.","authors":"M Capek, C Schnack, B Ludvik, A Kautzky-Willer, M Banyai, R Prager","doi":"10.1007/BF00577736","DOIUrl":"https://doi.org/10.1007/BF00577736","url":null,"abstract":"We evaluated the renal effect of long-term antihypertensive treatment (12 months) with the angiotensin-converting enzyme inhibitor captopril compared to placebo in 15 type 2 diabetic patients with microalbuminuria. The patients were randomly allocated to captopril (n = 9) or placebo (n = 6). After 1-year therapy no significant decrease in blood pressure was demonstrated with captopril (139 +/- 17/80 +/- 9 versus 138 +/- 13/76 +/- 6 mmHg) or placebo (138 +/- 9/75 +/- 6 versus 135 +/- 14/79 +/- 10 mmHg). Only in a small hypertensive subgroup (n = 4) treated with captopril did we find a significant reduction in blood pressure (154 +/- 2/88 +/- 1 versus 142 +/- 7/78 +/- 5 mmHg, P < 0.05). The urinary albumin excretion rate did not change significantly either in the captopril group (95.6 mg/24 h, 25th percentile 138.4, 75th percentile 25.1; versus 127.8 mg/24 h, 25th percentile 29.3, 75th percentile 222) or in the placebo group (99.2 mg/24 h, 25th percentile 58.5, 75th percentile 125.8; versus 120.9 mg/24 h, 25th percentile 62.1, 75th percentile 179.7). There were also no alterations in renal blood flow or filtration rate. In the hypertensive subgroup treated with captopril a reduction in urinary albumin excretion rate after 3 and 6 months of treatment was observed (captopril 73.4 versus 24 and 41 mg/24 h, P < 0.05), but not after 12 months. Triglyceride and cholesterol levels remained constant before and after treatment while glycosylated hemoglobin decreased significantly after 12 months captopril (7.8 +/- 0.9 versus 6.9 +/- 0.7 mg%, P < 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18713217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Treatment of atypical leishmaniasis with interferon gamma resulting in progression of Kaposi's sarcoma in an AIDS patient. 用干扰素治疗非典型利什曼病导致艾滋病患者卡波西肉瘤进展。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577752

H Albrecht, H J Stellbrink, G Gross, B Berg, U Helmchen, H Mensing

引用次数: 13

Effectiveness of prophylactic therapy on goiter recurrence in an area with low iodine intake--a sonographic follow-up study. 预防治疗对低碘摄入地区甲状腺肿复发的有效性——超声随访研究

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577737

A H Rzepka, K Cissewski, T Olbricht, D Reinwein

{"title":"Effectiveness of prophylactic therapy on goiter recurrence in an area with low iodine intake--a sonographic follow-up study.","authors":"A H Rzepka, K Cissewski, T Olbricht, D Reinwein","doi":"10.1007/BF00577737","DOIUrl":"https://doi.org/10.1007/BF00577737","url":null,"abstract":"There is no agreement as to whether or not drug treatment after surgery for nodular goiter is effective in preventing recurrence of goiter. Data about recurrences in areas of marginally low iodine intake (like Germany) vary widely. Therefore, we performed a retrospective study in 104 patients who had been treated surgically because of benign uninodular or multinodular goiter. The mean follow-up period was 6.4 years (minimal 1 year) with at least three examinations. Thyroid ultrasound with volumetric analysis was recorded in each patient. Thirty-two patients did not receive any prophylaxis, 50 patients were treated with L-thyroxine, 17 patients with a combination of L-thyroxine and iodine and 5 patients with iodine alone. Recurrence of goiter was documented in 28.0% of the untreated patients and in 8.9% of the patients on prophylaxis (P < 0.05). The mean increase of thyroid volume was 7.3 ml versus 3.1 ml in patients without versus with prophylactic drug treatment (not significant). No significant correlation was found between the increase of thyroid volume and age of the patients, follow-up time, or initial thyroid volume, respectively. These data clearly demonstrate the effectiveness of prophylactic drug therapy to prevent recurrence of goiter after thyroid surgery in an iodine-deficient area.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18713218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cauda equina syndrome with multiple lumbar diverticula complicating long-standing ankylosing spondylitis. 马尾综合征合并多发性腰椎憩室并发长期强直性脊柱炎。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577755

R Schröder, H Urbach, S Zierz

引用次数: 8

Serum amyloid A protein (SAA): a marker for liver allograft rejection in humans. 血清淀粉样蛋白A (SAA):人类同种异体肝移植排斥反应的标志物。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577745

G Feussner, C Stech, J Dobmeyer, H Schaefer, G Otto, R Ziegler

引用次数: 13

Lecithin-cholesterol acryltransferase activity in patients with coronary artery disease examined by coronary angiography. 冠状动脉造影检查冠心病患者卵磷脂-胆固醇丙烯转移酶活性

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577734

N Solajić-Bozicević, A Stavljenić-Rukavina, M Sesto

{"title":"Lecithin-cholesterol acryltransferase activity in patients with coronary artery disease examined by coronary angiography.","authors":"N Solajić-Bozicević, A Stavljenić-Rukavina, M Sesto","doi":"10.1007/BF00577734","DOIUrl":"https://doi.org/10.1007/BF00577734","url":null,"abstract":"This study grew out of observations of certain lecithin:cholesterol acyltransferase (LCAT) abnormalities in patients with atherosclerosis. We studied the interrelationships among LCAT, and total cholesterol, free and esterified cholesterol, cholesterol in individual lipoprotein fractions, triglycerides, phospholipids, free fatty acids, L-lactates in 90 angiographically examined patients with coronary artery disease and 30 control subjects without clinical manifestations of coronary artery disease. Results of the study showed LCAT activity to be significantly decreased (P < 0.05) in patients with single-, double-, or triple-vessel disease than in disease-free subjects. LCAT was also found to follow the stage of coronary artery disease in angiographically examined patients. Decreased LCAT activity was accompanied by lower high-density lipoprotein cholesterol, elevated ratio of unesterified to esterified cholesterol, and increased levels of L-lactates, free fatty acids, and low-density lipoprotein cholesterol. Total cholesterol and triglycerides were within or slightly above the normal limits. The results show LCAT to be a significantly better indicator of the risk of coronary artery disease than either total cholesterol or triglycerides.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18713215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Two cases of neurological manifestations in eosinophilia: variations of one disease? 嗜酸性粒细胞增多症的两例神经学表现:一种疾病的变异?

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577756

S Ostrowitzki, S Zierz

引用次数: 1

Comparison between ethanol sclerotherapy and emptying with injection of saline in treatment of thyroid cysts. 乙醇硬化疗法与生理盐水排空治疗甲状腺囊肿的比较。

The clinical investigator Pub Date : 1994-12-01 DOI: 10.1007/BF00577738

A Antonelli, A Campatelli, A Di Vito, B Alberti, V Baldi, G Salvioni, P Fallahi, L Baschieri

{"title":"Comparison between ethanol sclerotherapy and emptying with injection of saline in treatment of thyroid cysts.","authors":"A Antonelli, A Campatelli, A Di Vito, B Alberti, V Baldi, G Salvioni, P Fallahi, L Baschieri","doi":"10.1007/BF00577738","DOIUrl":"https://doi.org/10.1007/BF00577738","url":null,"abstract":"We compared the results of ethanol sclerotherapy in thyroid cysts with emptying of cysts and instillation of saline. Twenty-six patients with recurrent thyroid cysts were treated with cyst aspiration and subsequent ethanol sclerotherapy. A control group of 44 patients was submitted to cyst aspiration and subsequent injection with isotonic saline; among them 20 had previously been treated with repeated aspirations of the cyst fluid. The patients were followed up clinically and ultrasonically 1 and 12 months after treatment. Cure was defined as the absence of any residual cystic lesion or an ultrasonic cyst volume less than 50% of basal after 12 months from the start of treatment. Cytological study showed all of the lesions to be benign. Of the 44 patients in the saline group 16 (36%) were cured, among whom 6 of 20 had previously been submitted to repeated aspirations. Among the 26 patients treated with ethanol sclerotherapy 20 (77%) were cured. Statistical analysis revealed a significantly higher effectiveness of treatment with ethanol than that with emptying and saline instillation (chi-square, P = 0.002) or with repeated aspiration and saline instillation (chi-square, P = 0.003). Slight pain was observed in two patients treated with saline and five treated with ethanol sclerotherapy. Three patients treated with ethanol sclerotherapy presented severe pain and one transitory hyperthyroidism. We conclude that ethanol sclerotherapy is effective and safe in the treatment of thyroid cysts.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00577738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18713219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46