The clinical investigator最新文献_第10页

Attempted protection of spermatogenesis from irradiation in patients with seminoma by D-Tryptophan-6 luteinizing hormone releasing hormone. 尝试用d -色氨酸-6黄体生成素释放激素保护精原细胞瘤患者的精子发生。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190737

W Brennemann, K A Brensing, N Leipner, I Boldt, D Klingmüller

{"title":"Attempted protection of spermatogenesis from irradiation in patients with seminoma by D-Tryptophan-6 luteinizing hormone releasing hormone.","authors":"W Brennemann, K A Brensing, N Leipner, I Boldt, D Klingmüller","doi":"10.1007/BF00190737","DOIUrl":"https://doi.org/10.1007/BF00190737","url":null,"abstract":"Possible protective effects of D-Tryptophan-6 luteinizing hormone releasing hormone (D-Trp-6-LH-RH) against irradiation-induced testicular damage were investigated for the first time in patients with seminoma. After unilateral orchiectomy 12 men were allocated to receive the long-acting gonadotropin releasing hormone (GnRH) agonist D-Trp-6-LH-RH prior to and for the duration of radiotherapy. Eight patients with the same disease served as a control group. In contrast to several trials to protect spermatogenesis from chemotherapy by GnRH agonists, we first suppressed the pituitary-testicular axis before starting the treatment. As a new schedule this adjuvant GnRH agonist treatment was combined with cyproterone acetate for the first 20 days to diminish the amount and the duration of the initial stimulation of gonadotropins and testosterone. Irradiation started after suppression of the pituitary-gonadal axis. In all patients luteinizing hormone and testosterone were completely suppressed throughout the treatment compared to the controls, whereas the initial suppression of follicle-stimulating hormone was not completely maintained until radiotherapy was completed. At the follow-up at 18 months after completion of therapy, all patients reached their initial concentration of gonadotropins, testosterone, and motile spermatozoa independently of D-Trp-6-LH-RH treatment. With the dose and schedule investigated, the GnRH agonist showed no protective effects against testicular damage caused by radiotherapy.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00190737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18892464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Budd-Chiari syndrome and Epstein-Barr virus (EBV) associated plasmacytoma in a patient with chronic active EBV infection. 慢性活动性EBV感染患者的Budd-Chiari综合征和eb病毒(EBV)相关浆细胞瘤

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190746

S Nagafuchi, H Ishibashi, K Anzai, K Ohshima, Y Ohno, N Fukushima, M Hashizume, K Sugimachi, H Chuman, M Kikuchi

引用次数: 2

Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors. 多囊卵巢综合征高胰岛素血症:与临床和激素因素的关系。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190740

A Vidal-Puig, M Muñoz-Torres, E Jodar-Gimeno, C García-Calvente, P Lardelli, M E Ruiz-Requena, F Escobar-Jiménez

{"title":"Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors.","authors":"A Vidal-Puig, M Muñoz-Torres, E Jodar-Gimeno, C García-Calvente, P Lardelli, M E Ruiz-Requena, F Escobar-Jiménez","doi":"10.1007/BF00190740","DOIUrl":"https://doi.org/10.1007/BF00190740","url":null,"abstract":"We analyzed the association between hyperandrogenism and hyperinsulinemia, and their relationship to body mass index, in a large series of patients with polycystic ovary syndrome (PCOS). A characteristic hormonal profile was sought in women with marked hyperinsulinemia. The patient group consisted of 73 women with PCOS, ranging in age from 16 to 29 years. The control group consisted of 34 healthy women with no evidence of hyperandrogenism, aged 19-30 years. None of the patients or control women had a body mass index above 27 kg/m2. Follicle-stimulating hormone, luteinizing hormone, prolactin, testosterone, estradiol, androstenedione, dehydroepiandrosterone sulfate, sex hormone binding globulin, 17-hydroxyprogesterone, and free cortisol were determined by radioimmunoassay. The free testosterone index was calculated. The oral glucose tolerance test was used to analyze basal insulinemia, maximum insulin peak, and the insulinemia/glycemia index. In the group with PCOS body mass index was greater, free testosterone index was higher, and levels of dehydroepiandrosterone sulfate, testosterone, 17-hydroxyprogesterone (P < 0.001) and androstenedione (P < 0.05) were higher than in the control group. Of the insulin parameters, basal insulinemia, maximum insulin peak, and insulinemia/glycemia index were higher in the patient group (P < 0.001). In patients with marked insulinemia, free testosterone index was more markedly elevated, and gonadotrophin levels were normal. Our data confirm that a characteristic pattern of hyperinsulinemia is associated with PCOS. We found no causal relationship between hyperinsulinemia and androgen levels. A characteristic hormonal pattern was found in patients with marked hyperinsulinemia.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00190740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18892425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Aspergillus pneumonia successfully treated with itraconazole in a patient with systemic lupus erythematosus. 伊曲康唑成功治疗系统性红斑狼疮患者的曲霉性肺炎。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190752

J Collazos, E Martínez, M Flores, J Mayo

引用次数: 4

Evidence for cardiovascular remodeling in a patient with Bartter's syndrome. Bartter综合征患者心血管重构的证据。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190744

U Schmitz, Y Ko, H Becher, M Ludwig, H Vetter, R Düsing

{"title":"Evidence for cardiovascular remodeling in a patient with Bartter's syndrome.","authors":"U Schmitz, Y Ko, H Becher, M Ludwig, H Vetter, R Düsing","doi":"10.1007/BF00190744","DOIUrl":"https://doi.org/10.1007/BF00190744","url":null,"abstract":"In a 56-year-old normotensive white male subject with a 12-year history of hypokalemic alkalosis, hyperreninemia, and aldosteronism, the diagnosis of Bartter's syndrome was established on the basis of an impaired maximal renal diluting capacity and decreased distal fractional chloride absorption [CH2O/(CH2O+CCl)]. Negative urine analysis for diuretics suggested that this renal tubular defect was not secondary to diuretic (ab)use. In this normotensive patient with hyperreninemia and secondary aldosteronism, significant cardiovascular remodeling could be observed. Thus, in spite of normal arterial blood pressure and normal left ventricular systolic function (ejection fraction > 70%), impaired left ventricular diastolic function was observed using pulsed-wave Doppler echocardiography. Moreover, duplex analysis of the common carotid artery revealed significant intima-media hypertrophy with an average intima-media diameter of 0.9 mm (normal < or = 0.6 mm). Also, forearm venous occlusion plethysmography revealed an abnormally high minimal forearm vascular resistance following a 10-min period of forearm ischemia handgrip exercise suggesting remodeling within the peripheral arterioles. Thus, in a patient with Bartter's syndrome and activated neurohormonal systems such as the renin-angiotensin system, cardiac and vascular remodeling can be observed in the absence of hypertension. In analogy to the results of experimental studies showing that angiotensin II and noradrenaline act as growth factors on cardiac and vascular cells, cardiovascular remodeling present in our patient with Bartter's syndrome may be explained by increased activity of angiotensin II and/or noradrenaline.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00190744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18892972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Decrease in androgen binding and effect of androgen treatment in a case of X-linked bulbospinal neuronopathy. 1例x连锁球脊髓神经病变雄激素结合降低及雄激素治疗的效果。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190748

A Danek, T N Witt, K Mann, H U Schweikert, G Romalo, A R La Spada, K H Fischbeck

引用次数: 17

Effect of chronic nicotine delivery on the proliferation rate of endothelial and smooth muscle cells in experimentally induced vascular wall plaques. 慢性尼古丁对实验性血管壁斑块内皮细胞和平滑肌细胞增殖速率的影响。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190750

T Strohschneider, M Oberhoff, H Hanke, A Hannekum, K R Karsch

{"title":"Effect of chronic nicotine delivery on the proliferation rate of endothelial and smooth muscle cells in experimentally induced vascular wall plaques.","authors":"T Strohschneider, M Oberhoff, H Hanke, A Hannekum, K R Karsch","doi":"10.1007/BF00190750","DOIUrl":"https://doi.org/10.1007/BF00190750","url":null,"abstract":"To study the effect of nicotine, cholesterol feeding, and their combination on endothelial and smooth muscle cells in vascular wall plaques an experimental method was established which allows the immunohistochemical detection and quantification of the fractions of endothelial and smooth muscle cells in DNA synthesis under the effect of these stimuli. For this purpose standardized fibromuscular plaques were produced by electrostimulation in the common carotid arteries of rabbits. The animals received either nicotine via implanted osmotic minipumps or a cholesterol diet or both. Plaque size was determined at the end of the experiments after 7 or 14 days as well as the fraction of endothelial and smooth muscle cells in DNA synthesis during exposure to bromodeoxyuridine (BrdU). The BrdU labeling index of endothelial cells clearly increased under chronic nicotine administration for either 7 days or 14 days compared to controls. The combination of nicotine and cholesterol diet led to a more significant increase. In contrast, the BrdU labeling index of smooth muscle cells was not increased under nicotine delivery. The combination of nicotine and cholesterol, however, led to a significant increase of the BrdU labeling index of smooth muscle cells in the plaques compared to cholesterol feeding. Measurement of the plaque size revealed no difference between controls and nicotine-treated animals after 14 days of nicotine delivery, whereas the combination of cholesterol and nicotine produced increased plaque formation compared to a group of animals which received a cholesterol diet alone.","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00190750","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18891658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Successful treatment of meningoencephalitis caused by Mycobacterium avium intracellulare in AIDS. 艾滋病细胞内鸟分枝杆菌所致脑膜脑炎的成功治疗。

The clinical investigator Pub Date : 1994-11-01 DOI: 10.1007/BF00190739

R Malessa, H C Diener, T Olbricht, B Böhmer, N H Brockmeyer

引用次数: 5

Impact of long-term hemodialysis on nutritional status in patients with end-stage renal failure. 长期血液透析对终末期肾功能衰竭患者营养状况的影响。

The clinical investigator Pub Date : 1994-10-01 DOI: 10.1007/BF00180542

P Kaufmann, K H Smolle, J H Horina, R Zach, G J Krejs

{"title":"Impact of long-term hemodialysis on nutritional status in patients with end-stage renal failure.","authors":"P Kaufmann, K H Smolle, J H Horina, R Zach, G J Krejs","doi":"10.1007/BF00180542","DOIUrl":"https://doi.org/10.1007/BF00180542","url":null,"abstract":"We evaluated the way in which duration of hemodialysis treatment affects nutritional status in 96 end-stage renal failure patients. According to the length of previous hemodialysis treatment patients were divided into the groups: onset hemodialysis (ON-HD), early-stage hemodialysis (ES-HD, 1-8 months), mid-stage hemodialysis (MS-HD, 9-69 months), and advanced-stage hemodialysis (AS-HD, 70-207 months). Nutritional status was assessed by laboratory data (serum proteins, total lymphocyte count), intradermal skin antigen testing, anthropometric measurements (body mass index [BMI], infrared interactance), and records of food intake. ON-HD patients on a low-protein diet exhibited abnormally low values for serum total protein, albumin, transferrin, and total lymphocyte count and a high prevalence of anergy to skin antigens (69%). In the ES-HD and MS-HD groups values for serum proteins and total lymphocyte count were in the normal range and significantly higher than in ON-HD patients. In addition, a lower proportion of cutaneous anergy was observed (50% and 27%, respectively). Long-term hemodialysis therapy for 6-17 years (AS-HD) was associated with normal levels for all measured serum proteins. Subnormal levels of total lymphocyte count, significantly lower than in MS-HD patients, were associated with an increase in anergy to skin antigens (46%). Serum prealbumin, complement C3c, BMI, body fat, and lean body mass exhibited normal values in all patients and showed no differences between groups. These results indicate that diminished visceral protein stores, lymphopenia, and anergy to skin antigens are widespread in undialyzed uremic patients with end-stage renal failure but become uncommon after the initiation of regular hemodialysis therapy.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00180542","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18865607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Carotid artery stenosis and tachyarrhythmias: regional cerebral blood flow during high-rate ventricular pacing after one vessel occlusion in rats. 颈动脉狭窄和快速心律失常:大鼠单根血管闭塞后高速率心室起搏时的局部脑血流。

The clinical investigator Pub Date : 1994-10-01 DOI: 10.1007/BF00180546

A Hagendorff, C Dettmers, P Danos, S Wetter, M Lassau, L Pizzulli, H Omran, T Bauer, A Hartmann, B Lüderitz

{"title":"Carotid artery stenosis and tachyarrhythmias: regional cerebral blood flow during high-rate ventricular pacing after one vessel occlusion in rats.","authors":"A Hagendorff, C Dettmers, P Danos, S Wetter, M Lassau, L Pizzulli, H Omran, T Bauer, A Hartmann, B Lüderitz","doi":"10.1007/BF00180546","DOIUrl":"https://doi.org/10.1007/BF00180546","url":null,"abstract":"The aim of the present study was to investigate the effect of hypotensive tachycardias on cerebral blood flow (CBF) in the presence of significant carotid stenosis. The experiments were performed in 57 spontaneously breathing rats during arterial normoxia and normocapnia anesthetized with thiobarbital. CBF was determined with radiolabeled microspheres during control conditions (normofrequent sinus rhythm, normotension; group A; n = 15), during high-rate left ventricular pacing (660-840 ppm) at normotension (group B1; n = 13), borderline hypotension (group B2; n = 15) and severe hypotension (group B3; n = 7). In addition, CBF measurements were performed during borderline hypotension induced by hemorrhage (group C; n = 7). Global CBF was 1.09 +/- 0.29 ml g-1 min-1 in group A, 0.93 +/- 0.40 in group B1, 0.68 +/- 0.31 in group B2 (P < 0.05 vs. A), 0.42 +/- 0.16 in group B3 (P < 0.05 vs. A) and 0.83 +/- 0.2 in group C. The highest CBF values were found in the cerebellum (A; 1.43 +/- 0.5 ml g-1 min-1) and the lowest in the postocclusive tissue of the ipsilateral hemisphere (A; 0.74 +/- 0.2 ml g-1 min-1). In all groups a 15% mean CBF reduction in the right hemispherical cerebrum in comparison to the left hemisphere was observed (P < 0.01). In contrast, hemispherical CBF of the cerebellum did not differ. The CBF blood pressure relationship shifted to lower CBF values, the threshold of CBF regulation shifted to higher blood pressure values in the tissue regions distal to the occluded vessel during hypotensive tachycardias.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":22408,"journal":{"name":"The clinical investigator","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00180546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18865611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1