颈动脉狭窄和快速心律失常:大鼠单根血管闭塞后高速率心室起搏时的局部脑血流。

A Hagendorff, C Dettmers, P Danos, S Wetter, M Lassau, L Pizzulli, H Omran, T Bauer, A Hartmann, B Lüderitz
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引用次数: 1

摘要

本研究的目的是探讨在颈动脉明显狭窄的情况下,低血压心动过速对脑血流量(CBF)的影响。实验于57只经硫巴比妥麻醉的动脉常氧、常氧状态下自主呼吸的大鼠进行。在控制条件下(窦性心律正常,血压正常;A组;n = 15),正常血压下高速率左心室起搏(660-840 ppm)时(B1组;n = 13)、边缘性低血压(B2组;n = 15)和严重低血压(B3组;n = 7)。此外,在出血引起的交界性低血压期间进行CBF测量(C组;A组CBF为1.09 +/- 0.29 ml g-1 min-1, B1组为0.93 +/- 0.40,B2组为0.68 +/- 0.31 (P < 0.05), B3组为0.42 +/- 0.16 (P < 0.05), c组为0.83 +/- 0.2,CBF值最高的部位为小脑(A;1.43 +/- 0.5 ml g-1 min-1),同侧半球闭后组织最低(A;0.74±0.2 ml g-1分钟-1)。在所有组中,右半脑的CBF平均比左半球减少15% (P < 0.01)。相比之下,小脑半球CBF没有差异。在低血压心动过速期间,CBF血压关系转向较低的CBF值,CBF调节阈值转向闭塞血管远端组织区域的较高血压值。(摘要删节250字)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carotid artery stenosis and tachyarrhythmias: regional cerebral blood flow during high-rate ventricular pacing after one vessel occlusion in rats.

The aim of the present study was to investigate the effect of hypotensive tachycardias on cerebral blood flow (CBF) in the presence of significant carotid stenosis. The experiments were performed in 57 spontaneously breathing rats during arterial normoxia and normocapnia anesthetized with thiobarbital. CBF was determined with radiolabeled microspheres during control conditions (normofrequent sinus rhythm, normotension; group A; n = 15), during high-rate left ventricular pacing (660-840 ppm) at normotension (group B1; n = 13), borderline hypotension (group B2; n = 15) and severe hypotension (group B3; n = 7). In addition, CBF measurements were performed during borderline hypotension induced by hemorrhage (group C; n = 7). Global CBF was 1.09 +/- 0.29 ml g-1 min-1 in group A, 0.93 +/- 0.40 in group B1, 0.68 +/- 0.31 in group B2 (P < 0.05 vs. A), 0.42 +/- 0.16 in group B3 (P < 0.05 vs. A) and 0.83 +/- 0.2 in group C. The highest CBF values were found in the cerebellum (A; 1.43 +/- 0.5 ml g-1 min-1) and the lowest in the postocclusive tissue of the ipsilateral hemisphere (A; 0.74 +/- 0.2 ml g-1 min-1). In all groups a 15% mean CBF reduction in the right hemispherical cerebrum in comparison to the left hemisphere was observed (P < 0.01). In contrast, hemispherical CBF of the cerebellum did not differ. The CBF blood pressure relationship shifted to lower CBF values, the threshold of CBF regulation shifted to higher blood pressure values in the tissue regions distal to the occluded vessel during hypotensive tachycardias.(ABSTRACT TRUNCATED AT 250 WORDS)

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